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SUMATRIPTAN (SUMATRIPTAN)
- Migraine
10 mg/actuation nasal spray
- Spray 1 spray (10 mg) by intranasal route once; if headache returns, dose may be repeated once after 1 hour, not to exceed 30 mg per day
20 mg/actuation nasal spray
- Spray 1 spray (20 mg) by intranasal route once; if headache returns, dose may be repeated once after 2 hours, not to exceed 40 mg per day
5 mg/actuation nasal spray
- Spray 1 spray (5 mg) by intranasal route once; if headache returns, dose may be repeated once after 2 hours, not to exceed 40 mg per day
20 mg/actuation nasal spray
- Spray 1 spray (20 mg) by intranasal route once; if headache returns, dose may be repeated once after 2 hours, not to exceed 40 mg per day
5 mg/actuation nasal spray
- Spray 1 spray (5 mg) by intranasal route once; if headache returns, dose may be repeated once after 2 hours, not to exceed 40 mg per day
Migraine
- Spray 1 spray (5 mg) by intranasal route once; if headache returns, dose may be repeated once after 2 hours, not to exceed 40 mg per day
- Spray 1 spray (5 mg) by intranasal route into each nostril once; if headache returns, the dose may be repeated once after 2 hours, not to exceed 40 mg per day
- Spray 2 sprays (10 mg) by intranasal route into each nostril once; ifheadache returns, the dose may be repeated once after 2 hours, not toexceed 40 mg per day
- Spray 1 spray (20 mg) by intranasal route once; if headache returns, dose may be repeated once after 2 hours, not to exceed 40 mg per day
- Azilect
- bromocriptine
- Cafergot
- Cycloset
- D.h.e.45
- dihydroergotamine
- Eldepryl
- ergoloid
- Ergomar
- ergotamine tartrate
- ergotamine-caffeine
- isocarboxazid
- linezolid
- Marplan
- Matulane
- methylene blue (antidote)
- methylergonovine
- Migergot
- Migranal
- Nardil
- Parlodel
- Parnate
- phenelzine
- procarbazine
- rasagiline
- selegiline HCl
- tranylcypromine
- Zelapar
- Zyvox
Contraindicated
- Conzip
- Nucynta
- Nucynta Er
- Synapryn
- tapentadol
- tramadol
- tramadol-acetaminophen
- tramadol-glucosamine
- Ultracet
- Ultram
- Ultram Er
Severe
Moderate
- Brintellix
- Brisdelle
- Celexa
- citalopram
- Cymbalta
- desvenlafaxine
- desvenlafaxine fumarate
- desvenlafaxine succinate
- duloxetine
- Effexor Xr
- escitalopram oxalate
- Fetzima
- fluoxetine
- fluvoxamine
- Khedezla
- levomilnacipran
- Lexapro
- Luvox Cr
- milnacipran
- olanzapine-fluoxetine
- paroxetine HCl
- paroxetine mesylate
- Paxil
- Paxil Cr
- Pexeva
- Pristiq
- Prozac
- Prozac Weekly
- Sarafem
- Savella
- sertraline
- Symbyax
- venlafaxine
- Viibryd
- vilazodone
- vortioxetine
- Zoloft
- Acute myocardial infarction
- Angina
- Cerebral ischemia
- Cerebrovascular accident
- Coronary artery disease
- Hemiplegic migraine
- Ischemic bowel disease
- Myocardial ischemia
- Peripheral vascular disease
- Prinzmetal angina
- Serotonin syndrome
- Severe hepatic disease
- Severe uncontrolled hypertension
Contraindicated
- Increased cardiovascular event risk
- Tachyarrhythmia
Severe
Moderate
- Seizure disorder
SUMATRIPTAN (SUMATRIPTAN)
- Migraine
- None
- Dizziness
- Dysgeusia
- Flushing
- Hypesthesia
- Injection site sequelae
- Nasal passage irritation
- Nausea
- Paresthesia
- Sensation of warmth
- Stinging of skin
- Vertigo
- Vomiting
More Frequent
Severe
Less Severe
- None
- Drowsy
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abdominal pain with cramps
- Acquired dystonia
- Acute myocardial infarction
- Anaphylaxis
- Angioedema
- Cerebrovascular accident
- Chest pain
- Chest tightness
- Coronary artery spasm
- Dysphagia
- Hypersensitivity drug reaction
- Hypertension
- Hypotension
- Intracerebral hemorrhage
- Ischemic bowel disease
- Myocardial ischemia
- Neck stiffness
- Peripheral ischemia
- Raynaud's phenomenon
- Seizure disorder
- Serotonin syndrome
- Splenic infarction
- Subarachnoid intracranial hemorrhage
- Ventricular fibrillation
- Ventricular tachycardia
- Vision loss
Less Severe
- Cramps
- Fatigue
- Jaw pain
- Medication overuse headache
- Mouth irritation
- Muscle rigidity
- Muscle weakness
- Myalgias
- Nasal pain
- Palpitations
- Sinusitis
- Sore tongue
- Symptoms of anxiety
- Tremor
- Visual changes
Contraindicated
None
Severe Precaution
Sumatriptan
Efficacy not established over placebo for treatment of migraine. Adverse event risk similar to adults including visual loss and stroke.
