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VFEND IV (VORICONAZOLE)
- Aspergillosis
- Candidemia
- Disseminated candidiasis
- Esophageal candidiasis
- Fungal infection due to scedosporium apiospermum
- Fusarium infection
- Invasive pulmonary aspergillosis
200 mg intravenous solution
- Infuse 4 mg/kg over 1-2 hour(s) by intravenous route every 12 hours
200 mg intravenous solution
- Infuse 4 mg/kg over 1-2 hour(s) by intravenous route every 12 hours
Aspergillosis
- Infuse 4 mg/kg over 1-2 hour(s) by intravenous route every 12 hours
- Infuse 280 mg over 1-2 hour(s) by intravenous route every 12 hours
- Infuse 3 mg/kg over 1-2 hour(s) by intravenous route every 12 hours
Candidemia
- Infuse 4 mg/kg over 1-2 hour(s) by intravenous route every 12 hours
- Infuse 3 mg/kg over 1-2 hour(s) by intravenous route every 12 hours
Disseminated candidiasis
- Infuse 4 mg/kg over 1-2 hour(s) by intravenous route every 12 hours
- Infuse 3 mg/kg over 1-2 hour(s) by intravenous route every 12 hours
Fungal infection due to scedosporium apiospermum
- Infuse 4 mg/kg over 1-2 hour(s) by intravenous route every 12 hours
- Infuse 280 mg over 1-2 hour(s) by intravenous route every 12 hours
- Infuse 3 mg/kg over 1-2 hour(s) by intravenous route every 12 hours
Fusarium infection
- Infuse 4 mg/kg over 1-2 hour(s) by intravenous route every 12 hours
- Infuse 280 mg over 1-2 hour(s) by intravenous route every 12 hours
- Infuse 3 mg/kg over 1-2 hour(s) by intravenous route every 12 hours
Invasive pulmonary aspergillosis
- Infuse 4 mg/kg over 1-2 hour(s) by intravenous route every 12 hours
- Infuse 280 mg over 1-2 hour(s) by intravenous route every 12 hours
- Infuse 3 mg/kg over 1-2 hour(s) by intravenous route every 12 hours
- Advicor
- alfuzosin
- Altoprev
- amiodarone
- amiodarone in dextrose,iso-osm
- Atripla
- avanafil
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Belladonna-phenobarbital
- Brilinta
- bromocriptine
- cabergoline
- Cafergot
- calcium-mag-B complex-D3-hrb61
- Camptosar
- carbamazepine
- Carbatrol
- Cold & Flu Fighter
- conivaptan in 5 % dextrose
- Cordarone
- Cycloset
- D.h.e.45
- Detrol La
- dextromethorphan-quinidine
- dihydroergotamine
- Donnatal
- dronedarone
- dutasteride-tamsulosin
- efavirenz-emtricitabin-tenofov
- eletriptan HBr
- enzalutamide
- Epitol
- eplerenone
- Equetro
- ergoloid
- Ergomar
- ergotamine tartrate
- ergotamine-caffeine
- ezetimibe-simvastatin
- Fatigue Relief Complex
- Flomax
- Inspra
- irinotecan
- isoniazid-rifamp-pyrazinamide
- Jalyn
- Juxtapid
- Kombiglyze Xr
- Latuda
- lomitapide
- lovastatin
- Luminal
- lurasidone
- methylergonovine
- Mevacor
- Migergot
- Migranal
- Multaq
- Mycobutin
- Mysoline
- Nexterone
- niacin-lovastatin
- niacin-simvastatin
- Nuedexta
- Orap
- Pacerone
- Parlodel
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- pimozide
- primidone
- quinidine gluconate
- quinidine sulfate
- Rapaflo
- Rapamune
- Relpax
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- Samsca
