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ALDACTONE (SPIRONOLACTONE)
- Ascites
- Chronic heart failure
- Edema due to hepatic cirrhosis
- Aldosteronism
- Diagnostic test for primary aldosteronism
- Edema
- Edema due to nephrotic syndrome
- Hypertension
- Hypokalemia
- Hypokalemia prevention
- Peripheral edema due to chronic heart failure
- Pulmonary edema due to chronic heart failure
100 mg tablet
- 1 tablet (100 mg) by oral route once daily
25 mg tablet
- 1 tablet (25 mg) by oral route once daily
50 mg tablet
- 1 tablet (50 mg) by oral route once daily
100 mg tablet
- 1 tablet (100 mg) by oral route once daily
25 mg tablet
- 1 tablet (25 mg) by oral route once daily
50 mg tablet
- 1 tablet (50 mg) by oral route once daily
Ascites
- 1 tablet (25 mg) by oral route once daily
- 1 tablet (25 mg) by oral route 2 times per day
- 1 tablet (25 mg) by oral route 3 times per day
- 1 tablet (25 mg) by oral route 4 times per day
- 1 tablet (50 mg) by oral route 2 times per day
- 1 tablet (50 mg) by oral route 3 times per day
- 2 tablets (50 mg) by oral route 2 times per day
- 2 tablets (50 mg) by oral route 3 times per day
- 2 tablets (50 mg) by oral route once daily
- 1 tablet (50 mg) by oral route once daily
- 2 tablets (50 mg) by oral route 4 times per day
- 1 tablet (50 mg) by oral route 4 times per day
- 1 tablet (100 mg) by oral route once daily
- 2 tablets (100 mg) by oral route once daily
- 2 tablets (100 mg) by oral route 2 times per day
- 1 tablet (100 mg) by oral route 2 times per day
Chronic heart failure
- 1 tablet (25 mg) by oral route once daily
- 1 tablet (25 mg) by oral route every other day
- 2 tablets (50 mg) by oral route once daily
- 1 tablet (50 mg) by oral route once daily
Diagnostic test for primary aldosteronism
- 1 tablet (25 mg) by oral route 4 times per day
- 1 tablet (50 mg) by oral route 2 times per day
- 1 tablet (50 mg) by oral route 3 times per day
- 2 tablets (50 mg) by oral route 2 times per day
- 2 tablets (50 mg) by oral route 3 times per day
- 2 tablets (50 mg) by oral route 4 times per day
- 1 tablet (50 mg) by oral route 4 times per day
- 2 tablets (100 mg) by oral route 4 times per day
- 1 tablet (100 mg) by oral route 3 times per day
- 2 tablets (100 mg) by oral route 3 times per day
- 2 tablets (100 mg) by oral route 2 times per day
- 1 tablet (100 mg) by oral route 4 times per day
- 1 tablet (100 mg) by oral route 2 times per day
- 2 tablets (200 mg) by oral route 2 times per day
Hypertension
- 1 tablet (25 mg) by oral route once daily
- 1 tablet (25 mg) by oral route 2 times per day
- 1 tablet (25 mg) by oral route 3 times per day
- 1 tablet (25 mg) by oral route 4 times per day
- 1 tablet (50 mg) by oral route 2 times per day
- 1 tablet (50 mg) by oral route 3 times per day
- 2 tablets (50 mg) by oral route 2 times per day
- 2 tablets (50 mg) by oral route 3 times per day
- 2 tablets (50 mg) by oral route once daily
- 1 tablet (50 mg) by oral route once daily
- 2 tablets (50 mg) by oral route 4 times per day
- 1 tablet (50 mg) by oral route 4 times per day
- 1 tablet (100 mg) by oral route once daily
- 2 tablets (100 mg) by oral route once daily
- 2 tablets (100 mg) by oral route 2 times per day
- 1 tablet (100 mg) by oral route 2 times per day
Hypokalemia
- 1 tablet (25 mg) by oral route once daily
- 2 tablets (50 mg) by oral route once daily
- 1 tablet (50 mg) by oral route once daily
