Cefotan

Drug overview for CEFOTAN (cefotetan disodium):

Generic name: cefotetan disodium (sef-oh-TEE-tan)
Drug class: Beta-Lactams
Therapeutic class: Anti-Infective Agents

Cefotetan is a semisynthetic cephamycin beta-lactam antibiotic.

Cefotetan is used for treatment of urinary tract, lower respiratory tract, skin and skin structure, bone and joint, gynecologic, and intra-abdominal infections caused by susceptible bacteria and also is used for perioperative prophylaxis. Cefotetan should not be used for treatment of meningitis or other CNS infections. Prior to initiation of cefotetan therapy, appropriate specimens should be obtained for identification of the causative organism and in vitro susceptibility tests.

Cefotetan therapy may be started pending results of susceptibility tests, but should be discontinued if the organism is found to be resistant to the drug. In certain serious infections, including confirmed or suspected gram-positive or gram-negative sepsis, when the causative organism is unknown, cefotetan and concomitant therapy with an aminoglycoside may be indicated initially pending results of susceptibility tests. If an aminoglycoside is used concomitantly with cefotetan, renal function should be monitored. (See Drug Interactions: Aminoglycosides.)

DRUG IMAGES

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The following indications for CEFOTAN (cefotetan disodium) have been approved by the FDA:

Indications:
Acute gonococcal endometritis
Bacterial pneumonia
Bacterial sepsis
Bacterial urinary tract infection
Bacteroides endometritis
Bacteroides pelvic inflammatory disease
Bacteroides peritonitis
Clostridium peritonitis
E. coli endometritis
E. coli pelvic inflammatory disease
E. coli peritonitis
E. coli urinary tract infection
Endometritis
Escherichia coli pneumonia
Female genital tract infection
Fusobacterium endometritis
Fusobacterium pelvic inflammatory disease
Haemophilus influenzae pneumonia
Infectious disease of abdomen
Inflammatory disease of female pelvic organs
Klebsiella pneumonia
Klebsiella pneumoniae peritonitis
Klebsiella urinary tract infection
Lower respiratory infection
Pelvic inflammatory disease with Neisseria gonorrhea
Peptococcus endometritis
Peptococcus pelvic inflammatory disease
Peptococcus peritonitis
Peptostreptococcus endometritis
Peptostreptococcus pelvic inflammatory disease
Prevention of perioperative infection
Proteus endometritis
Proteus pelvic inflammatory disease
Proteus pneumonia
Proteus urinary tract infection
Skin and skin structure Bacteroides fragilis infection
Skin and skin structure E. coli infection
Skin and skin structure Fusobacterium infection
Skin and skin structure infection
Skin and skin structure Peptococcus infection
Skin and skin structure Peptostreptococcus infection
Skin and skin structure Proteus infection
Skin and skin structure Streptococcus agalactiae infection
Skin and skin structure Streptococcus pyogenes infection
Staphylococcal pneumonia
Staphylococcus aureus joint infection
Staphylococcus aureus osteomyelitis
Staphylococcus aureus skin and skin structure infection
Staphylococcus endometritis
Staphylococcus epidermidis skin and skin structure infection
Staphylococcus pelvic inflammatory disease
Streptococcal endometritis
Streptococcal pelvic inflammatory disease
Streptococcal peritonitis
Streptococcal pneumonia

Professional Synonyms:
Acute gonorrhea of the endometrium
Acute Neisseria gonorrhoeae infection of the endometrium
Bacteremia with sepsis
Bacterial septicemia
E. coli pneumonia
E. coli UTI
Endometritis due to Bacteroides species
Endometritis due to E. coli
Endometritis due to Escherichia coli
Endometritis due to Fusobacterium species
Endometritis due to Peptococcus
Endometritis due to Peptostreptococcus
Endometritis due to Proteus species
Endometritis due to Staphylococcus species
Endometritis due to Streptococcus species
Gynecologic infection
H. flu pneumonia
H. influenzae pneumonia
Hemophilus influenzae pneumonia
Infection of skin and/or subcutaneous tissue
Influenza Bacillus pneumonia
Intra-abdominal infection
Joint infection due to Staphylococcus aureus
Joint infection due to Staphylococcus pyogenes aureus
Klebsiella UTI
Lower respiratory tract infection
Osteomyelitis due to Staphylococcus aureus
Osteomyelitis due to Staphylococcus pyogenes aureus
Pelvic inflammatory disease due to Bacteroides
Pelvic inflammatory disease due to E. coli
Pelvic inflammatory disease due to Escherichia coli
Pelvic inflammatory disease due to Fusobacterium species
Pelvic inflammatory disease due to Neisseria gonorrhea
Pelvic inflammatory disease due to Peptococcus
Pelvic inflammatory disease due to Peptostreptococcus
Pelvic inflammatory disease due to Proteus species
Pelvic inflammatory disease due to Streptococcus species
Pelvic inflammatory disease from Staphylococcus species
Perioperative infection prophylaxis
Peritonitis due to Bacteroides
Peritonitis due to Clostridium species
Peritonitis due to Escherichia coli
Peritonitis due to Klebsiella pneumoniae
Peritonitis due to Peptococcus
Peritonitis due to Streptococcus species
Pfeiffer's Bacillus pneumonia
PID due to Bacteroides
PID due to Escherichia coli
PID due to Fusobacterium species
PID due to Peptococcus
PID due to Peptostreptococcus
PID due to Proteus species
PID due to Staphylococcus species
PID due to Streptococcus species
Pneumonia due to E. coli
Pneumonia due to Escherichia coli
Pneumonia due to Haemophilus influenzae
Pneumonia due to Klebsiella species
Pneumonia due to Klebsiella spp.
Pneumonia due to Proteus species
Pneumonia due to Staphylococcus species
Pneumonia due to Staphylococcus spp.
Pneumonia due to Streptococcus species
Pneumonia due to Streptococcus spp.
Proteus spp. pneumonia
Pyogenic bone infection due to Staphylococcus aureus
Skin & skin soft tissue Streptococcus pyogenes infection
Skin and skin soft tissue Bacteroides fragilis infection
Skin and skin soft tissue Escherichia coli infection
Skin and skin soft tissue fusiformis infection
Skin and skin soft tissue Fusobacterium infection
Skin and skin soft tissue infection due to S. agalactiae
Skin and skin soft tissue Peptococcus infection
Skin and skin soft tissue Peptostreptococcus infection
Skin and skin soft tissue Proteus infection
Skin and skin soft tissue S. agalactiae infection
Skin and skin soft tissue Staphylococcus aureus infection
Skin and skin soft tissue Staphylococcus epidermidis infection
Skin and soft tissue skin infection
Staphylococcal endometritis
Staphylococcal pelvic inflammatory disease
Urinary tract infection due to Escherichia coli
Urinary tract infection due to Klebsiella species
Urinary tract infection due to Proteus species
UTI due to Proteus species

The following dosing information is available for CEFOTAN (cefotetan disodium):

Dosing
Administration
CEFOTAN
CEFOTETAN

When perioperative prophylaxis is indicated in patients undergoing surgery, administration of an appropriate anti-infective should be timed to ensure that bactericidal concentrations of the drug are established in serum and tissues by the time the initial surgical incision is made; therapeutic concentrations of the drug should then be maintained in serum and tissues for the duration of the procedure.

An IV dose of an appropriate anti-infective should be administered within 60 minutes before the initial incision. If cefotetan is used prophylactically, the manufacturers recommend that the drug be given 30-60 minutes before surgery.

A single preoperative dose usually is sufficient for perioperative prophylaxis. However, if surgery is prolonged (more than 3-4 hours), major blood loss occurs, or other factors are present that shorten the half-life of the drug (e.g., extensive burns), additional doses should be administered during the procedure to ensure adequate serum and tissue concentrations of the anti-infective throughout the procedure. For prolonged procedures in patients with normal renal function, some clinicians suggest that intraoperative doses be given during the procedure at intervals that correspond to 1-2 times the half-life of the drug (e.g., every 6 hours for cefotetan, measured from the time the preoperative dose is initiated).

Intraoperative doses may not be warranted if there are factors that prolong the half-life of the drug (e.g., renal impairment).

For most procedures, the duration of prophylaxis should be less than 24 hours. There is no evidence to support continuing prophylaxis after wound closure or until all indwelling drains and intravascular catheters are removed.

Dosage of cefotetan disodium is expressed in terms of cefotetan.

The usual adult dosage of cefotetan is 1 or 2 g IV or IM every 12 hours; however, the dosage and route of administration should be determined by the type and severity of infection, the susceptibility of the causative organism, and the condition and renal function of the patient. The maximum adult dosage of cefotetan recommended by the manufacturers is 6 g daily.

For treatment of infections at sites other than the urinary tract, skin, or skin structure, the usual adult dosage is 1 or 2 g IV or IM every 12 hours. However, severe infections in adults may require 2 g IV every 12 hours and life-threatening infections may require 3 g IV every 12 hours.

Although safety and efficacy of cefotetan in children have not been established, the American Academy of Pediatrics (AAP) suggests that children beyond the neonatal period+ may receive IM or IV cefotetan in a dosage of 60 mg/kg daily given in 2 divided doses for treatment of mild to moderate infections or a dosage of 100 mg/kg daily given in 2 divided doses for treatment of severe infections.

In patients with renal impairment, doses and/or frequency of administration of cefotetan should be modified in response to the degree of renal impairment, type and severity of the infection, and susceptibility of the causative organisms.

The manufacturers and some clinicians recommend that adults with impaired renal function receive the following dosage of cefotetan given at dosage intervals based on the patient's creatinine clearance. (See Table 1.)

Table 1. Dosage of Cefotetan for Adults with Renal Impairment

Creatinine Clearance (mL/minute) Dosage >30 Usual dose every 12 hours 10-30 Usual dose every 24 hours or 50% of usual dose every 12 hours <10 Usual dose every 48 hours or 25% of usual dose every 12 hours Hemodialysis patients 25% of usual dose every 24 hours on days between dialysis and 50% of usual dose on the day of dialysis

No enhanced Administration information available for this drug.

Dosing information for CEFOTAN
DRUG LABEL	DOSING TYPE	DOSING INSTRUCTIONS
CEFOTAN 1 GM VIAL	Maintenance	Adults infuse 500 mg by intravenous route every 12 hours
CEFOTAN 2 GM VIAL	Maintenance	Adults infuse 1 gram by intravenous route every 12 hours

Generic dosing information for CEFOTETAN
DRUG LABEL	DOSING TYPE	DOSING INSTRUCTIONS
CEFOTETAN 1 GM VIAL	Maintenance	Adults infuse 500 mg by intravenous route every 12 hours
CEFOTETAN 2 GM VIAL	Maintenance	Adults infuse 1 gram by intravenous route every 12 hours

The following drug interaction information is available for CEFOTAN (cefotetan disodium):

Contraindicated
Severe
Moderate

There are 1 contraindications. These drug combinations generally should not be dispensed or administered to the same patient. A manufacturer label warning that indicates the contraindication warrants inclusion of a drug combination in this category, regardless of clinical evidence or lack of clinical evidence to support the contraindication.

Drug Interaction	Drug Names
Live Typhoid Vaccine/Antimicrobials SEVERITY LEVEL: 1-Contraindicated Drug Combination: This drug combination is contraindicated and generally should not be dispensed or administered to the same patient. MECHANISM OF ACTION: The antimicrobial may be active against the organism in the live-vaccine. Antimicrobial therapy may prevent the vaccine organism from replicating enough to trigger an immune response.(1) CLINICAL EFFECTS: Vaccination may be ineffective. PREDISPOSING FACTORS: None determined. PATIENT MANAGEMENT: Do not give oral typhoid vaccine until 72 hours after the last dose of antimicrobial. If possible, to optimize vaccine effectiveness, do not start antibacterial drugs for 72 hours after the last dose of oral typhoid vaccine. A longer interval should be considered for long-acting antimicrobials, such as azithromycin.(3) DISCUSSION: Because antimicrobial therapy may prevent sufficient vaccine-organism replication to generate an immune response, the manufacturer of live-attenuated typhoid vaccine and the Centers for Disease Control (CDC) state that the vaccine should not be administered to patients receiving antimicrobial therapy.(1-3)	VIVOTIF

Drug Interaction

Drug Names

Live Typhoid Vaccine/Antimicrobials

SEVERITY LEVEL: 1-Contraindicated Drug Combination: This drug combination is contraindicated and generally should not be dispensed or administered to the same patient.

