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PROLEUKIN (ALDESLEUKIN)
- Metastatic malignant melanoma
- Metastatic renal cell carcinoma
22 million unit intravenous solution
- Dosage information is not available
Metastatic malignant melanoma
- Infuse 0.6 million units/kg over 15 minute(s) by intravenous route every 8 hours for 14 doses; repeat once after a 9 day rest period
- Infuse 0.72 million units/kg over 15 minute(s) by intravenous route every 8 hours for 15 doses; repeat once after a 10 day rest period
- Infuse 0.6 million units/kg over 15 minute(s) by intravenous route every 8 hours for 14 doses; repeat once after a 6 day rest period
Metastatic renal cell carcinoma
- Inject 9 million units by subcutaneous route once daily on days 1 and2 of a 5 day cycle
- Inject 18 million units by subcutaneous route once daily for 5 days
- Inject 18 million units by subcutaneous route once daily on days 3, 4And 5 of a 5 day cycle
- Infuse 0.6 million units/kg over 15 minute(s) by intravenous route every 8 hours for 14 doses; repeat once after a 9 day rest period
- Infuse 0.72 million units/kg over 15 minute(s) by intravenous route every 8 hours for 15 doses; repeat once after a 10 day rest period
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- BCG vaccine, live (PF)
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- natalizumab
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- Tysabri
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- A-hydrocort
- A-methapred
- Anucort-hc
- Anusol-hc
- Aristospan Intra-articular
- Aristospan Intralesional
- betamethasone acet & sod phos
- budesonide
- Celestone Soluspan
- Colocort
- Cortef
- Cortenema
- Cortifoam
- cortisone
- Depo-medrol
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- Entocort Ec
- Ez Use Joint-tunnel-trigger
- First-duke's
- First-mary's Mouthwash
- Flo-pred
- fludrocortisone
- Grx Hicort 25
- Hemril-30
- hydrocortisone
- hydrocortisone acetate
- hydrocortisone sod succ (PF)
- hydrocortisone sod succinate
- Kenalog
- Medrol
- Medrol (pak)
- methylprednisolone
- methylprednisolone acetate
- methylprednisolone sod suc(PF)
- methylprednisolone sodium succ
- methylprednisolone-bupivacaine
- Millipred
- Millipred Dp
- nystatin-hydrocortisone-diphen
- nystatin-TCN-HC-diphenhydramin
- Orapred
- Orapred Odt
- Pediapred
- Physicians Ez Use M-pred
- prednisolone
- prednisolone acetate
- prednisolone sodium phosphate
- prednisone
- Prednisone Intensol
- Proctocort
- Rayos
- Rectacort-hc
- Solu-cortef
- Solu-cortef (pf)
- Solu-medrol
- Solu-medrol (pf)
- triamcinolone acetonide
- triamcinolone hexacetonide
- triamcinolone-lidocaine
- Uceris
- Veripred 20
Severe
Moderate
- None
- Acute myocardial infarction
- Acute respiratory insufficiency
- Angina
- Atrial fibrillation
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Coma
- Gastrointestinal hemorrhage
- Intestinal perforation
- Ischemic bowel disease
- Lactating mother
- Neoplasm metastatic to CNS
- Pericardial tamponade
- Recipient of organ transplant
- Renal dialysis
- Sepsis
- Status epilepticus
- Supraventricular tachycardia
- Toxic psychosis
- Ventricular tachycardia
Contraindicated
- Acute confusion
- Altered mental status
- Arthritis
- Autoimmune disease
- Bacterial endocarditis
- Bacterial infection
- Bradycardia
- Bullous pemphigoid
- Capillary leak syndrome
- Cardiac arrhythmia
- Cardiac disease
- Cerebral vasculitis
- Cholecystitis
- Crohn's disease
- Diabetes mellitus
- Disease of liver
- Edema
- Fungal infection
- Glomerulonephritis
- Hypotension
- Myasthenia gravis
- Opportunistic fungal infection
