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MULTAQ (DRONEDARONE HYDROCHLORIDE)
- Paroxysmal atrial fibrillation
- Prevention of recurrent atrial fibrillation
400 mg tablet
- 1 tablet (400 mg) by oral route 2 times per day with morning andevening meals
400 mg tablet
- 1 tablet (400 mg) by oral route 2 times per day with morning andevening meals
Paroxysmal atrial fibrillation
- 1 tablet (400 mg) by oral route 2 times per day with morning andevening meals
Prevention of recurrent atrial fibrillation
- 1 tablet (400 mg) by oral route 2 times per day with morning andevening meals
- Adasuve
- amiodarone
- amiodarone in dextrose,iso-osm
- amitriptyline
- amitriptyline-chlordiazepoxide
- amoxapine
- amoxicil-clarithromy-lansopraz
- Amrix
- Anafranil
- Apokyn
- apomorphine
- arsenic trioxide
- artemether-lumefantrine
- atazanavir
- azithromycin
- bedaquiline
- Betapace
- Betapace Af
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- boceprevir
- Caprelsa
- Celexa
- chloroquine phosphate
- chlorpromazine
- citalopram
- clarithromycin
- clomipramine
- Coartem
- Compazine
- Compro
- conivaptan in 5 % dextrose
- Cordarone
- Corvert
- Crixivan
- cyclobenzaprine
- cyclobenzaprine with msm
- cyclosporine
- cyclosporine modified
- dasatinib
- desipramine
- Diflucan
- Diskets
- disopyramide
- dofetilide
- Dolophine
- doxepin
- droperidol
- elvitegr-cobicist-emtric-tenof
- Erythrocin
- erythromycin
- erythromycin-sulfisoxazole
- escitalopram oxalate
- ezetimibe-simvastatin
- fingolimod
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- fluphenazine decanoate
- fluphenazine HCl
- Gengraf
- Gilenya
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- ibutilide fumarate
- imipramine HCl
- imipramine pamoate
- Incivek
- indinavir
- Invega
- Invega Sustenna
- Invirase
- isradipine
- itraconazole
- Juxtapid
- Kaletra
- Ketek
- ketoconazole
- Lexapro
- lomitapide
- lopinavir-ritonavir
- loxapine
- loxapine succinate
- Loxitane
- maprotiline
- methadone
- Methadone Intensol
- Methadose
- miconazole
- Nebupent
- nefazodone
- nelfinavir
- Neoral
- Nexterone
- niacin-simvastatin
- nilotinib
- norfloxacin
- Noroxin
- Norpace
- Norpace Cr
- Norpramin
- nortriptyline
- Norvir
- Norvir Soft Gelatin
- Noxafil
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- Onmel
- Orap
- Oravig
- Pacerone
- paliperidone
- paliperidone palmitate
- Pamelor
- pasireotide
- Pentam
- pentamidine
- perphenazine
- perphenazine-amitriptyline
- pimozide
- posaconazole
- Prevpac
- procainamide
- prochlorperazine
- prochlorperazine Edisylate
- prochlorperazine maleate
- propafenone
- protriptyline
- Qualaquin
- quinine sulfate
- Reyataz
- ritonavir
- Rythmol
- Sandimmune
- saquinavir mesylate
- Signifor
- Simcor
- Sirturo
- Sorine
- sotalol
- Sotalol Af
- Sporanox
- Sporanox Pulsepak
- Sprycel
- Stribild
- Surmontil
- Tabradol
- Tasigna
- telaprevir
- telithromycin
- thioridazine
- Tikosyn
- Tofranil
- Tofranil-pm
- trifluoperazine
- trimipramine
- Trisenox
- vandetanib
- Vaprisol
- Vfend
- Vfend Iv
- Victrelis
- Viracept
- Vivactil
- voriconazole
- Vytorin 10-20
- Vytorin 10-40
- Vytorin 10-80
- Zithromax
- Zithromax Tri-pak
- Zithromax Z-pak
- Zmax
Contraindicated
- Advair Diskus
- Advair Hfa
- alfuzosin
- Aloxi
- amantadine HCl
- Anzemet
- Astagraf Xl
- Avelox
- Avelox Abc Pack
- Avelox In Nacl (iso-osmotic)
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Belladonna-phenobarbital
- budesonide-formoterol
- calcium-mag-B complex-D3-hrb61
- carbamazepine
- Carbatrol
- Cardene Iv
- Cardene Iv In Dextrose
- Cardene Iv In Sodium Chloride
- Cardene Sr
- Cerebyx
- clozapine
- Clozaril
- Cold & Flu Fighter
- Complera
- crizotinib
- Digox
- digoxin
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- dolasetron
- Donnatal
- Dulera
- Edurant
- Effexor Xr
