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Drug overview for APEXOL (salicylic acid/sulfacetamide sodium):
Generic name: SALICYLIC ACID/SULFACETAMIDE SODIUM
Drug class: Acne Antibiotics
Therapeutic class: Dermatological
Salicylic acid is a keratolytic agent.
Salicylic acid is used topically for its keratolytic effect in the management of acne and other skin conditions such as seborrheic dermatitis, psoriasis, and dandruff; the drug also is used topically for the removal of warts, corns, and calluses. Salicylic acid is not used systemically because of its severe irritating effect on GI mucosa and other tissues. (See the Salicylates General Statement 28:08.04.24.)
Generic name: SALICYLIC ACID/SULFACETAMIDE SODIUM
Drug class: Acne Antibiotics
Therapeutic class: Dermatological
Salicylic acid is a keratolytic agent.
Salicylic acid is used topically for its keratolytic effect in the management of acne and other skin conditions such as seborrheic dermatitis, psoriasis, and dandruff; the drug also is used topically for the removal of warts, corns, and calluses. Salicylic acid is not used systemically because of its severe irritating effect on GI mucosa and other tissues. (See the Salicylates General Statement 28:08.04.24.)
DRUG IMAGES
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The following indications for APEXOL (salicylic acid/sulfacetamide sodium) have been approved by the FDA:
Indications:
None.
Professional Synonyms:
None.
Indications:
None.
Professional Synonyms:
None.
The following dosing information is available for APEXOL (salicylic acid/sulfacetamide sodium):
No enhanced Dosing information available for this drug.
Salicylic acid is applied topically to the skin as a cake, cream, gel, lotion, ointment, pledget, plaster, shampoo, solution, or suspension. Topical preparations of salicylic acid are for external use only. Contact with the eyes should be avoided; if contact occurs, the affected eye(s) should be washed thoroughly with water.
Prior to topical application, the affected area(s) to be treated should be cleansed and allowed to dry. Prior to removal of warts, corns, and calluses, the affected area may be soaked in warm water for 5 minutes. Salicylic acid is commercially available in various preparations, some of which are intended for self-medication; the manufacturer's product labeling should be consulted for complete directions regarding appropriate dosage and administration of specific products.
Prior to topical application, the affected area(s) to be treated should be cleansed and allowed to dry. Prior to removal of warts, corns, and calluses, the affected area may be soaked in warm water for 5 minutes. Salicylic acid is commercially available in various preparations, some of which are intended for self-medication; the manufacturer's product labeling should be consulted for complete directions regarding appropriate dosage and administration of specific products.
No dosing information available.
No generic dosing information available.
The following drug interaction information is available for APEXOL (salicylic acid/sulfacetamide sodium):
There are 0 contraindications.
There are 1 severe interactions.
These drug interactions can produce serious consequences in most patients. Actions required for severe interactions include, but are not limited to, discontinuing one or both agents, adjusting dosage, altering administration scheduling, and providing additional patient monitoring. Review the full interaction monograph for more information.
| Drug Interaction | Drug Names |
|---|---|
| Topical Sodium Sulfacetamide/Topical Silver SEVERITY LEVEL: 2-Severe Interaction: Action is required to reduce the risk of severe adverse interaction. MECHANISM OF ACTION: Topical sodium sulfacetamide and topical silver are physically incompatible.(1,2) CLINICAL EFFECTS: Concurrent application of topical sodium sulfacetamide and topical silver preparations may result in decreased clinical effectiveness of the products.(1,2) PREDISPOSING FACTORS: None determined. PATIENT MANAGEMENT: Avoid using topical silver preparations on the same location as topical sodium sulfacetamide products.(1,2) DISCUSSION: Topical sodium sulfacetamide and topical silver are physically incompatible.(1,2) |
ACESO AG, ACTICOAT, ACTICOAT 7, ACTICOAT FLEX 3, ACTICOAT FLEX 7, ACTICOAT SURGICAL, ALLEVYN AG, ALLEVYN AG ADHESIVE, ALLEVYN AG GENTLE, AZADROX, BASADROX, BIOSTEP AG, COLLATYL, DYNAFOAM AG, DYNAGINATE AG, NORMLGEL AG, PIVOT SILVER ALGINATE, PURACOL PLUS AG, RESTORE, RESTORE CALCIUM ALGINATE, SILIGENTLE AG, SILVADENE, SILVASORB, SILVER NITRATE, SILVER NITRATE APPLICATOR, SILVER PROTEIN, SILVER SULFADIAZINE, SILVRSTAT, SOLOX GEL, SSD |
There are 0 moderate interactions.
The following contraindication information is available for APEXOL (salicylic acid/sulfacetamide sodium):
Drug contraindication overview.
No enhanced Contraindications information available for this drug.
No enhanced Contraindications information available for this drug.
There are 4 contraindications.
Absolute contraindication.
| Contraindication List |
|---|
| Aspirin exacerbated respiratory disease |
| Glucose-6-phosphate dehydrogenase (g6Pd) deficiency |
| Hemoglobin H disease |
| Hemolytic anemia from pyruvate kinase and g6PD deficiencies |
There are 0 severe contraindications.
There are 1 moderate contraindications.
Clinically significant contraindication, where the condition can be managed or treated before the drug may be given safely.
| Moderate List |
|---|
| Peripheral vascular disease |
The following adverse reaction information is available for APEXOL (salicylic acid/sulfacetamide sodium):
Adverse reaction overview.
No enhanced Common Adverse Effects information available for this drug.
No enhanced Common Adverse Effects information available for this drug.
There are 23 severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
| None. | None. |
| Rare/Very Rare |
|---|
|
Agranulocytosis Anaphylaxis Blood dyscrasias Burns Dyspnea Erythema Facial edema Glucose-6-phosphate dehydrogenase (g6Pd) deficiency anemia Hepatic necrosis Hypersensitivity drug reaction Periorbital edema Pharyngeal edema Pruritus of skin Skin irritation Skin rash Skin ulcer Stevens-johnson syndrome Superficial skin ulcer Syncope Systemic lupus erythematosus Throat constriction Toxic epidermal necrolysis Urticaria |
There are 4 less severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
|
Stinging of skin |
Dry skin Skin irritation |
| Rare/Very Rare |
|---|
|
Pruritus of skin |
The following precautions are available for APEXOL (salicylic acid/sulfacetamide sodium):
No enhanced Pediatric Use information available for this drug.
Contraindicated
Severe Precaution
Management or Monitoring Precaution
Contraindicated
| None |
Severe Precaution
| None |
Management or Monitoring Precaution
| None |
There are no adequate and well-controlled studies of topical salicylic acid in pregnant women; the drug should be used during pregnancy only if the potential benefits justify the possible risks to the fetus.
Because of the potential for serious adverse reactions to salicylic acid in nursing infants, a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the woman. If used in nursing women, the drug should not be applied to the chest area to avoid accidental contamination of the infant.
No enhanced Geriatric Use information available for this drug.
The following prioritized warning is available for APEXOL (salicylic acid/sulfacetamide sodium):
No warning message for this drug.
No warning message for this drug.
The following icd codes are available for APEXOL (salicylic acid/sulfacetamide sodium)'s list of indications:
No ICD codes found for this drug.
No ICD codes found for this drug.
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