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Drug overview for MILRINONE IN 5% DEXTROSE (milrinone lactate/dextrose 5 % in water):
Generic name: MILRINONE LACTATE/DEXTROSE 5 % IN WATER (MIL-ri-none)
Drug class: Inotropic Agents
Therapeutic class: Cardiovascular Therapy Agents
Milrinone lactate, a selective phosphodiesterase (PDE) inhibitor, is a positive inotropic agent that has vasodilating effects.
No enhanced Uses information available for this drug.
Generic name: MILRINONE LACTATE/DEXTROSE 5 % IN WATER (MIL-ri-none)
Drug class: Inotropic Agents
Therapeutic class: Cardiovascular Therapy Agents
Milrinone lactate, a selective phosphodiesterase (PDE) inhibitor, is a positive inotropic agent that has vasodilating effects.
No enhanced Uses information available for this drug.
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The following indications for MILRINONE IN 5% DEXTROSE (milrinone lactate/dextrose 5 % in water) have been approved by the FDA:
Indications:
Acute decompensated heart failure
Professional Synonyms:
Acute heart failure
Overt cardiac failure
Overt CHF
Overt congestive heart failure
Overt heart failure
Uncontrolled cardiac failure
Indications:
Acute decompensated heart failure
Professional Synonyms:
Acute heart failure
Overt cardiac failure
Overt CHF
Overt congestive heart failure
Overt heart failure
Uncontrolled cardiac failure
The following dosing information is available for MILRINONE IN 5% DEXTROSE (milrinone lactate/dextrose 5 % in water):
Dosage of milrinone lactate is expressed in terms of milrinone.
No enhanced Administration information available for this drug.
No dosing information available.
No generic dosing information available.
The following drug interaction information is available for MILRINONE IN 5% DEXTROSE (milrinone lactate/dextrose 5 % in water):
There are 0 contraindications.
There are 0 severe interactions.
There are 0 moderate interactions.
The following contraindication information is available for MILRINONE IN 5% DEXTROSE (milrinone lactate/dextrose 5 % in water):
Drug contraindication overview.
Milrinone is contraindicated in patients who are hypersensitive to milrinone or any ingredient in the formulation.
Milrinone is contraindicated in patients who are hypersensitive to milrinone or any ingredient in the formulation.
There are 1 contraindications.
Absolute contraindication.
| Contraindication List |
|---|
| Pulmonic valve stenosis |
There are 3 severe contraindications.
Adequate patient monitoring is recommended for safer drug use.
| Severe List |
|---|
| Acute myocardial infarction |
| Cardiac arrhythmia |
| Hypertrophic cardiomyopathy |
There are 2 moderate contraindications.
Clinically significant contraindication, where the condition can be managed or treated before the drug may be given safely.
| Moderate List |
|---|
| Hypotension |
| Kidney disease with reduction in glomerular filtration rate (GFr) |
The following adverse reaction information is available for MILRINONE IN 5% DEXTROSE (milrinone lactate/dextrose 5 % in water):
Adverse reaction overview.
Adverse effects reported in 1% or more of patients receiving milrinone include ventricular arrhythmias (e.g., ventricular ectopy, nonsustained ventricular tachycardia, sustained ventricular tachycardia), supraventricular arrhythmias, hypotension, chest pain/angina, and headache. Ventricular fibrillation and torsades de pointes have been reported rarely.
Adverse effects reported in 1% or more of patients receiving milrinone include ventricular arrhythmias (e.g., ventricular ectopy, nonsustained ventricular tachycardia, sustained ventricular tachycardia), supraventricular arrhythmias, hypotension, chest pain/angina, and headache. Ventricular fibrillation and torsades de pointes have been reported rarely.
There are 9 severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
| None. |
Angina Hypotension Ventricular tachycardia |
| Rare/Very Rare |
|---|
|
Anaphylaxis Bronchospastic pulmonary disease Hypokalemia Injection site sequelae Thrombocytopenic disorder Ventricular fibrillation |
There are 5 less severe adverse reactions.
| More Frequent | Less Frequent |
|---|---|
|
Ventricular arrhythmias |
Headache disorder Supraventricular arrhythmias |
| Rare/Very Rare |
|---|
|
Skin rash Tremor |
The following precautions are available for MILRINONE IN 5% DEXTROSE (milrinone lactate/dextrose 5 % in water):
Safety and efficacy not established in children. However, milrinone has been used in pediatric patients for postresuscitation stabilization+.
Contraindicated
Severe Precaution
Management or Monitoring Precaution
Contraindicated
| None |
Severe Precaution
| None |
Management or Monitoring Precaution
| None |
Category C. (See Users Guide.)
Not known whether milrinone is distributed into milk. Caution is advised if the drug is administered in nursing women.
No substantial differences in safety and efficacy relative to younger adults.
The following prioritized warning is available for MILRINONE IN 5% DEXTROSE (milrinone lactate/dextrose 5 % in water):
No warning message for this drug.
No warning message for this drug.
The following icd codes are available for MILRINONE IN 5% DEXTROSE (milrinone lactate/dextrose 5 % in water)'s list of indications:
| Acute decompensated heart failure | |
| I50.21 | Acute systolic (congestive) heart failure |
| I50.23 | Acute on chronic systolic (congestive) heart failure |
| I50.31 | Acute diastolic (congestive) heart failure |
| I50.33 | Acute on chronic diastolic (congestive) heart failure |
| I50.41 | Acute combined systolic (congestive) and diastolic (congestive) heart failure |
| I50.43 | Acute on chronic combined systolic (congestive) and diastolic (congestive) heart failure |
| I50.811 | Acute right heart failure |
| I50.813 | Acute on chronic right heart failure |
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