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M-END DMX (dexbromphen-pseudoephedrine-dextromethorphan)
- cold symptoms
- cough
- inflammation of the nose due to an allergy
- runny nose
- stuffy nose
- vasomotor rhinitis
0.667 mg-20 mg-10 mg/5 mL oral liquid
- Dosage information is not available
- Azilect
- Eldepryl
- isocarboxazid
- linezolid
- Marplan
- Matulane
- methylene blue (antidote)
- Nardil
- Parnate
- phenelzine
- procarbazine
- rasagiline
- selegiline HCl
- tranylcypromine
- Zelapar
- Zyvox
Contraindicated
- bromocriptine
- cabergoline
- Cafergot
- Cycloset
- D.h.e.45
- dihydroergotamine
- ergoloid
- Ergomar
- ergotamine tartrate
- ergotamine-caffeine
- K-tab
- Klor-con
- Klor-con 10
- Klor-con M10
- Klor-con M15
- Klor-con M20
- Medi-lyte
- methylergonovine
- Migergot
- Migranal
- Parlodel
- potassium chloride
- potassium citrate
- potassium Cl-calcium phos-mag
- sodium Cl-potassium chloride
- Thermotabs
- Urocit-k 10
- Urocit-k 15
- Urocit-k 5
Severe
Moderate
- methyldopa
- methyldopa-hydrochlorothiazide
- methyldopate
- reserpine
- Severe coronary artery disease
- Severe uncontrolled hypertension
- Urinary retention
Contraindicated
- Angle-closure glaucoma
- Benign prostatic hyperplasia
- Bladder outflow obstruction
- Chronic idiopathic constipation
- Diabetes mellitus
- Hypertension
- Hyperthyroidism
- Stenosing peptic ulcer
- Systemic mastocytosis
- Urinary retention
Severe
Moderate
- Hypertension
- Hyperthyroidism
- Ocular hypertension
M-END DMX (dexbromphen-pseudoephedrine-dextromethorphan)
- cold symptoms
- cough
- inflammation of the nose due to an allergy
- runny nose
- stuffy nose
- vasomotor rhinitis
- None
- Dizziness
- Drowsy
- Headache disorder
- Insomnia
- Thick bronchial secretions
More Frequent
Severe
Less Severe
- None
- Agitation
- Anorexia
- Dizziness
- Drowsy
- Dysuria
- General weakness
- Nausea
- Nervousness
- Pallor
- Sedation
- Tachycardia
- Tremor
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute generalized exanthematous pustulosis
- Anaphylaxis
- Blood dyscrasias
- Dyspnea
- Extrasystoles
- Hallucinations
- Hemolytic anemia
- Hypersensitivity drug reaction
- Hypertension
- Hypotension
- Ischemic colitis
- Seizure disorder
- Vomiting
Less Severe
- Abdominal distension
- Abdominal pain with cramps
- Acute abdominal pain
- Acute confusion
- Anorexia
- Anticholinergic toxicity
- Ataxia
- Blurred vision
- Cardiac arrhythmia
- Chest discomfort
- Chills
- Constipation
- Diarrhea
- Diplopia
- Dizziness
- Drowsy
- Dry nose
- Dry throat
- Dyspepsia
- Dyspnea
- Dysuria
- Euphoria
- Excitement
- Fatigue
- Headache disorder
- Hyperhidrosis
- Increased urinary frequency
- Insomnia
- Irritability
- Maculopapular rash
- Malaise
- Migraine
- Nausea
- Nervousness
- Nightmares
- Palpitations
- Paresthesia
- Pruritus of skin
- Skin photosensitivity
- Skin rash
- Symptoms of anxiety
- Tachycardia
- Tinnitus
- Tremor
- Urinary retention
- Urticaria
- Vertigo
- Visual changes
- Vomiting
- Wheezing
- Xerostomia
Contraindicated
Dexbrompheniramine
Possible CNS excitation, convulsions in newborns.
Do not use in pediatrics <2 years of age unless clinician consultation.
Do not use in pediatrics <6 years of age unless clinician consultation.
High risk of adverse CNS effects. Not recommended for use age < 6 years.
- 1 Day – 29 Days
- 1 Possible CNS excitation, convulsions in newborns.
- 1 Do not use in pediatrics <2 years of age unless clinician consultation.
- 30 Days – 2 Years
- 1 Possible CNS excitation, convulsions in newborns.
- 1 Do not use in pediatrics <2 years of age unless clinician consultation.
- 1 Day – 6 Years
- 1 Possible CNS excitation, convulsions in newborns.
- 1 Do not use in pediatrics <2 years of age unless clinician consultation.
Dextromethorphan (OTC, Select)
Possible CNS excitation, convulsions in newborns.
Do not use in pediatrics <2 years of age unless clinician consultation.
Do not use in pediatrics <6 years of age unless clinician consultation.
