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APRISO (MESALAMINE)
- Ulcerative colitis
- Ulcerative colitis remission
0.375 gram capsule,extended release
- 4 capsules (1,500 mg) by oral route once daily in the morning
Ulcerative colitis
- 4 capsules (1,500 mg) by oral route once daily in the morning
Ulcerative colitis remission
- 4 capsules (1,500 mg) by oral route once daily in the morning
- None
Contraindicated
- Methotrexate (anti-rheumatic)
- methotrexate sodium
- methotrexate sodium (PF)
- Rheumatrex
- Trexall
Severe
Moderate
- acetazolamide
- acetazolamide sodium
- Amaryl
- Arixtra
- colchicine-probenecid
- dalteparin (porcine)
- Diabeta
- Diamox Sequels
- Duetact
- Elmiron
- enoxaparin
- fondaparinux
- Fragmin
- glimepiride
- glipizide
- glipizide-metformin
- Glucotrol
- Glucotrol Xl
- Glucovance
- glyburide
- glyburide micronized
- glyburide-metformin
- Glynase
- heparin (porcine)
- heparin (porcine) in D5W
- heparin(porcine) in 0.45% NaCl
- heparin, porcine (PF)
- Lovenox
- methazolamide
- nateglinide
- Neptazane
- pentosan polysulfate sodium
- pioglitazone-glimepiride
- probenecid
- Starlix
- tolazamide
- tolbutamide
- None
Contraindicated
- Interstitial nephritis
- Minimal change glomerulonephritis
Severe
Moderate
- Disease of liver
- Kidney disease with likely reduction in GFR
- Kidney disease with reduction in GFR
- Pyloroduodenal obstruction
APRISO (MESALAMINE)
- Ulcerative colitis
- Ulcerative colitis remission
- None
- Abdominal pain with cramps
- Cough
- Diarrhea
- Eructation
- Flatulence
- Headache disorder
- Nausea
- Pharyngitis
- Sinusitis
- Vomiting
More Frequent
Severe
Less Severe
- Abnormal hepatic function tests
- Alopecia
- Back pain
- Conjunctivitis
- Constipation
- Dizziness
- Dyspepsia
- General weakness
- Hypertension
- Lethargy
- Malaise
- Myalgias
- Pain
- Peripheral edema
- Pruritus of skin
- Skin rash
- Stomatitis
- Xerostomia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute pancreatitis
- Agranulocytosis
- Anaphylaxis
- Anemia
- Angioedema
- Aplastic anemia
- Asthma exacerbation
- Cholecystitis
- Cholestatic hepatitis
- DRESS syndrome
- Eosinophilia
- Eosinophilic pneumonia
- Erythema nodosum
- Gastrointestinal hemorrhage
- Gastrointestinal perforation
- Gout
- Guillain-barre syndrome
- Hepatic failure
- Hepatitis
- Hypersensitivity pneumonitis
- Interstitial nephritis
- Intracranial hypertension
- Jaundice
- Kidney disease with reduction in GFR
- Leukopenia
- Lupus-like syndrome
- Myelitis
- Myocarditis
- Nephrogenic diabetes insipidus
- Neutropenic disorder
- Obstructive hyperbilirubinemia
- Pericardial effusion
- Pericarditis
- Pleuritis
- Pyoderma gangrenosum
- Rectal bleeding
- Stevens-johnson syndrome
- Thrombocytopenic disorder
Less Severe
- Abdominal distension
- Acne vulgaris
- Acute confusion
- Anorexia
- Arthralgias
- Chest pain
- Cramps
- Drowsy
- Dyspnea
- Dysuria
- Earache
- Edema
- Epididymitis
- Facial edema
- Fatigue
- Fever
- Flu-like symptoms
- Gastritis
- Hematuria
- Hyperhidrosis
- Hypertriglyceridemia
- Hypotension
- Increased appetite
- Lymphadenopathy
- Menorrhagia
- Neck pain
- Ocular pain
- Oligospermia
- Peripheral neuropathy
- Renal failure
- Rhinitis
- Skin photosensitivity
- Sore throat
- Tachycardia
- Tenesmus
- Tinnitus
- Tremor
- Urticaria
- Vertigo
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Mesalamine
Safety and efficacy not established age < 5 years.
- 1 Day – 5 Years
- Safety and efficacy not established age < 5 years.
