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BUPRENEX (BUPRENORPHINE HCL)
- Postoperative acute pain
- Severe pain
0.3 mg/mL injection solution
- Inject 1 milliliter (0.3 mg) by intramuscular route every 6 hours as needed
Postoperative acute pain
- Inject 1 milliliter (0.3 mg) by intramuscular route every 6 hours as needed
- Inject 1 milliliter (0.3 mg) over at least 2 minute(s) by intravenousroute every 6 hours as needed
Severe pain
- Inject 1 milliliter (0.3 mg) by intramuscular route every 6 hours as needed
- Inject 1 milliliter (0.3 mg) over at least 2 minute(s) by intravenousroute every 6 hours as needed
- Depade
- naltrexone
- naltrexone microspheres
- Revia
- Vivitrol
Contraindicated
- amiodarone
- amiodarone in dextrose,iso-osm
- Betapace
- Betapace Af
- Cordarone
- Corvert
- dextromethorphan-quinidine
- disopyramide
- dofetilide
- ibutilide fumarate
- Nexterone
- Norpace
- Norpace Cr
- Nuedexta
- Pacerone
- procainamide
- quinidine gluconate
- quinidine sulfate
- sodium oxybate
- Sorine
- sotalol
- Sotalol Af
- Tikosyn
- Xyrem
Severe
Moderate
- acetaminophen-codeine
- Alfenta
- alfentanil
- alprazolam
- Alprazolam Intensol
- amitriptyline-chlordiazepoxide
- Ascomp With Codeine
- Astramorph-pf
- Ativan
- belladonna alkaloids-opium
- Belladonna-opium
- bromphen-pseudoephed-codeine
- brompheniramine-PE-codeine
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-acetaminop-caf-cod
- butorphanol tartrate
- Capcof
- Capital With Codeine
- carisoprodol-ASA-codeine
- Cheratussin Ac
- Cheratussin Dac
- chlorcyclizine-codeine
- chlordiazepoxide HCl
- chlordiazepoxide-clidinium
- chlorphen-pseudoephed-codeine
- chlorpheniramine-codeine
- chlorpheniramine-hydrocodone
- chlorpheniramine-PE-codeine
- clobazam
- clonazepam
- clorazepate dipotassium
- clrcycliz-pseudoephed-codeine
- codeine sulfate
- codeine-butalbital-ASA-caff
- codeine-guaifenesin
- codeine-pyrilamine
- cpm-pseudoephed-hydrocodone
- Demerol
- Demerol (pf)
- Depodur (pf)
- dexbrompheniramine-PSE-codeine
- dexchlorphen-phenyleph-codeine
- Diastat
- Diastat Acudial
- diazepam
- Diazepam Intensol
- dihydrocodeine-aspirin-caff
- Dilaudid
- Dilaudid (pf)
- diphenoxylate-atropine
- Doral
- Duramorph (pf)
- Endocet
- Endodan
- estazolam
- Fanatrex
- fentanyl citrate (PF)
- Fioricet With Codeine
- Fiorinal-codeine #3
- flurazepam
- gabapentin
- gabapentin enacarbil
- Gralise
- Gralise 30-day Starter Pack
- Guaiatussin Ac
- Guaifenesin Ac
- Guaifenesin Dac
- Guiatuss Ac
- Horizant
- Hycet
- hydrocodone bitartrate
- Hydrocodone Compound
- hydrocodone-acetaminophen
- hydrocodone-homatropine
- hydrocodone-ibuprofen
- Hydromet
- hydromorphone
- hydromorphone (PF)
- Ibudone
- ibuprofen-oxycodone
- Iophen C-nr
- isoniazid-rifamp-pyrazinamide
- Klonopin
- Librax (with Clidinium)
- Lomotil
- lorazepam
- Lorazepam Intensol
- Lortab Elixir
- Lortuss Ex
- M-clear Wc
- M-end Max D
- M-end Pe
- Mar-cof Bp
- Mar-cof Cg
- meperidine
- meperidine (PF)
- Meperitab
- midazolam
- morphine
- morphine (PF)
- morphine liposomal (PF)
- nalbuphine
- Neurontin
- Niravam
- Norco
- Onfi