MECHANISM OF ACTION: The antimicrobial may be active against the organism in the live-vaccine. Antimicrobial therapy may prevent the vaccine organism from replicating enough to trigger an immune response.(1)

CLINICAL EFFECTS: Vaccination may be ineffective.

PREDISPOSING FACTORS: None determined.

PATIENT MANAGEMENT: Do not give oral typhoid vaccine until 72 hours after the last dose of antimicrobial. If possible, to optimize vaccine effectiveness, do not start antibacterial drugs for 72 hours after the last dose of oral typhoid vaccine. A longer interval should be considered for long-acting antimicrobials, such as azithromycin.(3)

DISCUSSION: Because antimicrobial therapy may prevent sufficient vaccine-organism replication to generate an immune response, the manufacturer of live-attenuated typhoid vaccine and the Centers for Disease Control (CDC) state that the vaccine should not be administered to patients receiving antimicrobial therapy.(1-3)

VIVOTIF

There are 3 severe interactions. These drug interactions can produce serious consequences in most patients. Actions required for severe interactions include, but are not limited to, discontinuing one or both agents, adjusting dosage, altering administration scheduling, and providing additional patient monitoring. Review the full interaction monograph for more information.

Drug Interaction	Drug Names
Selected Anticoagulants (Vitamin K antagonists)/Selected Cephalosporins SEVERITY LEVEL: 2-Severe Interaction: Action is required to reduce the risk of severe adverse interaction. MECHANISM OF ACTION: The exact mechanism is unknown, but may involve a combination of the cephalosporin's N-methylthiotetrazole (NMTT) side chain antagonizing vitamin K, cephalosporin induced platelet inhibition, and alteration of gut flora. CLINICAL EFFECTS: Concurrent use of some cephalosporins may increase the hypoprothrombinemic effect of the anticoagulant with possible bleeding. PREDISPOSING FACTORS: High doses, hepatic and/or renal impairment, and poor nutrition may increase the risk of bleeding. The risk for bleeding episodes may be greater in patients with disease-associated factors (e.g. thrombocytopenia). Drug associated risk factors include concurrent use of multiple drugs which inhibit anticoagulant/antiplatelet metabolism and/or have an inherent risk for bleeding (e.g. NSAIDs). PATIENT MANAGEMENT: Monitor prothrombin activity (INR) and adjust the anticoagulant dosage accordingly. Consider using an alternative antibiotic. If concurrent therapy is warranted, monitor patients receiving concurrent therapy for signs of blood loss, including decreased hemoglobin, hematocrit, fecal occult blood, and/or decreased blood pressure and promptly evaluate patients with any symptoms. Discontinue anticoagulation in patients with active pathologic bleeding. Instruct patients to report any signs and symptoms of bleeding, such as unusual bleeding from the gums or nose; unusual bruising; red or black, tarry stools; red, pink or dark brown urine; acute abdominal or joint pain and/or swelling. The time of highest risk for a coumarin-type drug interaction is when the precipitant drug is initiated or discontinued. Contact the prescriber before initiating, altering the dose or discontinuing either drug. DISCUSSION: Cephalosporins with a NMTT side chain have been reported to significantly prolong bleeding time and cause hypoprothrombinemia; therefore, the risk of serious bleeding may be increased in patients taking concurrent anticoagulants. A large systematic review was performed on 72 warfarin drug-drug interactions studies that reported on bleeding, thromboembolic events, or death. Most studies were retrospective cohorts. A meta-analysis of 11 of those studies found a higher rate of clinically significant bleeding in patients on warfarin and antimicrobials (OR=1.63; 95% CI 1.45-1.83). Increased bleeding risk was also seen in subgroup analyses with cephalosporins (OR=1.50; 95% CI 1.21-1.86).	ANISINDIONE, DICUMAROL, JANTOVEN, PHENINDIONE, WARFARIN SODIUM
Ethyl Alcohol/Selected Cephalosporins SEVERITY LEVEL: 2-Severe Interaction: Action is required to reduce the risk of severe adverse interaction. MECHANISM OF ACTION: Certain cephalosporins have a methyltetrazolethiol side chain that resembles part of the disulfiram molecule. It has been suggested that the cephalosporins with this side chain interfere with the activity of the alcohol-metabolizing enzyme, aldehyde dehydrogenase, resulting in elevated concentrations of acetaldehyde and a "disulfiram-like" reaction.(1) CLINICAL EFFECTS: A disulfiram-like reaction may occur in patients who ingest alcohol during and after taking some cephalosporins. Symptoms include throbbing in the head and neck, palpitations, tachycardia, hypotension, sweating, nausea, and vomiting. PREDISPOSING FACTORS: None determined. PATIENT MANAGEMENT: Patients receiving cephalosporins with a methyltetrazolethiol side chain should be cautioned about consuming alcohol during and for several days after therapy. Patients should be informed about unsuspected sources of alcohol such as elixirs and topical preparations. Alcohol is used to improve docetaxel and paclitaxel solubility. - The quantity of alcohol in paclitaxel injection formulations (0.385-0.396 grams/mL) is similar across manufacturers. A paclitaxel 200 mg dose contains approximately 13 grams of alcohol. - The quantity of alcohol in docetaxel formulations varies approximately 3-fold depending upon the manufacturer. FDA data on alcohol content (17) : Product Manufacturer Alcohol/200 mg dose Docetaxel Inj. Pfizer 6.4 grams Docetaxel Inj. Sandoz 5.5 grams Docetaxel Inj. Accord 4.0 grams Taxotere-one vial Sanofi 4.0 grams formulation Docetaxel Inj. Hospira 3.7 grams Docefrez Sun Pharma 2.9 grams Taxotere-two vial Sanofi 2.0 grams formulation DISCUSSION: A disulfiram-like reaction has been reported following the ingestion of alcohol by patients receiving cefamandole,(2-4) cefoperazone, (5-7) cefotetan,(8) and moxalactam.(9-11) The reaction has been reported in patients who had been receiving the antibiotic periodically or continuously before alcohol consumption. The reaction occurred within 30 minutes of alcohol consumption.(5-7) In one patient, the reaction occurred after an injection of 15 ml of a 67% alcohol into the paraaortic space for celiac plexus alcohol block.(11) Cefonicid and ceforanide have exhibited these effects in animal studies. (12) However, another study showed that cefonicid did not interact with alcohol.(13) No interaction was found with cefazolin, cefotaxime, cefoxitin, cephalothin, or cephradine in animal studies.(14-15) A study in humans found no interaction with ceftizoxime.(1) These cephalosporins do not have a methyltetrazolethiol side chain. A single case reported a disulfiram-like reaction in a patient taking cefonicid therapy on two separate occasions.(16)	ABLYSINOL, ALCOHOL,DEHYDRATED, DILUENT FOR BICNU, DILUENT FOR CARMUSTINE, DILUENT FOR ISTODAX, DILUENT FOR IXEMPRA, DILUENT FOR JEVTANA, DILUENT FOR MELPHALAN, DILUENT FOR ROMIDEPSIN, DILUENT FOR TEMSIROLIMUS, ERY, ERYGEL, ERYTHROMYCIN, GENADUR
Fecal Microbiota Spores/Antibiotics SEVERITY LEVEL: 2-Severe Interaction: Action is required to reduce the risk of severe adverse interaction. MECHANISM OF ACTION: Fecal microbiota spores is a suspension of live bacterial spores, which may be compromised by concurrent use of antibiotics.(1) CLINICAL EFFECTS: Antibiotics may decrease the effectiveness of fecal microbiota spores.(1) PREDISPOSING FACTORS: None determined. PATIENT MANAGEMENT: Antibiotics should not be used concurrently with fecal microbiota spores. Antibacterial treatment should be completed for 2 to 4 days before initiating treatment with fecal microbiota spores.(1) DISCUSSION: Antibiotics may compromise the effectiveness of fecal microbiota spores.	VOWST

There are 1 moderate interactions. The clinician should assess the patient’s characteristics and take action as needed. Actions required for moderate interactions include, but are not limited to, discontinuing one or both agents, adjusting dosage, altering administration.

Drug Interaction	Drug Names
Selected Cephalosporins & Penicillins/Probenecid SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed. MECHANISM OF ACTION: Probenecid impairs the clearance of some cephalosporins and penicillins via inhibition of renal anion transporters in the proximal tubule.(49) It has also been hypothesized that probenecid may affect tissue distribution of cephalosporins.(1-5) CLINICAL EFFECTS: The concurrent administration of probenecid may result in increased maximum concentration (Cmax), area-under-curve (AUC), and half-life of the cephalosporin or penicillin.(49) While this may improve antibiotic efficacy,(46-48) increased levels may also increase the risk for antibiotic-associated nephrotoxicity.(4) PREDISPOSING FACTORS: Underlying renal dysfunction may increase the risk for nephrotoxicity. PATIENT MANAGEMENT: In patients receiving the combination to improve antibiotic efficacy, monitor for antibiotic adverse effects and consider monitoring renal function. In patients receiving probenecid therapy to prevent or treat hyperuricemia, exposure to the antibiotic will be increased. A decrease in antibiotic dose or frequency may be required. The US manufacturer of piperacillin-tazobactam states probenecid should not be coadministered with piperacillin-tazobactam unless the benefit outweighs the risk.(50) DISCUSSION: Concurrent use of probenecid with a cephalosporin or penicillin may cause an increase in the Cmax, AUC, and an increased elimination half life of the antibiotic.(6-8,49) This may be beneficial or necessary in difficult to treat infections,(46-48) but an increased risk for adverse effects should be expected. Antibiotics not dose adjusted for concurrent use with probenecid may be associated with an increased risk for adverse effects, such as nephrotoxicity. Probenecid administered concurrently with piperacillin-tazobactam prolongs the half-life of piperacillin by 21% and tazobactam by 71%. In a study in 8 healthy males, concurrent administration of probenecid (1 g) with piperacillin (1 g IM) increased piperacillin's Cmax and AUC by 30% and 60%. Renal clearance was reduced by 40%.(51) The cephalosporins affected by probenecid include cefazolin,(9-11) cephacetrile,(12,13) cephaloglycin,(14,15) cephalexin,(16-21) cephradine, (22-23) cefoxitin,(24-28) cefadroxil(29), cefaclor,(23) cefamandole,(30) ceftizoxime,(31,32) cefuroxime,(33,34) cefprozil,(35) cefonicid,(36) cefmetazole,(37) cefmenoxime,(38) and cefditoren.(39) Probenecid has been shown not to affect moxalactam,(4,40,41) ceforanide, (4,42), cefoperazone, ceftazidime(4,34,43) or ceftriaxone.(4)	PROBENECID, PROBENECID-COLCHICINE

Drug Interaction

Drug Names

Selected Cephalosporins & Penicillins/Probenecid

SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed.

MECHANISM OF ACTION: Probenecid impairs the clearance of some cephalosporins and penicillins via inhibition of renal anion transporters in the proximal tubule.(49) It has also been hypothesized that probenecid may affect tissue distribution of cephalosporins.(1-5)

CLINICAL EFFECTS: The concurrent administration of probenecid may result in increased maximum concentration (Cmax), area-under-curve (AUC), and half-life of the cephalosporin or penicillin.(49) While this may improve antibiotic efficacy,(46-48) increased levels may also increase the risk for antibiotic-associated nephrotoxicity.(4)

PREDISPOSING FACTORS: Underlying renal dysfunction may increase the risk for nephrotoxicity.

PATIENT MANAGEMENT: In patients receiving the combination to improve antibiotic efficacy, monitor for antibiotic adverse effects and consider monitoring renal function. In patients receiving probenecid therapy to prevent or treat hyperuricemia, exposure to the antibiotic will be increased. A decrease in antibiotic dose or frequency may be required. The US manufacturer of piperacillin-tazobactam states probenecid should not be coadministered with piperacillin-tazobactam unless the benefit outweighs the risk.(50)

DISCUSSION: Concurrent use of probenecid with a cephalosporin or penicillin may cause an increase in the Cmax, AUC, and an increased elimination half life of the antibiotic.(6-8,49) This may be beneficial or necessary in difficult to treat infections,(46-48) but an increased risk for adverse effects should be expected. Antibiotics not dose adjusted for concurrent use with probenecid may be associated with an increased risk for adverse effects, such as nephrotoxicity.

