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NERLYNX (NERATINIB MALEATE)
- HEr2 positive carcinoma of breast
40 mg tablet
- 6 tablets (240 mg) by oral route once daily at approximately thesame time each day
HEr2 positive carcinoma of breast
- 3 tablets (120 mg) by oral route once daily at approximately thesame time each day
- 4 tablets (160 mg) by oral route once daily at approximately thesame time each day
- 5 tablets (200 mg) by oral route once daily at approximately thesame time each day
- 6 tablets (240 mg) by oral route once daily at approximately thesame time each day
- None
Contraindicated
- Acid Control (ranitidine)
- Acid Controller
- Acid Controller Complete
- Acid Reducer (cimetidine)
- Acid Reducer (famotidine)
- Acid Reducer (ranitidine)
- Acid Reducer Complete (famot)
- Acid Relief (cimetidine)
- Aciphex
- Aciphex Sprinkle
- amoxicil-clarithromy-lansopraz
- cimetidine
- Complete
- Deprizine
- Dexilant
- dexlansoprazole
- Dual Action Complete
- Duexis
- esomeprazole magnesium
- esomeprazole sodium
- esomeprazole strontium
- famotidine
- famotidine (PF)
- famotidine (PF)-NaCl (iso-os)
- famotidine-Ca carb-mag hydrox
- First-lansoprazole
- First-omeprazole
- Heartburn Prevention
- Heartburn Relief
- Heartburn Relief (famotidine)
- Heartburn Relief (ranitidine)
- Heartburn Relief 24 Hour
- Heartburn Treatment 24 Hour
- Hycamtin
- ibuprofen-famotidine
- lansoprazole
- naproxen-esomeprazole
- Nexium
- Nexium Iv
- Nexium Packet
- nizatidine
- Omeclamox-pak
- omeprazole
- omeprazole magnesium
- Omeprazole+syrspend Sf Alka
- omeprazole-clarith-amoxicillin
- omeprazole-sodium bicarbonate
- pantoprazole
- Pepcid
- Pepcid Ac
- Pepcid Complete
- Prevacid
- Prevacid 24Hr
- Prevacid Solutab
- Prevpac
- Prilosec
- Prilosec Otc
- Protonix
- rabeprazole
- ranitidine HCl
- Tagamet Hb
- topotecan
- Tums Dual Action
- Vimovo
- Wal-zan 150
- Zantac
- Zantac Maximum Strength
- Zegerid
- Zegerid Otc
Severe
Moderate
- Acid Gone
- Acid Gone Antacid
- activated charcoal-calcium car
- Advanced Antacid-antigas
- afatinib
- Al hyd-Mg tr-alg ac-sod bicarb
- Alcalak
- Almacone
- Almacone-2
- alum-mag hydroxide-simeth
- aluminum hydrox-magnesium carb
- aluminum hydroxide gel
- aluminum-magnesium hydroxide
- Antacid
- Antacid Anti-gas
- Antacid Anti-gas Double Str
- Antacid Calcium
- Antacid Extra Strength
- Antacid Extra-strength
- Antacid Ii Plus Simethicone
- Antacid Liquid
- Antacid M
- Antacid Maximum Strength
- Antacid Multi-symptom
- Antacid Plus Anti-gas
- Antacid Plus Extra Strength
- Antacid Regular Strength
- Antacid Supreme
- Antacid Tablet
- Antacid Ultra Strength
- Antacid With Simethicone
- Antacid-antigas
- Antacid-antigas Ii
- Antacid-simethicone
- Antacid-simethicone Ds
- Anti-diarrhea
- Anti-diarrheal (lope)-anti-gas
- Anti-diarrheal (loperamide)
- ASA-acetaminophen-caff-buffers
- aspirin, buffered
- aspirin-calcium carbonate
- Bayer Plus Extra Strength
- Buffered Aspirin
- Bufferin
- cal phos-mag hydrx-C & D3-phos
- Cal-gest Antacid
- calcium & magnesium carbonates
- Calcium Antacid
- Calcium Antacid Tropical
- Calcium Antacid Ultra Max St
- calcium carb-mag hydrox-simeth
- calcium carbonate
- calcium carbonate-mag hydroxid
- calcium-simethicone
- Children's Pepto
- Children's Soothe
- Comfort Gel
- Comfort Gel Extra Strength
- Diamode
- diosmin complex no.1
- Etopophos
- etoposide
- etoposide phosphate
- Flanax
- Foaming Antacid
- Foaming Antacid Extra Strength
- Gaviscon
- Gaviscon Extra Strength
- Gelusil Antacid & Anti-gas
- Geri-lanta
- Geri-mox Antacid-antigas
- Gilotrif
- Heartburn Antacid
- Imodium Multi-symptom Relief
- Liquid Antacid
- Lo-peramide
- loperamide
- loperamide-simethicone
- Maalox Advanced
- Maalox Maximum Strength
- Mag-al
- Mag-al Plus
- Mag-al Plus Extra Strength
- magaldrate
- magaldrate-simethicone
- Maglox
- magnesium hydroxide
- magnesium-aluminum-alginic ac
- Masanti Double Strength
- Mi-acid
- Milk Of Magnesia
- Milk Of Magnesia Concentrated
- Mintox
- Mintox Maximum Strength
- Mintox Plus
- Ob Complete One
- Pedia-lax
- Phillips Milk Of Magnesia
- PN85-iron cb&asp g-FA-dha-fish
- Pro-cal
- Ri-gel
- Ri-gel Ii
- Ri-mag
- Ri-mag Plus
- Ri-mox
- Ri-mox Plus
- Riginic
- Rulox
- Smooth Antacid
- Supreme Antacid
- Toposar
- Toxin Control
- Tri-buffered Aspirin
- Tums
- Tums E-x