- 1 tablet (100 mg) by oral route once daily
- 2 tablets (100 mg) by oral route once daily
Peripheral edema due to chronic heart failure
- 1 tablet (25 mg) by oral route once daily
- 1 tablet (25 mg) by oral route 2 times per day
- 1 tablet (25 mg) by oral route 3 times per day
- 1 tablet (25 mg) by oral route 4 times per day
- 1 tablet (50 mg) by oral route 2 times per day
- 1 tablet (50 mg) by oral route 3 times per day
- 2 tablets (50 mg) by oral route 2 times per day
- 2 tablets (50 mg) by oral route 3 times per day
- 2 tablets (50 mg) by oral route once daily
- 1 tablet (50 mg) by oral route once daily
- 2 tablets (50 mg) by oral route 4 times per day
- 1 tablet (50 mg) by oral route 4 times per day
- 2 tablets (100 mg) by oral route 4 times per day
- 1 tablet (100 mg) by oral route once daily
- 1 tablet (100 mg) by oral route 3 times per day
- 2 tablets (100 mg) by oral route once daily
- 2 tablets (100 mg) by oral route 3 times per day
- 2 tablets (100 mg) by oral route 2 times per day
- 1 tablet (100 mg) by oral route 4 times per day
- 1 tablet (100 mg) by oral route 2 times per day
- 2 tablets (200 mg) by oral route 2 times per day
- 2 tablets (200 mg) by oral route once daily
- Astagraf Xl
- cyclosporine
- cyclosporine modified
- Gengraf
- Hecoria
- Neoral
- Prograf
- Sandimmune
- tacrolimus
Contraindicated
- Aldactazide
- Aldactone
- Alka-seltzer Gold
- amiloride
- amiloride-hydrochlorothiazide
- Bactrim
- Bactrim Ds
- Ceralyte-70
- Ceraors 75
- Cerasport
- Cerasport Ex1
- Curad Enema
- Cytra K Crystals
- Cytra-3
- Cytra-k
- Disposable Enema
- DM-GG-potassium citrate
- Dyazide
- Dyrenium
- Effer-k
- Enema
- Enema Disposable
- Fleet Enema
- Fleet Enema Extra
- Fleet Pediatric
- Hyperlyte Cr
- K-effervescent
- K-tab
- Kaochlor
- Klor-con
- Klor-con 10
- Klor-con M10
- Klor-con M15
- Klor-con M20
- Klor-con/ef
- Lysodren
- Maxzide
- Maxzide-25Mg
- Medi-lyte
- mitotane
- Nano Vm T/f
- Nutrilyte Ii
- Oral Saline Laxative
- Osmoprep
- Pedialyte
- Pediatric Electrolyte
- pediatric multivit #18-iron-FA
- PEG 3350-bowel 2,two part prep
- Phosphate Laxative
- pot & sod citrate-citric acid
- potassium
- potassium bicarb & chloride
- potassium bicarb-citric acid
- potassium chlorid-D5-0.45%NaCl
- potassium chloride
- potassium chloride in 0.9%NaCl
- potassium chloride in D5W
- potassium chloride in LR-D5
- potassium chloride-0.45 % NaCl
- potassium chloride-D5-0.2%NaCl
- potassium chloride-D5-0.3%NaCl
- potassium chloride-D5-0.9%NaCl
- potassium citrate
- potassium citrate-citric acid
- potassium Cl-calcium phos-mag
- potassium gluconate
- potassium phosphate dibasic
- Preparation Cleansing
- Primsol
- Ready-to-use Enema
- Reclast
- sod & pot chlorid-sod cit-rice
- sod phos mono-sod phos dibasic
- sodium & potassium bicarbonate
- sodium Cl-potassium chloride
- sodium phosphates
- sodium-K+-mag-Ca-chlor-acetate
- sodium-potas-chloride-dextrose
- Sorbutuss
- spironolacton-hydrochlorothiaz
- spironolactone
- Suclear
- sulfamethoxazole-trimethoprim
- Sulfatrim
- Taron-crystals
- Theralith Xr
- Thermotabs
- Tpn Electrolytes
- Tpn Electrolytes Ii
- triamterene
- triamterene-hydrochlorothiazid
- Tricitrates
- trimethoprim
- Urocit-k 10
- Urocit-k 15
- Urocit-k 5
- vit B6-mag cit & ox-potass cit
- zoledronic acid
- zoledronic acid-mannitol-water
- Zometa
Severe
Moderate
- Accupril
- Accuretic
- Aceon
- Altace
- amlodipine-benazepril