Probenecid administered concurrently with piperacillin-tazobactam prolongs the half-life of piperacillin by 21% and tazobactam by 71%. In a study in 8 healthy males, concurrent administration of probenecid (1 g) with piperacillin (1 g IM) increased piperacillin's Cmax and AUC by 30% and 60%. Renal clearance was reduced by 40%.(51)

The cephalosporins affected by probenecid include cefazolin,(9-11) cephacetrile,(12,13) cephaloglycin,(14,15) cephalexin,(16-21) cephradine, (22-23) cefoxitin,(24-28) cefadroxil(29), cefaclor,(23) cefamandole,(30) ceftizoxime,(31,32) cefuroxime,(33,34) cefprozil,(35) cefonicid,(36) cefmetazole,(37) cefmenoxime,(38) and cefditoren.(39) Probenecid has been shown not to affect moxalactam,(4,40,41) ceforanide, (4,42), cefoperazone, ceftazidime(4,34,43) or ceftriaxone.(4)

PROBENECID, PROBENECID-COLCHICINE

The following contraindication information is available for CEFOTAN (cefotetan disodium):

Overview
Contraindicated
Severe
Moderate

Drug contraindication overview.

No enhanced Contraindications information available for this drug.

There are 0 contraindications.

There are 2 severe contraindications. Adequate patient monitoring is recommended for safer drug use.

Severe List
Clostridioides difficile infection
Hemolytic anemia

There are 4 moderate contraindications. Clinically significant contraindication, where the condition can be managed or treated before the drug may be given safely.

Moderate List
Disease of liver
Hypoprothrombinemia
Kidney disease with reduction in glomerular filtration rate (GFr)
Vitamin K deficiency

The following adverse reaction information is available for CEFOTAN (cefotetan disodium):

Overview
Severe
Less Severe

Adverse reaction overview.

No enhanced Common Adverse Effects information available for this drug.

There are 17 severe adverse reactions.

More Frequent	Less Frequent
Hypoprothrombinemia	Abnormal hepatic function tests Hypersensitivity drug reaction

Rare/Very Rare
Agranulocytosis Anaphylaxis Angioedema Autoimmune hemolytic anemia Clostridioides difficile infection Eosinophilia Erythema multiforme Leukopenia Nephrotoxicity Seizure disorder Serum sickness Stevens-johnson syndrome Thrombocytopenic disorder Thrombocytosis

There are 13 less severe adverse reactions.

More Frequent	Less Frequent
Vulvovaginal candidiasis	Abdominal pain with cramps Diarrhea Nausea Oral candidiasis Vomiting

Rare/Very Rare
Drug fever Erythema Injection site sequelae Phlebitis after infusion Pruritus of skin Skin rash Urticaria

The following precautions are available for CEFOTAN (cefotetan disodium):

Pediatric
Pregnant
Lactation
Geriatric

No enhanced Pediatric Use information available for this drug.

Contraindicated

None

Severe Precaution

None

Management or Monitoring Precaution

None

No enhanced Pregnancy information available for this drug.

No enhanced Lactation information available for this drug.

No enhanced Geriatric Use information available for this drug.

The following icd codes are available for CEFOTAN (cefotetan disodium)'s list of indications:

Acute gonococcal endometritis
A54.24	Gonococcal female pelvic inflammatory disease
Bacterial pneumonia
J15.9	Unspecified bacterial pneumonia
Bacterial sepsis
A02.1	Salmonella sepsis
A20.7	Septicemic plague
A22.7	Anthrax sepsis
A26.7	Erysipelothrix sepsis
A32.7	Listerial sepsis
A40	Streptococcal sepsis
A40.0	Sepsis due to streptococcus, group A
A40.1	Sepsis due to streptococcus, group B
A40.3	Sepsis due to streptococcus pneumoniae
A40.8	Other streptococcal sepsis
A40.9	Streptococcal sepsis, unspecified
A41	Other sepsis
A41.0	Sepsis due to staphylococcus aureus
A41.01	Sepsis due to methicillin susceptible staphylococcus aureus
A41.02	Sepsis due to methicillin resistant staphylococcus aureus
A41.1	Sepsis due to other specified staphylococcus
A41.2	Sepsis due to unspecified staphylococcus
A41.3	Sepsis due to hemophilus influenzae
A41.4	Sepsis due to anaerobes
A41.5	Sepsis due to other gram-negative organisms
A41.50	Gram-negative sepsis, unspecified
A41.51	Sepsis due to escherichia coli [e. coli]
A41.52	Sepsis due to pseudomonas
A41.53	Sepsis due to serratia
A41.54	Sepsis due to acinetobacter baumannii
A41.59	Other gram-negative sepsis
A41.8	Other specified sepsis
A41.81	Sepsis due to enterococcus
A41.89	Other specified sepsis
A41.9	Sepsis, unspecified organism
A42.7	Actinomycotic sepsis
A54.86	Gonococcal sepsis
O03.37	Sepsis following incomplete spontaneous abortion
O08.82	Sepsis following ectopic and molar pregnancy
O85	Puerperal sepsis
O86.04	Sepsis following an obstetrical procedure
P36	Bacterial sepsis of newborn
P36.0	Sepsis of newborn due to streptococcus, group B
P36.1	Sepsis of newborn due to other and unspecified streptococci
P36.10	Sepsis of newborn due to unspecified streptococci
P36.19	Sepsis of newborn due to other streptococci
P36.2	Sepsis of newborn due to staphylococcus aureus
P36.3	Sepsis of newborn due to other and unspecified staphylococci
P36.30	Sepsis of newborn due to unspecified staphylococci
P36.39	Sepsis of newborn due to other staphylococci
P36.4	Sepsis of newborn due to escherichia coli
P36.5	Sepsis of newborn due to anaerobes
P36.8	Other bacterial sepsis of newborn
P36.9	Bacterial sepsis of newborn, unspecified
R65.2	Severe sepsis
T81.12	Postprocedural septic shock
T81.12xA	Postprocedural septic shock, initial encounter
T81.44	Sepsis following a procedure
T81.44xA	Sepsis following a procedure, initial encounter
Bacterial urinary tract infection
N30.0	Acute cystitis
N30.00	Acute cystitis without hematuria
N30.01	Acute cystitis with hematuria
N30.9	Cystitis, unspecified
N30.90	Cystitis, unspecified without hematuria
N30.91	Cystitis, unspecified with hematuria
N39.0	Urinary tract infection, site not specified
O23.0	Infections of kidney in pregnancy
O23.00	Infections of kidney in pregnancy, unspecified trimester
O23.01	Infections of kidney in pregnancy, first trimester
O23.02	Infections of kidney in pregnancy, second trimester
O23.03	Infections of kidney in pregnancy, third trimester
O23.1	Infections of bladder in pregnancy
O23.10	Infections of bladder in pregnancy, unspecified trimester
O23.11	Infections of bladder in pregnancy, first trimester
O23.12	Infections of bladder in pregnancy, second trimester
O23.13	Infections of bladder in pregnancy, third trimester
O23.2	Infections of urethra in pregnancy
O23.20	Infections of urethra in pregnancy, unspecified trimester
O23.21	Infections of urethra in pregnancy, first trimester
O23.22	Infections of urethra in pregnancy, second trimester
O23.23	Infections of urethra in pregnancy, third trimester
O23.3	Infections of other parts of urinary tract in pregnancy
O23.30	Infections of other parts of urinary tract in pregnancy, unspecified trimester
O23.31	Infections of other parts of urinary tract in pregnancy, first trimester
O23.32	Infections of other parts of urinary tract in pregnancy, second trimester
O23.33	Infections of other parts of urinary tract in pregnancy, third trimester
O23.4	Unspecified infection of urinary tract in pregnancy
O23.40	Unspecified infection of urinary tract in pregnancy, unspecified trimester
O23.41	Unspecified infection of urinary tract in pregnancy, first trimester
O23.42	Unspecified infection of urinary tract in pregnancy, second trimester
O23.43	Unspecified infection of urinary tract in pregnancy, third trimester
O23.90	Unspecified genitourinary tract infection in pregnancy, unspecified trimester
O23.91	Unspecified genitourinary tract infection in pregnancy, first trimester
O23.92	Unspecified genitourinary tract infection in pregnancy, second trimester
O23.93	Unspecified genitourinary tract infection in pregnancy, third trimester
P39.3	Neonatal urinary tract infection
T83	Complications of genitourinary prosthetic devices, implants and grafts
T83.5	Infection and inflammatory reaction due to prosthetic device, implant and graft in urinary system
T83.51	Infection and inflammatory reaction due to urinary catheter
T83.59	Infection and inflammatory reaction due to prosthetic device, implant and graft in urinary system
T83.6	Infection and inflammatory reaction due to prosthetic device, implant and graft in genital tract
Bacteroides endometritis
B96.6	Bacteroides fragilis [b. fragilis] as the cause of diseases classified elsewhere
N71	Inflammatory disease of uterus, except cervix
N71.0	Acute inflammatory disease of uterus
N71.1	Chronic inflammatory disease of uterus
N71.9	Inflammatory disease of uterus, unspecified
O86.12	Endometritis following delivery
Bacteroides pelvic inflammatory disease
B96.6	Bacteroides fragilis [b. fragilis] as the cause of diseases classified elsewhere
N70	Salpingitis and oophoritis
N70.0	Acute salpingitis and oophoritis
N70.01	Acute salpingitis
N70.02	Acute oophoritis
N70.03	Acute salpingitis and oophoritis
N70.1	Chronic salpingitis and oophoritis
N70.11	Chronic salpingitis
N70.12	Chronic oophoritis
N70.13	Chronic salpingitis and oophoritis
N70.9	Salpingitis and oophoritis, unspecified
N70.91	Salpingitis, unspecified
N70.92	Oophoritis, unspecified
N70.93	Salpingitis and oophoritis, unspecified
N71	Inflammatory disease of uterus, except cervix
N71.0	Acute inflammatory disease of uterus
N71.1	Chronic inflammatory disease of uterus
N71.9	Inflammatory disease of uterus, unspecified
N72	Inflammatory disease of cervix uteri
N73	Other female pelvic inflammatory diseases
N73.0	Acute parametritis and pelvic cellulitis
N73.1	Chronic parametritis and pelvic cellulitis
N73.2	Unspecified parametritis and pelvic cellulitis
N73.3	Female acute pelvic peritonitis
N73.4	Female chronic pelvic peritonitis
N73.5	Female pelvic peritonitis, unspecified
N73.8	Other specified female pelvic inflammatory diseases
N73.9	Female pelvic inflammatory disease, unspecified
Bacteroides peritonitis
B96.6	Bacteroides fragilis [b. fragilis] as the cause of diseases classified elsewhere
K65.0	Generalized (acute) peritonitis
K65.2	Spontaneous bacterial peritonitis
T85.71	Infection and inflammatory reaction due to peritoneal dialysis catheter
T85.71xA	Infection and inflammatory reaction due to peritoneal dialysis catheter, initial encounter
Clostridium peritonitis
B96.7	Clostridium perfringens [c. perfringens] as the cause of diseases classified elsewhere
K65.0	Generalized (acute) peritonitis
K65.2	Spontaneous bacterial peritonitis
T85.71	Infection and inflammatory reaction due to peritoneal dialysis catheter
T85.71xA	Infection and inflammatory reaction due to peritoneal dialysis catheter, initial encounter
E. coli endometritis
B96.2	Escherichia coli [e. coli ] as the cause of diseases classified elsewhere
B96.20	Unspecified escherichia coli [e. coli] as the cause of diseases classified elsewhere
B96.29	Other escherichia coli [e. coli] as the cause of diseases classified elsewhere
N71	Inflammatory disease of uterus, except cervix
N71.0	Acute inflammatory disease of uterus
N71.1	Chronic inflammatory disease of uterus
N71.9	Inflammatory disease of uterus, unspecified
O86.12	Endometritis following delivery
E. coli pelvic inflammatory disease
B96.2	Escherichia coli [e. coli ] as the cause of diseases classified elsewhere
B96.20	Unspecified escherichia coli [e. coli] as the cause of diseases classified elsewhere
B96.29	Other escherichia coli [e. coli] as the cause of diseases classified elsewhere
N70	Salpingitis and oophoritis
N70.0	Acute salpingitis and oophoritis
N70.01	Acute salpingitis
N70.02	Acute oophoritis
N70.03	Acute salpingitis and oophoritis
N70.1	Chronic salpingitis and oophoritis
N70.11	Chronic salpingitis
N70.12	Chronic oophoritis
N70.13	Chronic salpingitis and oophoritis
N70.9	Salpingitis and oophoritis, unspecified
N70.91	Salpingitis, unspecified
N70.92	Oophoritis, unspecified
N70.93	Salpingitis and oophoritis, unspecified
N71	Inflammatory disease of uterus, except cervix
N71.0	Acute inflammatory disease of uterus
N71.1	Chronic inflammatory disease of uterus
N71.9	Inflammatory disease of uterus, unspecified
N72	Inflammatory disease of cervix uteri
N73	Other female pelvic inflammatory diseases
N73.0	Acute parametritis and pelvic cellulitis
N73.1	Chronic parametritis and pelvic cellulitis
N73.2	Unspecified parametritis and pelvic cellulitis
N73.3	Female acute pelvic peritonitis
N73.4	Female chronic pelvic peritonitis
N73.5	Female pelvic peritonitis, unspecified
N73.8	Other specified female pelvic inflammatory diseases
N73.9	Female pelvic inflammatory disease, unspecified
E. coli peritonitis
B96.2	Escherichia coli [e. coli ] as the cause of diseases classified elsewhere
B96.20	Unspecified escherichia coli [e. coli] as the cause of diseases classified elsewhere
B96.29	Other escherichia coli [e. coli] as the cause of diseases classified elsewhere
K65.0	Generalized (acute) peritonitis
K65.2	Spontaneous bacterial peritonitis
T85.71	Infection and inflammatory reaction due to peritoneal dialysis catheter
T85.71xA	Infection and inflammatory reaction due to peritoneal dialysis catheter, initial encounter
E. coli urinary tract infection
B96.2	Escherichia coli [e. coli ] as the cause of diseases classified elsewhere
B96.20	Unspecified escherichia coli [e. coli] as the cause of diseases classified elsewhere
B96.29	Other escherichia coli [e. coli] as the cause of diseases classified elsewhere
N30.0	Acute cystitis
N30.00	Acute cystitis without hematuria
N30.01	Acute cystitis with hematuria
N30.9	Cystitis, unspecified
N30.90	Cystitis, unspecified without hematuria
N30.91	Cystitis, unspecified with hematuria
N39.0	Urinary tract infection, site not specified
O23.0	Infections of kidney in pregnancy
O23.00	Infections of kidney in pregnancy, unspecified trimester
O23.01	Infections of kidney in pregnancy, first trimester
O23.02	Infections of kidney in pregnancy, second trimester
O23.03	Infections of kidney in pregnancy, third trimester
O23.1	Infections of bladder in pregnancy
O23.10	Infections of bladder in pregnancy, unspecified trimester
O23.11	Infections of bladder in pregnancy, first trimester
O23.12	Infections of bladder in pregnancy, second trimester
O23.13	Infections of bladder in pregnancy, third trimester
O23.2	Infections of urethra in pregnancy
O23.20	Infections of urethra in pregnancy, unspecified trimester
O23.21	Infections of urethra in pregnancy, first trimester
O23.22	Infections of urethra in pregnancy, second trimester
O23.23	Infections of urethra in pregnancy, third trimester
O23.3	Infections of other parts of urinary tract in pregnancy
O23.30	Infections of other parts of urinary tract in pregnancy, unspecified trimester
O23.31	Infections of other parts of urinary tract in pregnancy, first trimester
O23.32	Infections of other parts of urinary tract in pregnancy, second trimester
O23.33	Infections of other parts of urinary tract in pregnancy, third trimester
O23.4	Unspecified infection of urinary tract in pregnancy
O23.40	Unspecified infection of urinary tract in pregnancy, unspecified trimester
O23.41	Unspecified infection of urinary tract in pregnancy, first trimester
O23.42	Unspecified infection of urinary tract in pregnancy, second trimester
O23.43	Unspecified infection of urinary tract in pregnancy, third trimester
O23.9	Unspecified genitourinary tract infection in pregnancy
O23.90	Unspecified genitourinary tract infection in pregnancy, unspecified trimester
O23.91	Unspecified genitourinary tract infection in pregnancy, first trimester
O23.92	Unspecified genitourinary tract infection in pregnancy, second trimester
O23.93	Unspecified genitourinary tract infection in pregnancy, third trimester
Endometritis
N71	Inflammatory disease of uterus, except cervix
N71.0	Acute inflammatory disease of uterus
N71.1	Chronic inflammatory disease of uterus
N71.9	Inflammatory disease of uterus, unspecified
O86.12	Endometritis following delivery
Escherichia coli pneumonia
J15.5	Pneumonia due to escherichia coli
Female genital tract infection
N70	Salpingitis and oophoritis
