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TIKOSYN (DOFETILIDE)
- Cardioversion of atrial fibrillation
- Cardioversion of atrial flutter
- Prevention of recurrent atrial fibrillation
125 mcg capsule
- 1 capsule (125 mcg) by oral route 2 times per day
250 mcg capsule
- 1 capsule (250 mcg) by oral route 2 times per day
500 mcg capsule
- 1 capsule (0.5 mg) by oral route 2 times per day
125 mcg capsule
- 1 capsule (125 mcg) by oral route 2 times per day
250 mcg capsule
- 1 capsule (250 mcg) by oral route 2 times per day
500 mcg capsule
- 1 capsule (0.5 mg) by oral route 2 times per day
Cardioversion of atrial fibrillation
- 1 capsule (0.5 mg) by oral route 2 times per day
- 2 capsules (0.5 mg) by oral route 2 times per day
- 4 capsules (0.5 mg) by oral route 2 times per day
- 1 capsule (125 mcg) by oral route once daily
- 1 capsule (125 mcg) by oral route 2 times per day
- 1 capsule (250 mcg) by oral route 2 times per day
Cardioversion of atrial flutter
- 1 capsule (0.5 mg) by oral route 2 times per day
- 2 capsules (0.5 mg) by oral route 2 times per day
- 4 capsules (0.5 mg) by oral route 2 times per day
- 1 capsule (125 mcg) by oral route once daily
- 1 capsule (125 mcg) by oral route 2 times per day
- 1 capsule (250 mcg) by oral route 2 times per day
Prevention of recurrent atrial fibrillation
- 1 capsule (0.5 mg) by oral route 2 times per day
- 2 capsules (0.5 mg) by oral route 2 times per day
- 4 capsules (0.5 mg) by oral route 2 times per day
- 1 capsule (125 mcg) by oral route once daily
- 1 capsule (125 mcg) by oral route 2 times per day
- 1 capsule (250 mcg) by oral route 2 times per day
- Accuretic
- Acid Reducer (cimetidine)
- Acid Relief (cimetidine)
- Aldactazide
- aliskiren-amlodipin-hcthiazide
- aliskiren-hydrochlorothiazide
- amiloride-hydrochlorothiazide
- amiodarone
- amiodarone in dextrose,iso-osm
- amlodipine-valsartan-hcthiazid
- Amturnide
- artemether-lumefantrine
- Atacand Hct
- Avalide
- Bactrim
- Bactrim Ds
- benazepril-hydrochlorothiazide
- Benicar Hct
- Betapace
- Betapace Af
- bisoprolol-hydrochlorothiazide
- Calan
- Calan Sr
- candesartan-hydrochlorothiazid
- captopril-hydrochlorothiazide
- cimetidine
- Coartem
- Compazine
- Compro
- Cordarone
- Corvert
- dextromethorphan-quinidine
- Diovan Hct
- disopyramide
- dolutegravir
- dronedarone
- droperidol
- Dutoprol
- Dyazide
- enalapril-hydrochlorothiazide
- eprosartan-hydrochlorothiazide
- Exforge Hct
- fingolimod
- flecainide
- fosinopril-hydrochlorothiazide
- Geodon
- Gilenya
- Heartburn Relief
- hydrochlorothiazide
- Hyzaar
- ibutilide fumarate
- Invirase
- irbesartan-hydrochlorothiazide
- itraconazole
- ketoconazole
- lisinopril-hydrochlorothiazide
- Lopressor Hct
- losartan-hydrochlorothiazide
- Maxzide
- Maxzide-25Mg
- Megace
- Megace Es
- megestrol
- methyldopa-hydrochlorothiazide
- metoprolol su-hydrochlorothiaz
- metoprolol ta-hydrochlorothiaz
- Micardis Hct
- Microzide
- moexipril-hydrochlorothiazide
- Multaq
- Nexterone
- Norpace
- Norpace Cr
- Nuedexta
- olmesartan-amlodipin-hcthiazid
- olmesartan-hydrochlorothiazide
- Onmel
- Orap
- Pacerone
- pimozide
- Primsol
- procainamide
- prochlorperazine
- prochlorperazine Edisylate