Mesalamine (5 Aminosalicylic Acid)
- Severity Level:
2
- Additional Notes: Insufficient human data; animal data do not suggest fetal risk
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Mesalamine (5-aminosalicylic Acid)
Metabolite excreted in high levels w/unknwn infant risk;Few cases of diarrhea
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Drug shown to have adverse effect | Metabolite excreted in high levels w/unknwn infant risk;Few cases of diarrhea |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Mesalamine
Renal-Monitor renal function as elderly are more sensitive to renal toxicity. Higher AUC and decreased elimination observed. Hematologic-Increased risk of neutropenia or pancytopenia. Monitor complete blood cell counts and platelet counts in elderly patients during treatment.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | N | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
| Ulcerative colitis | |
| K51 | Ulcerative colitis |
| K51.0 | Ulcerative (chronic) pancolitis |
| K51.00 | Ulcerative (chronic) pancolitis without complications |
| K51.01 | Ulcerative (chronic) pancolitis with complications |
| K51.011 | Ulcerative (chronic) pancolitis with rectal bleeding |
| K51.012 | Ulcerative (chronic) pancolitis with intestinal obstruction |
| K51.013 | Ulcerative (chronic) pancolitis with fistula |
| K51.014 | Ulcerative (chronic) pancolitis with abscess |
| K51.018 | Ulcerative (chronic) pancolitis with other complication |
| K51.019 | Ulcerative (chronic) pancolitis with unspecified complications |
| K51.2 | Ulcerative (chronic) proctitis |
| K51.20 | Ulcerative (chronic) proctitis without complications |
| K51.21 | Ulcerative (chronic) proctitis with complications |
| K51.211 | Ulcerative (chronic) proctitis with rectal bleeding |
| K51.212 | Ulcerative (chronic) proctitis with intestinal obstruction |
| K51.213 | Ulcerative (chronic) proctitis with fistula |
| K51.214 | Ulcerative (chronic) proctitis with abscess |
| K51.218 | Ulcerative (chronic) proctitis with other complication |
| K51.219 | Ulcerative (chronic) proctitis with unspecified complications |
| K51.3 | Ulcerative (chronic) rectosigmoiditis |
| K51.30 | Ulcerative (chronic) rectosigmoiditis without complications |
| K51.31 | Ulcerative (chronic) rectosigmoiditis with complications |
| K51.311 | Ulcerative (chronic) rectosigmoiditis with rectal bleeding |
| K51.312 | Ulcerative (chronic) rectosigmoiditis with intestinal obstruction |
| K51.313 | Ulcerative (chronic) rectosigmoiditis with fistula |
| K51.314 | Ulcerative (chronic) rectosigmoiditis with abscess |
| K51.318 | Ulcerative (chronic) rectosigmoiditis with other complication |
| K51.319 | Ulcerative (chronic) rectosigmoiditis with unspecified complications |
| K51.5 | Left sided colitis |
| K51.50 | Left sided colitis without complications |
| K51.51 | Left sided colitis with complications |
| K51.511 | Left sided colitis with rectal bleeding |
| K51.512 | Left sided colitis with intestinal obstruction |
| K51.513 | Left sided colitis with fistula |
| K51.514 | Left sided colitis with abscess |
| K51.518 | Left sided colitis with other complication |
| K51.519 | Left sided colitis with unspecified complications |
| K51.8 | Other ulcerative colitis |
| K51.80 | Other ulcerative colitis without complications |
| K51.81 | Other ulcerative colitis with complications |
| K51.811 | Other ulcerative colitis with rectal bleeding |
| K51.812 | Other ulcerative colitis with intestinal obstruction |
| K51.813 | Other ulcerative colitis with fistula |
| K51.814 | Other ulcerative colitis with abscess |
| K51.818 | Other ulcerative colitis with other complication |
| K51.819 | Other ulcerative colitis with unspecified complications |
| K51.9 | Ulcerative colitis, unspecified |
| K51.90 | Ulcerative colitis, unspecified, without complications |
| K51.91 | Ulcerative colitis, unspecified, with complications |
| K51.911 | Ulcerative colitis, unspecified with rectal bleeding |
| K51.912 | Ulcerative colitis, unspecified with intestinal obstruction |
| K51.913 | Ulcerative colitis, unspecified with fistula |
| K51.914 | Ulcerative colitis, unspecified with abscess |
| K51.918 | Ulcerative colitis, unspecified with other complication |
| K51.919 | Ulcerative colitis, unspecified with unspecified complications |
| Ulcerative colitis remission | |
