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Drug overview for PREDNISOLONE ACETATE (prednisolone acetate):
Generic name: PREDNISOLONE ACETATE (pred-NIS-oh-loan)
Drug class: Ophthalmic Steroids
Therapeutic class: Ophthalmic Agents
Prednisolone is a synthetic corticosteroid.
No enhanced Uses information available for this drug.
Generic name: PREDNISOLONE ACETATE (pred-NIS-oh-loan)
Drug class: Ophthalmic Steroids
Therapeutic class: Ophthalmic Agents
Prednisolone is a synthetic corticosteroid.
No enhanced Uses information available for this drug.
DRUG IMAGES
PREDNISOLONE AC 1% EYE DROP
The following indications for PREDNISOLONE ACETATE (prednisolone acetate) have been approved by the FDA:
Indications:
Severe ocular inflammation
Professional Synonyms:
Severe ophthalmic inflammation
Indications:
Severe ocular inflammation
Professional Synonyms:
Severe ophthalmic inflammation
The following dosing information is available for PREDNISOLONE ACETATE (prednisolone acetate):
Potency of some sodium phosphate preparations is expressed in terms of prednisolone phosphate.
For use in the eye, 1 or 2 drops of prednisolone acetate ophthalmic suspension or prednisolone sodium phosphate ophthalmic solution may be instilled into the conjunctival sac every hour during the day and every 2 hours during the night for initial therapy in severe cases. In mild or moderate inflammation or when a favorable response is attained in severe cases, dosage may be reduced to 1 or 2 drops every 3-12 hours.
Alternatively, prednisolone sodium phosphate ophthalmic ointment may be instilled into the conjunctival sac 3 or 4 times daily initially, and once or twice daily thereafter. The ointment also may be used at night in conjunction with daytime use of a suspension or solution to reduce the frequent applications required with the liquid dosage forms.
The lowest effective concentration should be used and, if improvement does not occur within several days, the drug should be discontinued and other therapy begun. The duration of treatment depends on the type and severity of the disease and may range from a few days to several weeks; long-term therapy should be avoided. When the drug is discontinued, dosage should be gradually tapered to avoid exacerbation of the disease.
For use in the eye, 1 or 2 drops of prednisolone acetate ophthalmic suspension or prednisolone sodium phosphate ophthalmic solution may be instilled into the conjunctival sac every hour during the day and every 2 hours during the night for initial therapy in severe cases. In mild or moderate inflammation or when a favorable response is attained in severe cases, dosage may be reduced to 1 or 2 drops every 3-12 hours.
Alternatively, prednisolone sodium phosphate ophthalmic ointment may be instilled into the conjunctival sac 3 or 4 times daily initially, and once or twice daily thereafter. The ointment also may be used at night in conjunction with daytime use of a suspension or solution to reduce the frequent applications required with the liquid dosage forms.
The lowest effective concentration should be used and, if improvement does not occur within several days, the drug should be discontinued and other therapy begun. The duration of treatment depends on the type and severity of the disease and may range from a few days to several weeks; long-term therapy should be avoided. When the drug is discontinued, dosage should be gradually tapered to avoid exacerbation of the disease.
Prednisolone acetate or sodium phosphate is applied topically to the eye. Care should be taken to avoid contamination of the tip of the ointment tube or dropper when the drug is used ophthalmically.
| DRUG LABEL | DOSING TYPE | DOSING INSTRUCTIONS |
|---|---|---|
| PREDNISOLONE AC 1% EYE DROP | Maintenance | Adults instill 1 drop into affected eye(s) by ophthalmic route 2 times per day |
| DRUG LABEL | DOSING TYPE | DOSING INSTRUCTIONS |
|---|---|---|
| PREDNISOLONE AC 1% EYE DROP | Maintenance | Adults instill 1 drop into affected eye(s) by ophthalmic route 2 times per day |
The following drug interaction information is available for PREDNISOLONE ACETATE (prednisolone acetate):
There are 0 contraindications.
There are 0 severe interactions.
There are 0 moderate interactions.
The following contraindication information is available for PREDNISOLONE ACETATE (prednisolone acetate):
Drug contraindication overview.
No enhanced Contraindications information available for this drug.
No enhanced Contraindications information available for this drug.
There are 4 contraindications.
Absolute contraindication.
| Contraindication List |
|---|
| Fungal infection of eye |
| Herpes simplex dendritic keratitis |
| Tuberculosis of the eye |
| Vaccinia virus keratitis |
There are 2 severe contraindications.
Adequate patient monitoring is recommended for safer drug use.
| Severe List |
|---|
| Amebic infection of the eye |
| Ocular hypertension |
There are 4 moderate contraindications.
Clinically significant contraindication, where the condition can be managed or treated before the drug may be given safely.
| Moderate List |
|---|
| Diabetes mellitus |
| Krukenberg spindle |
| Open angle glaucoma |
| Severe myopia |
The following adverse reaction information is available for PREDNISOLONE ACETATE (prednisolone acetate):
Adverse reaction overview.
No enhanced Common Adverse Effects information available for this drug.
No enhanced Common Adverse Effects information available for this drug.
There are 20 severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
| None. |
Ocular hypertension |
| Rare/Very Rare |
|---|
|
Adrenocortical insufficiency Cataracts Central serous chorioretinopathy Corneal degeneration Corneal edema Corneal erosion Corneal ulcer Fungal infection of eye Glaucoma Globe perforation Hypercortisolism Hypersensitivity drug reaction Keratitis Optic nerve damage Punctate keratitis Reduced visual acuity Uveitis Visual changes Visual field defect |
There are 23 less severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
|
Blurred vision |
Headache disorder Iritis Ocular pain |
| Rare/Very Rare |
|---|
|
Accommodation disorder Allergic dermatitis Blepharoptosis Calcification of cornea Chemosis Conjunctival hyperemia Conjunctivitis Dizziness Dysgeusia Eye tearing Foreign body sensation of eye Impaired wound healing Mydriasis Ocular infection Ocular irritation Ocular itching Ocular redness Photophobia Urticaria |
The following precautions are available for PREDNISOLONE ACETATE (prednisolone acetate):
No enhanced Pediatric Use information available for this drug.
Contraindicated
Severe Precaution
Management or Monitoring Precaution
Contraindicated
| None |
Severe Precaution
| None |
Management or Monitoring Precaution
| None |
No enhanced Pregnancy information available for this drug.
No enhanced Lactation information available for this drug.
No enhanced Geriatric Use information available for this drug.
The following prioritized warning is available for PREDNISOLONE ACETATE (prednisolone acetate):
No warning message for this drug.
No warning message for this drug.
The following icd codes are available for PREDNISOLONE ACETATE (prednisolone acetate)'s list of indications:
| Severe ocular inflammation | |
| H57.8 | Other specified disorders of eye and adnexa |
| H57.89 | Other specified disorders of eye and adnexa |
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