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DIPHENHYDRAMINE-0.9% NACL (DIPHENHYDRAMINE HCL IN 0.9 % SODIUM CHLORIDE)
- Allergic reaction
- Insomnia
- Allergic conjunctivitis
- Allergic rhinitis
- Anaphylaxis
- Cough
- Dermatographic urticaria
- Idiopathic parkinsonism
- Motion sickness
- Nasal congestion
- Nausea
- Nausea and vomiting
- Parkinsonism
- Pruritus of skin
- Sneezing
- Urticaria
- Vertigo
- Vomiting
diphenhydramine HCl 25 mg/50 mL in 0.9 % sodium chloride IV piggyback
- Dosage information is not available
diphenhydramine HCl 50 mg/50 mL in 0.9 % sodium chloride IV piggyback
- Dosage information is not available
- None
Contraindicated
- Soltamox
- tamoxifen
Severe
Moderate
- None
- None
Contraindicated
- Angle-closure glaucoma
- Benign prostatic hyperplasia
- Bladder outflow obstruction
- Chronic idiopathic constipation
- Stenosing peptic ulcer
- Urinary retention
Severe
Moderate
- Hypertension
- Hyperthyroidism
- Ocular hypertension
DIPHENHYDRAMINE-0.9% NACL (DIPHENHYDRAMINE HCL IN 0.9 % SODIUM CHLORIDE)
- Allergic reaction
- Insomnia
- Allergic conjunctivitis
- Allergic rhinitis
- Anaphylaxis
- Cough
- Dermatographic urticaria
- Idiopathic parkinsonism
- Motion sickness
- Nasal congestion
- Nausea
- Nausea and vomiting
- Parkinsonism
- Pruritus of skin
- Sneezing
- Urticaria
- Vertigo
- Vomiting
- None
- Dizziness
- Drowsy
- Thick bronchial secretions
More Frequent
Severe
Less Severe
- None
- Sedation
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Anaphylaxis
- Blood dyscrasias
- Extrasystoles
- Hallucinations
- Hemolytic anemia
- Hypotension
- Seizure disorder
Less Severe
- Abdominal distension
- Acute abdominal pain
- Acute confusion
- Anorexia
- Ataxia
- Blurred vision
- Chest discomfort
- Chills
- Constipation
- Diarrhea
- Diplopia
- Dry nose
- Dry throat
- Dyspnea
- Dysuria
- Euphoria
- Excitement
- Fatigue
- Headache disorder
- Hyperhidrosis
- Insomnia
- Irritability
- Maculopapular rash
- Malaise
- Migraine
- Nervousness
- Nightmares
- Palpitations
- Paresthesia
- Pruritus of skin
- Skin photosensitivity
- Skin rash
- Symptoms of anxiety
- Tachycardia
- Tinnitus
- Tremor
- Urinary retention
- Urticaria
- Vertigo
- Visual changes
- Wheezing
- Xerostomia
Contraindicated
Diphenhydramine (Systemic)
Possible risk of CNS excitation, convulsions in newborns.
- 1 Day – 29 Days
- 1 Possible risk of CNS excitation, convulsions in newborns.
Severe Precaution
Diphenhydramine (Syst.antihist.)
Use with caution and with clinician consultation. Risk of adverse CNS effects includes sedation or paradoxical excitation.
- 30 Days – 364 Days
- Use with caution and with clinician consultation. Risk of adverse CNS effects includes sedation or paradoxical excitation.
Management or Monitoring Precaution
Diphenhydramine (Syst.antihist.)
Use with caution and with clinician consultation. Risk of adverse CNS effects include sedation or paradoxical excitation.
- 1 Years – 13 Years
- Use with caution and with clinician consultation. Risk of adverse CNS effects include sedation or paradoxical excitation.
