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LOTRONEX (ALOSETRON HCL)
- Diarrhea predominant irritable bowel syndrome
0.5 mg tablet
- 1 tablet (0.5 mg) by oral route 2 times per day
1 mg tablet
- 1 tablet (1 mg) by oral route once daily
0.5 mg tablet
- 1 tablet (0.5 mg) by oral route 2 times per day
1 mg tablet
- 1 tablet (1 mg) by oral route once daily
alosetron 0.5 mg tablet
- 1 tablet (0.5 mg) by oral route 2 times per day
alosetron 1 mg tablet
- 1 tablet (1 mg) by oral route once daily
Diarrhea predominant irritable bowel syndrome
- 1 tablet (0.5 mg) by oral route once daily
- 1 tablet (0.5 mg) by oral route 2 times per day
- 2 tablets (1 mg) by oral route 2 times per day
- 2 tablets (1 mg) by oral route once daily
- 1 tablet (1 mg) by oral route once daily
- 1 tablet (1 mg) by oral route 2 times per day
- fluvoxamine
- Luvox Cr
Contraindicated
- None
Severe
Moderate
- Conzip
- Synapryn
- tramadol
- tramadol-acetaminophen
- tramadol-glucosamine
- Ultracet
- Ultram
- Ultram Er
- Adhesion of gastrointestinal tract
- Colitis
- Constipation
- Crohn's disease
- Diverticulitis of gastrointestinal tract
- Gastrointestinal obstruction
- Gastrointestinal perforation
- Ischemic bowel disease
- Rectal bleeding
- Severe hepatic disease
- Thrombophilia
- Thrombophlebitis
- Toxic megacolon
- Ulcerative colitis
Contraindicated
- Disease of liver
Severe
Moderate
- None
LOTRONEX (ALOSETRON HCL)
- Diarrhea predominant irritable bowel syndrome
- None
- Constipation
More Frequent
Severe
Less Severe
- Bleeding hemorrhoids
- Severe constipation
- Acute abdominal pain
- Diarrhea
- Flatulence
- Upper respiratory infection
- Urinary tract infection
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Bacterial infection
- Cardiac arrhythmia
- Extrasystoles
- Fecal impaction
- Gastrointestinal obstruction
- Gastrointestinal perforation
- Gastrointestinal ulcer
- Hyperbilirubinemia
- Hypertension
- Hypothalamic-pituitary insufficiency
- Ileus
- Intussusception of intestine
- Ischemic bowel disease
- Ischemic colitis
- Tachyarrhythmia
- Toxic megacolon
- Ulcerative colitis
- Urticaria
Less Severe
- Abdominal distension
- Abnormal sexual function
- Abnormal vaginal bleeding
- Acne vulgaris
- Allergic rhinitis
- Cough
- Depression
- Dysgeusia
- Dyspepsia
- Dyspnea
- Fatigue
- Folliculitis
- Gastritis
- Gastroesophageal reflux disease
- Headache disorder
- Hematoma
- Hemorrhage
- Hemorrhoids
- Hyperhidrosis
- Hypesthesia
- Hypnagogic hallucination
- Increased urinary frequency
- Insomnia
- Irregular menstrual periods
- Malaise
- Nausea
- Parosmia
- Pharyngitis
- Photophobia
- Polyuria
- Proctitis
- Sedation
- Sinusitis
- Skin rash
- Sore throat
- Symptoms of anxiety
- Viral infection
- Xerostomia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Alosetron
Severe constipation may result in serious complications or ischemic colitis. Not recommended in pediatrics.
- 1 Day – 18 Years
- Severe constipation may result in serious complications or ischemic colitis. Not recommended in pediatrics.
Alosetron
- Severity Level:
2
- Additional Notes: Insufficient human data available.
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Alosetron
Insufficient human data available
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient human data available |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Alosetron
Gastrointestinal-Drug plasma concentrations may be elevated by 40% in elderly. Postmarketing experience suggests that elderly patients may be at greater risk for complications of constipation. Discontinue immediately in patients who develop constipation or symptoms of ischemic colitis. Do not resume in patients who develop ischemic colitis.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | N | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- Alosetron has rarely caused serious, sometimes fatal side effects of the intestines. These effects include reduced blood flow to the large intestine (ischemic colitis) and serious complications of constipation. If you have constipation, new or worsening stomach/abdominal pain, or bloody diarrhea/stools, stop taking this medication and get medical help right away.<br /><br />If your constipation does not go away after stopping alosetron, again tell your doctor right away. Do not take this medication again unless your doctors tells you to do so. This medication should only be used by women with severe irritable bowel syndrome (IBS) whose main problem is diarrhea.<br /><br /> Only carefully selected patients may use this medication. Consult your doctor or pharmacist for more information about the risks and benefits of using alosetron.
| Diarrhea predominant irritable bowel syndrome | |
| K58.0 | Irritable bowel syndrome with diarrhea |
| 0-9 | A-Z |
|---|---|
| K58.0 | Irritable bowel syndrome with diarrhea |
Formulary Reference Tool