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Drug overview for EPINASTINE HCL (epinastine hcl):
Generic name: EPINASTINE HCL (EP-i-NAS-teen)
Drug class: Ophthalmic Antiallergic Agents
Therapeutic class: Ophthalmic Agents
Epinastine, a relatively selective histamine H1-receptor antagonist, has mast-cell stabilizing properties.
No enhanced Uses information available for this drug.
Generic name: EPINASTINE HCL (EP-i-NAS-teen)
Drug class: Ophthalmic Antiallergic Agents
Therapeutic class: Ophthalmic Agents
Epinastine, a relatively selective histamine H1-receptor antagonist, has mast-cell stabilizing properties.
No enhanced Uses information available for this drug.
DRUG IMAGES
EPINASTINE HCL 0.05% EYE DROPS
The following indications for EPINASTINE HCL (epinastine hcl) have been approved by the FDA:
Indications:
Allergic conjunctivitis
Ocular itching
Professional Synonyms:
Allergy eye itch
Atopic conjunctivitis
Itchy eyes due to allergies
Ocular itching due to allergies
Ocular pruritus
Indications:
Allergic conjunctivitis
Ocular itching
Professional Synonyms:
Allergy eye itch
Atopic conjunctivitis
Itchy eyes due to allergies
Ocular itching due to allergies
Ocular pruritus
The following dosing information is available for EPINASTINE HCL (epinastine hcl):
No enhanced Dosing information available for this drug.
For topical ophthalmic use only. Not for injection or oral use.
| DRUG LABEL | DOSING TYPE | DOSING INSTRUCTIONS |
|---|---|---|
| EPINASTINE HCL 0.05% EYE DROPS | Maintenance | Adults instill 1 drop into both eyes by ophthalmic route 2 times per day |
| DRUG LABEL | DOSING TYPE | DOSING INSTRUCTIONS |
|---|---|---|
| EPINASTINE HCL 0.05% EYE DROPS | Maintenance | Adults instill 1 drop into both eyes by ophthalmic route 2 times per day |
The following drug interaction information is available for EPINASTINE HCL (epinastine hcl):
There are 0 contraindications.
There are 0 severe interactions.
There are 0 moderate interactions.
The following contraindication information is available for EPINASTINE HCL (epinastine hcl):
Drug contraindication overview.
Known hypersensitivity to epinastine or any ingredient in the formulation.
Known hypersensitivity to epinastine or any ingredient in the formulation.
There are 0 contraindications.
There are 0 severe contraindications.
There are 1 moderate contraindications.
Clinically significant contraindication, where the condition can be managed or treated before the drug may be given safely.
| Moderate List |
|---|
| No disease contraindications |
The following adverse reaction information is available for EPINASTINE HCL (epinastine hcl):
Adverse reaction overview.
Adverse ocular effects reported in approximately 1-10% of patients include ocular burning, folliculosis, hyperemia, and pruritus. The most frequently reported adverse nonocular effect is infection (e.g., cold symptoms, upper respiratory infections), which occurred in approximately 10% of patients. Other adverse nonocular effects reported in approximately 1-3% of patients include headache, rhinitis, sinusitis, increased cough, and pharyngitis. Some events may be related to the underlying ocular disease rather than epinastine.
Adverse ocular effects reported in approximately 1-10% of patients include ocular burning, folliculosis, hyperemia, and pruritus. The most frequently reported adverse nonocular effect is infection (e.g., cold symptoms, upper respiratory infections), which occurred in approximately 10% of patients. Other adverse nonocular effects reported in approximately 1-3% of patients include headache, rhinitis, sinusitis, increased cough, and pharyngitis. Some events may be related to the underlying ocular disease rather than epinastine.
There are 1 severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
|
Follicular conjunctivitis |
None. |
| Rare/Very Rare |
|---|
| None. |
There are 12 less severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
|
Cold symptoms Rhinorrhea Sore throat Upper respiratory infection |
Cough Headache disorder Ocular irritation Ocular redness Pharyngitis Pruritus of skin Rhinitis Sinusitis |
| Rare/Very Rare |
|---|
| None. |
The following precautions are available for EPINASTINE HCL (epinastine hcl):
Safety and efficacy not established in children younger than 3 years of age.
Contraindicated
Severe Precaution
Management or Monitoring Precaution
Contraindicated
| None |
Severe Precaution
| None |
Management or Monitoring Precaution
| None |
Category C. (See Users Guide.)
Epinastine is distributed into milk in rats. It is not known whether the drug is distributed into human milk; therefore, caution should be exercised when ocular epinastine is administered to a nursing woman.
No overall differences in safety and efficacy relative to younger patients.
The following prioritized warning is available for EPINASTINE HCL (epinastine hcl):
No warning message for this drug.
No warning message for this drug.
The following icd codes are available for EPINASTINE HCL (epinastine hcl)'s list of indications:
| Allergic conjunctivitis | |
| H10.1 | Acute atopic conjunctivitis |
| H10.10 | Acute atopic conjunctivitis, unspecified eye |
| H10.11 | Acute atopic conjunctivitis, right eye |
| H10.12 | Acute atopic conjunctivitis, left eye |
| H10.13 | Acute atopic conjunctivitis, bilateral |
| H10.44 | Vernal conjunctivitis |
| H10.45 | Other chronic allergic conjunctivitis |
| H16.26 | Vernal keratoconjunctivitis, with limbar and corneal involvement |
| H16.261 | Vernal keratoconjunctivitis, with limbar and corneal involvement, right eye |
| H16.262 | Vernal keratoconjunctivitis, with limbar and corneal involvement, left eye |
| H16.263 | Vernal keratoconjunctivitis, with limbar and corneal involvement, bilateral |
| H16.269 | Vernal keratoconjunctivitis, with limbar and corneal involvement, unspecified eye |
| Ocular itching | |
| H57.89 | Other specified disorders of eye and adnexa |
| L29.8 | Other pruritus |
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