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XIFAXAN (RIFAXIMIN)
- Diarrhea predominant irritable bowel syndrome
- Hepatic encephalopathy
- Traveler's diarrhea due to noninvasive escherichia coli
200 mg tablet
- 1 tablet (200 mg) by oral route 3 times per day
550 mg tablet
- 1 tablet (550 mg) by oral route 2 times per day
Diarrhea predominant irritable bowel syndrome
- 1 tablet (550 mg) by oral route 3 times per day
- 1 tablet (550 mg) by oral route 3 times per day for 14 days
Hepatic encephalopathy
- 1 tablet (550 mg) by oral route 2 times per day
Traveler's diarrhea due to noninvasive escherichia coli
- 1 tablet (200 mg) by oral route 3 times per day
- 1 tablet (200 mg) by oral route 3 times per day for 3 days
- typhoid vaccine
- Vivotif Berna Vaccine
Contraindicated
- None
Severe
Moderate
- None
- None
Contraindicated
- Pregnancy
Severe
Moderate
- Severe hepatic disease
XIFAXAN (RIFAXIMIN)
- Diarrhea predominant irritable bowel syndrome
- Hepatic encephalopathy
- Traveler's diarrhea due to noninvasive escherichia coli
- None
- Abdominal pain with cramps
- Dizziness
- Fatigue
- Fecal urgency
- Flatulence
- Headache disorder
- Nausea
- Peripheral edema
- Tenesmus
More Frequent
Severe
Less Severe
- Abdominal herniation
- Constipation
- Dysgeusia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Anaphylaxis
- Angioedema
- Chest pain
- Clostridium difficile infection
- Dehydration
- Dyspnea
- Exfoliative dermatitis
- Flushing
- Hematuria
- Hypersensitivity drug reaction
- Lymphocytosis
- Neutropenic disorder
- Proteinuria
- Pruritus of skin
- Skin rash
- Sore throat
- Tinnitus
- Upper respiratory infection
- Urticaria
- Vomiting
Less Severe
- Abdominal distension
- Anorexia
- Arthralgias
- Clammy skin
- Diarrhea
- Dream disorder
- Dry throat
- Dysuria
- Earache
- General weakness
- Gingival disorders
- Hyperhidrosis
- Increased urinary frequency
- Insomnia
- Malaise
- Migraine
- Motion sickness
- Muscle spasm
- Myalgias
- Neck pain
- Pharyngitis
- Polyuria
- Rhinitis
- Rhinorrhea
- Skin photosensitivity
- Syncope
- Weight loss
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Rifaximin
Safety and efficacy in children less than 12 years not established.
- 1 Day – 12 Years
- Safety and efficacy in children less than 12 years not established.
Rifaximin
- Severity Level:
D
- Additional Notes: Insuff human data; poor oral bioavailability; teratogenic in rats and rabbits
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Rifaximin
Poor oral bioavailability; unlikely clinically significant effect on infant
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Poor oral bioavailability; unlikely clinically significant effect on infant |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Diarrhea predominant irritable bowel syndrome | |
| K58.0 | Irritable bowel syndrome with diarrhea |
| Hepatic encephalopathy | |
| B15.0 | Hepatitis A with hepatic coma |
| B16.0 | Acute hepatitis B with delta-agent with hepatic coma |
| B16.2 | Acute hepatitis B without delta-agent with hepatic coma |
| B17.11 | Acute hepatitis C with hepatic coma |
| B19.0 | Unspecified viral hepatitis with hepatic coma |
| B19.11 | Unspecified viral hepatitis B with hepatic coma |
| B19.21 | Unspecified viral hepatitis C with hepatic coma |
| K70.41 | Alcoholic hepatic failure with coma |
| K71.11 | Toxic liver disease with hepatic necrosis, with coma |
| K72.01 | Acute and subacute hepatic failure with coma |
| K72.11 | Chronic hepatic failure with coma |
| K72.90 | Hepatic failure, unspecified without coma |
| K72.91 | Hepatic failure, unspecified with coma |
| Traveler's diarrhea due to noninvasive escherichia coli | |
| A04.2 | Enteroinvasive escherichia coli infection |
| A04.4 | Other intestinal escherichia coli infections |
| A09 | Infectious gastroenteritis and colitis, unspecified |
| 0-9 | A-Z |
|---|---|
| A04.2 | Enteroinvasive escherichia coli infection |
| A04.4 | Other intestinal escherichia coli infections |
| A09 | Infectious gastroenteritis and colitis, unspecified |
| B15.0 | Hepatitis A with hepatic coma |
| B16.0 | Acute hepatitis B with delta-agent with hepatic coma |
| B16.2 | Acute hepatitis B without delta-agent with hepatic coma |
| B17.11 | Acute hepatitis C with hepatic coma |
| B19.0 | Unspecified viral hepatitis with hepatic coma |
| B19.11 | Unspecified viral hepatitis B with hepatic coma |
| B19.21 | Unspecified viral hepatitis C with hepatic coma |
| K58.0 | Irritable bowel syndrome with diarrhea |
| K70.41 | Alcoholic hepatic failure with coma |
| K71.11 | Toxic liver disease with hepatic necrosis, with coma |
| K72.01 | Acute and subacute hepatic failure with coma |
| K72.11 | Chronic hepatic failure with coma |
| K72.90 | Hepatic failure, unspecified without coma |
| K72.91 | Hepatic failure, unspecified with coma |
Formulary Reference Tool