- 1 Day – 18 Years
- Efficacy not established over placebo for treatment of migraine. Adverse event risk similar to adults including visual loss and stroke.
Management or Monitoring Precaution
None
Sumatriptan
- Severity Level:
2
- Additional Notes: Insufficient human data avail, consider maternal tx benefit vs pot fetal risk
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Sumatriptan (nasal)
Insufficient data available
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Sumatriptan
Hepatic-Elderly patients are more likely to have decreased hepatic function thus decreasing drug clearance. Cardiovascular-Hypertensive effects may be more pronounced in the elderly and increase the risk for cardiovascular events in those with cardiovascular disease. A cardiovascular evaluation is recommended in those with CV risk factors, Avoid use of the drug in any patient with a cerebrovascular syndrome.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | Y | Y | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
| Migraine | |
| G43 | Migraine |
| G43.0 | Migraine without aura |
| G43.00 | Migraine without aura, not intractable |
| G43.001 | Migraine without aura, not intractable, with status migrainosus |
| G43.009 | Migraine without aura, not intractable, without status migrainosus |
| G43.01 | Migraine without aura, intractable |
| G43.011 | Migraine without aura, intractable, with status migrainosus |
| G43.019 | Migraine without aura, intractable, without status migrainosus |
| G43.1 | Migraine with aura |
| G43.10 | Migraine with aura, not intractable |
| G43.101 | Migraine with aura, not intractable, with status migrainosus |
| G43.109 | Migraine with aura, not intractable, without status migrainosus |
| G43.11 | Migraine with aura, intractable |
| G43.111 | Migraine with aura, intractable, with status migrainosus |
| G43.119 | Migraine with aura, intractable, without status migrainosus |
| G43.4 | Hemiplegic migraine |
| G43.40 | Hemiplegic migraine, not intractable |
| G43.41 | Hemiplegic migraine, intractable |
| G43.7 | Chronic migraine without aura |
| G43.70 | Chronic migraine without aura, not intractable |
| G43.701 | Chronic migraine without aura, not intractable, with status migrainosus |
| G43.709 | Chronic migraine without aura, not intractable, without status migrainosus |
| G43.71 | Chronic migraine without aura, intractable |
| G43.711 | Chronic migraine without aura, intractable, with status migrainosus |
| G43.719 | Chronic migraine without aura, intractable, without status migrainosus |
| G43.8 | Other migraine |
| G43.80 | Other migraine, not intractable |
| G43.801 | Other migraine, not intractable, with status migrainosus |
| G43.809 | Other migraine, not intractable, without status migrainosus |
| G43.81 | Other migraine, intractable |
| G43.811 | Other migraine, intractable, with status migrainosus |
| G43.819 | Other migraine, intractable, without status migrainosus |
| G43.82 | Menstrual migraine, not intractable |
| G43.821 | Menstrual migraine, not intractable, with status migrainosus |
| G43.829 | Menstrual migraine, not intractable, without status migrainosus |
| G43.83 | Menstrual migraine, intractable |
| G43.831 | Menstrual migraine, intractable, with status migrainosus |
| G43.839 | Menstrual migraine, intractable, without status migrainosus |
| G43.9 | Migraine, unspecified |
| G43.90 | Migraine, unspecified, not intractable |
| G43.901 | Migraine, unspecified, not intractable, with status migrainosus |
| G43.909 | Migraine, unspecified, not intractable, without status migrainosus |
| G43.91 | Migraine, unspecified, intractable |
| G43.911 | Migraine, unspecified, intractable, with status migrainosus |
| G43.919 | Migraine, unspecified, intractable, without status migrainosus |