Diphenhydramine
- Severity Level:
B
- Additional Notes:
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Diphenhydramine
Limited data suggest increased drowsiness, and irritability
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited data suggest increased drowsiness, and irritability |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Diphenhydramine
Neuro/Psych-Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Maximum of 25mg/day. Cardiovascular-May cause orthostatic hypotension at higher doses. Gastrointestinal-May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | N | Y | N | N |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- None
| Allergic conjunctivitis | |
| H10.1 | Acute atopic conjunctivitis |
| H10.10 | Acute atopic conjunctivitis, unspecified eye |
| H10.11 | Acute atopic conjunctivitis, right eye |
| H10.12 | Acute atopic conjunctivitis, left eye |
| H10.13 | Acute atopic conjunctivitis, bilateral |
| H10.44 | Vernal conjunctivitis |
| H10.45 | Other chronic allergic conjunctivitis |
| H16.26 | Vernal keratoconjunctivitis, with limbar and corneal involvement |
| H16.261 | Vernal keratoconjunctivitis, with limbar and corneal involvement, right eye |
| H16.262 | Vernal keratoconjunctivitis, with limbar and corneal involvement, left eye |
| H16.263 | Vernal keratoconjunctivitis, with limbar and corneal involvement, bilateral |
| H16.269 | Vernal keratoconjunctivitis, with limbar and corneal involvement, unspecified eye |
| Allergic reaction | |
| T78.40 | Allergy, unspecified |
| T78.40xA | Allergy, unspecified, initial encounter |
| Allergic rhinitis | |
| J30.1 | Allergic rhinitis due to pollen |
| J30.2 | Other seasonal allergic rhinitis |
| J30.5 | Allergic rhinitis due to food |
| J30.8 | Other allergic rhinitis |
| J30.81 | Allergic rhinitis due to animal (cat) (dog) hair and dander |
| J30.89 | Other allergic rhinitis |
| J30.9 | Allergic rhinitis, unspecified |
| Anaphylaxis | |
| T78.0 | Anaphylactic reaction due to food |
| T78.00 | Anaphylactic reaction due to unspecified food |
| T78.00xA | Anaphylactic reaction due to unspecified food, initial encounter |
| T78.01 | Anaphylactic reaction due to peanuts |
| T78.01xA | Anaphylactic reaction due to peanuts, initial encounter |
| T78.02 | Anaphylactic reaction due to shellfish (crustaceans) |
| T78.02xA | Anaphylactic reaction due to shellfish (crustaceans), initial encounter |
| T78.03 | Anaphylactic reaction due to other fish |
| T78.03xA | Anaphylactic reaction due to other fish, initial encounter |
| T78.04 | Anaphylactic reaction due to fruits and vegetables |
| T78.04xA | Anaphylactic reaction due to fruits and vegetables, initial encounter |
| T78.05 | Anaphylactic reaction due to tree nuts and seeds |
| T78.05xA | Anaphylactic reaction due to tree nuts and seeds, initial encounter |
| T78.06 | Anaphylactic reaction due to food additives |
| T78.06xA | Anaphylactic reaction due to food additives, initial encounter |
| T78.07 | Anaphylactic reaction due to milk and dairy products |
| T78.07xA | Anaphylactic reaction due to milk and dairy products, initial encounter |
| T78.08 | Anaphylactic reaction due to eggs |
| T78.08xA | Anaphylactic reaction due to eggs, initial encounter |
| T78.09 | Anaphylactic reaction due to other food products |
| T78.09xA | Anaphylactic reaction due to other food products, initial encounter |
| T78.2 | Anaphylactic shock, unspecified |
| T78.2xxA | Anaphylactic shock, unspecified, initial encounter |
| T80.5 | Anaphylactic reaction due to serum |
| T80.51 | Anaphylactic reaction due to administration of blood and blood products |
| T80.51xA | Anaphylactic reaction due to administration of blood and blood products, initial encounter |
| T80.52 | Anaphylactic reaction due to vaccination |
