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INFLAMMACIN (DICLOFENAC SODIUM/CAPSICUM OLEORESIN)
75 mg-0.025 % kit
- Dosage information is not available
75 mg-0.025 % kit
- Dosage information is not available
- cidofovir
- ketorolac
- Sprix
- Vistide
Contraindicated
- Alimta
- apixaban
- Coumadin
- Curad Enema
- Disposable Enema
- Eliquis
- Enema
- Enema Disposable
- Fleet Enema
- Fleet Enema Extra
- Fleet Pediatric
- Folotyn
- Jantoven
- Methotrexate (anti-rheumatic)
- methotrexate sodium
- methotrexate sodium (PF)
- Oral Saline Laxative
- Osmoprep
- pemetrexed
- Phosphate Laxative
- pralatrexate
- Preparation Cleansing
- Ready-to-use Enema
- Rheumatrex
- rivaroxaban
- sod phos mono-sod phos dibasic
- sodium phosphates
- Trexall
- warfarin
- Xarelto
Severe
Moderate
- A-hydrocort
- A-methapred
- abciximab
- Accolate
- Accupril
- Accuretic
- Aceon
- adefovir
- Altace
- amiloride
- amiloride-hydrochlorothiazide
- amiodarone
- amiodarone in dextrose,iso-osm
- amlodipine-benazepril
- amlodipine-olmesartan
- amlodipine-valsartan
- amlodipine-valsartan-hcthiazid
- Angeliq
- Anucort-hc
- Anusol-hc
- Aristospan Intra-articular
- Aristospan Intralesional
- Arixtra
- Astagraf Xl
- Atacand
- Atacand Hct
- Atripla
- Avalide
- Avapro
- azilsartan med-chlorthalidone
- azilsartan medoxomil
- Azor
- benazepril
- benazepril-hydrochlorothiazide
- Benicar
- Benicar Hct
- betamethasone acet & sod phos
- Beyaz
- Brilinta
- Brintellix
- Brisdelle
- budesonide
- bumetanide
- candesartan
- candesartan-hydrochlorothiazid
- captopril
- captopril-hydrochlorothiazide
- Celestone Soluspan
- Celexa
- cilostazol
- citalopram
- clopidogrel
- colchicine-probenecid
- Colocort
- Complera
- Cordarone
- Cortef
- Cortenema
- Cortifoam
- cortisone
- Cozaar
- cyclosporine
- cyclosporine modified
- Cymbalta
- Daflonex-xl
- dalteparin (porcine)
- Demadex
- Depo-medrol
- desvenlafaxine
- desvenlafaxine fumarate
- desvenlafaxine succinate
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- Diflucan
- diosmin complex no.1
- Diovan Hct
- drospirenone-e.estradiol-lm.FA
- drospirenone-estradiol
- drospirenone-ethinyl estradiol
- duloxetine
- Dyazide
- Dyrenium
- Edarbi
- Edarbyclor
- efavirenz-emtricitabin-tenofov
- Effexor Xr
- Elmiron
- elvitegr-cobicist-emtric-tenof
- emtricitab-rilpivirine-tenofov
- emtricitabine-tenofovir
- enalapril maleate
- enalapril-hydrochlorothiazide
- enalaprilat
- enoxaparin
- Entocort Ec
- Epaned
- eprosartan
- eprosartan-hydrochlorothiazide
- eptifibatide
- erlotinib
- escitalopram oxalate
- ethacrynate sodium
- Exforge
- Exforge Hct
- Ez Use Joint-tunnel-trigger
- Fetzima
- First-duke's
- First-mary's Mouthwash
- Flo-pred
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- fludrocortisone
- fluoxetine
- fluvoxamine
- fondaparinux
- fosinopril
- fosinopril-hydrochlorothiazide
- Fragmin
- furosemide
- Gengraf
- Gianvi (28)
- Grx Hicort 25
- Hecoria
- Hemril-30
- heparin (porcine)
- heparin (porcine) in D5W
- heparin(porcine) in 0.45% NaCl
- heparin, porcine (PF)
- Hepsera
- hesp-diosm hyd-Ca dobe-diosmin
- hesperid-diosmin-grape seed xt
- hydrocortisone
- hydrocortisone acetate
- hydrocortisone sod succ (PF)
- hydrocortisone sod succinate
- Hyzaar
- Integrilin
- irbesartan
- irbesartan-hydrochlorothiazide
- Kenalog
- ketoconazole
- Khedezla
- Lasix
- levomilnacipran
- Lexapro
- lisinopril
- lisinopril-hydrochlorothiazide
- lithium carbonate
- lithium citrate
- Lithobid
- Loryna (28)
- losartan
- losartan-hydrochlorothiazide
- Lotensin
- Lotrel
- Lovenox
- Luvox Cr
- Mavik
- Maxzide
- Maxzide-25Mg
- Medrol
- Medrol (pak)
- methylprednisolone
- methylprednisolone acetate
- methylprednisolone sod suc(PF)
