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JEVTANA (CABAZITAXEL)
- Metastatic prostate carcinoma
10 mg/mL (first dilution) intravenous solution
- Infuse 20 mg/m2 over 60 minute(s) by intravenous route every 3 weeks
10 mg/mL (first dilution) intravenous solution
- Infuse 20 mg/m2 over 60 minute(s) by intravenous route every 3 weeks
Metastatic prostate carcinoma
- Infuse 25 mg/m2 over 60 minute(s) by intravenous route every 3 weeks
- Infuse 20 mg/m2 over 60 minute(s) by intravenous route every 3 weeks
- Infuse 15 mg/m2 over 60 minute(s) by intravenous route every 3 weeks
- Infuse 11.25 mg/m2 over 60 minute(s) by intravenous route every 3 weeks
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- BCG vaccine, live (PF)
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- natalizumab
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- Tysabri
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- clozapine
- Clozaril
- deferiprone
- Fazaclo
- Ferriprox
- Versacloz
Severe
Moderate
- None
- Lactating mother
- Pregnancy
- Severe hepatic disease
Contraindicated
- Acute renal failure
- Anemia
- Dehydration
- Disease of liver
- Interstitial lung disease
- Neutropenic disorder
- Protein-calorie malnutrition
- Severe diarrhea
- Severe infection
- Thrombocytopenic disorder
Severe
Moderate
- Vomiting
JEVTANA (CABAZITAXEL)
- Metastatic prostate carcinoma
- Dyspnea
- Neutropenic disorder
- Alopecia
- Anemia
- Anorexia
- Arthralgias
- Back pain
- Constipation
- Cough
- Diarrhea
- Dysgeusia
- Dysuria
- Fatigue
- Fever
- General weakness
- Hematuria
- Leukopenia
- Nausea
- Peripheral neuropathy
- Thrombocytopenic disorder
- Vomiting
More Frequent
Severe
Less Severe
- Hypotension
- Renal failure
- None
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute abdominal pain
- Acute respiratory distress syndrome
- Bacterial sepsis
- Bronchospastic pulmonary disease
- Cardiac arrhythmia
- Enterocolitis
- Gastrointestinal hemorrhage
- Gastrointestinal obstruction
- Gastrointestinal perforation
- Hypersensitivity drug reaction
- Ileus
- Infection
- Interstitial lung disease
- Interstitial pneumonitis
- Neutropenic colitis
- Severe diarrhea
- Severe neutropenic disorder
Less Severe
- Erythema
- Gastritis
- Skin rash
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Cabazitaxel
Safety and efficacy not established. Indicated for prostate cancer. Lack of efficacy in pediatric glioma studies.
- 1 Day – 18 Years
- Safety and efficacy not established. Indicated for prostate cancer. Lack of efficacy in pediatric glioma studies.
Cabazitaxel
- Severity Level:
1
- Additional Notes: Contraindicated during pregnancy.
Contraindicated
Cabazitaxel
Not indicated in females
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Not indicated in females |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Cabazitaxel
General:Increased risk of adverse events (e.g., dehydration, fatigue, UTI) and death in elderly. Hematologic: Elderly are more likely to develop neutropenia and infection. Cardiovascular-Greater incidence of cardiac disorders in the elderly compared to younger patients.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | Y | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- Cabazitaxel may cause a serious blood disorder (a low number of white blood cells). This effect can lower your body's ability to fight an infection and thus lead to serious (rarely fatal) infections. Your doctor will monitor you closely and check your blood often during treatment.<br /><br />You may also receive another medication to reduce the risk of this side effect. If your white blood cell count is too low, you should not receive cabazitaxel. Tell your doctor right away if you develop any signs of infection such as sore throat that doesn't go away, fever, chills, cough, painful/difficult urination.<br /><br /> Cabazitaxel may rarely cause serious allergic reactions. This drug must not be used in patients who have previously had an allergic reaction to it or to other medications containing polysorbate 80. Your doctor should prescribe other medications (such as antihistamines, H2 blockers, corticosteroids) to help prevent an allergic reaction. Get medical help right away if you develop any signs of an allergic reaction such as rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
| Metastatic prostate carcinoma | |
| C61 | Malignant neoplasm of prostate |
| 0-9 | A-Z |
|---|---|
| C61 | Malignant neoplasm of prostate |
Formulary Reference Tool