| T80.52xA | Anaphylactic reaction due to vaccination, initial encounter |
| T80.59 | Anaphylactic reaction due to other serum |
| T80.59xA | Anaphylactic reaction due to other serum, initial encounter |
| T88.6 | Anaphylactic reaction due to adverse effect of correct drug or medicament properly administered |
| T88.6xxA | Anaphylactic reaction due to adverse effect of correct drug or medicament properly administered, initial encounter |
| Cough | |
| R05 | Cough |
| Dermatographic urticaria | |
| L50.3 | Dermatographic urticaria |
| Idiopathic parkinsonism | |
| G20 | Parkinson's disease |
| Insomnia | |
| F51.0 | Insomnia not due to a substance or known physiological condition |
| F51.01 | Primary insomnia |
| F51.02 | Adjustment insomnia |
| F51.03 | Paradoxical insomnia |
| F51.04 | Psychophysiologic insomnia |
| F51.05 | Insomnia due to other mental disorder |
| F51.09 | Other insomnia not due to a substance or known physiological condition |
| G47.0 | Insomnia |
| G47.00 | Insomnia, unspecified |
| G47.01 | Insomnia due to medical condition |
| G47.09 | Other insomnia |
| Motion sickness | |
| T75.3xxA | Motion sickness, initial encounter |
| Nasal congestion | |
| R09.81 | Nasal congestion |
| Nausea | |
| R11 | Nausea and vomiting |
| R11.0 | Nausea |
| R11.2 | Nausea with vomiting, unspecified |
| Nausea and vomiting | |
| R11 | Nausea and vomiting |
| R11.2 | Nausea with vomiting, unspecified |
| Parkinsonism | |
| G20 | Parkinson's disease |
| G21 | Secondary parkinsonism |
| G21.2 | Secondary parkinsonism due to other external agents |
| G21.3 | Postencephalitic parkinsonism |
| G21.4 | Vascular parkinsonism |
| G21.8 | Other secondary parkinsonism |
| G21.9 | Secondary parkinsonism, unspecified |
| Pruritus of skin | |
| L29.8 | Other pruritus |
| L29.9 | Pruritus, unspecified |
| Sneezing | |
| R06.7 | Sneezing |
| Urticaria | |
| L50 | Urticaria |
| L50.0 | Allergic urticaria |
| L50.1 | Idiopathic urticaria |
| L50.2 | Urticaria due to cold and heat |
| L50.3 | Dermatographic urticaria |
| L50.4 | Vibratory urticaria |
| L50.5 | Cholinergic urticaria |
| L50.6 | Contact urticaria |
| L50.8 | Other urticaria |
| L50.9 | Urticaria, unspecified |
| L56.3 | Solar urticaria |
| O26.86 | Pruritic urticarial papules and plaques of pregnancy (PUPPp) |
| Vertigo | |
| A88.1 | Epidemic vertigo |
| H81.1 | Benign paroxysmal vertigo |
| H81.10 | Benign paroxysmal vertigo, unspecified ear |
| H81.11 | Benign paroxysmal vertigo, right ear |
| H81.12 | Benign paroxysmal vertigo, left ear |
| H81.13 | Benign paroxysmal vertigo, bilateral |
| H81.2 | Vestibular neuronitis |
| H81.20 | Vestibular neuronitis, unspecified ear |
| H81.21 | Vestibular neuronitis, right ear |
| H81.22 | Vestibular neuronitis, left ear |
| H81.23 | Vestibular neuronitis, bilateral |
| H81.3 | Other peripheral vertigo |
| H81.31 | Aural vertigo |
| H81.311 | Aural vertigo, right ear |
| H81.312 | Aural vertigo, left ear |
| H81.313 | Aural vertigo, bilateral |
| H81.319 | Aural vertigo, unspecified ear |
| H81.39 | Other peripheral vertigo |
| H81.391 | Other peripheral vertigo, right ear |
| H81.392 | Other peripheral vertigo, left ear |
| H81.393 | Other peripheral vertigo, bilateral |
| H81.399 | Other peripheral vertigo, unspecified ear |
| H81.4 | Vertigo of central origin |
| H82 | Vertiginous syndromes in diseases classified elsewhere |
| H82.1 | Vertiginous syndromes in diseases classified elsewhere, right ear |
| H82.2 | Vertiginous syndromes in diseases classified elsewhere, left ear |
| H82.3 | Vertiginous syndromes in diseases classified elsewhere, bilateral |
| H82.9 | Vertiginous syndromes in diseases classified elsewhere, unspecified ear |
| R42 | Dizziness and giddiness |