- Protozoal infection
- Pulmonary edema
- Scleroderma
- Seizure disorder
- Thyroiditis
- Untreated hypothyroidism
Severe
Moderate
- Hypovolemia
- Kidney disease with likely reduction in GFR
- Oliguria
PROLEUKIN (ALDESLEUKIN)
- Metastatic malignant melanoma
- Metastatic renal cell carcinoma
- Altered mental status
- Anemia
- Cardiac arrhythmia
- Chills
- Diarrhea
- Dizziness
- Edema
- Eosinophilia
- Exfoliative dermatitis
- Fever
- Hypotension
- Hypothyroidism
- Infection
- Nausea
- Oliguria
- Peripheral edema
- Pleural effusions
- Pulmonary congestion
- Pulmonary edema
- Sinus tachycardia
- Stomatitis
- Thrombocytopenic disorder
- Vomiting
- Anorexia
- Cough
- Drowsy
- Dyspnea
- Malaise
- Pruritus of skin
- Rhinitis
- Skin rash
- Symptoms of anxiety
- Weight gain
More Frequent
Severe
Less Severe
- Acute myocardial infarction
- Acute respiratory insufficiency
- Aphasia
- Ascites
- Gastrointestinal hemorrhage
- Intestinal perforation
- Tachypnea
- Acute abdominal pain
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Anaphylaxis
- Angioedema
- Bacterial sepsis
- Bullous pemphigoid
- Capillary leak syndrome
- Cardiomyopathy
- Cerebral vasculitis
- Cerebrovascular accident
- Cholecystitis
- Chronic heart failure
- Colitis
- Coma
- Crohn's disease
- Diabetes mellitus
- Encephalopathy
- Endocarditis
- Extrapyramidal disease
- Gangrene
- Gastrointestinal obstruction
- Glomerulonephritis
- Hepatitis
- Hypertension
- Hyperthyroidism
- Hypothermia
- Injection site sequelae
- Intestinal ischemic necrosis
- Intracerebral hemorrhage
- Kidney disease with reduction in GFR
- Lethargy
- Leukocytosis
- Leukopenia
- Lymphopenia
- Myocardial ischemia
- Myocarditis
- Myositis
- Ocular myasthenia
- Pancreatitis
- Pericardial effusion
- Peripheral demyelinating neuropathy
- Retroperitoneal hemorrhage
- Rhabdomyolysis
- Rheumatoid arthritis
- Scleroderma
- Seizure disorder
- Stevens-johnson syndrome
- Subdural intracranial hemorrhage
- Syncope
- Thrombotic disorder
- Thyroiditis
Less Severe
- Gastritis
- General weakness
- Hyperglycemia
- Insomnia
- Myopathy
- Neuralgia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Aldesleukin
Safety and efficacy not established.
- 1 Day – 18 Years
- Safety and efficacy not established.
Aldesleukin
- Severity Level:
C
- Additional Notes:
Contraindicated
Aldesleukin
Breastfeeding not recommended due to potential risk to infant
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Breastfeeding not recommended due to potential risk to infant |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- Aldesleukin must be given in a hospital setting by a health care professional. It must be used with extreme caution in patients with heart or lung problems. Infrequently, this medication can cause capillary leak syndrome (CLS), a serious condition that can sometimes be fatal.<br /><br /> If you develop any of the following signs of CLS, tell your doctor right away: swelling, severe dizziness, fainting, irregular heartbeat, chest pain (angina), trouble breathing, signs of kidney problems (such as change in the amount of urine), mental/mood changes, severe stomach/abdominal pain, black stools. Aldesleukin can also make you more likely to get serious infections. Before using this drug, tell your doctor if you currently have any infections.<br /><br />Also, tell your doctor right away if you develop any of the following signs of infection: persistent sore throat, fever. Rarely, this drug may cause a loss of consciousness. If this drug makes you unusually sleepy, stop using it and tell your doctor right away.