- saxagliptin-metformin
- silodosin
- Simcor
- simvastatin
- sirolimus
- St. John's wort
- Stendra
- tamsulosin
- Tegretol
- Tegretol Xr
- ticagrelor
- tolterodine
- tolvaptan
- Uroxatral
- Vaprisol
- vit C-St. John wort-elder-hb30
- Vytorin 10-10
- Vytorin 10-20
- Vytorin 10-40
- Vytorin 10-80
- Women's Complex
- Xtandi
- Zocor
Contraindicated
- Abstral
- Actiq
- Afinitor
- Afinitor Disperz
- Alfenta
- alfentanil
- artemether-lumefantrine
- Astagraf Xl
- citalopram
- clopidogrel
- Coartem
- colchicine
- colchicine-probenecid
- Colcrys
- Coumadin
- cyclosporine
- cyclosporine modified
- darunavir
- Diflucan
- Diskets
- Dolophine
- droperidol
- Duragesic
- efavirenz
- Endocet
- Endodan
- everolimus
- fentanyl
- fentanyl citrate
- fentanyl citrate (PF)
- Fentora
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- Gengraf
- Geodon
- guanfacine
- Hecoria
- ibuprofen-oxycodone
- Intuniv Er
- Jantoven
- Kaletra
- Korlym
- Lazanda
- lopinavir-ritonavir
- macitentan
- Marqibo
- methadone
- Methadone Intensol
- Methadose
- mifepristone
- Navelbine
- Neoral
- Norvir
- Norvir Soft Gelatin
- Oleptro Er
- Olysio
- Opsumit
- ospemifene
- Osphena
- Oxecta
- oxycodone
- oxycodone-acetaminophen
- oxycodone-aspirin
- Oxycontin
- Percocet
- Percodan
- Plavix
- Prezista
- Primlev
- Prograf
- quetiapine
- ritonavir
- Roxicet
- Sandimmune
- Seroquel
- Seroquel Xr
- simeprevir
- Sublimaze (pf)
- Subsys
- Sustiva
- tacrolimus
- temsirolimus
- Tenex
- thioridazine
- Torisel
- trazodone
- vinblastine
- Vincasar Pfs
- vincristine
- vincristine sulfate liposomal
- vinorelbine
- warfarin
- Xartemis Xr
- ziprasidone HCl
- ziprasidone mesylate
- Zortress
Severe
Moderate
- A-hydrocort
- A-methapred
- Abilify
- Abilify Discmelt
- Abilify Maintena
- Adalat Cc
- Adcirca
- Advair Diskus
- Advair Hfa
- Advil
- Advil Allergy Sinus
- Advil Allergy-congestion Rlf
- Advil Cold & Sinus
- Advil Congestion Relief
- Advil Liqui-gel
- Advil Migraine
- Advil Pm
- Advil Pm Liqui-gels
- Afeditab Cr
- Aleve
- Aleve Cold & Sinus
- Aleve Sinus & Headache
- Aleve-d Sinus & Cold
- Aleve-d Sinus & Headache
- aliskiren-amlodipin-hcthiazide
- aliskiren-amlodipine
- All Day Pain Relief
- All Day Pain Relief Sinus & Co
- All Day Relief
- Aloxi
- alprazolam
- Alprazolam Intensol
- Alvesco
- Amaryl
- Ambien
- Ambien Cr
- amlodipine
- amlodipine-atorvastatin
- amlodipine-benazepril
- amlodipine-olmesartan
- amlodipine-valsartan
- amlodipine-valsartan-hcthiazid
- Amturnide
- Anaprox
- Anaprox Ds
- Ansaid
- Anti-diarrhea
- Anti-diarrheal (lope)-anti-gas
- Anti-diarrheal (loperamide)
- Anucort-hc
- Anusol-hc
- Anzemet
- Apokyn
- apomorphine
- aripiprazole
- arsenic trioxide
- Arthrotec 50
- asenapine
- Asmanex Twisthaler
- atorvastatin
- Avelox
- Avelox Abc Pack
- Avelox In Nacl (iso-osmotic)
- azelastine-fluticasone
- Azor
- Betapace
- Betapace Af
- boceprevir
- bosentan
- Breo Ellipta
- budesonide
- budesonide-formoterol
- buspirone
- Caduet
- Calan
- Calan Sr
- Caldolor