- Tums Extra Strength Smoothies
- Tums Freshers
- Tums Ultra
- Ultra A-d
- Ultra Strength Antacid
- Ultra Strength Calcium Antacid
- Vanquish
- Vasculera
- Women's Aspirin With Calcium
- Lactating mother
Contraindicated
- Abnormal hepatic function tests
- Disease of liver
- Pregnancy
- Severe diarrhea
Severe
Moderate
- None
NERLYNX (NERATINIB MALEATE)
- HEr2 positive carcinoma of breast
- Diarrhea
- Increased alanine transaminase
- Increased aspartate transaminase
- Abdominal distension
- Acute abdominal pain
- Anorexia
- Dry skin
- Dyspepsia
- Fatigue
- Muscle spasm
- Nail disorders
- Nausea
- Skin rash
- Stomatitis
- Urinary tract infection
- Vomiting
- Weight loss
More Frequent
Severe
Less Severe
- Abnormal hepatic function tests
- Dehydration
- Hyperbilirubinemia
- Skin fissure
- Epistaxis
- Hypotension
- Xerostomia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Renal failure
Less Severe
- Acneiform eruption
- Cellulitis
- Cheilitis
- Erysipelas
- Glossitis
- Nail discoloration
- Onychoclasis
- Paronychia
- Pruritus of skin
- Skin inflammation
- Sore tongue
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Neratinib
Safety and efficacy not established.
- 1 Day – 18 Years
- Safety and efficacy not established.
Neratinib
- Severity Level:
D
- Additional Notes: Based on drug pharmacology and animal data dev tox may occur
Contraindicated
Neratinib
Insuff human data; potential for serious adverse events
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Insuff human data; potential for serious adverse events |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Neratinib
General-Increased incidence of serious ADRs in elderly leading to discontinuation. Renal-Monitor renal function closely for acute kidney injury. Gastrointestinal-Increased frequency of GI ADRs: diarrhea, vomiting leading to dehydration.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | N | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
| HEr2 positive carcinoma of breast | |
| C50 | Malignant neoplasm of breast |
| C50.1 | Malignant neoplasm of central portion of breast |
| C50.11 | Malignant neoplasm of central portion of breast, female |
| C50.111 | Malignant neoplasm of central portion of right female breast |
| C50.112 | Malignant neoplasm of central portion of left female breast |
| C50.119 | Malignant neoplasm of central portion of unspecified female breast |
| C50.12 | Malignant neoplasm of central portion of breast, male |
| C50.121 | Malignant neoplasm of central portion of right male breast |
| C50.122 | Malignant neoplasm of central portion of left male breast |
| C50.129 | Malignant neoplasm of central portion of unspecified male breast |
| C50.2 | Malignant neoplasm of upper-inner quadrant of breast |
| C50.21 | Malignant neoplasm of upper-inner quadrant of breast, female |
| C50.211 | Malignant neoplasm of upper-inner quadrant of right female breast |
| C50.212 | Malignant neoplasm of upper-inner quadrant of left female breast |
| C50.219 | Malignant neoplasm of upper-inner quadrant of unspecified female breast |
| C50.22 | Malignant neoplasm of upper-inner quadrant of breast, male |
| C50.221 | Malignant neoplasm of upper-inner quadrant of right male breast |
| C50.222 | Malignant neoplasm of upper-inner quadrant of left male breast |
| C50.229 | Malignant neoplasm of upper-inner quadrant of unspecified male breast |
| C50.3 | Malignant neoplasm of lower-inner quadrant of breast |
| C50.31 | Malignant neoplasm of lower-inner quadrant of breast, female |
| C50.311 | Malignant neoplasm of lower-inner quadrant of right female breast |
| C50.312 | Malignant neoplasm of lower-inner quadrant of left female breast |
| C50.319 | Malignant neoplasm of lower-inner quadrant of unspecified female breast |
| C50.32 | Malignant neoplasm of lower-inner quadrant of breast, male |
| C50.321 | Malignant neoplasm of lower-inner quadrant of right male breast |
| C50.322 | Malignant neoplasm of lower-inner quadrant of left male breast |
| C50.329 | Malignant neoplasm of lower-inner quadrant of unspecified male breast |
| C50.4 | Malignant neoplasm of upper-outer quadrant of breast |
| C50.41 | Malignant neoplasm of upper-outer quadrant of breast, female |
| C50.411 | Malignant neoplasm of upper-outer quadrant of right female breast |