- prochlorperazine maleate
- propafenone
- propranolol-hydrochlorothiazid
- quinapril-hydrochlorothiazide
- quinidine gluconate
- quinidine sulfate
- Rythmol
- saquinavir mesylate
- Sorine
- sotalol
- Sotalol Af
- spironolacton-hydrochlorothiaz
- Sporanox
- Sporanox Pulsepak
- sulfamethoxazole-trimethoprim
- Sulfatrim
- Tagamet Hb
- Tarka
- Tekturna Hct
- telmisartan-hydrochlorothiazid
- Teveten Hct
- Tivicay
- trandolapril-verapamil
- triamterene-hydrochlorothiazid
- Tribenzor
- trimethoprim
- Uniretic
- valsartan-hydrochlorothiazide
- Vaseretic
- verapamil
- Verelan
- Verelan Pm
- Zestoretic
- Ziac
- ziprasidone HCl
- ziprasidone mesylate
Contraindicated
- Anzemet
- Avelox
- Avelox Abc Pack
- Avelox In Nacl (iso-osmotic)
- Buprenex
- buprenorphine
- buprenorphine-naloxone
- Butrans
- Caprelsa
- chloroquine phosphate
- chlorpromazine
- Cipro
- Cipro In D5W
- Cipro Xr
- ciprofloxacin
- ciprofloxacin (mixture)
- ciprofloxacin in D5W
- Diskets
- dolasetron
- Dolophine
- Fareston
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- Invega
- Invega Sustenna
- Kaletra
- Ketek
- Levaquin
- Levaquin In 5 % Dextrose
- Levitra
- levofloxacin
- levofloxacin in D5W
- lopinavir-ritonavir
- methadone
- Methadone Intensol
- Methadose
- moxifloxacin
- moxifloxacin in NaCl (iso-osm)
- Nebupent
- nilotinib
- norfloxacin
- Noroxin
- ofloxacin
- ondansetron
- ondansetron HCl
- ondansetron HCl (PF)
- paliperidone
- paliperidone palmitate
- Pentam
- pentamidine
- Qualaquin
- quinine sulfate
- Suboxone
- Tasigna
- telithromycin
- tetrabenazine
- thioridazine
- toremifene
- vandetanib
- vardenafil
- Xenazine
- Zofran
- Zofran Odt
- Zubsolv
- Zuplenz
Severe
Moderate
- Advair Diskus
- Advair Hfa
- alfuzosin
- amantadine HCl
- Apokyn
- apomorphine
- Astagraf Xl
- Cardene Iv
- Cardene Iv In Dextrose
- Cardene Iv In Sodium Chloride
- Cardene Sr
- clozapine
- Clozaril
- Complera
- dasatinib
- Detrol
- Detrol La
- Diflucan
- Edurant
- Effexor Xr
- emtricitab-rilpivirine-tenofov
- Eovist
- Fazaclo
- felbamate
- Felbatol
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- fluticasone-salmeterol
- foscarnet
- Foscavir
- gadoxetate
- granisetron
- granisetron (PF)
- Granisol
- Hecoria
- indapamide
- isradipine
- lapatinib
- lithium carbonate
- lithium citrate
- Lithobid
- moexipril
- nicardipine
- nicardipine in dextrose,iso-os
- nicardipine in NaCl (iso-os)
- Noxafil
- octreotide acetate
- pasireotide
- pazopanib
- posaconazole
- Prograf
- quetiapine
- rilpivirine
- Risperdal
- Risperdal Consta
- Risperdal M-tab
- risperidone
- risperidone microspheres
- salmeterol
- Sancuso
- Sandostatin
- Sandostatin Lar Depot
- Serevent Diskus
- Seroquel
- Seroquel Xr
- Signifor
- Soltamox
- Sprycel
- sunitinib
- Sutent
- tacrolimus
- tamoxifen
- tizanidine
- tolterodine
- Tykerb
- Univasc
- Uroxatral
- venlafaxine
- Versacloz
- Vfend
- Vfend Iv
- voriconazole
- Votrient
- Zanaflex
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Congenital long QT syndrome
- Prolonged QT interval
- Torsades de pointes
Contraindicated
- Hypokalemia
- Hypomagnesemia
- Kidney disease with likely reduction in GFR
- Severe diarrhea
Severe
Moderate