- Cambia
- Caprelsa
- Cardene Iv
- Cardene Iv In Dextrose
- Cardene Iv In Sodium Chloride
- Cardene Sr
- Cardizem
- Cardizem Cd
- Cardizem La
- Cartia Xt
- Cataflam
- Celebrex
- celecoxib
- Celexa
- Child Ibuprofen
- Children's Advil
- Children's Ibu-drops
- Children's Ibuprofen
- Children's Medi-profen
- Children's Motrin
- Children's Profen Ib
- chlorphen-phenyleph-ibuprofen
- chlorphen-pseudoeph-ibuprofen
- Cialis
- ciclesonide
- cilostazol
- Cipro
- Cipro In D5W
- Cipro Xr
- ciprofloxacin
- ciprofloxacin (mixture)
- ciprofloxacin in D5W
- clobazam
- clozapine
- Clozaril
- Cold & Sinus Pain Relief
- Cold-sinus Relief
- Colocort
- Complera
- Cortef
- Cortenema
- Cortifoam
- darifenacin
- Depo-medrol
- Detrol
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- Diabeta
- Diamode
- Diastat
- Diastat Acudial
- diazepam
- Diazepam Intensol
- diclofenac epolamine
- diclofenac potassium
- diclofenac sodium
- diclofenac submicronized
- diclofenac-misoprostol
- Dilacor Xr
- Dilt-xr
- diltiazem HCl
- dofetilide
- dolasetron
- Duetact
- Duexis
- Dulera
- Dymista
- Ec-naprosyn
- Edluar
- Edurant
- emtricitab-rilpivirine-tenofov
- Enablex
- Entocort Ec
- erlotinib
- escitalopram oxalate
- estazolam
- eszopiclone
- Exforge
- Exforge Hct
- ezetimibe-atorvastatin
- Fazaclo
- Feldene
- felodipine
- fesoterodine
- Fetzima
- First-duke's
- First-mary's Mouthwash
- First-omeprazole
- Flanax
- Flector
- Flo-pred
- Flonase
- Flovent Diskus
- Flovent Hfa
- fludrocortisone
- flurbiprofen
- fluticasone
- fluticasone furoate
- fluticasone-salmeterol
- fluticasone-vilanterol
- fluvastatin
- Foradil Aerolizer
- formoterol fumarate
- Gleevec
- glimepiride
- glipizide
- glipizide-metformin
- Glucotrol
- Glucotrol Xl
- Glucovance
- glyburide
- glyburide micronized
- glyburide-metformin
- Glynase
- Grx Hicort 25
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- Hemril-30
- hydrocodone-ibuprofen
- hydrocortisone
- hydrocortisone acetate
- hydrocortisone sod succ (PF)
- hydrocortisone sod succinate
- I-prin
- Ibu-drops
- Ibudone
- ibuprofen
- Ibuprofen Cold
- Ibuprofen Cold-sinus(with Pse)
- Ibuprofen Ib
- Ibuprofen Jr Strength
- ibuprofen lysine (PF)
- Ibuprofen Pm
- ibuprofen-diphenhydramine
- ibuprofen-diphenhydramine HCl
- ibuprofen-famotidine
- ibuprofen-phenylephrine HCl
- imatinib
- Imodium Multi-symptom Relief
- Incivek
- Infant's Ibuprofen
- Infant's Medi-profen
- Infant's Motrin
- Infants Ibu-drops
- Infants Profenib
- Intermezzo
- Invega
- Invega Sustenna
- Invirase
- Istodax
- ivacaftor
- Kalydeco
- Lescol
- Lescol Xl
- Levaquin
- Levaquin In 5 % Dextrose
- levofloxacin
- levofloxacin in D5W
- levomilnacipran
- Lexapro
- Lipitor
- Liptruzet
- Lo-peramide
- loperamide
- loperamide-simethicone
- Lotrel
- Lunesta
- Matzim La
- Medi-profen
- Mediproxen
- Medrol
- Medrol (pak)
- mefloquine
- meloxicam
- methylprednisolone
- methylprednisolone acetate
- methylprednisolone sod suc(PF)
- methylprednisolone sodium succ
- methylprednisolone-bupivacaine