| T75.23 | Vertigo from infrasound |
| T75.23xA | Vertigo from infrasound, initial encounter |
| Vomiting | |
| K91.0 | Vomiting following gastrointestinal surgery |
| R11 | Nausea and vomiting |
| R11.1 | Vomiting |
| R11.10 | Vomiting, unspecified |
| R11.11 | Vomiting without nausea |
| R11.12 | Projectile vomiting |
| R11.13 | Vomiting of fecal matter |
| R11.14 | Bilious vomiting |
| R11.15 | Cyclical vomiting syndrome unrelated to migraine |
| R11.2 | Nausea with vomiting, unspecified |
| 0-9 | A-Z |
|---|---|
| A88.1 | Epidemic vertigo |
| F51.0 | Insomnia not due to a substance or known physiological condition |
| F51.01 | Primary insomnia |
| F51.02 | Adjustment insomnia |
| F51.03 | Paradoxical insomnia |
| F51.04 | Psychophysiologic insomnia |
| F51.05 | Insomnia due to other mental disorder |
| F51.09 | Other insomnia not due to a substance or known physiological condition |
| G20 | Parkinson's disease |
| G20 | Parkinson's disease |
| G21 | Secondary parkinsonism |
| G21.2 | Secondary parkinsonism due to other external agents |
| G21.3 | Postencephalitic parkinsonism |
| G21.4 | Vascular parkinsonism |
| G21.8 | Other secondary parkinsonism |
| G21.9 | Secondary parkinsonism, unspecified |
| G47.0 | Insomnia |
| G47.00 | Insomnia, unspecified |
| G47.01 | Insomnia due to medical condition |
| G47.09 | Other insomnia |
| H10.1 | Acute atopic conjunctivitis |
| H10.10 | Acute atopic conjunctivitis, unspecified eye |
| H10.11 | Acute atopic conjunctivitis, right eye |
| H10.12 | Acute atopic conjunctivitis, left eye |
| H10.13 | Acute atopic conjunctivitis, bilateral |
| H10.44 | Vernal conjunctivitis |
| H10.45 | Other chronic allergic conjunctivitis |
| H16.26 | Vernal keratoconjunctivitis, with limbar and corneal involvement |
| H16.261 | Vernal keratoconjunctivitis, with limbar and corneal involvement, right eye |
| H16.262 | Vernal keratoconjunctivitis, with limbar and corneal involvement, left eye |
| H16.263 | Vernal keratoconjunctivitis, with limbar and corneal involvement, bilateral |
| H16.269 | Vernal keratoconjunctivitis, with limbar and corneal involvement, unspecified eye |
| H81.1 | Benign paroxysmal vertigo |
| H81.10 | Benign paroxysmal vertigo, unspecified ear |
| H81.11 | Benign paroxysmal vertigo, right ear |
| H81.12 | Benign paroxysmal vertigo, left ear |
| H81.13 | Benign paroxysmal vertigo, bilateral |
| H81.2 | Vestibular neuronitis |
| H81.20 | Vestibular neuronitis, unspecified ear |
| H81.21 | Vestibular neuronitis, right ear |
| H81.22 | Vestibular neuronitis, left ear |
| H81.23 | Vestibular neuronitis, bilateral |
| H81.3 | Other peripheral vertigo |
| H81.31 | Aural vertigo |
| H81.311 | Aural vertigo, right ear |
| H81.312 | Aural vertigo, left ear |
| H81.313 | Aural vertigo, bilateral |
| H81.319 | Aural vertigo, unspecified ear |
| H81.39 | Other peripheral vertigo |
| H81.391 | Other peripheral vertigo, right ear |
| H81.392 | Other peripheral vertigo, left ear |
| H81.393 | Other peripheral vertigo, bilateral |
| H81.399 | Other peripheral vertigo, unspecified ear |
| H81.4 | Vertigo of central origin |
| H82 | Vertiginous syndromes in diseases classified elsewhere |
| H82.1 | Vertiginous syndromes in diseases classified elsewhere, right ear |
| H82.2 | Vertiginous syndromes in diseases classified elsewhere, left ear |
| H82.3 | Vertiginous syndromes in diseases classified elsewhere, bilateral |
| H82.9 | Vertiginous syndromes in diseases classified elsewhere, unspecified ear |
| J30.1 | Allergic rhinitis due to pollen |
| J30.2 | Other seasonal allergic rhinitis |
| J30.5 | Allergic rhinitis due to food |
| J30.8 | Other allergic rhinitis |
| J30.81 | Allergic rhinitis due to animal (cat) (dog) hair and dander |
| J30.89 | Other allergic rhinitis |