N70.0	Acute salpingitis and oophoritis
N70.01	Acute salpingitis
N70.02	Acute oophoritis
N70.03	Acute salpingitis and oophoritis
N70.1	Chronic salpingitis and oophoritis
N70.11	Chronic salpingitis
N70.12	Chronic oophoritis
N70.13	Chronic salpingitis and oophoritis
N70.9	Salpingitis and oophoritis, unspecified
N70.91	Salpingitis, unspecified
N70.92	Oophoritis, unspecified
N70.93	Salpingitis and oophoritis, unspecified
N71	Inflammatory disease of uterus, except cervix
N71.0	Acute inflammatory disease of uterus
N71.1	Chronic inflammatory disease of uterus
N71.9	Inflammatory disease of uterus, unspecified
N72	Inflammatory disease of cervix uteri
N73.8	Other specified female pelvic inflammatory diseases
N73.9	Female pelvic inflammatory disease, unspecified
N74	Female pelvic inflammatory disorders in diseases classified elsewhere
N75.0	Cyst of bartholin's gland
N75.1	Abscess of bartholin's gland
N76	Other inflammation of vagina and vulva
N76.0	Acute vaginitis
N76.1	Subacute and chronic vaginitis
N76.2	Acute vulvitis
N76.3	Subacute and chronic vulvitis
N76.4	Abscess of vulva
N76.5	Ulceration of vagina
N76.6	Ulceration of vulva
N76.8	Other specified inflammation of vagina and vulva
N76.81	Mucositis (ulcerative) of vagina and vulva
N76.89	Other specified inflammation of vagina and vulva
Fusobacterium endometritis
B96.89	Other specified bacterial agents as the cause of diseases classified elsewhere
N71	Inflammatory disease of uterus, except cervix
N71.0	Acute inflammatory disease of uterus
N71.1	Chronic inflammatory disease of uterus
N71.9	Inflammatory disease of uterus, unspecified
O86.12	Endometritis following delivery
Fusobacterium pelvic inflammatory disease
B96.89	Other specified bacterial agents as the cause of diseases classified elsewhere
N70	Salpingitis and oophoritis
N70.0	Acute salpingitis and oophoritis
N70.01	Acute salpingitis
N70.02	Acute oophoritis
N70.03	Acute salpingitis and oophoritis
N70.1	Chronic salpingitis and oophoritis
N70.11	Chronic salpingitis
N70.12	Chronic oophoritis
N70.13	Chronic salpingitis and oophoritis
N70.9	Salpingitis and oophoritis, unspecified
N70.91	Salpingitis, unspecified
N70.92	Oophoritis, unspecified
N70.93	Salpingitis and oophoritis, unspecified
N71	Inflammatory disease of uterus, except cervix
N71.0	Acute inflammatory disease of uterus
N71.1	Chronic inflammatory disease of uterus
N71.9	Inflammatory disease of uterus, unspecified
N72	Inflammatory disease of cervix uteri
N73	Other female pelvic inflammatory diseases
N73.0	Acute parametritis and pelvic cellulitis
N73.1	Chronic parametritis and pelvic cellulitis
N73.2	Unspecified parametritis and pelvic cellulitis
N73.3	Female acute pelvic peritonitis
N73.4	Female chronic pelvic peritonitis
N73.5	Female pelvic peritonitis, unspecified
N73.8	Other specified female pelvic inflammatory diseases
N73.9	Female pelvic inflammatory disease, unspecified
Haemophilus influenzae pneumonia
J14	Pneumonia due to hemophilus influenzae
Infectious disease of abdomen
A51.1	Primary anal syphilis
K35	Acute appendicitis
K35.2	Acute appendicitis with generalized peritonitis
K35.20	Acute appendicitis with generalized peritonitis, without abscess
K35.200	Acute appendicitis with generalized peritonitis, without perforation or abscess
K35.201	Acute appendicitis with generalized peritonitis, with perforation, without abscess
K35.209	Acute appendicitis with generalized peritonitis, without abscess, unspecified as to perforation
K35.21	Acute appendicitis with generalized peritonitis, with abscess
K35.210	Acute appendicitis with generalized peritonitis, without perforation, with abscess
K35.211	Acute appendicitis with generalized peritonitis, with perforation and abscess
K35.219	Acute appendicitis with generalized peritonitis, with abscess, unspecified as to perforation
K35.3	Acute appendicitis with localized peritonitis
K35.30	Acute appendicitis with localized peritonitis, without perforation or gangrene
K35.31	Acute appendicitis with localized peritonitis and gangrene, without perforation
K35.32	Acute appendicitis with perforation, localized peritonitis, and gangrene, without abscess
K35.33	Acute appendicitis with perforation, localized peritonitis, and gangrene, with abscess
K35.8	Other and unspecified acute appendicitis
K35.80	Unspecified acute appendicitis
K35.89	Other acute appendicitis
K35.890	Other acute appendicitis without perforation or gangrene
K35.891	Other acute appendicitis without perforation, with gangrene
K65.0	Generalized (acute) peritonitis
K65.2	Spontaneous bacterial peritonitis
Inflammatory disease of female pelvic organs
N70	Salpingitis and oophoritis
N70.0	Acute salpingitis and oophoritis
N70.01	Acute salpingitis
N70.02	Acute oophoritis
N70.03	Acute salpingitis and oophoritis
N70.1	Chronic salpingitis and oophoritis
N70.11	Chronic salpingitis
N70.12	Chronic oophoritis
N70.13	Chronic salpingitis and oophoritis
N70.9	Salpingitis and oophoritis, unspecified
N70.91	Salpingitis, unspecified
N70.92	Oophoritis, unspecified
N70.93	Salpingitis and oophoritis, unspecified
N71	Inflammatory disease of uterus, except cervix
N71.0	Acute inflammatory disease of uterus
N71.1	Chronic inflammatory disease of uterus
N71.9	Inflammatory disease of uterus, unspecified
N72	Inflammatory disease of cervix uteri
N73	Other female pelvic inflammatory diseases
N73.0	Acute parametritis and pelvic cellulitis
N73.1	Chronic parametritis and pelvic cellulitis
N73.2	Unspecified parametritis and pelvic cellulitis
N73.3	Female acute pelvic peritonitis
N73.4	Female chronic pelvic peritonitis
N73.5	Female pelvic peritonitis, unspecified
N73.8	Other specified female pelvic inflammatory diseases
N73.9	Female pelvic inflammatory disease, unspecified
Klebsiella pneumonia
J15.0	Pneumonia due to klebsiella pneumoniae
Klebsiella pneumoniae peritonitis
B96.1	Klebsiella pneumoniae [k. pneumoniae] as the cause of diseases classified elsewhere
K65.0	Generalized (acute) peritonitis
K65.2	Spontaneous bacterial peritonitis
T85.71	Infection and inflammatory reaction due to peritoneal dialysis catheter
T85.71xA	Infection and inflammatory reaction due to peritoneal dialysis catheter, initial encounter
Klebsiella urinary tract infection
B96.1	Klebsiella pneumoniae [k. pneumoniae] as the cause of diseases classified elsewhere
N30.0	Acute cystitis
N30.00	Acute cystitis without hematuria
N30.01	Acute cystitis with hematuria
N30.9	Cystitis, unspecified
N30.90	Cystitis, unspecified without hematuria
N30.91	Cystitis, unspecified with hematuria
N39.0	Urinary tract infection, site not specified
O23.0	Infections of kidney in pregnancy
O23.00	Infections of kidney in pregnancy, unspecified trimester
O23.01	Infections of kidney in pregnancy, first trimester
O23.02	Infections of kidney in pregnancy, second trimester
O23.03	Infections of kidney in pregnancy, third trimester
O23.1	Infections of bladder in pregnancy
O23.10	Infections of bladder in pregnancy, unspecified trimester
O23.11	Infections of bladder in pregnancy, first trimester
O23.12	Infections of bladder in pregnancy, second trimester
O23.13	Infections of bladder in pregnancy, third trimester
O23.2	Infections of urethra in pregnancy
O23.20	Infections of urethra in pregnancy, unspecified trimester
O23.21	Infections of urethra in pregnancy, first trimester
O23.22	Infections of urethra in pregnancy, second trimester
O23.23	Infections of urethra in pregnancy, third trimester
O23.3	Infections of other parts of urinary tract in pregnancy
O23.30	Infections of other parts of urinary tract in pregnancy, unspecified trimester
O23.31	Infections of other parts of urinary tract in pregnancy, first trimester
O23.32	Infections of other parts of urinary tract in pregnancy, second trimester
O23.33	Infections of other parts of urinary tract in pregnancy, third trimester
O23.4	Unspecified infection of urinary tract in pregnancy
O23.40	Unspecified infection of urinary tract in pregnancy, unspecified trimester
O23.41	Unspecified infection of urinary tract in pregnancy, first trimester
O23.42	Unspecified infection of urinary tract in pregnancy, second trimester
O23.43	Unspecified infection of urinary tract in pregnancy, third trimester
O23.9	Unspecified genitourinary tract infection in pregnancy
O23.90	Unspecified genitourinary tract infection in pregnancy, unspecified trimester
O23.91	Unspecified genitourinary tract infection in pregnancy, first trimester
O23.92	Unspecified genitourinary tract infection in pregnancy, second trimester
O23.93	Unspecified genitourinary tract infection in pregnancy, third trimester
Lower respiratory infection
J15.9	Unspecified bacterial pneumonia
J18.9	Pneumonia, unspecified organism
J22	Unspecified acute lower respiratory infection
Pelvic inflammatory disease with neisseria gonorrhea
A54.24	Gonococcal female pelvic inflammatory disease
Peptococcus endometritis
B96.89	Other specified bacterial agents as the cause of diseases classified elsewhere
N71	Inflammatory disease of uterus, except cervix
N71.0	Acute inflammatory disease of uterus
N71.1	Chronic inflammatory disease of uterus
N71.9	Inflammatory disease of uterus, unspecified
O86.12	Endometritis following delivery
Peptococcus pelvic inflammatory disease
B96.89	Other specified bacterial agents as the cause of diseases classified elsewhere
N70	Salpingitis and oophoritis
N70.0	Acute salpingitis and oophoritis
N70.01	Acute salpingitis
N70.02	Acute oophoritis
N70.03	Acute salpingitis and oophoritis
N70.1	Chronic salpingitis and oophoritis
N70.11	Chronic salpingitis
N70.12	Chronic oophoritis
N70.13	Chronic salpingitis and oophoritis
N70.9	Salpingitis and oophoritis, unspecified
N70.91	Salpingitis, unspecified
N70.92	Oophoritis, unspecified
N70.93	Salpingitis and oophoritis, unspecified
N71	Inflammatory disease of uterus, except cervix
N71.0	Acute inflammatory disease of uterus
N71.1	Chronic inflammatory disease of uterus
N71.9	Inflammatory disease of uterus, unspecified
N72	Inflammatory disease of cervix uteri
N73	Other female pelvic inflammatory diseases
N73.0	Acute parametritis and pelvic cellulitis
N73.1	Chronic parametritis and pelvic cellulitis
N73.2	Unspecified parametritis and pelvic cellulitis
N73.3	Female acute pelvic peritonitis
N73.4	Female chronic pelvic peritonitis
N73.5	Female pelvic peritonitis, unspecified
N73.8	Other specified female pelvic inflammatory diseases
N73.9	Female pelvic inflammatory disease, unspecified
Peptococcus peritonitis
B96.89	Other specified bacterial agents as the cause of diseases classified elsewhere
K65.0	Generalized (acute) peritonitis
K65.2	Spontaneous bacterial peritonitis
T85.71	Infection and inflammatory reaction due to peritoneal dialysis catheter
T85.71xA	Infection and inflammatory reaction due to peritoneal dialysis catheter, initial encounter
Peptostreptococcus endometritis
B96.89	Other specified bacterial agents as the cause of diseases classified elsewhere
N71	Inflammatory disease of uterus, except cervix
N71.0	Acute inflammatory disease of uterus
N71.1	Chronic inflammatory disease of uterus
N71.9	Inflammatory disease of uterus, unspecified
O86.12	Endometritis following delivery
Peptostreptococcus pelvic inflammatory disease
B96.89	Other specified bacterial agents as the cause of diseases classified elsewhere
N70	Salpingitis and oophoritis
N70.0	Acute salpingitis and oophoritis
N70.01	Acute salpingitis
N70.02	Acute oophoritis
N70.03	Acute salpingitis and oophoritis
N70.1	Chronic salpingitis and oophoritis
N70.11	Chronic salpingitis
N70.12	Chronic oophoritis
N70.13	Chronic salpingitis and oophoritis
N70.9	Salpingitis and oophoritis, unspecified
N70.91	Salpingitis, unspecified
N70.92	Oophoritis, unspecified
N70.93	Salpingitis and oophoritis, unspecified
N71	Inflammatory disease of uterus, except cervix
N71.0	Acute inflammatory disease of uterus
N71.1	Chronic inflammatory disease of uterus
N71.9	Inflammatory disease of uterus, unspecified
N72	Inflammatory disease of cervix uteri
N73	Other female pelvic inflammatory diseases
N73.0	Acute parametritis and pelvic cellulitis
N73.1	Chronic parametritis and pelvic cellulitis
N73.2	Unspecified parametritis and pelvic cellulitis
N73.3	Female acute pelvic peritonitis
N73.4	Female chronic pelvic peritonitis
N73.5	Female pelvic peritonitis, unspecified
N73.8	Other specified female pelvic inflammatory diseases
N73.9	Female pelvic inflammatory disease, unspecified
N74	Female pelvic inflammatory disorders in diseases classified elsewhere
Proteus endometritis
B96.4	Proteus (mirabilis) (morganii) as the cause of diseases classified elsewhere
N71	Inflammatory disease of uterus, except cervix
N71.0	Acute inflammatory disease of uterus
N71.1	Chronic inflammatory disease of uterus
N71.9	Inflammatory disease of uterus, unspecified
O86.12	Endometritis following delivery
Proteus pelvic inflammatory disease