- Opana
- opium tincture
- oxazepam
- Oxecta
- oxycodone
- oxycodone-acetaminophen
- oxycodone-aspirin
- oxymorphone
- paregoric
- pentazocine lactate
- pentazocine-naloxone
- Percocet
- Percodan
- Phenylhistine
- Phenylhistine Dh
- Poly-tussin
- Poly-tussin Ac
- Poly-tussin D
- Primlev
- Pro-clear Ac
- Pro-clear Caps
- Pro-red Ac (w/ Dexchlorphenir)
- Promethazine Vc-codeine
- promethazine-codeine
- promethazine-phenyleph-codeine
- pseudoephedrine-codeine-GG
- pseudoephedrine-hydrocodone
- quazepam
- Relcof C
- remifentanil
- Reprexain
- Restoril
- Rezira
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- Roxicet
- Rydex
- Statuss Green (codeine)
- Sublimaze (pf)
- Sufenta
- sufentanil citrate
- Synalgos-dc
- Talwin
- temazepam
- Tranxene T-tab
- triazolam
- Trymine Cg
- Tusnel C
- Tussicaps
- Tussigon
- Tussionex Pennkinetic Er
- Tylenol-codeine #3
- Tylenol-codeine #4
- Ultiva
- Valium
- Vicodin
- Vicodin Es
- Vicodin Hp
- Vicoprofen
- Virtussin Ac
- Vituz
- Xanax
- Xanax Xr
- Xartemis Xr
- Xodol 10/300
- Xodol 5/300
- Xodol 7.5/300
- Z-tuss Ac
- Z-tuss E
- Zamicet
- Zodryl Ac 25
- Zodryl Ac 30
- Zodryl Ac 35
- Zodryl Ac 40
- Zodryl Ac 50
- Zodryl Ac 60
- Zodryl Ac 80
- Zodryl Dac 25
- Zodryl Dac 30
- Zodryl Dac 35
- Zodryl Dac 40
- Zodryl Dac 50
- Zodryl Dac 60
- Zodryl Dac 80
- Zodryl Dec 25
- Zodryl Dec 30
- Zodryl Dec 35
- Zodryl Dec 40
- Zodryl Dec 50
- Zodryl Dec 60
- Zodryl Dec 80
- Zohydro Er
- Zutripro
- Acute asthma attack
- Congenital long QT syndrome
- Paralytic ileus
Contraindicated
- Alcohol intoxication
- Drug abuse
- History of opioid overdose
- Intracranial hypertension
- Respiratory depression
- Severe hepatic disease
Severe
Moderate
- Adrenal cortical insufficiency
- Alcohol withdrawal delirium
- Benign prostatic hyperplasia
- Biliary tract disorder
- Chronic obstructive pulmonary disease
- Cor pulmonale
- Debilitation
- Untreated hypothyroidism
- Urethral stricture
BUPRENEX (BUPRENORPHINE HCL)
- Postoperative acute pain
- Severe pain
- Abnormal hepatic function tests
- Constipation
- Headache disorder
- Injection site sequelae
- Nausea
- Vomiting
More Frequent
Severe
Less Severe
- Increased alanine transaminase
- Increased aspartate transaminase
- Respiratory depression
- Dizziness
- Drowsy
- Fatigue
- Hyperhidrosis
- Pruritus of skin
- Sedation
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute confusion
- Adrenal cortical insufficiency
- Allergic dermatitis
- Anaphylaxis
- Androgen deficiency
- Bradycardia
- Depression
- Disorder of adrenal gland
- Hallucinations
- Orthostatic hypotension
- Paresthesia
- Skin rash
- Tachycardia
- Urinary retention
- Urticaria
- Wenckebach's block
Less Severe
- Blurred vision
- Erectile dysfunction
- False sense of well-being
- General weakness
- Infertility
- Libido changes
- Malaise
- Tremor
- Visual changes
Contraindicated
None
Severe Precaution
Buprenorphine (INJ)
No safety/efficacy. Potential increased sensitivity to effects and adverse effects.
- 1 Day – 2 Years
- No safety/efficacy. Potential increased sensitivity to effects and adverse effects.