| C50.412 | Malignant neoplasm of upper-outer quadrant of left female breast |
| C50.419 | Malignant neoplasm of upper-outer quadrant of unspecified female breast |
| C50.42 | Malignant neoplasm of upper-outer quadrant of breast, male |
| C50.421 | Malignant neoplasm of upper-outer quadrant of right male breast |
| C50.422 | Malignant neoplasm of upper-outer quadrant of left male breast |
| C50.429 | Malignant neoplasm of upper-outer quadrant of unspecified male breast |
| C50.5 | Malignant neoplasm of lower-outer quadrant of breast |
| C50.51 | Malignant neoplasm of lower-outer quadrant of breast, female |
| C50.511 | Malignant neoplasm of lower-outer quadrant of right female breast |
| C50.512 | Malignant neoplasm of lower-outer quadrant of left female breast |
| C50.519 | Malignant neoplasm of lower-outer quadrant of unspecified female breast |
| C50.52 | Malignant neoplasm of lower-outer quadrant of breast, male |
| C50.521 | Malignant neoplasm of lower-outer quadrant of right male breast |
| C50.522 | Malignant neoplasm of lower-outer quadrant of left male breast |
| C50.529 | Malignant neoplasm of lower-outer quadrant of unspecified male breast |
| C50.6 | Malignant neoplasm of axillary tail of breast |
| C50.61 | Malignant neoplasm of axillary tail of breast, female |
| C50.611 | Malignant neoplasm of axillary tail of right female breast |
| C50.612 | Malignant neoplasm of axillary tail of left female breast |
| C50.619 | Malignant neoplasm of axillary tail of unspecified female breast |
| C50.62 | Malignant neoplasm of axillary tail of breast, male |
| C50.621 | Malignant neoplasm of axillary tail of right male breast |
| C50.622 | Malignant neoplasm of axillary tail of left male breast |
| C50.629 | Malignant neoplasm of axillary tail of unspecified male breast |
| C50.8 | Malignant neoplasm of overlapping sites of breast |
| C50.81 | Malignant neoplasm of overlapping sites of breast, female |
| C50.811 | Malignant neoplasm of overlapping sites of right female breast |
| C50.812 | Malignant neoplasm of overlapping sites of left female breast |
| C50.819 | Malignant neoplasm of overlapping sites of unspecified female breast |
| C50.82 | Malignant neoplasm of overlapping sites of breast, male |
| C50.821 | Malignant neoplasm of overlapping sites of right male breast |
| C50.822 | Malignant neoplasm of overlapping sites of left male breast |
| C50.829 | Malignant neoplasm of overlapping sites of unspecified male breast |
| C50.9 | Malignant neoplasm of breast of unspecified site |
| C50.91 | Malignant neoplasm of breast of unspecified site, female |
| C50.911 | Malignant neoplasm of unspecified site of right female breast |
| C50.912 | Malignant neoplasm of unspecified site of left female breast |
| C50.919 | Malignant neoplasm of unspecified site of unspecified female breast |
| C50.92 | Malignant neoplasm of breast of unspecified site, male |
| C50.921 | Malignant neoplasm of unspecified site of right male breast |
| C50.922 | Malignant neoplasm of unspecified site of left male breast |
| C50.929 | Malignant neoplasm of unspecified site of unspecified male breast |
| 0-9 | A-Z |
|---|---|
| C50 | Malignant neoplasm of breast |
| C50.1 | Malignant neoplasm of central portion of breast |
| C50.11 | Malignant neoplasm of central portion of breast, female |
| C50.111 | Malignant neoplasm of central portion of right female breast |
| C50.112 | Malignant neoplasm of central portion of left female breast |
| C50.119 | Malignant neoplasm of central portion of unspecified female breast |
| C50.12 | Malignant neoplasm of central portion of breast, male |
| C50.121 | Malignant neoplasm of central portion of right male breast |
| C50.122 | Malignant neoplasm of central portion of left male breast |
| C50.129 | Malignant neoplasm of central portion of unspecified male breast |
| C50.2 | Malignant neoplasm of upper-inner quadrant of breast |
| C50.21 | Malignant neoplasm of upper-inner quadrant of breast, female |
| C50.211 | Malignant neoplasm of upper-inner quadrant of right female breast |
| C50.212 | Malignant neoplasm of upper-inner quadrant of left female breast |
| C50.219 | Malignant neoplasm of upper-inner quadrant of unspecified female breast |
| C50.22 | Malignant neoplasm of upper-inner quadrant of breast, male |