B96.4	Proteus (mirabilis) (morganii) as the cause of diseases classified elsewhere
N70.0	Acute salpingitis and oophoritis
N70.01	Acute salpingitis
N70.02	Acute oophoritis
N70.03	Acute salpingitis and oophoritis
N70.1	Chronic salpingitis and oophoritis
N70.11	Chronic salpingitis
N70.12	Chronic oophoritis
N70.13	Chronic salpingitis and oophoritis
N70.9	Salpingitis and oophoritis, unspecified
N70.91	Salpingitis, unspecified
N70.92	Oophoritis, unspecified
N70.93	Salpingitis and oophoritis, unspecified
N71	Inflammatory disease of uterus, except cervix
N71.0	Acute inflammatory disease of uterus
N71.1	Chronic inflammatory disease of uterus
N71.9	Inflammatory disease of uterus, unspecified
N72	Inflammatory disease of cervix uteri
N73	Other female pelvic inflammatory diseases
N73.0	Acute parametritis and pelvic cellulitis
N73.1	Chronic parametritis and pelvic cellulitis
N73.2	Unspecified parametritis and pelvic cellulitis
N73.3	Female acute pelvic peritonitis
N73.4	Female chronic pelvic peritonitis
N73.5	Female pelvic peritonitis, unspecified
N73.8	Other specified female pelvic inflammatory diseases
N73.9	Female pelvic inflammatory disease, unspecified
Proteus pneumonia
J15.6	Pneumonia due to other gram-negative bacteria
Proteus urinary tract infection
B96.4	Proteus (mirabilis) (morganii) as the cause of diseases classified elsewhere
N30.0	Acute cystitis
N30.00	Acute cystitis without hematuria
N30.01	Acute cystitis with hematuria
N30.9	Cystitis, unspecified
N30.90	Cystitis, unspecified without hematuria
N30.91	Cystitis, unspecified with hematuria
N39.0	Urinary tract infection, site not specified
O23.0	Infections of kidney in pregnancy
O23.00	Infections of kidney in pregnancy, unspecified trimester
O23.01	Infections of kidney in pregnancy, first trimester
O23.02	Infections of kidney in pregnancy, second trimester
O23.03	Infections of kidney in pregnancy, third trimester
O23.1	Infections of bladder in pregnancy
O23.10	Infections of bladder in pregnancy, unspecified trimester
O23.11	Infections of bladder in pregnancy, first trimester
O23.12	Infections of bladder in pregnancy, second trimester
O23.13	Infections of bladder in pregnancy, third trimester
O23.2	Infections of urethra in pregnancy
O23.20	Infections of urethra in pregnancy, unspecified trimester
O23.21	Infections of urethra in pregnancy, first trimester
O23.22	Infections of urethra in pregnancy, second trimester
O23.23	Infections of urethra in pregnancy, third trimester
O23.3	Infections of other parts of urinary tract in pregnancy
O23.30	Infections of other parts of urinary tract in pregnancy, unspecified trimester
O23.31	Infections of other parts of urinary tract in pregnancy, first trimester
O23.32	Infections of other parts of urinary tract in pregnancy, second trimester
O23.33	Infections of other parts of urinary tract in pregnancy, third trimester
O23.4	Unspecified infection of urinary tract in pregnancy
O23.40	Unspecified infection of urinary tract in pregnancy, unspecified trimester
O23.41	Unspecified infection of urinary tract in pregnancy, first trimester
O23.42	Unspecified infection of urinary tract in pregnancy, second trimester
O23.43	Unspecified infection of urinary tract in pregnancy, third trimester
O23.9	Unspecified genitourinary tract infection in pregnancy
O23.90	Unspecified genitourinary tract infection in pregnancy, unspecified trimester
O23.91	Unspecified genitourinary tract infection in pregnancy, first trimester
O23.92	Unspecified genitourinary tract infection in pregnancy, second trimester
O23.93	Unspecified genitourinary tract infection in pregnancy, third trimester
Skin and skin structure bacteroides fragilis infection
B96.6	Bacteroides fragilis [b. fragilis] as the cause of diseases classified elsewhere
L08.9	Local infection of the skin and subcutaneous tissue, unspecified
Skin and skin structure e. coli infection
B96.2	Escherichia coli [e. coli ] as the cause of diseases classified elsewhere
B96.20	Unspecified escherichia coli [e. coli] as the cause of diseases classified elsewhere
B96.29	Other escherichia coli [e. coli] as the cause of diseases classified elsewhere
L08.9	Local infection of the skin and subcutaneous tissue, unspecified
Skin and skin structure fusobacterium infection
B96.89	Other specified bacterial agents as the cause of diseases classified elsewhere
L08.9	Local infection of the skin and subcutaneous tissue, unspecified
Skin and skin structure infection
H05.01	Cellulitis of orbit
H05.011	Cellulitis of right orbit
H05.012	Cellulitis of left orbit
H05.013	Cellulitis of bilateral orbits
H05.019	Cellulitis of unspecified orbit
H60.1	Cellulitis of external ear
H60.10	Cellulitis of external ear, unspecified ear
H60.11	Cellulitis of right external ear
H60.12	Cellulitis of left external ear
H60.13	Cellulitis of external ear, bilateral
K12.2	Cellulitis and abscess of mouth
L03	Cellulitis and acute lymphangitis
L03.0	Cellulitis and acute lymphangitis of finger and toe
L03.01	Cellulitis of finger
L03.011	Cellulitis of right finger
L03.012	Cellulitis of left finger
L03.019	Cellulitis of unspecified finger
L03.03	Cellulitis of toe
L03.031	Cellulitis of right toe
L03.032	Cellulitis of left toe
L03.039	Cellulitis of unspecified toe
L03.1	Cellulitis and acute lymphangitis of other parts of limb
L03.11	Cellulitis of other parts of limb
L03.111	Cellulitis of right axilla
L03.112	Cellulitis of left axilla
L03.113	Cellulitis of right upper limb
L03.114	Cellulitis of left upper limb
L03.115	Cellulitis of right lower limb
L03.116	Cellulitis of left lower limb
L03.119	Cellulitis of unspecified part of limb
L03.2	Cellulitis and acute lymphangitis of face and neck
L03.21	Cellulitis and acute lymphangitis of face
L03.211	Cellulitis of face
L03.22	Cellulitis and acute lymphangitis of neck
L03.221	Cellulitis of neck
L03.3	Cellulitis and acute lymphangitis of trunk
L03.31	Cellulitis of trunk
L03.311	Cellulitis of abdominal wall
L03.312	Cellulitis of back [any part except buttock]
L03.313	Cellulitis of chest wall
L03.314	Cellulitis of groin
L03.315	Cellulitis of perineum
L03.316	Cellulitis of umbilicus
L03.317	Cellulitis of buttock
L03.319	Cellulitis of trunk, unspecified
L03.8	Cellulitis and acute lymphangitis of other sites
L03.81	Cellulitis of other sites
L03.811	Cellulitis of head [any part, except face]
L03.818	Cellulitis of other sites
L03.9	Cellulitis and acute lymphangitis, unspecified
L03.90	Cellulitis, unspecified
L08.9	Local infection of the skin and subcutaneous tissue, unspecified
N48.22	Cellulitis of corpus cavernosum and penis
Skin and skin structure peptococcus infection
B96.89	Other specified bacterial agents as the cause of diseases classified elsewhere
L08.9	Local infection of the skin and subcutaneous tissue, unspecified
Skin and skin structure peptostreptococcus infection
L08.89	Other specified local infections of the skin and subcutaneous tissue
L08.9	Local infection of the skin and subcutaneous tissue, unspecified
Skin and skin structure proteus infection
B96.4	Proteus (mirabilis) (morganii) as the cause of diseases classified elsewhere
L08.9	Local infection of the skin and subcutaneous tissue, unspecified
Skin and skin structure strep agalactiae infection
B95.1	Streptococcus, group b, as the cause of diseases classified elsewhere
B95.4	Other streptococcus as the cause of diseases classified elsewhere
L08.89	Other specified local infections of the skin and subcutaneous tissue
L08.9	Local infection of the skin and subcutaneous tissue, unspecified
Skin and skin structure strep. pyogenes infection
B95.0	Streptococcus, group a, as the cause of diseases classified elsewhere
B95.4	Other streptococcus as the cause of diseases classified elsewhere
L08.89	Other specified local infections of the skin and subcutaneous tissue
L08.9	Local infection of the skin and subcutaneous tissue, unspecified
Staph epidermidis skin and skin structure infection
B95.7	Other staphylococcus as the cause of diseases classified elsewhere
H60.1	Cellulitis of external ear
H60.10	Cellulitis of external ear, unspecified ear
H60.11	Cellulitis of right external ear
H60.12	Cellulitis of left external ear
H60.13	Cellulitis of external ear, bilateral
J34.0	Abscess, furuncle and carbuncle of nose
L02	Cutaneous abscess, furuncle and carbuncle
L02.0	Cutaneous abscess, furuncle and carbuncle of face
L02.02	Furuncle of face
L02.03	Carbuncle of face
L02.1	Cutaneous abscess, furuncle and carbuncle of neck
L02.12	Furuncle of neck
L02.13	Carbuncle of neck
L02.2	Cutaneous abscess, furuncle and carbuncle of trunk
L02.22	Furuncle of trunk
L02.221	Furuncle of abdominal wall
L02.222	Furuncle of back [any part, except buttock]
L02.223	Furuncle of chest wall
L02.224	Furuncle of groin
L02.225	Furuncle of perineum
L02.226	Furuncle of umbilicus
L02.229	Furuncle of trunk, unspecified
L02.23	Carbuncle of trunk
L02.231	Carbuncle of abdominal wall
L02.232	Carbuncle of back [any part, except buttock]
L02.233	Carbuncle of chest wall
L02.234	Carbuncle of groin
L02.235	Carbuncle of perineum
L02.236	Carbuncle of umbilicus
L02.239	Carbuncle of trunk, unspecified
L02.3	Cutaneous abscess, furuncle and carbuncle of buttock
L02.32	Furuncle of buttock
L02.33	Carbuncle of buttock
L02.4	Cutaneous abscess, furuncle and carbuncle of limb
L02.42	Furuncle of limb
L02.421	Furuncle of right axilla
L02.422	Furuncle of left axilla
L02.423	Furuncle of right upper limb
L02.424	Furuncle of left upper limb
L02.425	Furuncle of right lower limb
L02.426	Furuncle of left lower limb
L02.429	Furuncle of limb, unspecified
L02.43	Carbuncle of limb
L02.431	Carbuncle of right axilla
L02.432	Carbuncle of left axilla
L02.433	Carbuncle of right upper limb
L02.434	Carbuncle of left upper limb
L02.435	Carbuncle of right lower limb
L02.436	Carbuncle of left lower limb
L02.439	Carbuncle of limb, unspecified
L02.5	Cutaneous abscess, furuncle and carbuncle of hand
L02.52	Furuncle hand
L02.521	Furuncle right hand
L02.522	Furuncle left hand
L02.529	Furuncle unspecified hand
L02.53	Carbuncle of hand
L02.531	Carbuncle of right hand
L02.532	Carbuncle of left hand
L02.539	Carbuncle of unspecified hand
L02.6	Cutaneous abscess, furuncle and carbuncle of foot
L02.62	Furuncle of foot
L02.621	Furuncle of right foot
L02.622	Furuncle of left foot
L02.629	Furuncle of unspecified foot
L02.63	Carbuncle of foot
L02.631	Carbuncle of right foot
L02.632	Carbuncle of left foot
L02.639	Carbuncle of unspecified foot
L02.8	Cutaneous abscess, furuncle and carbuncle of other sites
L02.82	Furuncle of other sites
L02.821	Furuncle of head [any part, except face]
L02.828	Furuncle of other sites
L02.83	Carbuncle of other sites
L02.831	Carbuncle of head [any part, except face]
L02.838	Carbuncle of other sites
L02.9	Cutaneous abscess, furuncle and carbuncle, unspecified
L02.92	Furuncle, unspecified
L02.93	Carbuncle, unspecified
L03	Cellulitis and acute lymphangitis
L03.0	Cellulitis and acute lymphangitis of finger and toe
L03.01	Cellulitis of finger
L03.011	Cellulitis of right finger
L03.012	Cellulitis of left finger
L03.019	Cellulitis of unspecified finger
L03.03	Cellulitis of toe
L03.031	Cellulitis of right toe
L03.032	Cellulitis of left toe
L03.039	Cellulitis of unspecified toe
L03.1	Cellulitis and acute lymphangitis of other parts of limb
L03.11	Cellulitis of other parts of limb
L03.111	Cellulitis of right axilla
L03.112	Cellulitis of left axilla
L03.113	Cellulitis of right upper limb
L03.114	Cellulitis of left upper limb
L03.115	Cellulitis of right lower limb
L03.116	Cellulitis of left lower limb
L03.119	Cellulitis of unspecified part of limb
L03.2	Cellulitis and acute lymphangitis of face and neck
L03.21	Cellulitis and acute lymphangitis of face
L03.211	Cellulitis of face
L03.22	Cellulitis and acute lymphangitis of neck
L03.221	Cellulitis of neck
L03.3	Cellulitis and acute lymphangitis of trunk
L03.31	Cellulitis of trunk
L03.311	Cellulitis of abdominal wall
L03.312	Cellulitis of back [any part except buttock]
L03.313	Cellulitis of chest wall
L03.314	Cellulitis of groin
L03.315	Cellulitis of perineum
L03.316	Cellulitis of umbilicus
L03.317	Cellulitis of buttock
L03.319	Cellulitis of trunk, unspecified
L03.8	Cellulitis and acute lymphangitis of other sites
L03.81	Cellulitis of other sites
L03.811	Cellulitis of head [any part, except face]
L03.818	Cellulitis of other sites
L03.9	Cellulitis and acute lymphangitis, unspecified
L03.90	Cellulitis, unspecified
L08.9	Local infection of the skin and subcutaneous tissue, unspecified
N48.22	Cellulitis of corpus cavernosum and penis
Staphylococcal pneumonia
J15.2	Pneumonia due to staphylococcus
J15.20	Pneumonia due to staphylococcus, unspecified
J15.21	Pneumonia due to staphylococcus aureus
J15.211	Pneumonia due to methicillin susceptible staphylococcus aureus
J15.212	Pneumonia due to methicillin resistant staphylococcus aureus
J15.29	Pneumonia due to other staphylococcus
