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NOXAFIL (POSACONAZOLE)
- Oropharyngeal candidiasis
- Prevention of disseminated candidiasis
- Prevention of invasive pulmonary aspergillosis
- Refractory oropharyngeal candidiasis
- Posaconazole Tablet,delayed Release
- Noxafil Tablet,delayed Release
- Noxafil Oral Suspension
- Noxafil Oral Susp
- Noxafil Intravenous Solution
- By Indication
100 mg tablet,delayed release
- 3 tablets (300 mg) by oral route once daily
100 mg tablet,delayed release
- 3 tablets (300 mg) by oral route once daily
200 mg/5 mL (40 mg/mL) oral suspension
- 5 milliliters (200 mg) by oral route 3 times per day with meals
200 mg/5 mL (40 mg/mL) oral suspension
- 5 milliliters (200 mg) by oral route 3 times per day with meals
300 mg/16.7 mL intravenous solution
- Infuse 300 mg over 90 minute(s) by intravenous route once daily
Oropharyngeal candidiasis
- 2.5 milliliters (100 mg) by oral route 2 times per day for 1 daythen 2.5 ml (100 mg) once daily for 13 days
- 2.5 milliliters (100 mg) by oral route once daily with food
- 2.5 milliliters (100 mg) by oral route once daily with food for 13 days
- 5 milliliters (200 mg) by oral route 3 times per day with meals
Prevention of disseminated candidiasis
- Infuse 300 mg over 90 minute(s) by intravenous route once daily
- Infuse 300 mg over 90 minute(s) by intravenous route every 12 hours for 1 day then infuse 300 mg over 90 minutes once daily
- 5 milliliters (200 mg) by oral route 3 times per day with meals
- 3 tablets (300 mg) by oral route once daily
- 3 tablets (300 mg) by oral route every 12 hours for 1 day then 3 tablets (300 mg) once daily
Prevention of invasive pulmonary aspergillosis
- Infuse 300 mg over 90 minute(s) by intravenous route once daily
- Infuse 300 mg over 90 minute(s) by intravenous route every 12 hours for 1 day then infuse 300 mg over 90 minutes once daily
- 5 milliliters (200 mg) by oral route 3 times per day with meals
- 3 tablets (300 mg) by oral route once daily
- 3 tablets (300 mg) by oral route every 12 hours for 1 day then 3 tablets (300 mg) once daily
Refractory oropharyngeal candidiasis
- 10 milliliters (400 mg) by oral route 2 times per day with meals
- Advicor
- alfuzosin
- Altoprev
- amiodarone
- amiodarone in dextrose,iso-osm
- apixaban
- avanafil
- Brilinta
- bromocriptine
- cabergoline
- Cafergot
- Camptosar
- conivaptan in 5 % dextrose
- Cordarone
- Cycloset
- D.h.e.45
- Detrol La
- dextromethorphan-quinidine
- dihydroergotamine
- dronedarone
- dutasteride-tamsulosin
- eletriptan HBr
- Eliquis
- eplerenone
- ergoloid
- Ergomar
- ergotamine tartrate
- ergotamine-caffeine
- ezetimibe-simvastatin
- Flomax
- Inspra
- irinotecan
- Jalyn
- Juxtapid
- Kombiglyze Xr
- Latuda
- lomitapide
- lovastatin
- lurasidone
- methylergonovine
- Mevacor
- Migergot
- Migranal
- Multaq
- Nexterone
- niacin-lovastatin
- niacin-simvastatin
- Nuedexta
- Orap
- Pacerone
- Parlodel
- pimozide
- quinidine gluconate
- quinidine sulfate
- Rapaflo
- Rapamune
- Relpax
- rivaroxaban
- Samsca
- saxagliptin-metformin
- silodosin
- Simcor
- simvastatin
- sirolimus
- Stendra
- tamsulosin
- ticagrelor
- tolterodine
- tolvaptan
- Uroxatral
- Vaprisol
- Vytorin 10-10
- Vytorin 10-20
- Vytorin 10-40
- Vytorin 10-80
- Xarelto
- Zocor
Contraindicated
- Abstral
- Acid Reducer (cimetidine)
- Acid Relief (cimetidine)
- Aciphex
- Aciphex Sprinkle
- Actiq
- Afinitor
- Afinitor Disperz
- Alfenta
- alfentanil
- amoxicil-clarithromy-lansopraz
- artemether-lumefantrine
- Astagraf Xl
- Atripla
- Belladonna-phenobarbital
- carbamazepine
- Carbatrol
- Cerebyx