Management or Monitoring Precaution
None
Buprenorphine
- Severity Level:
2
- Additional Notes: Neonatal withdrawal/resp.depress. w/chronic or high dose
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
Buprenorphine
Low levels in breastmilk; poor oral bioavail in infants; monitor for cns dep
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Drug shown to have adverse effect | Low levels in breastmilk; poor oral bioavail in infants; monitor for cns dep |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
Postoperative acute pain | |
G89.12 | Acute post-thoracotomy pain |
G89.18 | Other acute postprocedural pain |
Severe pain | |
G89 | Pain, not elsewhere classified |
G89.1 | Acute pain, not elsewhere classified |
G89.11 | Acute pain due to trauma |
G89.12 | Acute post-thoracotomy pain |
G89.18 | Other acute postprocedural pain |
G89.2 | Chronic pain, not elsewhere classified |
G89.21 | Chronic pain due to trauma |
G89.22 | Chronic post-thoracotomy pain |
G89.28 | Other chronic postprocedural pain |
G89.29 | Other chronic pain |
G89.3 | Neoplasm related pain (acute) (chronic) |
M25.5 | Pain in joint |
M25.50 | Pain in unspecified joint |
M25.51 | Pain in shoulder |
M25.511 | Pain in right shoulder |
M25.512 | Pain in left shoulder |
M25.519 | Pain in unspecified shoulder |
M25.52 | Pain in elbow |
M25.521 | Pain in right elbow |
M25.522 | Pain in left elbow |
M25.529 | Pain in unspecified elbow |
M25.53 | Pain in wrist |
M25.531 | Pain in right wrist |
M25.532 | Pain in left wrist |
M25.539 | Pain in unspecified wrist |
M25.54 | Pain in joints of hand |
M25.541 | Pain in joints of right hand |
M25.542 | Pain in joints of left hand |
M25.549 | Pain in joints of unspecified hand |
M25.55 | Pain in hip |
M25.551 | Pain in right hip |
M25.552 | Pain in left hip |
M25.559 | Pain in unspecified hip |
M25.56 | Pain in knee |
M25.561 | Pain in right knee |
M25.562 | Pain in left knee |
M25.569 | Pain in unspecified knee |
M25.57 | Pain in ankle and joints of foot |
M25.571 | Pain in right ankle and joints of right foot |
M25.572 | Pain in left ankle and joints of left foot |
M25.579 | Pain in unspecified ankle and joints of unspecified foot |
M26.62 | Arthralgia of temporomandibular joint |
M54.5 | Low back pain |
M54.6 | Pain in thoracic spine |
M79.6 | Pain in limb, hand, foot, fingers and toes |
M79.60 | Pain in limb, unspecified |
M79.601 | Pain in right arm |
M79.602 | Pain in left arm |
M79.603 | Pain in arm, unspecified |
M79.604 | Pain in right leg |
M79.605 | Pain in left leg |
M79.606 | Pain in leg, unspecified |
M79.609 | Pain in unspecified limb |
M79.62 | Pain in upper arm |
M79.621 | Pain in right upper arm |
M79.622 | Pain in left upper arm |
M79.629 | Pain in unspecified upper arm |
M79.63 | Pain in forearm |
M79.631 | Pain in right forearm |
M79.632 | Pain in left forearm |
M79.639 | Pain in unspecified forearm |
M79.64 | Pain in hand and fingers |
M79.641 | Pain in right hand |
M79.642 | Pain in left hand |
M79.643 | Pain in unspecified hand |
M79.644 | Pain in right finger(s) |
M79.645 | Pain in left finger(s) |
M79.646 | Pain in unspecified finger(s) |
M79.65 | Pain in thigh |
M79.651 | Pain in right thigh |
M79.652 | Pain in left thigh |
M79.659 | Pain in unspecified thigh |
M79.66 | Pain in lower leg |
M79.661 | Pain in right lower leg |
M79.662 | Pain in left lower leg |
M79.669 | Pain in unspecified lower leg |
M79.67 | Pain in foot and toes |
M79.671 | Pain in right foot |
M79.672 | Pain in left foot |
M79.673 | Pain in unspecified foot |
M79.674 | Pain in right toe(s) |
M79.675 | Pain in left toe(s) |
M79.676 | Pain in unspecified toe(s) |
R07.82 | Intercostal pain |
R10.0 | Acute abdomen |
R10.1 | Pain localized to upper abdomen |
R10.10 | Upper abdominal pain, unspecified |
R10.11 | Right upper quadrant pain |
R10.12 | Left upper quadrant pain |
R10.2 | Pelvic and perineal pain |
R10.3 | Pain localized to other parts of lower abdomen |
R10.30 | Lower abdominal pain, unspecified |