Staphylococcus aureus joint infection
M00.0	Staphylococcal arthritis and polyarthritis
M00.00	Staphylococcal arthritis, unspecified joint
M00.01	Staphylococcal arthritis, shoulder
M00.011	Staphylococcal arthritis, right shoulder
M00.012	Staphylococcal arthritis, left shoulder
M00.019	Staphylococcal arthritis, unspecified shoulder
M00.02	Staphylococcal arthritis, elbow
M00.021	Staphylococcal arthritis, right elbow
M00.022	Staphylococcal arthritis, left elbow
M00.029	Staphylococcal arthritis, unspecified elbow
M00.03	Staphylococcal arthritis, wrist
M00.031	Staphylococcal arthritis, right wrist
M00.032	Staphylococcal arthritis, left wrist
M00.039	Staphylococcal arthritis, unspecified wrist
M00.04	Staphylococcal arthritis, hand
M00.041	Staphylococcal arthritis, right hand
M00.042	Staphylococcal arthritis, left hand
M00.049	Staphylococcal arthritis, unspecified hand
M00.05	Staphylococcal arthritis, hip
M00.051	Staphylococcal arthritis, right hip
M00.052	Staphylococcal arthritis, left hip
M00.059	Staphylococcal arthritis, unspecified hip
M00.06	Staphylococcal arthritis, knee
M00.061	Staphylococcal arthritis, right knee
M00.062	Staphylococcal arthritis, left knee
M00.069	Staphylococcal arthritis, unspecified knee
M00.07	Staphylococcal arthritis, ankle and foot
M00.071	Staphylococcal arthritis, right ankle and foot
M00.072	Staphylococcal arthritis, left ankle and foot
M00.079	Staphylococcal arthritis, unspecified ankle and foot
M00.08	Staphylococcal arthritis, vertebrae
M00.09	Staphylococcal polyarthritis
Staphylococcus aureus osteomyelitis
B95.6	Staphylococcus aureus as the cause of diseases classified elsewhere
B95.61	Methicillin susceptible staphylococcus aureus infection as the cause of diseases classified elsewhere
B95.62	Methicillin resistant staphylococcus aureus infection as the cause of diseases classified elsewhere
H05.02	Osteomyelitis of orbit
H05.021	Osteomyelitis of right orbit
H05.022	Osteomyelitis of left orbit
H05.023	Osteomyelitis of bilateral orbits
H05.029	Osteomyelitis of unspecified orbit
M46.2	Osteomyelitis of vertebra
M46.20	Osteomyelitis of vertebra, site unspecified
M46.21	Osteomyelitis of vertebra, occipito-atlanto-axial region
M46.22	Osteomyelitis of vertebra, cervical region
M46.23	Osteomyelitis of vertebra, cervicothoracic region
M46.24	Osteomyelitis of vertebra, thoracic region
M46.25	Osteomyelitis of vertebra, thoracolumbar region
M46.26	Osteomyelitis of vertebra, lumbar region
M46.27	Osteomyelitis of vertebra, lumbosacral region
M46.28	Osteomyelitis of vertebra, sacral and sacrococcygeal region
M86	Osteomyelitis
M86.0	Acute hematogenous osteomyelitis
M86.00	Acute hematogenous osteomyelitis, unspecified site
M86.01	Acute hematogenous osteomyelitis, shoulder
M86.011	Acute hematogenous osteomyelitis, right shoulder
M86.012	Acute hematogenous osteomyelitis, left shoulder
M86.019	Acute hematogenous osteomyelitis, unspecified shoulder
M86.02	Acute hematogenous osteomyelitis, humerus
M86.021	Acute hematogenous osteomyelitis, right humerus
M86.022	Acute hematogenous osteomyelitis, left humerus
M86.029	Acute hematogenous osteomyelitis, unspecified humerus
M86.03	Acute hematogenous osteomyelitis, radius and ulna
M86.031	Acute hematogenous osteomyelitis, right radius and ulna
M86.032	Acute hematogenous osteomyelitis, left radius and ulna
M86.039	Acute hematogenous osteomyelitis, unspecified radius and ulna
M86.04	Acute hematogenous osteomyelitis, hand
M86.041	Acute hematogenous osteomyelitis, right hand
M86.042	Acute hematogenous osteomyelitis, left hand
M86.049	Acute hematogenous osteomyelitis, unspecified hand
M86.05	Acute hematogenous osteomyelitis, femur
M86.051	Acute hematogenous osteomyelitis, right femur
M86.052	Acute hematogenous osteomyelitis, left femur
M86.059	Acute hematogenous osteomyelitis, unspecified femur
M86.06	Acute hematogenous osteomyelitis, tibia and fibula
M86.061	Acute hematogenous osteomyelitis, right tibia and fibula
M86.062	Acute hematogenous osteomyelitis, left tibia and fibula
M86.069	Acute hematogenous osteomyelitis, unspecified tibia and fibula
M86.07	Acute hematogenous osteomyelitis, ankle and foot
M86.071	Acute hematogenous osteomyelitis, right ankle and foot
M86.072	Acute hematogenous osteomyelitis, left ankle and foot
M86.079	Acute hematogenous osteomyelitis, unspecified ankle and foot
M86.08	Acute hematogenous osteomyelitis, other sites
M86.09	Acute hematogenous osteomyelitis, multiple sites
M86.1	Other acute osteomyelitis
M86.10	Other acute osteomyelitis, unspecified site
M86.11	Other acute osteomyelitis, shoulder
M86.111	Other acute osteomyelitis, right shoulder
M86.112	Other acute osteomyelitis, left shoulder
M86.119	Other acute osteomyelitis, unspecified shoulder
M86.12	Other acute osteomyelitis, humerus
M86.121	Other acute osteomyelitis, right humerus
M86.122	Other acute osteomyelitis, left humerus
M86.129	Other acute osteomyelitis, unspecified humerus
M86.13	Other acute osteomyelitis, radius and ulna
M86.131	Other acute osteomyelitis, right radius and ulna
M86.132	Other acute osteomyelitis, left radius and ulna
M86.139	Other acute osteomyelitis, unspecified radius and ulna
M86.14	Other acute osteomyelitis, hand
M86.141	Other acute osteomyelitis, right hand
M86.142	Other acute osteomyelitis, left hand
M86.149	Other acute osteomyelitis, unspecified hand
M86.15	Other acute osteomyelitis, femur
M86.151	Other acute osteomyelitis, right femur
M86.152	Other acute osteomyelitis, left femur
M86.159	Other acute osteomyelitis, unspecified femur
M86.16	Other acute osteomyelitis, tibia and fibula
M86.161	Other acute osteomyelitis, right tibia and fibula
M86.162	Other acute osteomyelitis, left tibia and fibula
M86.169	Other acute osteomyelitis, unspecified tibia and fibula
M86.17	Other acute osteomyelitis, ankle and foot
M86.171	Other acute osteomyelitis, right ankle and foot
M86.172	Other acute osteomyelitis, left ankle and foot
M86.179	Other acute osteomyelitis, unspecified ankle and foot
M86.18	Other acute osteomyelitis, other site
M86.19	Other acute osteomyelitis, multiple sites
M86.2	Subacute osteomyelitis
M86.20	Subacute osteomyelitis, unspecified site
M86.21	Subacute osteomyelitis, shoulder
M86.211	Subacute osteomyelitis, right shoulder
M86.212	Subacute osteomyelitis, left shoulder
M86.219	Subacute osteomyelitis, unspecified shoulder
M86.22	Subacute osteomyelitis, humerus
M86.221	Subacute osteomyelitis, right humerus
M86.222	Subacute osteomyelitis, left humerus
M86.229	Subacute osteomyelitis, unspecified humerus
M86.23	Subacute osteomyelitis, radius and ulna
M86.231	Subacute osteomyelitis, right radius and ulna
M86.232	Subacute osteomyelitis, left radius and ulna
M86.239	Subacute osteomyelitis, unspecified radius and ulna
M86.24	Subacute osteomyelitis, hand
M86.241	Subacute osteomyelitis, right hand
M86.242	Subacute osteomyelitis, left hand
M86.249	Subacute osteomyelitis, unspecified hand
M86.25	Subacute osteomyelitis, femur
M86.251	Subacute osteomyelitis, right femur
M86.252	Subacute osteomyelitis, left femur
M86.259	Subacute osteomyelitis, unspecified femur
M86.26	Subacute osteomyelitis, tibia and fibula
M86.261	Subacute osteomyelitis, right tibia and fibula
M86.262	Subacute osteomyelitis, left tibia and fibula
M86.269	Subacute osteomyelitis, unspecified tibia and fibula
M86.27	Subacute osteomyelitis, ankle and foot
M86.271	Subacute osteomyelitis, right ankle and foot
M86.272	Subacute osteomyelitis, left ankle and foot
M86.279	Subacute osteomyelitis, unspecified ankle and foot
M86.28	Subacute osteomyelitis, other site
M86.29	Subacute osteomyelitis, multiple sites
M86.3	Chronic multifocal osteomyelitis
M86.30	Chronic multifocal osteomyelitis, unspecified site
M86.31	Chronic multifocal osteomyelitis, shoulder
M86.311	Chronic multifocal osteomyelitis, right shoulder
M86.312	Chronic multifocal osteomyelitis, left shoulder
M86.319	Chronic multifocal osteomyelitis, unspecified shoulder
M86.32	Chronic multifocal osteomyelitis, humerus
M86.321	Chronic multifocal osteomyelitis, right humerus
M86.322	Chronic multifocal osteomyelitis, left humerus
M86.329	Chronic multifocal osteomyelitis, unspecified humerus
M86.33	Chronic multifocal osteomyelitis, radius and ulna
M86.331	Chronic multifocal osteomyelitis, right radius and ulna
M86.332	Chronic multifocal osteomyelitis, left radius and ulna
M86.339	Chronic multifocal osteomyelitis, unspecified radius and ulna
M86.34	Chronic multifocal osteomyelitis, hand
M86.341	Chronic multifocal osteomyelitis, right hand
M86.342	Chronic multifocal osteomyelitis, left hand
M86.349	Chronic multifocal osteomyelitis, unspecified hand
M86.35	Chronic multifocal osteomyelitis, femur
M86.351	Chronic multifocal osteomyelitis, right femur
M86.352	Chronic multifocal osteomyelitis, left femur
M86.359	Chronic multifocal osteomyelitis, unspecified femur
M86.36	Chronic multifocal osteomyelitis, tibia and fibula
M86.361	Chronic multifocal osteomyelitis, right tibia and fibula
M86.362	Chronic multifocal osteomyelitis, left tibia and fibula
M86.369	Chronic multifocal osteomyelitis, unspecified tibia and fibula
M86.37	Chronic multifocal osteomyelitis, ankle and foot
M86.371	Chronic multifocal osteomyelitis, right ankle and foot
M86.372	Chronic multifocal osteomyelitis, left ankle and foot
M86.379	Chronic multifocal osteomyelitis, unspecified ankle and foot
M86.38	Chronic multifocal osteomyelitis, other site
M86.39	Chronic multifocal osteomyelitis, multiple sites
M86.4	Chronic osteomyelitis with draining sinus
M86.40	Chronic osteomyelitis with draining sinus, unspecified site
M86.41	Chronic osteomyelitis with draining sinus, shoulder
M86.411	Chronic osteomyelitis with draining sinus, right shoulder
M86.412	Chronic osteomyelitis with draining sinus, left shoulder
M86.419	Chronic osteomyelitis with draining sinus, unspecified shoulder
M86.42	Chronic osteomyelitis with draining sinus, humerus
M86.421	Chronic osteomyelitis with draining sinus, right humerus
M86.422	Chronic osteomyelitis with draining sinus, left humerus
M86.429	Chronic osteomyelitis with draining sinus, unspecified humerus
M86.43	Chronic osteomyelitis with draining sinus, radius and ulna
M86.431	Chronic osteomyelitis with draining sinus, right radius and ulna
M86.432	Chronic osteomyelitis with draining sinus, left radius and ulna
M86.439	Chronic osteomyelitis with draining sinus, unspecified radius and ulna
M86.44	Chronic osteomyelitis with draining sinus, hand
M86.441	Chronic osteomyelitis with draining sinus, right hand
M86.442	Chronic osteomyelitis with draining sinus, left hand
M86.449	Chronic osteomyelitis with draining sinus, unspecified hand
M86.45	Chronic osteomyelitis with draining sinus, femur
M86.451	Chronic osteomyelitis with draining sinus, right femur
M86.452	Chronic osteomyelitis with draining sinus, left femur
M86.459	Chronic osteomyelitis with draining sinus, unspecified femur
M86.46	Chronic osteomyelitis with draining sinus, tibia and fibula
M86.461	Chronic osteomyelitis with draining sinus, right tibia and fibula
M86.462	Chronic osteomyelitis with draining sinus, left tibia and fibula
M86.469	Chronic osteomyelitis with draining sinus, unspecified tibia and fibula
M86.47	Chronic osteomyelitis with draining sinus, ankle and foot
M86.471	Chronic osteomyelitis with draining sinus, right ankle and foot
M86.472	Chronic osteomyelitis with draining sinus, left ankle and foot
M86.479	Chronic osteomyelitis with draining sinus, unspecified ankle and foot
M86.48	Chronic osteomyelitis with draining sinus, other site
M86.49	Chronic osteomyelitis with draining sinus, multiple sites
M86.5	Other chronic hematogenous osteomyelitis
M86.50	Other chronic hematogenous osteomyelitis, unspecified site
M86.51	Other chronic hematogenous osteomyelitis, shoulder
M86.511	Other chronic hematogenous osteomyelitis, right shoulder
M86.512	Other chronic hematogenous osteomyelitis, left shoulder
M86.519	Other chronic hematogenous osteomyelitis, unspecified shoulder
M86.52	Other chronic hematogenous osteomyelitis, humerus
M86.521	Other chronic hematogenous osteomyelitis, right humerus
M86.522	Other chronic hematogenous osteomyelitis, left humerus
M86.529	Other chronic hematogenous osteomyelitis, unspecified humerus
M86.53	Other chronic hematogenous osteomyelitis, radius and ulna
M86.531	Other chronic hematogenous osteomyelitis, right radius and ulna
M86.532	Other chronic hematogenous osteomyelitis, left radius and ulna
M86.539	Other chronic hematogenous osteomyelitis, unspecified radius and ulna
M86.54	Other chronic hematogenous osteomyelitis, hand
M86.541	Other chronic hematogenous osteomyelitis, right hand
M86.542	Other chronic hematogenous osteomyelitis, left hand
M86.549	Other chronic hematogenous osteomyelitis, unspecified hand
M86.55	Other chronic hematogenous osteomyelitis, femur