| G43.B | Ophthalmoplegic migraine |
| G43.B0 | Ophthalmoplegic migraine, not intractable |
| G43.B1 | Ophthalmoplegic migraine, intractable |
| G43.C | Periodic headache syndromes in child or adult |
| G43.C0 | Periodic headache syndromes in child or adult, not intractable |
| G43.C1 | Periodic headache syndromes in child or adult, intractable |
| G43.D | Abdominal migraine |
| G43.D0 | Abdominal migraine, not intractable |
| G43.D1 | Abdominal migraine, intractable |
| 0-9 | A-Z |
|---|---|
| G43 | Migraine |
| G43.0 | Migraine without aura |
| G43.00 | Migraine without aura, not intractable |
| G43.001 | Migraine without aura, not intractable, with status migrainosus |
| G43.009 | Migraine without aura, not intractable, without status migrainosus |
| G43.01 | Migraine without aura, intractable |
| G43.011 | Migraine without aura, intractable, with status migrainosus |
| G43.019 | Migraine without aura, intractable, without status migrainosus |
| G43.1 | Migraine with aura |
| G43.10 | Migraine with aura, not intractable |
| G43.101 | Migraine with aura, not intractable, with status migrainosus |
| G43.109 | Migraine with aura, not intractable, without status migrainosus |
| G43.11 | Migraine with aura, intractable |
| G43.111 | Migraine with aura, intractable, with status migrainosus |
| G43.119 | Migraine with aura, intractable, without status migrainosus |
| G43.4 | Hemiplegic migraine |
| G43.40 | Hemiplegic migraine, not intractable |
| G43.41 | Hemiplegic migraine, intractable |
| G43.7 | Chronic migraine without aura |
| G43.70 | Chronic migraine without aura, not intractable |
| G43.701 | Chronic migraine without aura, not intractable, with status migrainosus |
| G43.709 | Chronic migraine without aura, not intractable, without status migrainosus |
| G43.71 | Chronic migraine without aura, intractable |
| G43.711 | Chronic migraine without aura, intractable, with status migrainosus |
| G43.719 | Chronic migraine without aura, intractable, without status migrainosus |
| G43.8 | Other migraine |
| G43.80 | Other migraine, not intractable |
| G43.801 | Other migraine, not intractable, with status migrainosus |
| G43.809 | Other migraine, not intractable, without status migrainosus |
| G43.81 | Other migraine, intractable |
| G43.811 | Other migraine, intractable, with status migrainosus |
| G43.819 | Other migraine, intractable, without status migrainosus |
| G43.82 | Menstrual migraine, not intractable |
| G43.821 | Menstrual migraine, not intractable, with status migrainosus |
| G43.829 | Menstrual migraine, not intractable, without status migrainosus |
| G43.83 | Menstrual migraine, intractable |
| G43.831 | Menstrual migraine, intractable, with status migrainosus |
| G43.839 | Menstrual migraine, intractable, without status migrainosus |
| G43.9 | Migraine, unspecified |
| G43.90 | Migraine, unspecified, not intractable |
| G43.901 | Migraine, unspecified, not intractable, with status migrainosus |
| G43.909 | Migraine, unspecified, not intractable, without status migrainosus |
| G43.91 | Migraine, unspecified, intractable |
| G43.911 | Migraine, unspecified, intractable, with status migrainosus |
| G43.919 | Migraine, unspecified, intractable, without status migrainosus |
| G43.B | Ophthalmoplegic migraine |
| G43.B0 | Ophthalmoplegic migraine, not intractable |
| G43.B1 | Ophthalmoplegic migraine, intractable |
| G43.C | Periodic headache syndromes in child or adult |
| G43.C0 | Periodic headache syndromes in child or adult, not intractable |
| G43.C1 | Periodic headache syndromes in child or adult, intractable |
| G43.D | Abdominal migraine |
| G43.D0 | Abdominal migraine, not intractable |
| G43.D1 | Abdominal migraine, intractable |
Formulary Reference Tool