| C50.221 | Malignant neoplasm of upper-inner quadrant of right male breast |
| C50.222 | Malignant neoplasm of upper-inner quadrant of left male breast |
| C50.229 | Malignant neoplasm of upper-inner quadrant of unspecified male breast |
| C50.3 | Malignant neoplasm of lower-inner quadrant of breast |
| C50.31 | Malignant neoplasm of lower-inner quadrant of breast, female |
| C50.311 | Malignant neoplasm of lower-inner quadrant of right female breast |
| C50.312 | Malignant neoplasm of lower-inner quadrant of left female breast |
| C50.319 | Malignant neoplasm of lower-inner quadrant of unspecified female breast |
| C50.32 | Malignant neoplasm of lower-inner quadrant of breast, male |
| C50.321 | Malignant neoplasm of lower-inner quadrant of right male breast |
| C50.322 | Malignant neoplasm of lower-inner quadrant of left male breast |
| C50.329 | Malignant neoplasm of lower-inner quadrant of unspecified male breast |
| C50.4 | Malignant neoplasm of upper-outer quadrant of breast |
| C50.41 | Malignant neoplasm of upper-outer quadrant of breast, female |
| C50.411 | Malignant neoplasm of upper-outer quadrant of right female breast |
| C50.412 | Malignant neoplasm of upper-outer quadrant of left female breast |
| C50.419 | Malignant neoplasm of upper-outer quadrant of unspecified female breast |
| C50.42 | Malignant neoplasm of upper-outer quadrant of breast, male |
| C50.421 | Malignant neoplasm of upper-outer quadrant of right male breast |
| C50.422 | Malignant neoplasm of upper-outer quadrant of left male breast |
| C50.429 | Malignant neoplasm of upper-outer quadrant of unspecified male breast |
| C50.5 | Malignant neoplasm of lower-outer quadrant of breast |
| C50.51 | Malignant neoplasm of lower-outer quadrant of breast, female |
| C50.511 | Malignant neoplasm of lower-outer quadrant of right female breast |
| C50.512 | Malignant neoplasm of lower-outer quadrant of left female breast |
| C50.519 | Malignant neoplasm of lower-outer quadrant of unspecified female breast |
| C50.52 | Malignant neoplasm of lower-outer quadrant of breast, male |
| C50.521 | Malignant neoplasm of lower-outer quadrant of right male breast |
| C50.522 | Malignant neoplasm of lower-outer quadrant of left male breast |
| C50.529 | Malignant neoplasm of lower-outer quadrant of unspecified male breast |
| C50.6 | Malignant neoplasm of axillary tail of breast |
| C50.61 | Malignant neoplasm of axillary tail of breast, female |
| C50.611 | Malignant neoplasm of axillary tail of right female breast |
| C50.612 | Malignant neoplasm of axillary tail of left female breast |
| C50.619 | Malignant neoplasm of axillary tail of unspecified female breast |
| C50.62 | Malignant neoplasm of axillary tail of breast, male |
| C50.621 | Malignant neoplasm of axillary tail of right male breast |
| C50.622 | Malignant neoplasm of axillary tail of left male breast |
| C50.629 | Malignant neoplasm of axillary tail of unspecified male breast |
| C50.8 | Malignant neoplasm of overlapping sites of breast |
| C50.81 | Malignant neoplasm of overlapping sites of breast, female |
| C50.811 | Malignant neoplasm of overlapping sites of right female breast |
| C50.812 | Malignant neoplasm of overlapping sites of left female breast |
| C50.819 | Malignant neoplasm of overlapping sites of unspecified female breast |
| C50.82 | Malignant neoplasm of overlapping sites of breast, male |
| C50.821 | Malignant neoplasm of overlapping sites of right male breast |
| C50.822 | Malignant neoplasm of overlapping sites of left male breast |
| C50.829 | Malignant neoplasm of overlapping sites of unspecified male breast |
| C50.9 | Malignant neoplasm of breast of unspecified site |
| C50.91 | Malignant neoplasm of breast of unspecified site, female |
| C50.911 | Malignant neoplasm of unspecified site of right female breast |
| C50.912 | Malignant neoplasm of unspecified site of left female breast |
| C50.919 | Malignant neoplasm of unspecified site of unspecified female breast |
| C50.92 | Malignant neoplasm of breast of unspecified site, male |
| C50.921 | Malignant neoplasm of unspecified site of right male breast |
| C50.922 | Malignant neoplasm of unspecified site of left male breast |
| C50.929 | Malignant neoplasm of unspecified site of unspecified male breast |
Formulary Reference Tool