- amlodipine-olmesartan
- amlodipine-valsartan
- amlodipine-valsartan-hcthiazid
- Angeliq
- Atacand
- Atacand Hct
- Avalide
- Avapro
- azilsartan med-chlorthalidone
- azilsartan medoxomil
- Azor
- benazepril
- benazepril-hydrochlorothiazide
- Benicar
- Benicar Hct
- Beyaz
- candesartan
- candesartan-hydrochlorothiazid
- captopril
- captopril-hydrochlorothiazide
- Cozaar
- Digox
- digoxin
- Diovan Hct
- drospirenone-e.estradiol-lm.FA
- drospirenone-estradiol
- drospirenone-ethinyl estradiol
- Edarbi
- Edarbyclor
- enalapril maleate
- enalapril-hydrochlorothiazide
- enalaprilat
- Epaned
- eprosartan
- eprosartan-hydrochlorothiazide
- Exforge
- Exforge Hct
- fosinopril
- fosinopril-hydrochlorothiazide
- Gianvi (28)
- Hyzaar
- irbesartan
- irbesartan-hydrochlorothiazide
- Lanoxin
- Lanoxin Pediatric
- lisinopril
- lisinopril-hydrochlorothiazide
- lithium carbonate
- lithium citrate
- Lithobid
- Loryna (28)
- losartan
- losartan-hydrochlorothiazide
- Lotensin
- Lotrel
- Mavik
- Micardis
- Micardis Hct
- moexipril
- moexipril-hydrochlorothiazide
- Ocella
- olmesartan
- olmesartan-amlodipin-hcthiazid
- olmesartan-hydrochlorothiazide
- perindopril erbumine
- Prinivil
- quinapril
- quinapril-hydrochlorothiazide
- ramipril
- Safyral
- Syeda
- Tarka
- telmisartan
- telmisartan-amlodipine
- telmisartan-hydrochlorothiazid
- Teveten
- Teveten Hct
- trandolapril
- trandolapril-verapamil
- Tribenzor
- Twynsta
- Uniretic
- Univasc
- valsartan-hydrochlorothiazide
- Vaseretic
- Vasotec
- Vestura (28)
- Yasmin (28)
- Yaz 28
- Zarah
- Zestoretic
- Zestril
- Acute renal failure
- Anuria
- Primary adrenocortical insufficiency
Contraindicated
- Hyperchloremic acidosis
- Hyperkalemia
- Hypochloremic alkalosis
- Hyponatremia
- Hypovolemia
Severe
Moderate
- Kidney disease with reduction in GFR
ALDACTONE (SPIRONOLACTONE)
- Ascites
- Chronic heart failure
- Edema due to hepatic cirrhosis
- Aldosteronism
- Diagnostic test for primary aldosteronism
- Edema
- Edema due to nephrotic syndrome
- Hypertension
- Hypokalemia
- Hypokalemia prevention
- Peripheral edema due to chronic heart failure
- Pulmonary edema due to chronic heart failure
- Hyperkalemia
- Gastrointestinal irritation
More Frequent
Severe
Less Severe
- Hypomagnesemia
- Hyponatremia
- Abnormal sexual function
- Dizziness
- Erectile dysfunction
- Gynecomastia
- Headache disorder
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Agranulocytosis
- Anaphylaxis
- Cholestatic hepatitis
- Dehydration
- DRESS syndrome
- Dyspnea
- Eosinophilia
- Gastric ulcer
- Gastrointestinal hemorrhage
- Hyperglycemia
- Hypersensitivity angiitis
- Hyperuricemia
- Hypocalcemia
- Hypochloremic alkalosis
- Hypotension
- Hypovolemia
- Kidney disease with reduction in GFR
- Leukopenia
- Neutropenic disorder
- Stevens-johnson syndrome
- Thrombocytopenic disorder
- Toxic epidermal necrolysis
- Vasculitis
Less Severe
- Abdominal pain with cramps
- Acute confusion
- Allergic dermatitis
- Alopecia
- Amenorrhea
- Ataxia
- Cramps in legs
- Diarrhea
- Drowsy
- Fever
- Gastritis
- Irregular menstrual periods
- Lethargy
- Libido changes
- Maculopapular rash
- Mastalgia
- Menstrual disorder
- Nausea
- Postmenopausal bleeding
- Pruritus of skin
- Skin rash
- Urticaria
- Vomiting
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
None
Spironolactone
- Severity Level:
2
- Additional Notes: Theoretical risk based on drug mechanism of action.
