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FOLOTYN (pralatrexate)
- Peripheral t-cell lymphoma
20 mg/mL (1 mL) intravenous solution
- Inject 30 mg/m2 over 3-5 minute(s) by intravenous route every 7 days for 6 weeks of each 7-week treatment cycle
40 mg/2 mL (20 mg/mL) intravenous solution
- Inject 30 mg/m2 over 3-5 minute(s) by intravenous route every 7 days for 6 weeks of each 7-week treatment cycle
Peripheral t-cell lymphoma
- Inject 30 mg/m2 over 3-5 minute(s) by intravenous route every 7 days for 6 weeks of each 7-week treatment cycle
- Infuse 30 mg/m2 over 3-5 minute(s) by intravenous route every 7 days for 6 weeks of each 7-week treatment cycle
- Inject 20 mg/m2 over 3-5 minute(s) by intravenous route every 7 days for 6 weeks of each 7-week treatment cycle
- Infuse 20 mg/m2 over 3-5 minute(s) by intravenous route every 7 days for 6 weeks of each 7-week treatment cycle
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- BCG vaccine, live (PF)
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- natalizumab
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- Tysabri
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- Advil
- Advil Allergy Sinus
- Advil Allergy-congestion Rlf
- Advil Cold & Sinus
- Advil Congestion Relief
- Advil Liqui-gel
- Advil Migraine
- Advil Pm
- Advil Pm Liqui-gels
- Aleve
- Aleve Cold & Sinus
- Aleve Sinus & Headache
- Aleve-d Sinus & Cold
- Aleve-d Sinus & Headache
- All Day Pain Relief
- All Day Pain Relief Sinus & Co
- All Day Relief
- Anaprox
- Anaprox Ds
- Ansaid
- Arthrotec 50
- Azulfidine
- Azulfidine En-tabs
- Bactrim
- Bactrim Ds
- Caldolor
- Cambia
- Cataflam
- Child Ibuprofen
- Children's Advil
- Children's Ibu-drops
- Children's Ibuprofen
- Children's Medi-profen
- Children's Motrin
- Children's Profen Ib
- chlorphen-phenyleph-ibuprofen
- chlorphen-pseudoeph-ibuprofen
- clozapine
- Clozaril
- colchicine-probenecid
- Cold & Sinus Pain Relief
- Cold-sinus Relief
- Daypro
- deferiprone
- diclofenac epolamine
- diclofenac potassium
- diclofenac sodium
- diclofenac submicronized
- diclofenac-misoprostol
- Duexis
- Ec-naprosyn
- erythromycin-sulfisoxazole
- etodolac
- Fazaclo
- Feldene
- fenoprofen
- Ferriprox
- Flanax
- Flector
- flurbiprofen
- hydrocodone-ibuprofen
- I-prin
- Ibu-drops
- Ibudone
- ibuprofen
- Ibuprofen Cold
- Ibuprofen Cold-sinus(with Pse)
- Ibuprofen Ib
- Ibuprofen Jr Strength
- ibuprofen lysine (PF)
- Ibuprofen Pm
- ibuprofen-diphenhydramine
- ibuprofen-diphenhydramine HCl
- ibuprofen-famotidine
- ibuprofen-oxycodone
- ibuprofen-phenylephrine HCl
- Indocin
- indomethacin
- indomethacin sodium
- Infant's Ibuprofen
- Infant's Medi-profen
- Infant's Motrin
- Infants Ibu-drops
- Infants Profenib
- ketoprofen
- ketorolac
- Medi-profen
- Mediproxen
- mefenamic acid
- meloxicam
- Midol (naproxen)
- Mobic
- Motrin Ib
- Motrin Pm
- nabumetone
- Nalfon
- Naprelan Cr
- Naprosyn
- naproxen
- naproxen sodium
- naproxen-esomeprazole
- naproxen-pseudoephedrine
- Neoprofen (ibuprofen Lysn)(pf)
- oxaprozin
- Pennsaid
- piroxicam
- Ponstel
- Primsol
- probenecid
- Provil
- pseudoephedrine-ibuprofen
- Reprexain
- Sinus & Cold-d
- Solaraze
- Sprix
- sulfadiazine
- sulfamethoxazole-trimethoprim
- sulfasalazine
- Sulfatrim
- Sulfazine
- Sulfazine Ec
- sulindac
- tolmetin
- trimethoprim
- Versacloz
- Vicoprofen
- Vimovo
- Voltaren-xr
- Wal-profen