- emtricitab-rilpivirine-tenofov
- Eovist
- Epitol
- Equetro
- eribulin
- ezogabine
- Fareston
- Fatigue Relief Complex
- Fazaclo
- felbamate
- Felbatol
- flecainide
- fluticasone-salmeterol
- Foradil Aerolizer
- formoterol fumarate
- foscarnet
- Foscavir
- fosphenytoin
- gadoxetate
- Geodon
- granisetron
- granisetron (PF)
- Granisol
- guanfacine
- Halaven
- Hecoria
- Hycamtin
- ibrutinib
- Imbruvica
- indapamide
- Intuniv Er
- isoniazid-rifamp-pyrazinamide
- Istodax
- Lanoxin
- Lanoxin Pediatric
- lapatinib
- Levaquin
- Levaquin In 5 % Dextrose
- Levitra
- levofloxacin
- levofloxacin in D5W
- lithium carbonate
- lithium citrate
- Lithobid
- Luminal
- moexipril
- moexipril-hydrochlorothiazide
- mometasone-formoterol
- moxifloxacin
- moxifloxacin in NaCl (iso-osm)
- Mysoline
- Nexavar
- nicardipine
- nicardipine in dextrose,iso-os
- nicardipine in NaCl (iso-os)
- octreotide acetate
- ofloxacin
- Olysio
- ondansetron
- ondansetron HCl
- ondansetron HCl (PF)
- palonosetron
- pazopanib
- Perforomist
- Phenadoz
- Phenergan
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- Potiga
- primidone
- Prograf
- promethazine
- Promethazine Vc
- Promethazine Vc-codeine
- promethazine-codeine
- promethazine-DM
- promethazine-phenyleph-codeine
- promethazine-phenylephrine
- Promethegan
- quetiapine
- quinupristin-dalfopristin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- rilpivirine
- Risperdal
- Risperdal Consta
- Risperdal M-tab
- risperidone
- risperidone microspheres
- romidepsin
- salmeterol
- Sancuso
- Sandostatin
- Sandostatin Lar Depot
- Serevent Diskus
- Seroquel
- Seroquel Xr
- simeprevir
- Soltamox
- sorafenib
- St. John's wort
- sunitinib
- Sutent
- Symbicort
- Synercid
- tacrolimus
- tamoxifen
- Tegretol
- Tegretol Xr
- telavancin
- Tenex
- tetrabenazine
- tizanidine
- topotecan
- toremifene
- Tykerb
- Uniretic
- Univasc
- Uroxatral
- vardenafil
- vemurafenib
- venlafaxine
- Versacloz
- Vibativ
- vit C-St. John wort-elder-hb30
- Votrient
- Women's Complex
- Xalkori
- Xenazine
- Zanaflex
- Zelboraf
- ziprasidone HCl
- ziprasidone mesylate
- Zofran
- Zofran Odt
- Zuplenz
Severe
Moderate
- Abstral
- Actiq
- Adalat Cc
- Advicor
- afatinib
- Afeditab Cr
- Alfenta
- alfentanil
- Altoprev
- amlodipine-atorvastatin
- Anti-diarrhea
- Anti-diarrheal (lope)-anti-gas
- Anti-diarrheal (loperamide)
- atorvastatin
- avanafil
- bosentan
- Bystolic
- Caduet
- Calan
- Calan Sr
- Cardizem
- Cardizem Cd
- Cardizem La
- Cartia Xt
- cilostazol
- Conzip
- Diamode
- Dilacor Xr
- Dilt-xr
- diltiazem HCl
- Duragesic
- dutasteride-tamsulosin
- Dutoprol
- Endocet
- Endodan
- ezetimibe-atorvastatin
- fentanyl
- fentanyl citrate
- fentanyl citrate (PF)
- Fentora
- Flomax
- Gilotrif
- ibuprofen-oxycodone
- Imodium Multi-symptom Relief
- Inderal La
- Inderal Xl
- Innopran Xl
- ivacaftor
- Jalyn
- Kalydeco
- Lazanda
- Lipitor
- Liptruzet
- Lo-peramide
- loperamide
- loperamide-simethicone
- Lopressor
- Lopressor Hct
- lovastatin
- Matzim La
- metoprolol su-hydrochlorothiaz
- metoprolol succinate
- metoprolol ta-hydrochlorothiaz
- metoprolol tartrate
- Mevacor
- nebivolol
- niacin-lovastatin
- Nifedical Xl
- nifedipine
- Oxecta
- oxycodone
- oxycodone-acetaminophen
- oxycodone-aspirin
- Oxycontin
- Percocet
- Percodan
- Pletal
- Primlev
- Procardia
- Procardia Xl
- propranolol
- propranolol-hydrochlorothiazid
- Rapamune
- Roxicet
- simvastatin
- sirolimus
- Stendra
- Sublimaze (pf)
- Subsys
- Synapryn
- tamsulosin
- Tarka
- Taztia Xt
- Tiazac
- Toprol Xl
- Tracleer
- tramadol
- tramadol-acetaminophen
- tramadol-glucosamine
- trandolapril-verapamil
- Ultra A-d
- Ultracet
- Ultram
- Ultram Er
- verapamil
- Verelan
- Verelan Pm
- Vytorin 10-10
- Xartemis Xr
- Zocor
- Acute decompensated heart failure
- Bradycardia
- Complete atrioventricular block