- midazolam
- midazolam (PF)
- Midol (naproxen)
- Millipred
- Millipred Dp
- Mobic
- mometasone
- mometasone-formoterol
- Motrin Ib
- Motrin Pm
- moxifloxacin
- moxifloxacin in NaCl (iso-osm)
- Naprelan Cr
- Naprosyn
- naproxen
- naproxen sodium
- naproxen-esomeprazole
- naproxen-pseudoephedrine
- Neoprofen (ibuprofen Lysn)(pf)
- nicardipine
- nicardipine in dextrose,iso-os
- nicardipine in NaCl (iso-os)
- Nifedical Xl
- nifedipine
- Niravam
- nisoldipine
- norfloxacin
- Noroxin
- Norvasc
- Noxafil
- nystatin-hydrocortisone-diphen
- nystatin-TCN-HC-diphenhydramin
- olmesartan-amlodipin-hcthiazid
- Omeclamox-pak
- omeprazole
- omeprazole magnesium
- Omeprazole+syrspend Sf Alka
- omeprazole-clarith-amoxicillin
- omeprazole-sodium bicarbonate
- Omnaris
- ondansetron
- ondansetron HCl
- ondansetron HCl (PF)
- Onfi
- Onglyza
- Orapred
- Orapred Odt
- paliperidone
- paliperidone palmitate
- palonosetron
- Pediapred
- Perforomist
- Physicians Ez Use M-pred
- pioglitazone-glimepiride
- piroxicam
- Pletal
- pomalidomide
- Pomalyst
- posaconazole
- prednisolone
- prednisolone acetate
- prednisolone sodium phosphate
- prednisone
- Prednisone Intensol
- Prilosec
- Prilosec Otc
- Procardia
- Procardia Xl
- Proctocort
- propafenone
- Provil
- pseudoephedrine-ibuprofen
- Pulmicort
- Pulmicort Flexhaler
- Qualaquin
- quinine sulfate
- Rayos
- Rectacort-hc
- regorafenib
- Reprexain
- Revatio
- Rhinocort Aqua
- rilpivirine
- Risperdal
- Risperdal Consta
- Risperdal M-tab
- risperidone
- risperidone microspheres
- romidepsin
- Rythmol
- Saphris
- Saphris (black Cherry)
- saquinavir mesylate
- saxagliptin
- sildenafil
- Sinus & Cold-d
- solifenacin
- Solu-cortef
- Solu-cortef (pf)
- Solu-medrol
- Solu-medrol (pf)
- Sorine
- sotalol
- Sotalol Af
- Stivarga
- Sular
- Symbicort
- tadalafil
- Tarceva
- Tarka
- Taztia Xt
- Tekamlo
- telaprevir
- telavancin
- telmisartan-amlodipine
- tetrabenazine
- Tiazac
- Tikosyn
- tolazamide
- tolbutamide
- Toviaz
- Tracleer
- trandolapril-verapamil
- triazolam
- Tribenzor
- Trisenox
- Twynsta
- Uceris
- Ultra A-d
- Valium
- vandetanib
- Veramyst
- verapamil
- Verelan
- Verelan Pm
- Veripred 20
- Versacloz
- Vesicare
- Viagra
- Vibativ
- Vicoprofen
- Victrelis
- Vimovo
- Voltaren-xr
- Wal-profen
- Wal-profen Cold-sinus
- Wal-proxen
- Xanax
- Xanax Xr
- Xenazine
- Zegerid
- Zegerid Otc
- Zetonna
- Zipsor
- Zofran
- Zofran Odt
- zolpidem
- Zolpimist
- Zorvolex
- Zuplenz
- Lactating mother
- Torsades de pointes
Contraindicated
- Acute pancreatitis
- Congenital long QT syndrome
- CYp2c19 poor metabolizer
- Hepatic cirrhosis
- Hypocalcemia
- Hypokalemia
- Hypomagnesemia
- Optic neuritis
- Periostitis
- Pregnancy
- Prolonged QT interval
- Renal disease with moderate to severe impairment
- Skeletal fluorosis
Severe
Moderate
- Abnormal hepatic function tests
- Cardiomyopathy
VFEND IV (VORICONAZOLE)
- Aspergillosis
- Candidemia
- Disseminated candidiasis
- Esophageal candidiasis