- Wal-profen Cold-sinus
- Wal-proxen
- Zipsor
- Zorvolex
Severe
Moderate
- None
- Lactating mother
Contraindicated
- Abnormal hepatic function tests
- Anemia
- Neutropenic disorder
- Pregnancy
- Renal disease with moderate to severe impairment
- Stomatitis
- Thrombocytopenic disorder
Severe
Moderate
- None
FOLOTYN (pralatrexate)
- Peripheral t-cell lymphoma
- Anemia
- Bacterial sepsis
- Leukopenia
- Neutropenic disorder
- Stomatitis
- Thrombocytopenic disorder
- Anorexia
- Constipation
- Cough
- Edema
- Epistaxis
- Fatigue
- Fever
- Nausea
- Vomiting
More Frequent
Severe
Less Severe
- Chemotherapy-induced hyperuricemia
- Dehydration
- Dyspnea
- Hypokalemia
- Abdominal pain with cramps
- Alopecia
- Diarrhea
- Night sweats
- Pruritus of skin
- Skin rash
- Sore throat
- Tachycardia
- Upper respiratory infection
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Drug-induced hepatitis
- Exfoliative dermatitis
- Pancytopenia
- Skin ulcer
- Toxic epidermal necrolysis
Less Severe
- None
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Pralatrexate
No safety and efficacy established.
- 1 Day – 18 Years
- No safety and efficacy established.
Pralatrexate
- Severity Level:
D
- Additional Notes:
Contraindicated
Pralatrexate
Mfr does not recommend; potential serious adverse effects in infant
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Mfr does not recommend; potential serious adverse effects in infant |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Peripheral t-cell lymphoma | |
| C84.4 | Peripheral t-cell lymphoma, not classified |
| C84.40 | Peripheral t-cell lymphoma, not classified, unspecified site |
| C84.41 | Peripheral t-cell lymphoma, not classified, lymph nodes of head, face, and neck |
| C84.42 | Peripheral t-cell lymphoma, not classified, intrathoracic lymph nodes |
| C84.43 | Peripheral t-cell lymphoma, not classified, intra-abdominal lymph nodes |
| C84.44 | Peripheral t-cell lymphoma, not classified, lymph nodes of axilla and upper limb |
| C84.45 | Peripheral t-cell lymphoma, not classified, lymph nodes of inguinal region and lower limb |
| C84.46 | Peripheral t-cell lymphoma, not classified, intrapelvic lymph nodes |
| C84.47 | Peripheral t-cell lymphoma, not classified, spleen |
| C84.48 | Peripheral t-cell lymphoma, not classified, lymph nodes of multiple sites |
| C84.49 | Peripheral t-cell lymphoma, not classified, extranodal and solid organ sites |
| 0-9 | A-Z |
|---|---|
| C84.4 | Peripheral t-cell lymphoma, not classified |
| C84.40 | Peripheral t-cell lymphoma, not classified, unspecified site |
| C84.41 | Peripheral t-cell lymphoma, not classified, lymph nodes of head, face, and neck |
| C84.42 | Peripheral t-cell lymphoma, not classified, intrathoracic lymph nodes |
| C84.43 | Peripheral t-cell lymphoma, not classified, intra-abdominal lymph nodes |
| C84.44 | Peripheral t-cell lymphoma, not classified, lymph nodes of axilla and upper limb |
| C84.45 | Peripheral t-cell lymphoma, not classified, lymph nodes of inguinal region and lower limb |
| C84.46 | Peripheral t-cell lymphoma, not classified, intrapelvic lymph nodes |
| C84.47 | Peripheral t-cell lymphoma, not classified, spleen |
| C84.48 | Peripheral t-cell lymphoma, not classified, lymph nodes of multiple sites |
| C84.49 | Peripheral t-cell lymphoma, not classified, extranodal and solid organ sites |
Formulary Reference Tool