Allevyn Ag

The following drug interaction information is available for ALLEVYN AG (silver sulfadiazine/foam bandage):

Contraindicated
Severe
Moderate

There are 0 contraindications.

There are 2 severe interactions. These drug interactions can produce serious consequences in most patients. Actions required for severe interactions include, but are not limited to, discontinuing one or both agents, adjusting dosage, altering administration scheduling, and providing additional patient monitoring. Review the full interaction monograph for more information.

Drug Interaction	Drug Names
Topical Sodium Sulfacetamide/Topical Silver SEVERITY LEVEL: 2-Severe Interaction: Action is required to reduce the risk of severe adverse interaction. MECHANISM OF ACTION: Topical sodium sulfacetamide and topical silver are physically incompatible.(1,2) CLINICAL EFFECTS: Concurrent application of topical sodium sulfacetamide and topical silver preparations may result in decreased clinical effectiveness of the products.(1,2) PREDISPOSING FACTORS: None determined. PATIENT MANAGEMENT: Avoid using topical silver preparations on the same location as topical sodium sulfacetamide products.(1,2) DISCUSSION: Topical sodium sulfacetamide and topical silver are physically incompatible.(1,2)	ABENOR, ABENOR HP, APEXOL, APEXOL HP, AVAR, AVAR LS, AVAR-E, BP 10-1, CLEANSING WASH, CLENIA PLUS, DRAXACE, DRAXACEY, DRIXECE, ECEOXIA, KLARON, OVACE, OVACE PLUS, OVACE PLUS WASH, OXIAICE, PLEXION, PLEXION NS, ROSULA, SODIUM SULFACETAMIDE, SODIUM SULFACETAMIDE-SULFUR, SSS 10-5, SULFACETAMIDE, SULFACETAMIDE SOD MONOHYDRATE, SULFACETAMIDE SODIUM, SULFACETAMIDE SODIUM-SULFUR, SULFACLEANSE 8-4, SUMADAN, SUMADAN XLT, SUMAXIN, SUMAXIN CP, SUMAXIN TS, ZMA CLEAR
Topical Collagenase; Papain/Topical Heavy Metals SEVERITY LEVEL: 2-Severe Interaction: Action is required to reduce the risk of severe adverse interaction. MECHANISM OF ACTION: Heavy metal ions may inactivate collagenase(1) and papain(2-10). CLINICAL EFFECTS: Application of heavy metal ions such as lead, mercury, and silver may inactivate collagenase(1) and papain,(2-8) limiting their effectiveness. PREDISPOSING FACTORS: None determined. PATIENT MANAGEMENT: Avoid applying topical products that contain heavy metals such as lead, mercury, or silver to the same wound areas as collagenase(1) and papain.(2-10) DISCUSSION: The enzymatic activity of collagenase is adversely affected by heavy metal ions such as mercury and silver, which are used in some antiseptics.(1) Papain may be inactivated by heavy metal ions such as lead, mercury, and silver.(2-10)	COLLAGENASE, SANTYL

Drug Interaction

Drug Names

Topical Sodium Sulfacetamide/Topical Silver

SEVERITY LEVEL: 2-Severe Interaction: Action is required to reduce the risk of severe adverse interaction.

MECHANISM OF ACTION: Topical sodium sulfacetamide and topical silver are physically incompatible.(1,2)

CLINICAL EFFECTS: Concurrent application of topical sodium sulfacetamide and topical silver preparations may result in decreased clinical effectiveness of the products.(1,2)

PREDISPOSING FACTORS: None determined.

PATIENT MANAGEMENT: Avoid using topical silver preparations on the same location as topical sodium sulfacetamide products.(1,2)

DISCUSSION: Topical sodium sulfacetamide and topical silver are physically incompatible.(1,2)

ABENOR, ABENOR HP, APEXOL, APEXOL HP, AVAR, AVAR LS, AVAR-E, BP 10-1, CLEANSING WASH, CLENIA PLUS, DRAXACE, DRAXACEY, DRIXECE, ECEOXIA, KLARON, OVACE, OVACE PLUS, OVACE PLUS WASH, OXIAICE, PLEXION, PLEXION NS, ROSULA, SODIUM SULFACETAMIDE, SODIUM SULFACETAMIDE-SULFUR, SSS 10-5, SULFACETAMIDE, SULFACETAMIDE SOD MONOHYDRATE, SULFACETAMIDE SODIUM, SULFACETAMIDE SODIUM-SULFUR, SULFACLEANSE 8-4, SUMADAN, SUMADAN XLT, SUMAXIN, SUMAXIN CP, SUMAXIN TS, ZMA CLEAR

Topical Collagenase; Papain/Topical Heavy Metals

SEVERITY LEVEL: 2-Severe Interaction: Action is required to reduce the risk of severe adverse interaction.

MECHANISM OF ACTION: Heavy metal ions may inactivate collagenase(1) and papain(2-10).

CLINICAL EFFECTS: Application of heavy metal ions such as lead, mercury, and silver may inactivate collagenase(1) and papain,(2-8) limiting their effectiveness.

PREDISPOSING FACTORS: None determined.

PATIENT MANAGEMENT: Avoid applying topical products that contain heavy metals such as lead, mercury, or silver to the same wound areas as collagenase(1) and papain.(2-10)

DISCUSSION: The enzymatic activity of collagenase is adversely affected by heavy metal ions such as mercury and silver, which are used in some antiseptics.(1) Papain may be inactivated by heavy metal ions such as lead, mercury, and silver.(2-10)

COLLAGENASE, SANTYL

There are 0 moderate interactions.

The following contraindication information is available for ALLEVYN AG (silver sulfadiazine/foam bandage):

Overview
Contraindicated
Severe
Moderate

Drug contraindication overview.

No enhanced Contraindications information available for this drug.

There are 2 contraindications. Absolute contraindication.

Contraindication List
Hemolytic anemia from pyruvate kinase and g6PD deficiencies
Pregnancy

There are 1 severe contraindications. Adequate patient monitoring is recommended for safer drug use.

Severe List
Porphyria

There are 5 moderate contraindications. Clinically significant contraindication, where the condition can be managed or treated before the drug may be given safely.

Moderate List
Anemia
Disease of liver
Kidney disease with reduction in glomerular filtration rate (GFr)
Leukopenia
Thrombocytopenic disorder

The following adverse reaction information is available for ALLEVYN AG (silver sulfadiazine/foam bandage):

Overview
Severe
Less Severe

Adverse reaction overview.

No enhanced Common Adverse Effects information available for this drug.

There are 10 severe adverse reactions.

More Frequent	Less Frequent
None.	None.

Rare/Very Rare
Agranulocytosis Aplastic anemia Erythema multiforme Exfoliative dermatitis Hemolytic anemia Interstitial nephritis Leukopenia Stevens-johnson syndrome Thrombocytopenic disorder Toxic epidermal necrolysis

There are 5 less severe adverse reactions.

More Frequent	Less Frequent
None.	Pruritus of skin Stinging of skin

Rare/Very Rare
Dyschromia Skin photosensitivity Skin rash