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Spironolactone
Limited data suggest minimal amount excreted, w/ no resulting adverse effects
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited data suggest minimal amount excreted, w/ no resulting adverse effects |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Spironolactone
Renal-Increased risk for hyperkalemia in patients with severe renal impairment due to potassium sparing effects. Avoid if CrCl <30 mL/min.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | Y | N | N | N |
BEERS: Y HEDIS: N STOPP: Y
No Known Risk
None
- None
| Aldosteronism | |
| E26.0 | Primary hyperaldosteronism |
| E26.01 | Conn's syndrome |
| E26.09 | Other primary hyperaldosteronism |
| Ascites | |
| R18 | Ascites |
| R18.0 | Malignant ascites |
| R18.8 | Other ascites |
| Chronic heart failure | |
| I50.22 | Chronic systolic (congestive) heart failure |
| I50.32 | Chronic diastolic (congestive) heart failure |
| I50.42 | Chronic combined systolic (congestive) and diastolic (congestive) heart failure |
| I50.812 | Chronic right heart failure |
| I50.814 | Right heart failure due to left heart failure |
| Edema | |
| R60 | Edema, not elsewhere classified |
| R60.0 | Localized edema |
| R60.1 | Generalized edema |
| R60.9 | Edema, unspecified |
| Edema due to hepatic cirrhosis | |
| K70.11 | Alcoholic hepatitis with ascites |
| K70.31 | Alcoholic cirrhosis of liver with ascites |
| K71.51 | Toxic liver disease with chronic active hepatitis with ascites |
| Edema due to nephrotic syndrome | |
| R60.1 | Generalized edema |
| R60.9 | Edema, unspecified |
| Hypertension | |
| I10 | Essential (primary) hypertension |
| I11 | Hypertensive heart disease |
| I11.0 | Hypertensive heart disease with heart failure |
| I11.9 | Hypertensive heart disease without heart failure |
| I12 | Hypertensive chronic kidney disease |
| I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
| I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13 | Hypertensive heart and chronic kidney disease |
| I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
| I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
| I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
| I15.1 | Hypertension secondary to other renal disorders |
| Hypokalemia | |
| E87.6 | Hypokalemia |
| Peripheral edema due to chronic heart failure | |
| R60 | Edema, not elsewhere classified |
| R60.9 | Edema, unspecified |
| Pulmonary edema due to chronic heart failure | |
| J81.0 | Acute pulmonary edema |
| 0-9 | A-Z |
|---|---|
| E26.0 | Primary hyperaldosteronism |
| E26.01 | Conn's syndrome |
| E26.09 | Other primary hyperaldosteronism |
| E87.6 | Hypokalemia |
| I10 | Essential (primary) hypertension |
| I11 | Hypertensive heart disease |
| I11.0 | Hypertensive heart disease with heart failure |
| I11.9 | Hypertensive heart disease without heart failure |
| I12 | Hypertensive chronic kidney disease |
| I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
| I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13 | Hypertensive heart and chronic kidney disease |
| I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
| I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
| I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
| I15.1 | Hypertension secondary to other renal disorders |
| I50.22 | Chronic systolic (congestive) heart failure |
| I50.32 | Chronic diastolic (congestive) heart failure |
| I50.42 | Chronic combined systolic (congestive) and diastolic (congestive) heart failure |
| I50.812 | Chronic right heart failure |
| I50.814 | Right heart failure due to left heart failure |
| J81.0 | Acute pulmonary edema |
| K70.11 | Alcoholic hepatitis with ascites |
| K70.31 | Alcoholic cirrhosis of liver with ascites |
| K71.51 | Toxic liver disease with chronic active hepatitis with ascites |
| R18 | Ascites |
| R18.0 | Malignant ascites |
| R18.8 | Other ascites |
| R60 | Edema, not elsewhere classified |
| R60 | Edema, not elsewhere classified |
| R60.0 | Localized edema |
| R60.1 | Generalized edema |
| R60.1 | Generalized edema |
| R60.9 | Edema, unspecified |
| R60.9 | Edema, unspecified |
| R60.9 | Edema, unspecified |
Formulary Reference Tool