High risk of adverse CNS effects. Not recommended for use age < 6 years.
- 1 Day – 29 Days
- 1 Do not use in pediatrics <6 years of age unless clinician consultation.
- 30 Days – 2 Years
- 1 Do not use in pediatrics <6 years of age unless clinician consultation.
- 1 Day – 6 Years
- 1 Do not use in pediatrics <6 years of age unless clinician consultation.
Pseudoephedrine (Immed. Release)
Possible CNS excitation, convulsions in newborns.
Do not use in pediatrics <2 years of age unless clinician consultation.
Do not use in pediatrics <6 years of age unless clinician consultation.
High risk of adverse CNS effects. Not recommended for use age < 6 years.
- 1 Day – 29 Days
- 1 High risk of adverse CNS effects. Not recommended for use age < 6 years.
- 30 Days – 2 Years
- 1 High risk of adverse CNS effects. Not recommended for use age < 6 years.
- 1 Day – 6 Years
- 1 High risk of adverse CNS effects. Not recommended for use age < 6 years.
Severe Precaution
None
Management or Monitoring Precaution
None
Dexbrompheniramine
- Severity Level:
2
- Additional Notes: No fda cat; low risk, premature infant at risk of retrolental fibroplasia
Dextromethorphan
- Severity Level:
2
- Additional Notes: Available human data show no increased risk for major birth defects
Pseudoephedrine
- Severity Level:
2
- Additional Notes: Limited human data are inconclusive on developmental toxicity risk
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Dexbrompheniramine
Not recommended. may cause paradoxical excitation/inhibit lactation.
Insufficient data available; molecular wt low enough for possible excretion
May decrease milk supply and cause irritability
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Not recommended. may cause paradoxical excitation/inhibit lactation. |
Dextromethorphan
Not recommended. may cause paradoxical excitation/inhibit lactation.
Insufficient data available; molecular wt low enough for possible excretion
May decrease milk supply and cause irritability
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available; molecular wt low enough for possible excretion |
Pseudoephedrine
Not recommended. may cause paradoxical excitation/inhibit lactation.
Insufficient data available; molecular wt low enough for possible excretion
May decrease milk supply and cause irritability
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Drug shown to have adverse effect | May decrease milk supply and cause irritability |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Dexbrompheniramine
Neuro/Psych-Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Non-sedating agents preferred. Gastrointestinal-May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.
Cardiovascular-Elderly are more sensitive to tachycardia and hypertensive effects. May exacerbate symptomatic coronary insufficiency. Genitourinary-May cause urinary retention. Neuro/Psych-May worsen cognitive impairment in some elderly with dementia. Insomnia risk.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | N | Y | N | N |
BEERS: Y HEDIS: Y STOPP: Y
Pseudoephedrine
Neuro/Psych-Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Non-sedating agents preferred. Gastrointestinal-May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.
Cardiovascular-Elderly are more sensitive to tachycardia and hypertensive effects. May exacerbate symptomatic coronary insufficiency. Genitourinary-May cause urinary retention. Neuro/Psych-May worsen cognitive impairment in some elderly with dementia. Insomnia risk.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | Y | Y | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
| Allergic rhinitis | |
| J30.1 | Allergic rhinitis due to pollen |
| J30.2 | Other seasonal allergic rhinitis |
| J30.5 | Allergic rhinitis due to food |
| J30.8 | Other allergic rhinitis |
| J30.81 | Allergic rhinitis due to animal (cat) (dog) hair and dander |
| J30.89 | Other allergic rhinitis |
| J30.9 | Allergic rhinitis, unspecified |
| Cold symptoms | |
| J00 | Acute nasopharyngitis [common cold] |
| Cough | |
| R05 | Cough |
| R05.1 | Acute cough |
| R05.2 | Subacute cough |
| R05.3 | Chronic cough |
| R05.9 | Cough, unspecified |
| Nasal congestion | |
| R09.81 | Nasal congestion |
| Rhinorrhea | |
| R09.82 | Postnasal drip |
| Vasomotor rhinitis | |
| J30.0 | Vasomotor rhinitis |
| 0-9 | A-Z |
|---|---|
| J00 | Acute nasopharyngitis [common cold] |
| J30.0 | Vasomotor rhinitis |
| J30.1 | Allergic rhinitis due to pollen |
| J30.2 | Other seasonal allergic rhinitis |
| J30.5 | Allergic rhinitis due to food |
| J30.8 | Other allergic rhinitis |
| J30.81 | Allergic rhinitis due to animal (cat) (dog) hair and dander |
| J30.89 | Other allergic rhinitis |
| J30.9 | Allergic rhinitis, unspecified |
| R05 | Cough |
| R05.1 | Acute cough |
| R05.2 | Subacute cough |
| R05.3 | Chronic cough |
| R05.9 | Cough, unspecified |
| R09.81 | Nasal congestion |
| R09.82 | Postnasal drip |
Formulary Reference Tool