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PREPIDIL (DINOPROSTONE)
- Cervical ripening procedure
- Induction of labor
0.5 mg/3 g vaginal gel
- Insert 1 applicatorful (0.5 mg) by cervical route once, repeat dose in 6 hours as needed; do not exceed 7.5 ml (1.5 mg) in 24Hrs
Cervical ripening procedure
- Insert 1 applicatorful (0.5 mg) by cervical route once, repeat dose in 6 hours as needed; do not exceed 7.5 ml (1.5 mg) in 24Hrs
Induction of labor
- Insert 1 applicatorful (0.5 mg) by cervical route once, repeat dose in 6 hours as needed; do not exceed 7.5 ml (1.5 mg) in 24Hrs
- None
Contraindicated
- None
Severe
Moderate
- None
- Abnormal uterine bleeding
- Cephalopelvic disproportion
- Fetal distress
- Genital herpes simplex
- Grand multiparity
- Placenta previa
- Previous cesarean section
Contraindicated
- Disseminated intravascular coagulation
- Pulmonary disease
- Uterine hypertonic patterns
Severe
Moderate
- Amniotic membrane rupture
- Anemia
- Asthma
- Cervicitis
- Diabetes mellitus
- Disease of liver
- Endocervical lesions
- Glaucoma
- Hypertension
- Hypotension
- Kidney disease with reduction in GFR
- Multiple pregnancy
- Ocular hypertension
- Seizure disorder
- Stenosis of cervix
- Uterine leiomyoma
PREPIDIL (DINOPROSTONE)
- Cervical ripening procedure
- Induction of labor
- None
- Abdominal pain with cramps
- Diarrhea
- Fever
- Nausea
- Vomiting
More Frequent
Severe
Less Severe
- Uterine hypertonic patterns
- Chills
- Headache disorder
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Anaphylaxis
- Angioedema
- Bradycardia
- Bronchospastic pulmonary disease
- Chest pain
- Chest tightness
- Contact dermatitis
- Disseminated intravascular coagulation
- Dyspnea
- Hypertension
- Hypotension
- Peripheral vasoconstriction
- Postpartum hemorrhage
- Pruritus of skin
- Skin rash
- Tachycardia
- Urticaria
- Wheezing
Less Severe
- Back pain
- Dizziness
- Flushing
- Hiccups
- Paralytic ileus
- Vulvar edema
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Dinoprostone
Safety and efficacy not established.
- 1 Day – 18 Years
- Safety and efficacy not established.
Dinoprostone (cervical Ripening)
- Severity Level:
2
- Additional Notes: No fda category; insufficient human data
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Dinoprostone
Potential suppression of lactation.
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Potential suppression of lactation. |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Induction of labor | |
| O75.5 | Delayed delivery after artificial rupture of membranes |
| 0-9 | A-Z |
|---|---|
| O75.5 | Delayed delivery after artificial rupture of membranes |
Formulary Reference Tool