URIMAR-T (methenamine/methylene blue/salicylate/sodium phos/hyoscyamin)
120 mg-0.12 mg-10.8 mg tablet
- Dosage information is not available
81.6 mg-10.8 mg-40.8 mg tablet
- Dosage information is not available
- acetazolamide
- acetazolamide sodium
- Azulfidine
- Azulfidine En-tabs
- Bactrim
- Bactrim Ds
- Diamox Sequels
- erythromycin-sulfisoxazole
- ketorolac
- methazolamide
- Neptazane
- pramlintide
- Sprix
- sulfadiazine
- sulfamethoxazole-trimethoprim
- sulfasalazine
- Sulfatrim
- Sulfazine
- Sulfazine Ec
- Symlinpen 120
- Symlinpen 60
Contraindicated
- Coumadin
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- Jantoven
- K-tab
- Klor-con
- Klor-con 10
- Klor-con M10
- Klor-con M15
- Klor-con M20
- Medi-lyte
- Methotrexate (anti-rheumatic)
- methotrexate sodium
- methotrexate sodium (PF)
- potassium chloride
- potassium citrate
- potassium Cl-calcium phos-mag
- Rheumatrex
- sodium Cl-potassium chloride
- Thermotabs
- Trexall
- Urocit-k 10
- Urocit-k 15
- Urocit-k 5
- varicella virus vacc live (PF)
- Varivax (pf)
- warfarin
Severe
Moderate
- A-hydrocort
- A-methapred
- Adasuve
- Amaryl
- Anucort-hc
- Anusol-hc
- Aristospan Intra-articular
- Aristospan Intralesional
- Arixtra
- betamethasone acet & sod phos
- budesonide
- Celestone Soluspan
- chlorpromazine
- colchicine-probenecid
- Colocort
- Compazine
- Compro
- Cortef
- Cortenema
- Cortifoam
- cortisone
- dalteparin (porcine)
- Depacon
- Depakene
- Depakote
- Depakote Er
- Depakote Sprinkles
- Depo-medrol
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- Diabeta
- divalproex
- Duetact
- Elmiron
- enoxaparin
- Entocort Ec
- Ez Use Joint-tunnel-trigger
- First-duke's
- First-mary's Mouthwash
- Flo-pred
- fludrocortisone
- fluphenazine decanoate
- fluphenazine HCl
- fondaparinux
- Fragmin
- glimepiride
- glipizide
- glipizide-metformin
- Glucotrol
- Glucotrol Xl
- Glucovance
- glyburide
- glyburide micronized
- glyburide-metformin
- Glynase
- Grx Hicort 25
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- Hemril-30
- heparin (porcine)
- heparin (porcine) in D5W
- heparin(porcine) in 0.45% NaCl
- heparin, porcine (PF)
- hydrocortisone
- hydrocortisone acetate
- hydrocortisone sod succ (PF)
- hydrocortisone sod succinate
- itraconazole
- Kenalog
- ketoconazole
- Lovenox
- loxapine
- loxapine succinate
- Loxitane
- Medrol
- Medrol (pak)
- methylprednisolone
- methylprednisolone acetate
- methylprednisolone sod suc(PF)
- methylprednisolone sodium succ
- methylprednisolone-bupivacaine
- Millipred
- Millipred Dp
- nateglinide
- nystatin-hydrocortisone-diphen
- nystatin-TCN-HC-diphenhydramin
- Onmel
- Orapred
- Orapred Odt
- Pediapred
- pentosan polysulfate sodium
- perphenazine
- perphenazine-amitriptyline
- Phenadoz
- Phenergan
- Physicians Ez Use M-pred
- pioglitazone-glimepiride
- prednisolone
- prednisolone acetate
- prednisolone sodium phosphate
- prednisone
- Prednisone Intensol
- probenecid
- prochlorperazine
- prochlorperazine Edisylate
- prochlorperazine maleate
- Proctocort
- promethazine
- Promethazine Vc
- Promethazine Vc-codeine
- promethazine-codeine
- promethazine-DM
- promethazine-phenyleph-codeine
- promethazine-phenylephrine
- Promethegan
- Rayos
- Rectacort-hc
- Solu-cortef
- Solu-cortef (pf)
- Solu-medrol
- Solu-medrol (pf)
- Sporanox
- Sporanox Pulsepak
- Starlix
- Stavzor
- thioridazine
- tolazamide
- tolbutamide
- triamcinolone acetonide
- triamcinolone hexacetonide
- triamcinolone-lidocaine
- trifluoperazine
- Uceris
- valproate sodium
- valproic acid
- valproic acid (as sodium salt)
- Veripred 20
- Achalasia of esophagus
- Atony of colon
- Benign prostatic hyperplasia
- Bladder outflow obstruction
- Glaucoma
- Glucose-6-phosphate dehydrogenase (g6Pd) deficiency
- Hemolytic anemia from pyruvate kinase and g6PD deficienc
- Hypernatremia
- Hyperphosphatemia
- Hypocalcemia
- Hypovolemic shock
- Lactation
- Myasthenia gravis
- Paralytic ileus
- Pyloroduodenal obstruction
- Severe dehydration
- Severe hepatic disease
- Severe ulcerative colitis
- Toxic megacolon
Contraindicated
- Chronic heart failure
- Chronic kidney disease stage 3A (moderate) GFR 45-59
- Chronic kidney disease stage 3B (moderate) GFR 30-44
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Edema
- Kidney disease with reduction in GFR
- Pregnancy
- Severe renal impairment
Severe
Moderate
- Abnormal hepatic function tests
- Autonomic neuropathy
- Cardiac arrhythmia
- Child-pugh class A hepatic impairment
- Child-pugh class B hepatic impairment
- Child-pugh class C hepatic impairment
- Chronic heart failure
- Coronary artery disease
- Disease of liver
- Gastroesophageal reflux disease
- Hepatic cirrhosis
- Hiatal hernia
- High fever >101 degrees fahrenheit
- Hypertension
- Hyperthyroidism
- Kidney disease with reduction in GFR
- Severe hepatic disease
URIMAR-T (methenamine/methylene blue/salicylate/sodium phos/hyoscyamin)
- None
- Blurred vision
- Decreased sweating
- Urine discoloration
More Frequent