- cimetidine
- Coartem
- colchicine
- colchicine-probenecid
- Colcrys
- cyclosporine
- cyclosporine modified
- Dexilant
- dexlansoprazole
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Donnatal
- droperidol
- Duragesic
- efavirenz
- efavirenz-emtricitabin-tenofov
- Endocet
- Endodan
- Epitol
- Equetro
- esomeprazole magnesium
- esomeprazole sodium
- esomeprazole strontium
- everolimus
- fentanyl
- fentanyl citrate
- fentanyl citrate (PF)
- Fentora
- First-lansoprazole
- First-omeprazole
- fosphenytoin
- Gengraf
- Geodon
- guanfacine
- Heartburn Relief
- Heartburn Relief 24 Hour
- Heartburn Treatment 24 Hour
- Hecoria
- ibuprofen-oxycodone
- Intuniv Er
- isoniazid-rifamp-pyrazinamide
- Korlym
- lansoprazole
- Lazanda
- Luminal
- macitentan
- Marqibo
- mifepristone
- Mysoline
- naproxen-esomeprazole
- Navelbine
- Neoral
- Nexium
- Nexium Iv
- Nexium Packet
- Oleptro Er
- Olysio
- Omeclamox-pak
- omeprazole
- omeprazole magnesium
- Omeprazole+syrspend Sf Alka
- omeprazole-clarith-amoxicillin
- omeprazole-sodium bicarbonate
- Opsumit
- Oxecta
- oxycodone
- oxycodone-acetaminophen
- oxycodone-aspirin
- Oxycontin
- pantoprazole
- Percocet
- Percodan
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- Prevacid
- Prevacid 24Hr
- Prevacid Solutab
- Prevpac
- Priftin
- Prilosec
- Prilosec Otc
- primidone
- Primlev
- Prograf
- Protonix
- quetiapine
- rabeprazole
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- rifapentine
- Rifater
- Roxicet
- Sandimmune
- Seroquel
- Seroquel Xr
- simeprevir
- Sublimaze (pf)
- Subsys
- Sustiva
- tacrolimus
- Tagamet Hb
- Tegretol
- Tegretol Xr
- temsirolimus
- Tenex
- thioridazine
- Torisel
- trazodone
- Vimovo
- vinblastine
- Vincasar Pfs
- vincristine
- vincristine sulfate liposomal
- vinorelbine
- Xartemis Xr
- Zegerid
- Zegerid Otc
- ziprasidone HCl
- ziprasidone mesylate
- Zortress
Severe
Moderate
- A-hydrocort
- A-methapred
- Abilify
- Abilify Discmelt
- Abilify Maintena
- Adalat Cc
- Adcirca
- Advair Diskus
- Advair Hfa
- Afeditab Cr
- aliskiren-amlodipin-hcthiazide
- aliskiren-amlodipine
- Aloxi
- alprazolam
- Alprazolam Intensol
- Alvesco
- amantadine HCl
- Amaryl
- Ambien
- Ambien Cr
- amlodipine
- amlodipine-atorvastatin
- amlodipine-benazepril
- amlodipine-olmesartan
- amlodipine-valsartan
- amlodipine-valsartan-hcthiazid
- Amturnide
- Anti-diarrhea
- Anti-diarrheal (lope)-anti-gas
- Anti-diarrheal (loperamide)
- Anucort-hc
- Anusol-hc
- Anzemet
- Apokyn
- apomorphine
- arformoterol
- aripiprazole
- arsenic trioxide
- Asmanex Twisthaler
- atazanavir
- atorvastatin
- Avelox
- Avelox Abc Pack
- Avelox In Nacl (iso-osmotic)
- azelastine-fluticasone
- azithromycin
- Azor
- Betapace
- Betapace Af
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- boceprevir
- bosentan
- Breo Ellipta
- Brovana
- budesonide
- budesonide-formoterol
- buspirone
- Caduet
- Calan
- Calan Sr
- Cardene Iv
- Cardene Iv In Dextrose
- Cardene Iv In Sodium Chloride
- Cardene Sr
- Cardizem
- Cardizem Cd
- Cardizem La
- Cartia Xt
- chloroquine phosphate
- chlorpromazine
- Cialis
- ciclesonide
- cilostazol
- Cipro
- Cipro In D5W
- Cipro Xr
- ciprofloxacin
- ciprofloxacin (mixture)
- ciprofloxacin in D5W
- clarithromycin
- clozapine
- Clozaril
- Colocort
- Complera
- Cortef
- Cortenema
- Cortifoam
- Corvert
- darifenacin
- Depo-medrol
- Detrol
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- Diabeta
- Diamode
- Diastat
- Diastat Acudial
- diazepam
- Diazepam Intensol
- Diflucan
- Dilacor Xr
- Dilt-xr
- diltiazem HCl
- Diskets
- dofetilide
- dolasetron
- Dolophine
- Duetact
- Dulera