- methylprednisolone sodium succ
- methylprednisolone-bupivacaine
- Micardis
- Micardis Hct
- miconazole
- Millipred
- Millipred Dp
- milnacipran
- moexipril
- moexipril-hydrochlorothiazide
- Neoral
- Nexterone
- nystatin-hydrocortisone-diphen
- nystatin-TCN-HC-diphenhydramin
- Ocella
- olanzapine-fluoxetine
- olmesartan
- olmesartan-amlodipin-hcthiazid
- olmesartan-hydrochlorothiazide
- Orapred
- Orapred Odt
- Oravig
- Oxandrin
- oxandrolone
- Pacerone
- paroxetine HCl
- paroxetine mesylate
- Paxil
- Paxil Cr
- Pediapred
- pentosan polysulfate sodium
- perindopril erbumine
- Pexeva
- Physicians Ez Use M-pred
- Plavix
- Pletal
- prednisolone
- prednisolone acetate
- prednisolone sodium phosphate
- prednisone
- Prednisone Intensol
- Prinivil
- Pristiq
- probenecid
- Proctocort
- Prograf
- Prozac
- Prozac Weekly
- quinapril
- quinapril-hydrochlorothiazide
- ramipril
- Rapamune
- Rayos
- Rectacort-hc
- Reopro
- Safyral
- Sandimmune
- Sarafem
- Savella
- sertraline
- sirolimus
- Sodium Edecrin
- Solu-cortef
- Solu-cortef (pf)
- Solu-medrol
- Solu-medrol (pf)
- Stribild
- Syeda
- Symbyax
- tacrolimus
- Tarceva
- Tarka
- telmisartan
- telmisartan-amlodipine
- telmisartan-hydrochlorothiazid
- tenofovir disoproxil fumarate
- Teveten
- Teveten Hct
- ticagrelor
- torsemide
- trandolapril
- trandolapril-verapamil
- triamcinolone acetonide
- triamcinolone hexacetonide
- triamcinolone-lidocaine
- triamterene
- triamterene-hydrochlorothiazid
- Tribenzor
- Trombonex-d
- Truvada
- Twynsta
- Uceris
- Uniretic
- Univasc
- valsartan-hydrochlorothiazide
- Vasculera
- Vaseretic
- Vasoflex Hd
- Vasotec
- Venaliv
- venlafaxine
- Veripred 20
- Vestura (28)
- Vfend
- Vfend Iv
- Viibryd
- vilazodone
- Viread
- vit C-but.broom-hesperidn-dios
- vit C-dios-rut-bioflav-butc br
- voriconazole
- vortioxetine
- Yasmin (28)
- Yaz 28
- zafirlukast
- Zarah
- Zestoretic
- Zestril
- Zoloft
- Aspirin exacerbated respiratory disease
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Drug-induced hepatitis
- Hepatic failure
- History of roux-en-Y gastric bypass
- Post-operative from CABG surgery
- Pregnancy
- Severe hepatic disease
Contraindicated
- Abnormal hepatic function tests
- Acute myocardial infarction
- Alcoholism
- Cerebrovascular accident
- Chronic heart failure
- Disease of liver
- Gastrointestinal hemorrhage
- Gastrointestinal perforation
- Gastrointestinal ulcer
- Hepatic porphyria
- Hypertension
- Increased cardiovascular event risk
- Increased risk of bleeding
- Increased risk of bleeding due to coagulation disorder
- Kidney disease with likely reduction in GFR
- Non-infective meningitis
- Systemic mastocytosis
- Thrombotic disorder
- Tobacco smoker
Severe
Moderate
- Anemia
- Asthma
- Dehydration
- Edema
- Gastritis
- Gastrointestinal ulcer
INFLAMMACIN (DICLOFENAC SODIUM/CAPSICUM OLEORESIN)
- None
- Abdominal pain with cramps
- Constipation
- Diarrhea
- Dyspepsia
- Insomnia
- Nausea
- Vomiting
More Frequent
Severe
Less Severe
- Abnormal hepatic function tests
- Body fluid retention
- Edema
- Esophageal ulcer
- Gastrointestinal ulcer
- Peptic ulcer
- Pruritus of skin
- Skin rash
- Tinnitus
- Dizziness
- Flatulence
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal vaginal bleeding
- Acute myocardial infarction
- Acute pancreatitis
- Agranulocytosis
- Allergic dermatitis
- Anaphylaxis
- Anemia
- Angioedema
- Aplastic anemia
- Black tarry stools
- Bloody stools
- Bloody vomit
- Bronchospastic pulmonary disease
- Bullous dermatitis
- Cerebrovascular accident
- Colitis
- Dyspnea
- Eosinophilia
- Epistaxis
- Erythema multiforme
- Esophagitis
- Exfoliative dermatitis
- Gastric ulcer
- Gastrointestinal hemorrhage
- Gastrointestinal perforation