| K51.00 | Ulcerative (chronic) pancolitis without complications |
| K51.20 | Ulcerative (chronic) proctitis without complications |
| K51.30 | Ulcerative (chronic) rectosigmoiditis without complications |
| K51.40 | Inflammatory polyps of colon without complications |
| K51.50 | Left sided colitis without complications |
| K51.80 | Other ulcerative colitis without complications |
| K51.90 | Ulcerative colitis, unspecified, without complications |
| 0-9 | A-Z |
|---|---|
| K51 | Ulcerative colitis |
| K51.0 | Ulcerative (chronic) pancolitis |
| K51.00 | Ulcerative (chronic) pancolitis without complications |
| K51.00 | Ulcerative (chronic) pancolitis without complications |
| K51.01 | Ulcerative (chronic) pancolitis with complications |
| K51.011 | Ulcerative (chronic) pancolitis with rectal bleeding |
| K51.012 | Ulcerative (chronic) pancolitis with intestinal obstruction |
| K51.013 | Ulcerative (chronic) pancolitis with fistula |
| K51.014 | Ulcerative (chronic) pancolitis with abscess |
| K51.018 | Ulcerative (chronic) pancolitis with other complication |
| K51.019 | Ulcerative (chronic) pancolitis with unspecified complications |
| K51.2 | Ulcerative (chronic) proctitis |
| K51.20 | Ulcerative (chronic) proctitis without complications |
| K51.20 | Ulcerative (chronic) proctitis without complications |
| K51.21 | Ulcerative (chronic) proctitis with complications |
| K51.211 | Ulcerative (chronic) proctitis with rectal bleeding |
| K51.212 | Ulcerative (chronic) proctitis with intestinal obstruction |
| K51.213 | Ulcerative (chronic) proctitis with fistula |
| K51.214 | Ulcerative (chronic) proctitis with abscess |
| K51.218 | Ulcerative (chronic) proctitis with other complication |
| K51.219 | Ulcerative (chronic) proctitis with unspecified complications |
| K51.3 | Ulcerative (chronic) rectosigmoiditis |
| K51.30 | Ulcerative (chronic) rectosigmoiditis without complications |
| K51.30 | Ulcerative (chronic) rectosigmoiditis without complications |
| K51.31 | Ulcerative (chronic) rectosigmoiditis with complications |
| K51.311 | Ulcerative (chronic) rectosigmoiditis with rectal bleeding |
| K51.312 | Ulcerative (chronic) rectosigmoiditis with intestinal obstruction |
| K51.313 | Ulcerative (chronic) rectosigmoiditis with fistula |
| K51.314 | Ulcerative (chronic) rectosigmoiditis with abscess |
| K51.318 | Ulcerative (chronic) rectosigmoiditis with other complication |
| K51.319 | Ulcerative (chronic) rectosigmoiditis with unspecified complications |
| K51.40 | Inflammatory polyps of colon without complications |
| K51.5 | Left sided colitis |
| K51.50 | Left sided colitis without complications |
| K51.50 | Left sided colitis without complications |
| K51.51 | Left sided colitis with complications |
| K51.511 | Left sided colitis with rectal bleeding |
| K51.512 | Left sided colitis with intestinal obstruction |
| K51.513 | Left sided colitis with fistula |
| K51.514 | Left sided colitis with abscess |
| K51.518 | Left sided colitis with other complication |
| K51.519 | Left sided colitis with unspecified complications |
| K51.8 | Other ulcerative colitis |
| K51.80 | Other ulcerative colitis without complications |
| K51.80 | Other ulcerative colitis without complications |
| K51.81 | Other ulcerative colitis with complications |
| K51.811 | Other ulcerative colitis with rectal bleeding |
| K51.812 | Other ulcerative colitis with intestinal obstruction |
| K51.813 | Other ulcerative colitis with fistula |
| K51.814 | Other ulcerative colitis with abscess |
| K51.818 | Other ulcerative colitis with other complication |
| K51.819 | Other ulcerative colitis with unspecified complications |
| K51.9 | Ulcerative colitis, unspecified |
| K51.90 | Ulcerative colitis, unspecified, without complications |
| K51.90 | Ulcerative colitis, unspecified, without complications |
| K51.91 | Ulcerative colitis, unspecified, with complications |
| K51.911 | Ulcerative colitis, unspecified with rectal bleeding |
| K51.912 | Ulcerative colitis, unspecified with intestinal obstruction |
| K51.913 | Ulcerative colitis, unspecified with fistula |
| K51.914 | Ulcerative colitis, unspecified with abscess |
| K51.918 | Ulcerative colitis, unspecified with other complication |
| K51.919 | Ulcerative colitis, unspecified with unspecified complications |
Formulary Reference Tool