- Dymista
- Edluar
- Edurant
- Effexor Xr
- emtricitab-rilpivirine-tenofov
- Enablex
- Entocort Ec
- Eovist
- erlotinib
- Erythrocin
- erythromycin
- erythromycin-sulfisoxazole
- estazolam
- eszopiclone
- Exforge
- Exforge Hct
- ezetimibe-atorvastatin
- Fazaclo
- felbamate
- Felbatol
- felodipine
- fesoterodine
- Fetzima
- First-duke's
- First-mary's Mouthwash
- flecainide
- Flo-pred
- Flonase
- Flovent Diskus
- Flovent Hfa
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- fludrocortisone
- fluticasone
- fluticasone furoate
- fluticasone-salmeterol
- fluticasone-vilanterol
- Foradil Aerolizer
- formoterol fumarate
- fosamprenavir
- foscarnet
- Foscavir
- gadoxetate
- Gleevec
- glimepiride
- glipizide
- glipizide-metformin
- Glucotrol
- Glucotrol Xl
- Glucovance
- glyburide
- glyburide micronized
- glyburide-metformin
- Glynase
- granisetron
- granisetron (PF)
- Granisol
- Grx Hicort 25
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- Hemril-30
- hydrocortisone
- hydrocortisone acetate
- hydrocortisone sod succ (PF)
- hydrocortisone sod succinate
- ibutilide fumarate
- imatinib
- Imodium Multi-symptom Relief
- Incivek
- indapamide
- Intermezzo
- isradipine
- Istodax
- ivacaftor
- Kaletra
- Kalydeco
- Ketek
- lapatinib
- Levaquin
- Levaquin In 5 % Dextrose
- Levitra
- levofloxacin
- levofloxacin in D5W
- levomilnacipran
- Lexiva
- Lipitor
- Liptruzet
- lithium carbonate
- lithium citrate
- Lithobid
- Lo-peramide
- loperamide
- loperamide-simethicone
- lopinavir-ritonavir
- Lotrel
- Lunesta
- Matzim La
- Medrol
- Medrol (pak)
- mefloquine
- methadone
- Methadone Intensol
- Methadose
- methylprednisolone
- methylprednisolone acetate
- methylprednisolone sod suc(PF)
- methylprednisolone sodium succ
- methylprednisolone-bupivacaine
- midazolam
- midazolam (PF)
- Millipred
- Millipred Dp
- moexipril
- moexipril-hydrochlorothiazide
- mometasone
- mometasone-formoterol
- moxifloxacin
- moxifloxacin in NaCl (iso-osm)
- Nebupent
- nicardipine
- nicardipine in dextrose,iso-os
- nicardipine in NaCl (iso-os)
- Nifedical Xl
- nifedipine
- Niravam
- nisoldipine
- norfloxacin
- Noroxin
- Norvasc
- Norvir
- Norvir Soft Gelatin
- nystatin-hydrocortisone-diphen
- nystatin-TCN-HC-diphenhydramin
- octreotide acetate
- ofloxacin
- olmesartan-amlodipin-hcthiazid
- Omnaris
- ondansetron
- ondansetron HCl
- ondansetron HCl (PF)
- Onglyza
- Orapred
- Orapred Odt
- palonosetron
- pazopanib
- Pediapred
- Pentam
- pentamidine
- Perforomist
- Physicians Ez Use M-pred
- pioglitazone-glimepiride
- Pletal
- pomalidomide
- Pomalyst
- prednisolone
- prednisolone acetate
- prednisolone sodium phosphate
- prednisone
- Prednisone Intensol
- procainamide
- Procardia
- Procardia Xl
- Proctocort
- propafenone
- Pulmicort
- Pulmicort Flexhaler
- Rayos
- Rectacort-hc
- regorafenib
- Revatio
- Reyataz
- Rhinocort Aqua
- rilpivirine
- Risperdal
- Risperdal Consta
- Risperdal M-tab
- risperidone
- risperidone microspheres
- ritonavir
- romidepsin
- Rythmol
- salmeterol
- Sancuso
- Sandostatin
- Sandostatin Lar Depot
- saxagliptin
- Serevent Diskus
- sildenafil
- solifenacin
- Soltamox
- Solu-cortef
- Solu-cortef (pf)
- Solu-medrol
- Solu-medrol (pf)
- Sorine
- sotalol
- Sotalol Af
- Stivarga
- Sular
- sunitinib
- Sutent
- Symbicort
- tadalafil
- tamoxifen
- Tarceva
- Tarka
- Taztia Xt
- Tekamlo
- telaprevir
- telavancin
- telithromycin
- telmisartan-amlodipine
- Tiazac
- Tikosyn
- tizanidine
- tolazamide
- tolbutamide
- Toviaz
- Tracleer
- trandolapril-verapamil
- triazolam
- Tribenzor
- Trisenox
- Twynsta
- Tykerb
- Uceris
- Ultra A-d