Severe
Less Severe
- Skin rash
- Abdominal pain with cramps
- Breast milk flow decreased
- Constipation
- Diarrhea
- Dyspepsia
- Gastric acid hypersecretory conditions
- Gastrointestinal irritation
- Heartburn
- Increased urinary frequency
- Mydriasis
- Nausea
- Nausea and vomiting
- Vomiting
- Xerostomia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute confusion
- Allergic dermatitis
- Anaphylaxis
- Anemia
- Angioedema
- Bronchospastic pulmonary disease
- Cardiac arrhythmia
- Dyspnea
- Erythema
- Gastrointestinal hemorrhage
- Gastrointestinal perforation
- Gastrointestinal ulcer
- Hematuria
- Hemolytic anemia
- Hypernatremia
- Hyperphosphatemia
- Hypocalcemia
- Nephrocalcinosis
- Ocular hypertension
- Oliguria
- Orthostatic hypotension
- Pruritus of skin
- Renal failure
- Seizure disorder
- Skin rash
- Urticaria
- Wheezing
Less Severe
- Acute abdominal pain
- Acute confusion
- Anticholinergic toxicity
- Arthralgia
- Bone pain
- Cramps
- Dizziness
- Drowsy
- Dysuria
- Fatigue
- Fever
- Flatulence
- General weakness
- Headache disorder
- Memory impairment
- Nausea
- Oral paresthesia
- Paresthesia
- Peripheral edema
- Polydipsia
- Pruritus of skin
- Vomiting
- Weight gain
Contraindicated
Salicylates
Do not use in viral illness due to possible increased risk of Reye syndrome.
- 1 Day – 12 Years
- 1 Do not use in viral illness due to possible increased risk of Reye syndrome.
Severe Precaution
Hyoscyamine
Infants and children are more sensitive to anticholinergic and adverse effects.
Do not use in viral illness due to possible increased risk of Reye syndrome.
- 1 Day – 13 Years
- Infants and children are more sensitive to anticholinergic and adverse effects.
- 12 Years – 18 Years
- Infants and children are more sensitive to anticholinergic and adverse effects.
Salicylates
Infants and children are more sensitive to anticholinergic and adverse effects.
Do not use in viral illness due to possible increased risk of Reye syndrome.
- 1 Day – 13 Years
- Do not use in viral illness due to possible increased risk of Reye syndrome.
- 12 Years – 18 Years
- Do not use in viral illness due to possible increased risk of Reye syndrome.
Management or Monitoring Precaution
None
Hyoscyamine
- Severity Level:
2
- Additional Notes: Limited data suggest an increased risk of congenital malformations
Methenamine
- Severity Level:
2
- Additional Notes: Insuff human data avail; consider maternal benefit vs neonatal risk
Methylene Blue
- Severity Level:
D
- Additional Notes: Serious fetal/neonatal adverse effects with intra-amniotic admin
Salicylate(low Dose In Combo Prod)
- Severity Level:
C
- Additional Notes: Insuff human data avail; consider risk vs benefit
Contraindicated
Methylene Blue
Manufacturer does not rec during treatment and for 8 days after last dose
One report of metabol acidosis w/asa;Risk of reye's syn w/viral illness/fever
General | Excretion Potential | Effect on Infant | Notes |
Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Manufacturer does not rec during treatment and for 8 days after last dose |
Salicylates
Manufacturer does not rec during treatment and for 8 days after last dose
One report of metabol acidosis w/asa;Risk of reye's syn w/viral illness/fever
General | Excretion Potential | Effect on Infant | Notes |
Drug should not be given to breast feeding mothers | Excreted | Not known; no or inclusive data | One report of metabol acidosis w/asa;Risk of reye's syn w/viral illness/fever |
Precaution Exists
Hyoscyamine
Limited data suggest minimal amounts excreted into breastmilk.
Limited data suggest low excretion with no known infant adverse effects
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited data suggest minimal amounts excreted into breastmilk. |
Methenamine
Limited data suggest minimal amounts excreted into breastmilk.
Limited data suggest low excretion with no known infant adverse effects
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited data suggest low excretion with no known infant adverse effects |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
Hyoscyamine
Neuro/Psych-Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Non-sedating agents preferred. Gastrointestinal-Avoid with gastrointestinal ileus. May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.
General-Elderly have a higher incidence of systemic toxicities. Dose reduction may be needed.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | Y | N | N | Y | N | N |
BEERS: Y HEDIS: Y STOPP: Y
Phenyl Salicylate (salol)
Neuro/Psych-Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Non-sedating agents preferred. Gastrointestinal-Avoid with gastrointestinal ileus. May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.
General-Elderly have a higher incidence of systemic toxicities. Dose reduction may be needed.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | Y | N | N | Y | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None