R10.31 | Right lower quadrant pain |
R10.32 | Left lower quadrant pain |
R10.33 | Periumbilical pain |
R10.8 | Other abdominal pain |
R10.84 | Generalized abdominal pain |
R10.9 | Unspecified abdominal pain |
R52 | Pain, unspecified |
R68.84 | Jaw pain |
0-9 | A-Z |
---|---|
G89 | Pain, not elsewhere classified |
G89.1 | Acute pain, not elsewhere classified |
G89.11 | Acute pain due to trauma |
G89.12 | Acute post-thoracotomy pain |
G89.12 | Acute post-thoracotomy pain |
G89.18 | Other acute postprocedural pain |
G89.18 | Other acute postprocedural pain |
G89.2 | Chronic pain, not elsewhere classified |
G89.21 | Chronic pain due to trauma |
G89.22 | Chronic post-thoracotomy pain |
G89.28 | Other chronic postprocedural pain |
G89.29 | Other chronic pain |
G89.3 | Neoplasm related pain (acute) (chronic) |
M25.5 | Pain in joint |
M25.50 | Pain in unspecified joint |
M25.51 | Pain in shoulder |
M25.511 | Pain in right shoulder |
M25.512 | Pain in left shoulder |
M25.519 | Pain in unspecified shoulder |
M25.52 | Pain in elbow |
M25.521 | Pain in right elbow |
M25.522 | Pain in left elbow |
M25.529 | Pain in unspecified elbow |
M25.53 | Pain in wrist |
M25.531 | Pain in right wrist |
M25.532 | Pain in left wrist |
M25.539 | Pain in unspecified wrist |
M25.54 | Pain in joints of hand |
M25.541 | Pain in joints of right hand |
M25.542 | Pain in joints of left hand |
M25.549 | Pain in joints of unspecified hand |
M25.55 | Pain in hip |
M25.551 | Pain in right hip |
M25.552 | Pain in left hip |
M25.559 | Pain in unspecified hip |
M25.56 | Pain in knee |
M25.561 | Pain in right knee |
M25.562 | Pain in left knee |
M25.569 | Pain in unspecified knee |
M25.57 | Pain in ankle and joints of foot |
M25.571 | Pain in right ankle and joints of right foot |
M25.572 | Pain in left ankle and joints of left foot |
M25.579 | Pain in unspecified ankle and joints of unspecified foot |
M26.62 | Arthralgia of temporomandibular joint |
M54.5 | Low back pain |
M54.6 | Pain in thoracic spine |
M79.6 | Pain in limb, hand, foot, fingers and toes |
M79.60 | Pain in limb, unspecified |
M79.601 | Pain in right arm |
M79.602 | Pain in left arm |
M79.603 | Pain in arm, unspecified |
M79.604 | Pain in right leg |
M79.605 | Pain in left leg |
M79.606 | Pain in leg, unspecified |
M79.609 | Pain in unspecified limb |
M79.62 | Pain in upper arm |
M79.621 | Pain in right upper arm |
M79.622 | Pain in left upper arm |
M79.629 | Pain in unspecified upper arm |
M79.63 | Pain in forearm |
M79.631 | Pain in right forearm |
M79.632 | Pain in left forearm |
M79.639 | Pain in unspecified forearm |
M79.64 | Pain in hand and fingers |
M79.641 | Pain in right hand |
M79.642 | Pain in left hand |
M79.643 | Pain in unspecified hand |
M79.644 | Pain in right finger(s) |
M79.645 | Pain in left finger(s) |
M79.646 | Pain in unspecified finger(s) |
M79.65 | Pain in thigh |
M79.651 | Pain in right thigh |
M79.652 | Pain in left thigh |
M79.659 | Pain in unspecified thigh |
M79.66 | Pain in lower leg |
M79.661 | Pain in right lower leg |
M79.662 | Pain in left lower leg |
M79.669 | Pain in unspecified lower leg |
M79.67 | Pain in foot and toes |
M79.671 | Pain in right foot |
M79.672 | Pain in left foot |
M79.673 | Pain in unspecified foot |
M79.674 | Pain in right toe(s) |
M79.675 | Pain in left toe(s) |
M79.676 | Pain in unspecified toe(s) |
R07.82 | Intercostal pain |
R10.0 | Acute abdomen |
R10.1 | Pain localized to upper abdomen |
R10.10 | Upper abdominal pain, unspecified |
R10.11 | Right upper quadrant pain |
R10.12 | Left upper quadrant pain |
R10.2 | Pelvic and perineal pain |
R10.3 | Pain localized to other parts of lower abdomen |
R10.30 | Lower abdominal pain, unspecified |
R10.31 | Right lower quadrant pain |
R10.32 | Left lower quadrant pain |
R10.33 | Periumbilical pain |
R10.8 | Other abdominal pain |
R10.84 | Generalized abdominal pain |
R10.9 | Unspecified abdominal pain |
R52 | Pain, unspecified |
R68.84 | Jaw pain |
Formulary Reference Tool