- Uniretic
- Univasc
- Valium
- vardenafil
- venlafaxine
- Veramyst
- verapamil
- Verelan
- Verelan Pm
- Veripred 20
- Versacloz
- Vesicare
- Vfend
- Vfend Iv
- Viagra
- Vibativ
- Victrelis
- voriconazole
- Votrient
- Xanax
- Xanax Xr
- Zanaflex
- Zetonna
- Zithromax
- Zithromax Tri-pak
- Zithromax Z-pak
- Zmax
- Zofran
- Zofran Odt
- zolpidem
- Zolpimist
- Zuplenz
- None
Contraindicated
- Chronic kidney disease stage 3A (moderate) GFR 45-59
- Chronic kidney disease stage 3B (moderate) GFR 30-44
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Congenital long QT syndrome
- Drug-induced hepatitis
- Hypocalcemia
- Hypokalemia
- Hypomagnesemia
- Prolonged QT interval
- Torsades de pointes
Severe
Moderate
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Hyperbilirubinemia
- Kidney disease with likely reduction in GFR
NOXAFIL (POSACONAZOLE)
- Oropharyngeal candidiasis
- Prevention of disseminated candidiasis
- Prevention of invasive pulmonary aspergillosis
- Refractory oropharyngeal candidiasis
- Dyspnea
- Edema
- Fever
- Hypokalemia
- Neutropenic disorder
- Peripheral edema
- Skin rash
- Thrombocytopenic disorder
- Thrombophlebitis
- Anorexia
- Cough
- Diarrhea
- Dizziness
- Fatigue
- General weakness
- Headache disorder
- Insomnia
- Myalgias
- Nausea
- Vomiting
More Frequent
Severe
Less Severe
- Abnormal hepatic function tests
- Abnormal vaginal bleeding
- Anemia
- Back pain
- Epistaxis
- Herpes simplex infection
- Hyperbilirubinemia
- Hypertension
- Hypocalcemia
- Hypomagnesemia
- Pneumonia
- Stomatitis
- Tachycardia
- Acute abdominal pain
- Arthralgias
- Chills
- Constipation
- Dyspepsia
- Hyperglycemia
- Hyperhidrosis
- Hypotension
- Petechiae
- Pharyngitis
- Pruritus of skin
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute renal failure
- Adrenal cortical insufficiency
- Hemolytic uremic syndrome
- Hepatic failure
- Pancreatitis
- Prolonged QT interval
- Pseudoaldosteronism
- Pulmonary thromboembolism
- Thrombotic thrombocytopenic purpura
- Torsades de pointes
Less Severe
- Paresthesia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Posaconazole ( IV)
Safety and efficacy not established for IV formulation. Oral dose form approved for age equal to and > 13 years.
Safety and efficacy under 13 years of age not established.
- 13 Years – 18 Years
- Safety and efficacy not established for IV formulation. Oral dose form approved for age equal to and > 13 years.
- 1 Day – 13 Years
- Safety and efficacy not established for IV formulation. Oral dose form approved for age equal to and > 13 years.
Posaconazole (Oral, IV)
Safety and efficacy not established for IV formulation. Oral dose form approved for age equal to and > 13 years.
Safety and efficacy under 13 years of age not established.
- 13 Years – 18 Years
- Safety and efficacy under 13 years of age not established.
- 1 Day – 13 Years
- Safety and efficacy under 13 years of age not established.
Posaconazole
- Severity Level:
2
- Additional Notes: Insufficient human data; animal data shows dev tox, consider tx benefit vs risks
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Posaconazole
Insufficient human data; manufacturer does not recommend
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient human data; manufacturer does not recommend |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Oropharyngeal candidiasis | |
| B37.0 | Candidal stomatitis |
| Refractory oropharyngeal candidiasis | |
| B37.0 | Candidal stomatitis |
| 0-9 | A-Z |
|---|---|
| B37.0 | Candidal stomatitis |
| B37.0 | Candidal stomatitis |
Formulary Reference Tool