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PROMETHAZINE-DM (PROMETHAZINE HCL/DEXTROMETHORPHAN HBR)
- Allergic rhinitis
- Cold symptoms
- Cough
- Nasal congestion
- Rhinorrhea
6.25 mg-15 mg/5 mL oral syrup
- 5 milliliters by oral route every 4-6 hours as needed, not to exceed 30 ml in 24 hours
6.25 mg-15 mg/5 mL oral syrup
- 5 milliliters by oral route every 4-6 hours as needed, not to exceed 30 ml in 24 hours
Allergic rhinitis
- 5 milliliters by oral route every 6 hours as needed
- 5 milliliters by oral route every 4-6 hours as needed, not to exceed 30 ml in 24 hours
- 5 milliliters by oral route every 4 hours as needed, not to exceed 30 ml in 24 hours
Cold symptoms
- 5 milliliters by oral route every 6 hours as needed
- 5 milliliters by oral route every 4-6 hours as needed, not to exceed 30 ml in 24 hours
- 5 milliliters by oral route every 4 hours as needed, not to exceed 30 ml in 24 hours
Cough
- 5 milliliters by oral route every 6 hours as needed
- 5 milliliters by oral route every 4-6 hours as needed, not to exceed 30 ml in 24 hours
- 5 milliliters by oral route every 4 hours as needed, not to exceed 30 ml in 24 hours
Nasal congestion
- 5 milliliters by oral route every 6 hours as needed
- 5 milliliters by oral route every 4-6 hours as needed, not to exceed 30 ml in 24 hours
- 5 milliliters by oral route every 4 hours as needed, not to exceed 30 ml in 24 hours
Rhinorrhea
- 5 milliliters by oral route every 6 hours as needed
- 5 milliliters by oral route every 4-6 hours as needed, not to exceed 30 ml in 24 hours
- 5 milliliters by oral route every 4 hours as needed, not to exceed 30 ml in 24 hours
- Azilect
- Eldepryl
- isocarboxazid
- linezolid
- Marplan
- Matulane
- methylene blue (antidote)
- Nardil
- Orap
- Parnate
- phenelzine
- pimozide
- procarbazine
- rasagiline
- selegiline HCl
- tranylcypromine
- Zelapar
- Zyvox
Contraindicated
- sodium oxybate
- Xyrem
Severe
Moderate
- Alagesic Lq
- amobarbital
- Amytal
- Anaspaz
- Aplenzin
- Ascomp With Codeine
- Atropen
- atropine
- belladonna alkaloids-opium
- Belladonna-opium
- Belladonna-phenobarbital
- Bentyl
- benztropine
- Bupap
- Buproban
- bupropion HBr
- bupropion HCl
- butabarbital
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-acetaminop-caf-cod
- butalbital-acetaminophen
- butalbital-acetaminophen-caff
- butalbital-aspirin-caffeine
- Butisol
- Cantil
- Capacet
- chlordiazepoxide-clidinium
- chlorphen-pseudoeph-bellad alk
- codeine-butalbital-ASA-caff
- Cogentin
- Cuvposa
- dicyclomine
- diphenoxylate-atropine
- Ditropan Xl
- Donnatal
- Duodote
- Ed-spaz
- edrophonium Cl-atropine
- Enlon-plus
- Esgic
- Fioricet
- Fioricet With Codeine
- Fiorinal
- Fiorinal-codeine #3
- flavoxate
- Forfivo Xl
- Gelnique
- Glycate
- glycopyrrolate
- Hydrocodone Compound
- hydrocodone-homatropine
- Hydromet
- Hyophen
- hyoscyamine sulfate
- Hyosyne
- Levbid
- Levsin
- Levsin/sl
- Librax (with Clidinium)
- Lomotil
- Luminal
- Margesic
- Marten-tab
- mepenzolate bromide
- methen-hyos-me blue-ba-salicyl
- methen-hyosc-m.blue-sal-naphos
- methen-sod phos-meth blue-hyos
- methscopolamine
- mth-me blue-sod phos-phsal-hyo
- Mysoline
- Nembutal Sodium
- Nulev
- Oscimin
- Oscimin Sl
- Oscimin Sr
- oxybutynin
- oxybutynin chloride
- Oxytrol
- Oxytrol For Women
- Pamine
- Pamine Forte
- pentobarbital sodium
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phosphasal
- pralidoxime-atropine
- primidone
- propantheline
- Prosed/ds (atropine Free)
- Respa-ar
- Robinul
- Robinul Forte
- scopolamine base
- scopolamine HBr
- secobarbital sodium
- Seconal Sodium
- Symax Duotab
- Symax Fastabs
- Symax-sl
- Symax-sr
- Tencon
- Transderm-scop
- trihexyphenidyl
- Tussigon
- Ur N-c
- Urelle
- Uretron D-s
- Uribel
- Urimar-t
- Urin Ds
- Urogesic-blue
- Uryl
- Ustell
- Uta
- Wellbutrin
- Wellbutrin Sr
- Wellbutrin Xl
- Zebutal
- Zyban
- Coma
- Congenital long QT syndrome
- Neuroleptic malignant syndrome
- Torsades de pointes
Contraindicated
- Angle-closure glaucoma
- Benign prostatic hyperplasia
- Bladder outflow obstruction
- Chronic idiopathic constipation
- Chronic obstructive pulmonary disease
- Parkinsonism
- Prolonged QT interval
- Pyloroduodenal obstruction