| J30.9 | Allergic rhinitis, unspecified |
| K91.0 | Vomiting following gastrointestinal surgery |
| L29.8 | Other pruritus |
| L29.9 | Pruritus, unspecified |
| L50 | Urticaria |
| L50.0 | Allergic urticaria |
| L50.1 | Idiopathic urticaria |
| L50.2 | Urticaria due to cold and heat |
| L50.3 | Dermatographic urticaria |
| L50.3 | Dermatographic urticaria |
| L50.4 | Vibratory urticaria |
| L50.5 | Cholinergic urticaria |
| L50.6 | Contact urticaria |
| L50.8 | Other urticaria |
| L50.9 | Urticaria, unspecified |
| L56.3 | Solar urticaria |
| O26.86 | Pruritic urticarial papules and plaques of pregnancy (PUPPp) |
| R05 | Cough |
| R06.7 | Sneezing |
| R09.81 | Nasal congestion |
| R11 | Nausea and vomiting |
| R11 | Nausea and vomiting |
| R11 | Nausea and vomiting |
| R11.0 | Nausea |
| R11.1 | Vomiting |
| R11.10 | Vomiting, unspecified |
| R11.11 | Vomiting without nausea |
| R11.12 | Projectile vomiting |
| R11.13 | Vomiting of fecal matter |
| R11.14 | Bilious vomiting |
| R11.15 | Cyclical vomiting syndrome unrelated to migraine |
| R11.2 | Nausea with vomiting, unspecified |
| R11.2 | Nausea with vomiting, unspecified |
| R11.2 | Nausea with vomiting, unspecified |
| R42 | Dizziness and giddiness |
| T75.23 | Vertigo from infrasound |
| T75.23xA | Vertigo from infrasound, initial encounter |
| T75.3xxA | Motion sickness, initial encounter |
| T78.0 | Anaphylactic reaction due to food |
| T78.00 | Anaphylactic reaction due to unspecified food |
| T78.00xA | Anaphylactic reaction due to unspecified food, initial encounter |
| T78.01 | Anaphylactic reaction due to peanuts |
| T78.01xA | Anaphylactic reaction due to peanuts, initial encounter |
| T78.02 | Anaphylactic reaction due to shellfish (crustaceans) |
| T78.02xA | Anaphylactic reaction due to shellfish (crustaceans), initial encounter |
| T78.03 | Anaphylactic reaction due to other fish |
| T78.03xA | Anaphylactic reaction due to other fish, initial encounter |
| T78.04 | Anaphylactic reaction due to fruits and vegetables |
| T78.04xA | Anaphylactic reaction due to fruits and vegetables, initial encounter |
| T78.05 | Anaphylactic reaction due to tree nuts and seeds |
| T78.05xA | Anaphylactic reaction due to tree nuts and seeds, initial encounter |
| T78.06 | Anaphylactic reaction due to food additives |
| T78.06xA | Anaphylactic reaction due to food additives, initial encounter |
| T78.07 | Anaphylactic reaction due to milk and dairy products |
| T78.07xA | Anaphylactic reaction due to milk and dairy products, initial encounter |
| T78.08 | Anaphylactic reaction due to eggs |
| T78.08xA | Anaphylactic reaction due to eggs, initial encounter |
| T78.09 | Anaphylactic reaction due to other food products |
| T78.09xA | Anaphylactic reaction due to other food products, initial encounter |
| T78.2 | Anaphylactic shock, unspecified |
| T78.2xxA | Anaphylactic shock, unspecified, initial encounter |
| T78.40 | Allergy, unspecified |
| T78.40xA | Allergy, unspecified, initial encounter |
| T80.5 | Anaphylactic reaction due to serum |
| T80.51 | Anaphylactic reaction due to administration of blood and blood products |
| T80.51xA | Anaphylactic reaction due to administration of blood and blood products, initial encounter |
| T80.52 | Anaphylactic reaction due to vaccination |
| T80.52xA | Anaphylactic reaction due to vaccination, initial encounter |
| T80.59 | Anaphylactic reaction due to other serum |
| T80.59xA | Anaphylactic reaction due to other serum, initial encounter |
| T88.6 | Anaphylactic reaction due to adverse effect of correct drug or medicament properly administered |
| T88.6xxA | Anaphylactic reaction due to adverse effect of correct drug or medicament properly administered, initial encounter |
Formulary Reference Tool