| Metastatic malignant melanoma | |
| C43 | Malignant melanoma of skin |
| C43.0 | Malignant melanoma of lip |
| C43.1 | Malignant melanoma of eyelid, including canthus |
| C43.10 | Malignant melanoma of unspecified eyelid, including canthus |
| C43.11 | Malignant melanoma of right eyelid, including canthus |
| C43.111 | Malignant melanoma of right upper eyelid, including canthus |
| C43.112 | Malignant melanoma of right lower eyelid, including canthus |
| C43.12 | Malignant melanoma of left eyelid, including canthus |
| C43.121 | Malignant melanoma of left upper eyelid, including canthus |
| C43.122 | Malignant melanoma of left lower eyelid, including canthus |
| C43.2 | Malignant melanoma of ear and external auricular canal |
| C43.20 | Malignant melanoma of unspecified ear and external auricular canal |
| C43.21 | Malignant melanoma of right ear and external auricular canal |
| C43.22 | Malignant melanoma of left ear and external auricular canal |
| C43.3 | Malignant melanoma of other and unspecified parts of face |
| C43.30 | Malignant melanoma of unspecified part of face |
| C43.31 | Malignant melanoma of nose |
| C43.39 | Malignant melanoma of other parts of face |
| C43.4 | Malignant melanoma of scalp and neck |
| C43.5 | Malignant melanoma of trunk |
| C43.51 | Malignant melanoma of anal skin |
| C43.52 | Malignant melanoma of skin of breast |
| C43.59 | Malignant melanoma of other part of trunk |
| C43.6 | Malignant melanoma of upper limb, including shoulder |
| C43.60 | Malignant melanoma of unspecified upper limb, including shoulder |
| C43.61 | Malignant melanoma of right upper limb, including shoulder |
| C43.62 | Malignant melanoma of left upper limb, including shoulder |
| C43.7 | Malignant melanoma of lower limb, including hip |
| C43.70 | Malignant melanoma of unspecified lower limb, including hip |
| C43.71 | Malignant melanoma of right lower limb, including hip |
| C43.72 | Malignant melanoma of left lower limb, including hip |
| C43.8 | Malignant melanoma of overlapping sites of skin |
| C43.9 | Malignant melanoma of skin, unspecified |
| Metastatic renal cell carcinoma | |
| C64 | Malignant neoplasm of kidney, except renal pelvis |
| C64.1 | Malignant neoplasm of right kidney, except renal pelvis |
| C64.2 | Malignant neoplasm of left kidney, except renal pelvis |
| C64.9 | Malignant neoplasm of unspecified kidney, except renal pelvis |
| 0-9 | A-Z |
|---|---|
| C43 | Malignant melanoma of skin |
| C43.0 | Malignant melanoma of lip |
| C43.1 | Malignant melanoma of eyelid, including canthus |
| C43.10 | Malignant melanoma of unspecified eyelid, including canthus |
| C43.11 | Malignant melanoma of right eyelid, including canthus |
| C43.111 | Malignant melanoma of right upper eyelid, including canthus |
| C43.112 | Malignant melanoma of right lower eyelid, including canthus |
| C43.12 | Malignant melanoma of left eyelid, including canthus |
| C43.121 | Malignant melanoma of left upper eyelid, including canthus |
| C43.122 | Malignant melanoma of left lower eyelid, including canthus |
| C43.2 | Malignant melanoma of ear and external auricular canal |
| C43.20 | Malignant melanoma of unspecified ear and external auricular canal |
| C43.21 | Malignant melanoma of right ear and external auricular canal |
| C43.22 | Malignant melanoma of left ear and external auricular canal |
| C43.3 | Malignant melanoma of other and unspecified parts of face |
| C43.30 | Malignant melanoma of unspecified part of face |
| C43.31 | Malignant melanoma of nose |
| C43.39 | Malignant melanoma of other parts of face |
| C43.4 | Malignant melanoma of scalp and neck |
| C43.5 | Malignant melanoma of trunk |
| C43.51 | Malignant melanoma of anal skin |
| C43.52 | Malignant melanoma of skin of breast |
| C43.59 | Malignant melanoma of other part of trunk |
| C43.6 | Malignant melanoma of upper limb, including shoulder |
| C43.60 | Malignant melanoma of unspecified upper limb, including shoulder |
| C43.61 | Malignant melanoma of right upper limb, including shoulder |
| C43.62 | Malignant melanoma of left upper limb, including shoulder |
| C43.7 | Malignant melanoma of lower limb, including hip |
| C43.70 | Malignant melanoma of unspecified lower limb, including hip |
| C43.71 | Malignant melanoma of right lower limb, including hip |
| C43.72 | Malignant melanoma of left lower limb, including hip |
| C43.8 | Malignant melanoma of overlapping sites of skin |
| C43.9 | Malignant melanoma of skin, unspecified |
| C64 | Malignant neoplasm of kidney, except renal pelvis |
| C64.1 | Malignant neoplasm of right kidney, except renal pelvis |
| C64.2 | Malignant neoplasm of left kidney, except renal pelvis |
| C64.9 | Malignant neoplasm of unspecified kidney, except renal pelvis |
Formulary Reference Tool