- Respiratory depression
- Sleep apnea
- Stenosing peptic ulcer
- Systemic mastocytosis
Severe
Moderate
- Bone marrow depression
- Disease of liver
- Gastrointestinal obstruction
- Hyperbilirubinemia
- Lower seizure threshold
- Seizure disorder
PROMETHAZINE-DM (PROMETHAZINE HCL/DEXTROMETHORPHAN HBR)
- Allergic rhinitis
- Cold symptoms
- Cough
- Nasal congestion
- Rhinorrhea
- Hypotension
- Tachycardia
- Acute confusion
- Blurred vision
- Dizziness
- Drowsy
- Excitement
- Irritability
- Nervousness
- Nightmares
- Skin photosensitivity
- Skin rash
- Thick bronchial secretions
- Tinnitus
- Visual changes
- Xerostomia
More Frequent
Severe
Less Severe
- Sedation
- Hyperhidrosis
- Nasal congestion
- Syncope
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Agranulocytosis
- Angioedema
- Apnea
- Asthma
- Bradycardia
- Delirium
- Dissociative disorder
- Extrapyramidal disease
- Hallucinations
- Hypertension
- Jaundice
- Leukopenia
- Lower seizure threshold
- Neuroleptic malignant syndrome
- Obstructive hyperbilirubinemia
- Respiratory depression
- Seizure disorder
- Thrombocytopenic disorder
- Thrombotic thrombocytopenic purpura
- Urticaria
- Vomiting
Less Severe
- Abdominal pain with cramps
- Anorexia
- Ataxia
- Diplopia
- Dizziness
- Drowsy
- Dysuria
- Euphoria
- Fatigue
- Insomnia
- Nausea
- Skin inflammation
- Tremor
- Vomiting
Contraindicated
Promethazine
Potential for fatal respiratory depression age < 2 years. Avoid use.
- 1 Day – 2 Years
- 1 Potential for fatal respiratory depression age < 2 years. Avoid use.
Severe Precaution
Promethazine
Caution:use the lowest effective dose due to risk of respiratory depression.
- 2 Years – 18 Years
- Caution:use the lowest effective dose due to risk of respiratory depression.
Management or Monitoring Precaution
None
Dextromethorphan
- Severity Level:
C
- Additional Notes:
Promethazine Hydrochloride
- Severity Level:
C
- Additional Notes: Caution with use; risk of platelet aggregation in newborn
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Dextromethorphan
Insufficient data available; molecular wt low enough for possible excretion
Limited amount may be excreted due to low mw; monitor infant for resp depress
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available; molecular wt low enough for possible excretion |
Promethazine
Insufficient data available; molecular wt low enough for possible excretion
Limited amount may be excreted due to low mw; monitor infant for resp depress
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Limited amount may be excreted due to low mw; monitor infant for resp depress |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- Promethazine should not be used in children younger than 2 years since it might cause serious (possibly fatal) slow/shallow breathing. This problem has occurred even with normal doses in this age group. The lowest effective dosage should be used, and other drugs that affect breathing should be avoided.<br /><br />Seek immediate medical attention in the unlikely event that slow/shallow breathing occurs. Promethazine should not be used in children with liver disease (including possible Reyes syndrome).
| Allergic rhinitis | |
| J30.1 | Allergic rhinitis due to pollen |
| J30.2 | Other seasonal allergic rhinitis |
| J30.5 | Allergic rhinitis due to food |
| J30.8 | Other allergic rhinitis |
| J30.81 | Allergic rhinitis due to animal (cat) (dog) hair and dander |
| J30.89 | Other allergic rhinitis |
| J30.9 | Allergic rhinitis, unspecified |
| Cold symptoms | |
| J00 | Acute nasopharyngitis [common cold] |
| Cough | |
| R05 | Cough |
| Nasal congestion | |
| R09.81 | Nasal congestion |
| Rhinorrhea | |
| R09.82 | Postnasal drip |
| 0-9 | A-Z |
|---|---|
| J00 | Acute nasopharyngitis [common cold] |
| J30.1 | Allergic rhinitis due to pollen |
| J30.2 | Other seasonal allergic rhinitis |
| J30.5 | Allergic rhinitis due to food |
| J30.8 | Other allergic rhinitis |
| J30.81 | Allergic rhinitis due to animal (cat) (dog) hair and dander |
| J30.89 | Other allergic rhinitis |
| J30.9 | Allergic rhinitis, unspecified |
| R05 | Cough |
| R09.81 | Nasal congestion |
| R09.82 | Postnasal drip |
Formulary Reference Tool