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DUPIXENT (DUPILUMAB)
- Atopic dermatitis
- Chronic rhinosinusitis with nasal polyposis
- Refractory extrinsic asthma
200 mg/1.14 mL subcutaneous syringe
- Inject 1.14 milliliters (200 mg) by subcutaneous route every 2 weeks in the abdomen, thigh, or upper arm rotating injection sites
300 mg/2 mL subcutaneous syringe
- Inject 2 milliliters (300 mg) by subcutaneous route every 2 weeks in the abdomen, thigh, or upper arm rotating injection sites
Atopic dermatitis
- Inject 2 milliliters (300 mg) by subcutaneous route every 2 weeks in the abdomen, thigh, or upper arm rotating injection sites
- Inject 1.71 milliliters (300 mg) by subcutaneous route every 2 weeks in the abdomen, thigh, or upper arm rotating injection sites
- Inject 3.42 milliliters (600 mg) once by subcutaneous route using 2 separate injection sites in the abdomen, thigh, or upper arm
- Inject 4 milliliters (600 mg) once by subcutaneous route using 2 separate injection sites in the abdomen, thigh, or upper arm
Chronic rhinosinusitis with nasal polyposis
- Inject 2 milliliters (300 mg) by subcutaneous route every 2 weeks in the abdomen, thigh, or upper arm rotating injection sites
- Inject 1.71 milliliters (300 mg) by subcutaneous route every 2 weeks in the abdomen, thigh, or upper arm rotating injection sites
Refractory extrinsic asthma
- Inject 1.14 milliliters (200 mg) by subcutaneous route every 2 weeks in the abdomen, thigh, or upper arm rotating injection sites
- Inject 2 milliliters (300 mg) by subcutaneous route every 2 weeks in the abdomen, thigh, or upper arm rotating injection sites
- Inject 1.71 milliliters (300 mg) by subcutaneous route every 2 weeks in the abdomen, thigh, or upper arm rotating injection sites
- Inject 2.28 milliliters (400 mg) once by subcutaneous route using 2 separate injection sites in the abdomen, thigh, or upper arm
- Inject 3.42 milliliters (600 mg) once by subcutaneous route using 2 separate injection sites in the abdomen, thigh, or upper arm
- Inject 4 milliliters (600 mg) once by subcutaneous route using 2 separate injection sites in the abdomen, thigh, or upper arm
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- BCG vaccine, live (PF)
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- None
Severe
Moderate
- None
- None
Contraindicated
- None
Severe
Moderate
- Conjunctivitis
- Keratitis
DUPIXENT (DUPILUMAB)
- Atopic dermatitis
- Chronic rhinosinusitis with nasal polyposis
- Refractory extrinsic asthma
- None
- Conjunctivitis
- Eosinophilia
- Herpes simplex infection
- Injection site sequelae
- Pain in oropharynx
More Frequent
Severe
Less Severe
- None
- Blepharitis
- Dry eye
- Keratitis
- Ocular itching
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Anaphylaxis
- Eosinophilic granulomatosis with polyangiitis
- Eosinophilic pneumonia
- Erythema nodosum
- Serum sickness
- Urticaria
Less Severe
- Skin rash
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Dupilumab
Safety and efficacy not established age < 12 years.
- 1 Day – 12 Years
- Safety and efficacy not established age < 12 years.
Dupilumab
- Severity Level:
2
- Additional Notes: Limited human data do not suggest a clear association for major birth defects.
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
Dupilumab
Insuff data avail; human igg excreted into human milk
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Unknown | Not known; no or inclusive data | Insuff data avail; human igg excreted into human milk |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
Atopic dermatitis | |
L20 | Atopic dermatitis |
L20.0 | Besnier's prurigo |
L20.8 | Other atopic dermatitis |
L20.81 | Atopic neurodermatitis |
L20.82 | Flexural eczema |
L20.84 | Intrinsic (allergic) eczema |
L20.89 | Other atopic dermatitis |
L20.9 | Atopic dermatitis, unspecified |
Chronic rhinosinusitis with nasal polyposis | |
J32 | Chronic sinusitis |
J32.0 | Chronic maxillary sinusitis |
J32.1 | Chronic frontal sinusitis |
J32.2 | Chronic ethmoidal sinusitis |
J32.3 | Chronic sphenoidal sinusitis |
J32.4 | Chronic pansinusitis |
J32.8 | Other chronic sinusitis |
J32.9 | Chronic sinusitis, unspecified |
J33 | Nasal polyp |
J33.8 | Other polyp of sinus |
J33.9 | Nasal polyp, unspecified |
Refractory extrinsic asthma | |
J45.4 | Moderate persistent asthma |
J45.40 | Moderate persistent asthma, uncomplicated |
J45.5 | Severe persistent asthma |
J45.50 | Severe persistent asthma, uncomplicated |
0-9 | A-Z |
---|---|
J32 | Chronic sinusitis |
J32.0 | Chronic maxillary sinusitis |
J32.1 | Chronic frontal sinusitis |
J32.2 | Chronic ethmoidal sinusitis |
J32.3 | Chronic sphenoidal sinusitis |
J32.4 | Chronic pansinusitis |
J32.8 | Other chronic sinusitis |
J32.9 | Chronic sinusitis, unspecified |
J33 | Nasal polyp |
J33.8 | Other polyp of sinus |
J33.9 | Nasal polyp, unspecified |
J45.4 | Moderate persistent asthma |
J45.40 | Moderate persistent asthma, uncomplicated |
J45.5 | Severe persistent asthma |
J45.50 | Severe persistent asthma, uncomplicated |
L20 | Atopic dermatitis |
L20.0 | Besnier's prurigo |
L20.8 | Other atopic dermatitis |
L20.81 | Atopic neurodermatitis |
L20.82 | Flexural eczema |
L20.84 | Intrinsic (allergic) eczema |
L20.89 | Other atopic dermatitis |
L20.9 | Atopic dermatitis, unspecified |
Formulary Reference Tool