GATIFLOXACIN (gatifloxacin)

There are 0 contraindications.

There are 0 severe contraindications.

There are 1 moderate contraindications. Clinically significant contraindication, where the condition can be managed or treated before the drug may be given safely.

Moderate List
No disease contraindications

There are 15 severe adverse reactions.

More Frequent	Less Frequent
Keratitis	Ocular itching Reduced visual acuity

Rare/Very Rare
Allergic dermatitis Anaphylaxis Angioedema Chemosis Conjunctival hemorrhage Dyspnea Facial edema Hypersensitivity drug reaction Laryngeal edema Pharyngeal edema Stevens-johnson syndrome Urticaria

There are 14 less severe adverse reactions.

More Frequent	Less Frequent
Dry eye Eye tearing Ocular pain Ocular redness	Dysgeusia Eyelid edema Headache disorder Ocular discharge Ocular irritation

Rare/Very Rare
Blepharitis Blurred vision Nausea Pruritus of skin Skin rash

Data are not available regarding use of gatifloxacin 0.5% ophthalmic solution in pregnant women. In animal studies using oral gatifloxacin, teratogenic effects (e.g., skeletal/craniofacial malformations, delayed ossification, atrial enlargement) and reduced fetal weight were reported at dosages equal to or greater than 150 mg/kg daily (approximately 600-fold higher than recommended human ophthalmic dosage on a mg/m2 basis).

Gatifloxacin is distributed into milk in rats after oral administration. It is not known whether gatifloxacin is distributed into human milk following topical application to the eye. Benefits of breast-feeding and the importance of gatifloxacin ophthalmic solution to the woman should be considered along with the potential adverse effects on the breast-fed child from the drug or from the underlying maternal condition.

No overall differences in safety and efficacy of gatifloxacin 0.5% ophthalmic solution have been observed between geriatric and younger adults.