- Fungal infection due to scedosporium apiospermum
- Fusarium infection
- Invasive pulmonary aspergillosis
- Abnormal hepatic function tests
- Fever
- Tachycardia
- Visual changes
- Chills
- Nausea
- Skin rash
- Vomiting
More Frequent
Severe
Less Severe
- Chest pain
- Hypertension
- Hypokalemia
- Hypomagnesemia
- Hypotension
- Obstructive hyperbilirubinemia
- Peripheral edema
- Pruritus of skin
- Vasodilation of blood vessels
- Acquired chromatopsia
- Acute abdominal pain
- Cheilitis
- Diarrhea
- Hallucinations
- Headache disorder
- Maculopapular rash
- Papilledema
- Photophobia
- Xerostomia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute hepatic failure
- Acute pancreatitis
- Acute respiratory distress syndrome
- Adrenal cortical insufficiency
- Agranulocytosis
- Anaphylaxis
- Anemia
- Angioedema
- Anuria
- Aplastic anemia
- Ascites
- Atrial arrhythmia
- Bacterial sepsis
- Bloody vomit
- Bradycardia
- Bundle branch block
- Cardiomegaly
- Cerebral ischemia
- Cerebrovascular accident
- Cholestasis
- Clostridium difficile infection
- Complete atrioventricular block
- Corneal opacity
- Diabetes insipidus
- Disseminated intravascular coagulation
- Erythema multiforme
- Esophageal ulcer
- Esophagitis
- Extrapyramidal disease
- Gastroenteritis
- Gastrointestinal hemorrhage
- Gastrointestinal perforation
- Gingival bleeding
- Hematuria
- Hemolytic anemia
- Hemorrhagic cystitis
- Hepatic failure
- Hepatitis
- Hyperbilirubinemia
- Hyperthyroidism
- Hypothyroidism
- Interstitial nephritis
- Intracranial hypertension
- Jaundice
- Leukopenia
- Malignant melanoma
- Multiple organ failure
- Neutropenic disorder
- Ocular hemorrhage
- Optic neuritis
- Osteomalacia
- Osteoporosis
- Pancytopenia
- Periostitis
- Prolonged QT interval
- Psoriasis
- Rectal bleeding
- Renal failure
- Renal tubular necrosis
- Retinal hemorrhage
- Seizure disorder
- Skeletal fluorosis
- Squamous cell carcinoma
- Stevens-johnson syndrome
- Subacute cutaneous lupus erythematosus
- Suicidal ideation
- Thrombocytopenic disorder
- Thrombotic thrombocytopenic purpura
- Tongue swelling
- Torsades de pointes
- Toxic epidermal necrolysis
- Ventricular arrhythmias
- Visual field defect
Less Severe
- Abnormal vaginal bleeding
- Acute confusion
- Alopecia
- Anorexia
- Arthralgias
- Back pain
- Blepharitis
- Bronchospastic pulmonary disease
- Constipation
- Cramps in legs
- Delirium
- Dizziness
- Dysmenorrhea
- Dyspepsia
- Dysphagia
- Dysuria
- Epididymitis
- Erectile dysfunction
- Facial edema
- Flank pain
- Flatulence
- General weakness
- Gingivitis
- Glossitis
- Myalgias
- Nasal congestion
- Non-cardiac chest pain
- Pseudoporphyria
- Skin inflammation
- Skin photosensitivity
- Thrombophlebitis
- Tinnitus
- Urinary incontinence
- Urinary tract infection
- Urticaria
- Uveitis
- Voice change
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Voriconazole
Increased risk of phototoxicity. Potential adverse effects on bone development. No safety and efficacy established age <2 years.