- Interstitial pneumonitis
- Lactating mother
- Pregnancy
- Pulmonary fibrosis
- Second degree atrioventricular heart block
- Severe chronic heart failure
- Severe hepatic disease
- Torsades de pointes
Contraindicated
- Abnormal hepatic function tests
- Congenital long QT syndrome
- Hypokalemia
- Hypomagnesemia
- Prolonged QT interval
- Sick sinus syndrome
- Worsening of chronic heart failure
Severe
Moderate
- Acute renal failure
- Increased cardiovascular event risk
- Kidney disease with reduction in GFR
MULTAQ (DRONEDARONE HYDROCHLORIDE)
- Paroxysmal atrial fibrillation
- Prevention of recurrent atrial fibrillation
- None
- Abdominal pain with cramps
- Diarrhea
- General weakness
- Nausea
- Vomiting
More Frequent
Severe
Less Severe
- Acute arterial thromboembolism
- Bradycardia
- Cerebrovascular accident
- Chronic heart failure
- Prolonged QT interval
- Worsening of chronic heart failure
- Dyspepsia
- Eczema
- Pruritus of skin
- Skin inflammation
- Skin rash
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Anaphylaxis
- Angioedema
- Atrial flutter
- Hepatic failure
- Hepatocellular damage
- Hyperbilirubinemia
- Hypersensitivity angiitis
- Interstitial lung disease
- Interstitial pneumonitis
- Pulmonary fibrosis
- Renal failure
- Skin photosensitivity
- Torsades de pointes
- Vasculitis
Less Severe
- Dysgeusia
- Kidney disease with reduction in GFR
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Dronedarone
Safety and efficacy not established.
- 1 Day – 18 Years
- Safety and efficacy not established.
Dronedarone
- Severity Level:
X
- Additional Notes:
Contraindicated
Dronedarone
Contraindicated by manufacturer for women of childbearing age
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Contraindicated by manufacturer for women of childbearing age |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Dronedarone
Cardiovascular-Contraindicated in NYHA Class IV heart failure, recent decompensation with hospitalization or persistent A. fib. Minimize QT prolongation risk by correcting hypokalemia or hypomagnesemia. Avoid in patients with unpaced bradyarrhythmias. Hepatic-Monitor hepatic function for acute liver injury. Contraindicated with previous liver injury with amiodarone. Renal-Monitor serum creatine for reversible increase. Pulmonary-Contraindicated with previous lung injury with amiodarone.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | Y | N | Y | N |
BEERS: Y HEDIS: N STOPP: Y
No Known Risk
None
- Do not take this medication if you have severe heart failure that makes you short of breath during light activity or even while resting, or if you recently had to stay in a hospital because your heart failure got worse. Also, do not take this medication if you have a certain kind of irregular heartbeat (permanent atrial fibrillation) that will not or cannot be changed back to a normal heart rhythm. Dronedarone may increase your risk of death, stroke, or the need to be treated in the hospital for heart failure if you have any of these conditions.<br /><br /> Consult your doctor for more details and to discuss the risks and benefits of dronedarone. Tell your doctor right away if you have new or worsening symptoms of heart failure such as shortness of breath, swelling ankles/feet, unusual tiredness, unusual/sudden weight gain.
| Paroxysmal atrial fibrillation | |
| I48.0 | Paroxysmal atrial fibrillation |
| Prevention of recurrent atrial fibrillation | |
| I48.0 | Paroxysmal atrial fibrillation |
| I48.1 | Persistent atrial fibrillation |
| I48.91 | Unspecified atrial fibrillation |
| 0-9 | A-Z |
|---|---|
| I48.0 | Paroxysmal atrial fibrillation |
| I48.0 | Paroxysmal atrial fibrillation |
| I48.1 | Persistent atrial fibrillation |
| I48.91 | Unspecified atrial fibrillation |
Formulary Reference Tool