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CYTOTEC (MISOPROSTOL)
- Prevention of NSAId-induced gastric ulcer
100 mcg tablet
- 1 tablet (100 mcg) by oral route 4 times per day after meals andat bedtime
200 mcg tablet
- 1 tablet (200 mcg) by oral route 4 times per day after meals andat bedtime
100 mcg tablet
- 1 tablet (100 mcg) by oral route 4 times per day after meals andat bedtime
200 mcg tablet
- 1 tablet (200 mcg) by oral route 4 times per day after meals andat bedtime
Duodenal ulcer
- 1 tablet (100 mcg) by oral route 4 times per day after meals andat bedtime for 4 weeks
- 1 tablet (100 mcg) by oral route 4 times per day after meals andat bedtime for 8 weeks
- 1 tablet (100 mcg) by oral route 4 times per day after meals andat bedtime
- 2 tablets (200 mcg) by oral route after meals and at bedtime for4 weeks
- 2 tablets (200 mcg) by oral route 4 times per day after meals and at bedtime for 8 weeks
- 2 tablets (200 mcg) by oral route 4 times per day after meals and at bedtime
- 1 tablet (200 mcg) by oral route 4 times per day after meals andat bedtime for 4 weeks
- 1 tablet (200 mcg) by oral route 4 times per day after meals andat bedtime for 8 weeks
- 1 tablet (200 mcg) by oral route 4 times per day after meals andat bedtime
- 2 tablets (400 mcg) by oral route 2 times per day in the morningand at bedtime with food for 4 weeks
- 2 tablets (400 mcg) by oral route 2 times per day in the morningand at bedtime with food for 8 weeks
- 2 tablets (400 mcg) by oral route 2 times per day in the morningand at bedtime with food
Gastric ulcer
- 1 tablet (100 mcg) by oral route 4 times per day after meals andat bedtime for 8 weeks
- 2 tablets (200 mcg) by oral route 4 times per day after meals and at bedtime for 8 weeks
- 1 tablet (200 mcg) by oral route 4 times per day after meals andat bedtime for 8 weeks
NSAId-induced gastric ulcer
- 1 tablet (100 mcg) by oral route 4 times per day after meals andat bedtime
- 2 tablets (200 mcg) by oral route 4 times per day after meals and at bedtime
- 1 tablet (200 mcg) by oral route 4 times per day after meals andat bedtime
- 2 tablets (400 mcg) by oral route 2 times per day in the morningand at bedtime with food
Prevention of NSAId-induced gastric ulcer
- 1 tablet (100 mcg) by oral route 4 times per day after meals andat bedtime
- 2 tablets (200 mcg) by oral route 4 times per day after meals and at bedtime
- 1 tablet (200 mcg) by oral route 4 times per day after meals andat bedtime
- 2 tablets (200 mcg) by oral route 2 times per day with food
- 1 tablet (200 mcg) by oral route 2 times per day with meals
- None
Contraindicated
- None
Severe
Moderate
- None
- Pregnancy
Contraindicated
- Inflammatory bowel disease
- Uterine rupture in pregnancy
Severe
Moderate
- Dehydration
- Previous cesarean section
- Uterine scar present
CYTOTEC (MISOPROSTOL)
- Prevention of NSAId-induced gastric ulcer
- None
- Abdominal pain with cramps
- Diarrhea
More Frequent
Severe
Less Severe
- Abnormal hepatic function tests
- Constipation
- Dyspepsia
- Flatulence
- Headache disorder
- Nausea
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute myocardial infarction
- Anaphylaxis
- Anemia
- Bronchospastic pulmonary disease
- Cardiac arrhythmia
- CNS toxicity
- Gout
- Hearing loss
- Purpura
- Seizure disorder
- Tachycardia
- Thrombocytopenic disorder
- Thromboembolic disorder
- Uterine rupture in pregnancy
Less Severe
- Abnormal vaginal bleeding
- Acute confusion
- Agitation
- Alopecia
- Arthralgias
- Back pain
- Chest pain
- Chills
- Conjunctivitis
- Cramps
- Depression
- Dizziness
- Drowsy
- Dysgeusia
- Dysmenorrhea
- Dysphagia
- Dyspnea
- Dysuria
- Earache
- Edema
- Epistaxis
- Erectile dysfunction
- Fatigue
- Fever
- General weakness
- Gingivitis
- Hematuria
- Hyperhidrosis
- Hypertension
- Hypotension
- Mastalgia
- Menstrual disorder
- Myalgias
- Pallor
- Phlebitis
- Polyuria
- Skin inflammation
- Skin rash
- Symptoms of anxiety
- Syncope
- Tinnitus
- Upper respiratory infection
- Uterine cramps
- Visual changes
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Misoprostol
No safety and efficacy in pediatrics.
- 1 Day – 18 Years
- No safety and efficacy in pediatrics.
Misoprostol
- Severity Level:
X
- Additional Notes: Abortifacient and teratogenic
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Misoprostol
Low levels excreted into breastmilk, unlikely to cause adverse effects
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Low levels excreted into breastmilk, unlikely to cause adverse effects |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- Do not take this medication if you think that you may be pregnant. It may cause abortion, premature birth, or birth defects. In rare cases, serious complications (e.g., uterine rupture) have occurred when misoprostol was used to start labor or when used in combination with another drug to cause abortion after the eighth week of pregnancy.<br /><br />These complications have resulted in harm to the unborn baby and mother. Avoid pregnancy while taking misoprostol and for at least one month or one completed menstrual cycle after you have stopped treatment. If you become pregnant while taking misoprostol, contact your doctor right away.<br /><br /> If you are pregnant, do not take this medication to reduce the risk of stomach ulcers due to aspirin or other related drugs (non-steroidal anti-inflammatory drugs-NSAIDs such as ibuprofen). Also, if you are of childbearing age, do not use this drug to reduce the risk of ulcers from NSAIDs unless you are at high risk of having an ulcer or ulcer complications. Female patients must meet the following four requirements in order to use this drug: 1) test negative for pregnancy within two weeks before starting treatment; 2) use effective birth control to prevent pregnancy; 3) receive oral and written warnings on the dangers of using misoprostol while of childbearing age and the risks of possible birth control failure; 4) start taking misoprostol only on the second or third day of the next normal menstrual period. This medication must not be shared with others.
| Prevention of NSAId-induced gastric ulcer | |
| Z79.1 | Long term (current) use of non-steroidal anti-inflammatories (NSAId) |
| 0-9 | A-Z |
|---|---|
| Z79.1 | Long term (current) use of non-steroidal anti-inflammatories (NSAId) |
Formulary Reference Tool