TRIPLE ANTIBIOTIC (neomycin sulfate/bacitracin zinc/polymyxin b sulfate)

There are 0 contraindications.

There are 1 severe contraindications. Adequate patient monitoring is recommended for safer drug use.

Severe List
Severe burns

There are 2 moderate contraindications. Clinically significant contraindication, where the condition can be managed or treated before the drug may be given safely.

Moderate List
Large open wound
No disease contraindications

There are 4 severe adverse reactions.

More Frequent	Less Frequent
Dermatitis due to topical drug Skin rash	None.

Rare/Very Rare
Anaphylaxis Ototoxicity

There are 2 less severe adverse reactions.

More Frequent	Less Frequent
None.	None.

Rare/Very Rare
Fungal infection of skin Skin rash

Bacitracin and bacitracin zinc should be used during pregnancy only if potential benefits justify potential risks to the fetus. Some manufacturers state that patients who are pregnant should consult a clinician before using topical preparations containing bacitracin or bacitracin zinc. The topical preparation containing bacitracin zinc, neomycin sulfate, polymyxin B sulfate, and hydrocortisone should be used during pregnancy only if potential benefits justify potential risks to the fetus.

Corticosteroids have been teratogenic in mice and rabbits when applied topically. Aminoglycosides may cause fetal harm following systemic absorption in pregnant women. The drugs cross the placenta and total, irreversible, bilateral, congenital deafness has been reported in some children whose mothers received parenteral streptomycin during pregnancy.

Fixed-combination topical preparations containing neomycin sulfate and a corticosteroid should be used during pregnancy only if potential benefits justify potential risks to the fetus. Corticosteroids have been teratogenic in animals (mice, rabbits) when applied topically. If the irrigation solution containing neomycin sulfate and polymyxin B sulfate is used for bladder irrigation during pregnancy, the patient should be informed of the potential hazard to the fetus.

It is not known whether topical bacitracin is distributed into milk. Some experts consider topical bacitracin compatible with nursing. Some manufacturers state that patients who are breast-feeding should consult a clinician before using topical preparations containing bacitracin or bacitracin zinc.

The topical preparation containing bacitracin zinc, neomycin sulfate, polymyxin B sulfate, and hydrocortisone should be used with caution in nursing women. Hydrocortisone is distributed into human milk following oral administration, and systemic absorption may occur when hydrocortisone is applied topically. Clinically unimportant amounts of neomycin may distribute into breast milk following systemic absorption of the drug.

Fixed-combination topical preparations containing neomycin sulfate and a corticosteroid should be used with caution in nursing women. Corticosteroids administered systemically (e.g., orally) are distributed into human milk, and systemic absorption may occur when the drugs are applied topically.

No enhanced Geriatric Use information available for this drug.