- Heart failure
- Hematuria
- Hemolytic anemia
- Hemorrhage
- Hepatic failure
- Hepatic necrosis
- Hepatitis
- Hyperkalemia
- Hypertension
- Infection
- Interstitial nephritis
- Jaundice
- Kidney disease with reduction in GFR
- Leukopenia
- Memory impairment
- Nephrotic syndrome
- Nephrotoxicity
- Neutropenic disorder
- Non-infective meningitis
- Oliguria
- Pancytopenia
- Pneumonia
- Proteinuria
- Renal failure
- Renal papillary necrosis
- Respiratory depression
- Seizure disorder
- Stevens-johnson syndrome
- Thrombocytopenic disorder
- Thrombotic disorder
- Toxic epidermal necrolysis
- Urticaria
Less Severe
- Acute confusion
- Alopecia
- Appetite changes
- Asthma
- Conjunctivitis
- Depression
- Dream disorder
- Drowsy
- Ecchymosis
- Eructation
- Fever
- Flushing
- General weakness
- Hearing loss
- Hyperglycemia
- Hyperhidrosis
- Irritability
- Lymphadenopathy
- Medication overuse headache
- Palpitations
- Purpura
- Skin photosensitivity
- Stomatitis
- Symptoms of anxiety
- Syncope
- Tachycardia
- Tremor
- Weight loss
- Xerostomia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Diclofenac (Select Routes)
Safety and efficacy in pediatrics have not been established.
- 1 Day – 18 Years
- Safety and efficacy in pediatrics have not been established.
Diclofenac
- Severity Level:
1
- Additional Notes: Fda c before 30wks;premature closure of ductus arteriosus;early miscarriage risk
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Capsicum (systemic)
Insufficient data available
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available |
Diclofenac
Insufficient data available
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Insufficient data available |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Diclofenac
Gastrointestinal-Increased risk for ulceration or serious GI bleed with history of PUD or GI bleed. Renal-Risk of AKI and exacerbation of CKD. Avoid with CrCl <30 mL/min. Cardiovascular-May exacerbate pre-existing hypertension, CHF. Cardiovascular thrombotic event risk, including MI and stroke, increases with duration of use. Risk for reinfarction with minimal NSAID use post-MI. Contraindicated in the setting of CABG. Hepatic-Elevated hepatic transaminases may occur with chronic use.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | Y | N | N | N |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- Nonsteroidal anti-inflammatory drugs (including diclofenac) may rarely increase the risk for a heart attack or stroke. This effect can happen at any time while taking this drug but is more likely if you take it for a long time. The risk may be greater if you have heart disease or increased risk for heart disease (for example, due to smoking, family history of heart disease, or conditions such as high blood pressure or diabetes).<br /><br /> Do not take this drug right before or after heart bypass surgery (CABG). Also, this drug may rarely cause serious (rarely fatal) bleeding from the stomach or intestines. This effect can occur without warning symptoms at any time while taking this drug.<br /><br /> Older adults may be at higher risk for this effect. (See also Precautions and Drug Interactions sections.) Stop taking diclofenac and get medical help right away if you notice any of the following rare but serious side effects: bloody or black/tarry stools, persistent stomach/abdominal pain, vomit that looks like coffee grounds, chest/jaw/left arm pain, shortness of breath, unusual sweating, weakness on one side of the body, sudden vision changes, slurred speech. Talk with your doctor or pharmacist about the risks and benefits of treatment with this medication.
Formulary Reference Tool