M86.551	Other chronic hematogenous osteomyelitis, right femur
M86.552	Other chronic hematogenous osteomyelitis, left femur
M86.559	Other chronic hematogenous osteomyelitis, unspecified femur
M86.56	Other chronic hematogenous osteomyelitis, tibia and fibula
M86.561	Other chronic hematogenous osteomyelitis, right tibia and fibula
M86.562	Other chronic hematogenous osteomyelitis, left tibia and fibula
M86.569	Other chronic hematogenous osteomyelitis, unspecified tibia and fibula
M86.57	Other chronic hematogenous osteomyelitis, ankle and foot
M86.571	Other chronic hematogenous osteomyelitis, right ankle and foot
M86.572	Other chronic hematogenous osteomyelitis, left ankle and foot
M86.579	Other chronic hematogenous osteomyelitis, unspecified ankle and foot
M86.58	Other chronic hematogenous osteomyelitis, other site
M86.59	Other chronic hematogenous osteomyelitis, multiple sites
M86.6	Other chronic osteomyelitis
M86.60	Other chronic osteomyelitis, unspecified site
M86.61	Other chronic osteomyelitis, shoulder
M86.611	Other chronic osteomyelitis, right shoulder
M86.612	Other chronic osteomyelitis, left shoulder
M86.619	Other chronic osteomyelitis, unspecified shoulder
M86.62	Other chronic osteomyelitis, humerus
M86.621	Other chronic osteomyelitis, right humerus
M86.622	Other chronic osteomyelitis, left humerus
M86.629	Other chronic osteomyelitis, unspecified humerus
M86.63	Other chronic osteomyelitis, radius and ulna
M86.631	Other chronic osteomyelitis, right radius and ulna
M86.632	Other chronic osteomyelitis, left radius and ulna
M86.639	Other chronic osteomyelitis, unspecified radius and ulna
M86.64	Other chronic osteomyelitis, hand
M86.641	Other chronic osteomyelitis, right hand
M86.642	Other chronic osteomyelitis, left hand
M86.649	Other chronic osteomyelitis, unspecified hand
M86.65	Other chronic osteomyelitis, thigh
M86.651	Other chronic osteomyelitis, right thigh
M86.652	Other chronic osteomyelitis, left thigh
M86.659	Other chronic osteomyelitis, unspecified thigh
M86.66	Other chronic osteomyelitis, tibia and fibula
M86.661	Other chronic osteomyelitis, right tibia and fibula
M86.662	Other chronic osteomyelitis, left tibia and fibula
M86.669	Other chronic osteomyelitis, unspecified tibia and fibula
M86.67	Other chronic osteomyelitis, ankle and foot
M86.671	Other chronic osteomyelitis, right ankle and foot
M86.672	Other chronic osteomyelitis, left ankle and foot
M86.679	Other chronic osteomyelitis, unspecified ankle and foot
M86.68	Other chronic osteomyelitis, other site
M86.69	Other chronic osteomyelitis, multiple sites
M86.8	Other osteomyelitis
M86.8x	Other osteomyelitis
M86.8x0	Other osteomyelitis, multiple sites
M86.8x1	Other osteomyelitis, shoulder
M86.8x2	Other osteomyelitis, upper arm
M86.8x3	Other osteomyelitis, forearm
M86.8x4	Other osteomyelitis, hand
M86.8x5	Other osteomyelitis, thigh
M86.8x6	Other osteomyelitis, lower leg
M86.8x7	Other osteomyelitis, ankle and foot
M86.8x8	Other osteomyelitis, other site
M86.8x9	Other osteomyelitis, unspecified sites
M86.9	Osteomyelitis, unspecified
Staphylococcus aureus skin and skin structure infection
B95.6	Staphylococcus aureus as the cause of diseases classified elsewhere
H60.1	Cellulitis of external ear
H60.10	Cellulitis of external ear, unspecified ear
H60.11	Cellulitis of right external ear
H60.12	Cellulitis of left external ear
H60.13	Cellulitis of external ear, bilateral
J34.0	Abscess, furuncle and carbuncle of nose
L02	Cutaneous abscess, furuncle and carbuncle
L02.0	Cutaneous abscess, furuncle and carbuncle of face
L02.02	Furuncle of face
L02.03	Carbuncle of face
L02.1	Cutaneous abscess, furuncle and carbuncle of neck
L02.12	Furuncle of neck
L02.13	Carbuncle of neck
L02.2	Cutaneous abscess, furuncle and carbuncle of trunk
L02.22	Furuncle of trunk
L02.221	Furuncle of abdominal wall
L02.222	Furuncle of back [any part, except buttock]
L02.223	Furuncle of chest wall
L02.224	Furuncle of groin
L02.225	Furuncle of perineum
L02.226	Furuncle of umbilicus
L02.229	Furuncle of trunk, unspecified
L02.23	Carbuncle of trunk
L02.231	Carbuncle of abdominal wall
L02.232	Carbuncle of back [any part, except buttock]
L02.233	Carbuncle of chest wall
L02.234	Carbuncle of groin
L02.235	Carbuncle of perineum
L02.236	Carbuncle of umbilicus
L02.239	Carbuncle of trunk, unspecified
L02.3	Cutaneous abscess, furuncle and carbuncle of buttock
L02.32	Furuncle of buttock
L02.33	Carbuncle of buttock
L02.4	Cutaneous abscess, furuncle and carbuncle of limb
L02.42	Furuncle of limb
L02.421	Furuncle of right axilla
L02.422	Furuncle of left axilla
L02.423	Furuncle of right upper limb
L02.424	Furuncle of left upper limb
L02.425	Furuncle of right lower limb
L02.426	Furuncle of left lower limb
L02.429	Furuncle of limb, unspecified
L02.43	Carbuncle of limb
L02.431	Carbuncle of right axilla
L02.432	Carbuncle of left axilla
L02.433	Carbuncle of right upper limb
L02.434	Carbuncle of left upper limb
L02.435	Carbuncle of right lower limb
L02.436	Carbuncle of left lower limb
L02.439	Carbuncle of limb, unspecified
L02.5	Cutaneous abscess, furuncle and carbuncle of hand
L02.52	Furuncle hand
L02.521	Furuncle right hand
L02.522	Furuncle left hand
L02.529	Furuncle unspecified hand
L02.53	Carbuncle of hand
L02.531	Carbuncle of right hand
L02.532	Carbuncle of left hand
L02.539	Carbuncle of unspecified hand
L02.6	Cutaneous abscess, furuncle and carbuncle of foot
L02.62	Furuncle of foot
L02.621	Furuncle of right foot
L02.622	Furuncle of left foot
L02.629	Furuncle of unspecified foot
L02.63	Carbuncle of foot
L02.631	Carbuncle of right foot
L02.632	Carbuncle of left foot
L02.639	Carbuncle of unspecified foot
L02.8	Cutaneous abscess, furuncle and carbuncle of other sites
L02.82	Furuncle of other sites
L02.821	Furuncle of head [any part, except face]
L02.828	Furuncle of other sites
L02.83	Carbuncle of other sites
L02.831	Carbuncle of head [any part, except face]
L02.838	Carbuncle of other sites
L02.9	Cutaneous abscess, furuncle and carbuncle, unspecified
L02.92	Furuncle, unspecified
L02.93	Carbuncle, unspecified
L03.01	Cellulitis of finger
L03.011	Cellulitis of right finger
L03.012	Cellulitis of left finger
L03.019	Cellulitis of unspecified finger
L03.03	Cellulitis of toe
L03.031	Cellulitis of right toe
L03.032	Cellulitis of left toe
L03.039	Cellulitis of unspecified toe
L03.1	Cellulitis and acute lymphangitis of other parts of limb
L03.11	Cellulitis of other parts of limb
L03.111	Cellulitis of right axilla
L03.112	Cellulitis of left axilla
L03.113	Cellulitis of right upper limb
L03.114	Cellulitis of left upper limb
L03.115	Cellulitis of right lower limb
L03.116	Cellulitis of left lower limb
L03.119	Cellulitis of unspecified part of limb
L03.2	Cellulitis and acute lymphangitis of face and neck
L03.21	Cellulitis and acute lymphangitis of face
L03.211	Cellulitis of face
L03.22	Cellulitis and acute lymphangitis of neck
L03.221	Cellulitis of neck
L03.3	Cellulitis and acute lymphangitis of trunk
L03.31	Cellulitis of trunk
L03.311	Cellulitis of abdominal wall
L03.312	Cellulitis of back [any part except buttock]
L03.313	Cellulitis of chest wall
L03.314	Cellulitis of groin
L03.315	Cellulitis of perineum
L03.316	Cellulitis of umbilicus
L03.317	Cellulitis of buttock
L03.319	Cellulitis of trunk, unspecified
L03.8	Cellulitis and acute lymphangitis of other sites
L03.81	Cellulitis of other sites
L03.811	Cellulitis of head [any part, except face]
L03.818	Cellulitis of other sites
L03.9	Cellulitis and acute lymphangitis, unspecified
L03.90	Cellulitis, unspecified
L08.89	Other specified local infections of the skin and subcutaneous tissue
L08.9	Local infection of the skin and subcutaneous tissue, unspecified
N48.22	Cellulitis of corpus cavernosum and penis
Staphylococcus endometritis
B95.6	Staphylococcus aureus as the cause of diseases classified elsewhere
B95.61	Methicillin susceptible staphylococcus aureus infection as the cause of diseases classified elsewhere
B95.62	Methicillin resistant staphylococcus aureus infection as the cause of diseases classified elsewhere
B95.7	Other staphylococcus as the cause of diseases classified elsewhere
B95.8	Unspecified staphylococcus as the cause of diseases classified elsewhere
N71	Inflammatory disease of uterus, except cervix
N71.0	Acute inflammatory disease of uterus
N71.1	Chronic inflammatory disease of uterus
N71.9	Inflammatory disease of uterus, unspecified
O86.12	Endometritis following delivery
Staphylococcus pelvic inflammatory disease
B95.6	Staphylococcus aureus as the cause of diseases classified elsewhere
B95.61	Methicillin susceptible staphylococcus aureus infection as the cause of diseases classified elsewhere
B95.62	Methicillin resistant staphylococcus aureus infection as the cause of diseases classified elsewhere
B95.7	Other staphylococcus as the cause of diseases classified elsewhere
B95.8	Unspecified staphylococcus as the cause of diseases classified elsewhere
N70	Salpingitis and oophoritis
N70.0	Acute salpingitis and oophoritis
N70.01	Acute salpingitis
N70.02	Acute oophoritis
N70.03	Acute salpingitis and oophoritis
N70.1	Chronic salpingitis and oophoritis
N70.11	Chronic salpingitis
N70.12	Chronic oophoritis
N70.13	Chronic salpingitis and oophoritis
N70.9	Salpingitis and oophoritis, unspecified
N70.91	Salpingitis, unspecified
N70.92	Oophoritis, unspecified
N70.93	Salpingitis and oophoritis, unspecified
N71	Inflammatory disease of uterus, except cervix
N71.0	Acute inflammatory disease of uterus
N71.1	Chronic inflammatory disease of uterus
N71.9	Inflammatory disease of uterus, unspecified
N72	Inflammatory disease of cervix uteri
N73	Other female pelvic inflammatory diseases
N73.0	Acute parametritis and pelvic cellulitis
N73.1	Chronic parametritis and pelvic cellulitis
N73.2	Unspecified parametritis and pelvic cellulitis
N73.3	Female acute pelvic peritonitis
N73.4	Female chronic pelvic peritonitis
N73.5	Female pelvic peritonitis, unspecified
N73.8	Other specified female pelvic inflammatory diseases
N73.9	Female pelvic inflammatory disease, unspecified
Streptococcal endometritis
B95.1	Streptococcus, group b, as the cause of diseases classified elsewhere
B95.4	Other streptococcus as the cause of diseases classified elsewhere
B95.5	Unspecified streptococcus as the cause of diseases classified elsewhere
N71	Inflammatory disease of uterus, except cervix
N71.0	Acute inflammatory disease of uterus
N71.1	Chronic inflammatory disease of uterus
N71.9	Inflammatory disease of uterus, unspecified
O86.12	Endometritis following delivery
Streptococcal pelvic inflammatory disease
B95.0	Streptococcus, group a, as the cause of diseases classified elsewhere
B95.1	Streptococcus, group b, as the cause of diseases classified elsewhere
B95.3	Streptococcus pneumoniae as the cause of diseases classified elsewhere
B95.4	Other streptococcus as the cause of diseases classified elsewhere
B95.5	Unspecified streptococcus as the cause of diseases classified elsewhere
N70	Salpingitis and oophoritis
N70.0	Acute salpingitis and oophoritis
N70.01	Acute salpingitis
N70.02	Acute oophoritis
N70.03	Acute salpingitis and oophoritis
N70.1	Chronic salpingitis and oophoritis
N70.11	Chronic salpingitis
N70.12	Chronic oophoritis
N70.13	Chronic salpingitis and oophoritis
N70.9	Salpingitis and oophoritis, unspecified
N70.91	Salpingitis, unspecified
N70.92	Oophoritis, unspecified
N70.93	Salpingitis and oophoritis, unspecified
N71	Inflammatory disease of uterus, except cervix
N71.0	Acute inflammatory disease of uterus
N71.1	Chronic inflammatory disease of uterus
N71.9	Inflammatory disease of uterus, unspecified
N72	Inflammatory disease of cervix uteri
N73	Other female pelvic inflammatory diseases
N73.0	Acute parametritis and pelvic cellulitis
N73.1	Chronic parametritis and pelvic cellulitis
N73.2	Unspecified parametritis and pelvic cellulitis
N73.3	Female acute pelvic peritonitis
N73.4	Female chronic pelvic peritonitis
N73.5	Female pelvic peritonitis, unspecified
N73.8	Other specified female pelvic inflammatory diseases
N73.9	Female pelvic inflammatory disease, unspecified
Streptococcal peritonitis
B95.0	Streptococcus, group a, as the cause of diseases classified elsewhere
B95.1	Streptococcus, group b, as the cause of diseases classified elsewhere
B95.3	Streptococcus pneumoniae as the cause of diseases classified elsewhere
B95.4	Other streptococcus as the cause of diseases classified elsewhere
B95.5	Unspecified streptococcus as the cause of diseases classified elsewhere
K65.0	Generalized (acute) peritonitis
K65.2	Spontaneous bacterial peritonitis
T85.71	Infection and inflammatory reaction due to peritoneal dialysis catheter
T85.71xA	Infection and inflammatory reaction due to peritoneal dialysis catheter, initial encounter
Streptococcal pneumonia
J13	Pneumonia due to streptococcus pneumoniae
J15.3	Pneumonia due to streptococcus, group B
J15.4	Pneumonia due to other streptococci