- Anorexia
- Disease of liver
- Hyperhidrosis
- Vomiting
TIKOSYN (DOFETILIDE)
- Cardioversion of atrial fibrillation
- Cardioversion of atrial flutter
- Prevention of recurrent atrial fibrillation
- Chest pain
- Prolonged QT interval
- Ventricular arrhythmias
- Ventricular tachycardia
- Headache disorder
More Frequent
Severe
Less Severe
- Angioedema
- Atrioventricular block
- Bradycardia
- Bundle branch block
- Edema
- Heart block
- Paresthesia
- Syncope
- Ventricular fibrillation
- Abdominal pain with cramps
- Back pain
- Cough
- Diarrhea
- Dizziness
- Dyspnea
- Flu-like symptoms
- Insomnia
- Migraine
- Nausea
- Skin rash
- Upper respiratory infection
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute myocardial infarction
- Cardiac arrest
- Cerebral ischemia
- Cerebrovascular accident
- Disease of liver
- Torsades de pointes
Less Severe
- None
Contraindicated
None
Severe Precaution
Dofetilide
Safety and efficacy not established age less than 18 years.
- 1 Day – 18 Years
- Safety and efficacy not established age less than 18 years.
Management or Monitoring Precaution
None
Dofetilide
- Severity Level:
C
- Additional Notes: Insufficient human data; animal data suggest developmental toxicity
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Dofetilide
Use not recomm. molecular weight low enough for possible breastmilk excretion
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Use not recomm. molecular weight low enough for possible breastmilk excretion |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Dofetilide
Cardiovascular-Monitor QTc particularly in patients with renal impairment. Manage hypokalemia in patients predisposed to minimize risk for QTc prolongation. Renal-Adjust dose for CrCL<61 mL/min. Avoid for CrCL < 20 mL/min.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | N | Y | N | N | N |
BEERS: Y HEDIS: N STOPP: Y
No Known Risk
None
- Though this medication often gives great benefits to people with irregular heartbeat, it may rarely cause a serious new irregular heartbeat. Therefore, when starting, restarting, or increasing your dose with this drug, your doctor will recommend that you stay in the hospital for at least 3 days for proper monitoring. Before your doctor can prescribe this medication for you, your doctor must have completed the Tikosyn Education Distribution Program.<br /><br />Only pharmacies that have enrolled in the T.I.P.S.<br /><br />program may dispense this medication to you. Talk with your doctor about the benefits and risks of taking this medication.
| Cardioversion of atrial flutter | |
| I48.3 | Typical atrial flutter |
| I48.4 | Atypical atrial flutter |
| I48.92 | Unspecified atrial flutter |
| Prevention of recurrent atrial fibrillation | |
| I48.0 | Paroxysmal atrial fibrillation |
| I48.1 | Persistent atrial fibrillation |
| I48.91 | Unspecified atrial fibrillation |
| 0-9 | A-Z |
|---|---|
| I48.0 | Paroxysmal atrial fibrillation |
| I48.1 | Persistent atrial fibrillation |
| I48.3 | Typical atrial flutter |
| I48.4 | Atypical atrial flutter |
| I48.91 | Unspecified atrial fibrillation |
| I48.92 | Unspecified atrial flutter |
Formulary Reference Tool