Increased risk of phototoxicity. Use photoprotection during and post treatment. Increased frequency of liver enzyme elevation. Fluorosis, periostitis and pancreatitis reported.
- 1 Day – 2 Years
- Increased risk of phototoxicity. Potential adverse effects on bone development. No safety and efficacy established age <2 years.
- Increased risk of phototoxicity. Use photoprotection during and post treatment. Increased frequency of liver enzyme elevation. Fluorosis, periostitis and pancreatitis reported.
- 2 Years – 18 Years
- Increased risk of phototoxicity. Potential adverse effects on bone development. No safety and efficacy established age <2 years.
- Increased risk of phototoxicity. Use photoprotection during and post treatment. Increased frequency of liver enzyme elevation. Fluorosis, periostitis and pancreatitis reported.
Voriconazole
- Severity Level:
D
- Additional Notes: Insuff human data; animal data sugg dev tox at doses less than 10 times mrhd
Contraindicated
Voriconazole
Potential toxicity,esp in neonates;Molecular wt low enough for poss excretion
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Potential toxicity,esp in neonates;Molecular wt low enough for poss excretion |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Aspergillosis | |
| B44 | Aspergillosis |
| B44.0 | Invasive pulmonary aspergillosis |
| B44.1 | Other pulmonary aspergillosis |
| B44.2 | Tonsillar aspergillosis |
| B44.7 | Disseminated aspergillosis |
| B44.8 | Other forms of aspergillosis |
| B44.81 | Allergic bronchopulmonary aspergillosis |
| B44.89 | Other forms of aspergillosis |
| B44.9 | Aspergillosis, unspecified |
| Candidemia | |
| B37.7 | Candidal sepsis |
| Disseminated candidiasis | |
| B37.5 | Candidal meningitis |
| B37.6 | Candidal endocarditis |
| B37.7 | Candidal sepsis |
| B37.89 | Other sites of candidiasis |
| Esophageal candidiasis | |
| B37.81 | Candidal esophagitis |
| Fungal infection due to scedosporium apiospermum | |
| B48.2 | Allescheriasis |
| Fusarium infection | |
| B48.8 | Other specified mycoses |
| Invasive pulmonary aspergillosis | |
| B44.0 | Invasive pulmonary aspergillosis |
| 0-9 | A-Z |
|---|---|
| B37.5 | Candidal meningitis |
| B37.6 | Candidal endocarditis |
| B37.7 | Candidal sepsis |
| B37.7 | Candidal sepsis |
| B37.81 | Candidal esophagitis |
| B37.89 | Other sites of candidiasis |
| B44 | Aspergillosis |
| B44.0 | Invasive pulmonary aspergillosis |
| B44.0 | Invasive pulmonary aspergillosis |
| B44.1 | Other pulmonary aspergillosis |
| B44.2 | Tonsillar aspergillosis |
| B44.7 | Disseminated aspergillosis |
| B44.8 | Other forms of aspergillosis |
| B44.81 | Allergic bronchopulmonary aspergillosis |
| B44.89 | Other forms of aspergillosis |
| B44.9 | Aspergillosis, unspecified |
| B48.2 | Allescheriasis |
| B48.8 | Other specified mycoses |
Formulary Reference Tool