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TAPAZOLE (METHIMAZOLE)
- Hyperthyroidism
10 mg tablet
- 1 tablet (10 mg) by oral route once daily
5 mg tablet
- 1 tablet (5 mg) by oral route once daily
10 mg tablet
- 1 tablet (10 mg) by oral route once daily
5 mg tablet
- 1 tablet (5 mg) by oral route once daily
Hyperthyroidism
- 1 tablet (5 mg) by oral route once daily
- 1 tablet (5 mg) by oral route every 8 hours
- 1 tablet (10 mg) by oral route once daily
- None
Contraindicated
- clozapine
- Clozaril
- deferiprone
- Fazaclo
- Ferriprox
- Versacloz
Severe
Moderate
- Coumadin
- Digox
- digoxin
- Dutoprol
- Inderal La
- Inderal Xl
- Innopran Xl
- Jantoven
- Lanoxin
- Lanoxin Pediatric
- Lopressor
- Lopressor Hct
- metoprolol su-hydrochlorothiaz
- metoprolol succinate
- metoprolol ta-hydrochlorothiaz
- metoprolol tartrate
- propranolol
- propranolol-hydrochlorothiazid
- Toprol Xl
- warfarin
- Agranulocytosis
- Drug-induced hepatitis
- Pancytopenia
Contraindicated
- Abnormal hepatic function tests
- Bone marrow depression
- Leukopenia
- Pregnancy
- Thrombocytopenic disorder
Severe
Moderate
- Hypoprothrombinemia
- Hypothyroidism
TAPAZOLE (METHIMAZOLE)
- Hyperthyroidism
- Fever
- Leukopenia
- Pruritus of skin
- Skin rash
- None
More Frequent
Severe
Less Severe
- Agranulocytosis
- Peripheral neuropathy
- Dizziness
- Dysgeusia
- Nausea
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute pancreatitis
- Aplastic anemia
- Granulocytopenic disorder
- Hepatitis
- Lymphadenopathy
- Nephritis
- Neutropenic disorder
- Obstructive hyperbilirubinemia
- Parotitis
- Thrombocytopenic disorder
Less Severe
- Edema
- Jaundice
- Lupus-like syndrome
- Paresthesia
- Skin pigmentation enhancement
- Vertigo
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
None
Methimazole
- Severity Level:
D
- Additional Notes:
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Methimazole
Monitor infant for adverse effects and thyroid function
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Monitor infant for adverse effects and thyroid function |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Hyperthyroidism | |
| E05 | Thyrotoxicosis [hyperthyroidism] |
| E05.0 | Thyrotoxicosis with diffuse goiter |
| E05.00 | Thyrotoxicosis with diffuse goiter without thyrotoxic crisis or storm |
| E05.01 | Thyrotoxicosis with diffuse goiter with thyrotoxic crisis or storm |
| E05.1 | Thyrotoxicosis with toxic single thyroid nodule |
| E05.10 | Thyrotoxicosis with toxic single thyroid nodule without thyrotoxic crisis or storm |
| E05.11 | Thyrotoxicosis with toxic single thyroid nodule with thyrotoxic crisis or storm |
| E05.2 | Thyrotoxicosis with toxic multinodular goiter |
| E05.20 | Thyrotoxicosis with toxic multinodular goiter without thyrotoxic crisis or storm |
| E05.21 | Thyrotoxicosis with toxic multinodular goiter with thyrotoxic crisis or storm |
| E05.3 | Thyrotoxicosis from ectopic thyroid tissue |
| E05.30 | Thyrotoxicosis from ectopic thyroid tissue without thyrotoxic crisis or storm |
| E05.31 | Thyrotoxicosis from ectopic thyroid tissue with thyrotoxic crisis or storm |
| E05.4 | Thyrotoxicosis factitia |
| E05.40 | Thyrotoxicosis factitia without thyrotoxic crisis or storm |
| E05.41 | Thyrotoxicosis factitia with thyrotoxic crisis or storm |
| E05.8 | Other thyrotoxicosis |
| E05.80 | Other thyrotoxicosis without thyrotoxic crisis or storm |
| E05.81 | Other thyrotoxicosis with thyrotoxic crisis or storm |
| E05.9 | Thyrotoxicosis, unspecified |
| E05.90 | Thyrotoxicosis, unspecified without thyrotoxic crisis or storm |
| E05.91 | Thyrotoxicosis, unspecified with thyrotoxic crisis or storm |
| 0-9 | A-Z |
|---|---|
| E05 | Thyrotoxicosis [hyperthyroidism] |
| E05.0 | Thyrotoxicosis with diffuse goiter |
| E05.00 | Thyrotoxicosis with diffuse goiter without thyrotoxic crisis or storm |
| E05.01 | Thyrotoxicosis with diffuse goiter with thyrotoxic crisis or storm |
| E05.1 | Thyrotoxicosis with toxic single thyroid nodule |
| E05.10 | Thyrotoxicosis with toxic single thyroid nodule without thyrotoxic crisis or storm |
| E05.11 | Thyrotoxicosis with toxic single thyroid nodule with thyrotoxic crisis or storm |
| E05.2 | Thyrotoxicosis with toxic multinodular goiter |
| E05.20 | Thyrotoxicosis with toxic multinodular goiter without thyrotoxic crisis or storm |
| E05.21 | Thyrotoxicosis with toxic multinodular goiter with thyrotoxic crisis or storm |
| E05.3 | Thyrotoxicosis from ectopic thyroid tissue |
| E05.30 | Thyrotoxicosis from ectopic thyroid tissue without thyrotoxic crisis or storm |
| E05.31 | Thyrotoxicosis from ectopic thyroid tissue with thyrotoxic crisis or storm |
| E05.4 | Thyrotoxicosis factitia |
| E05.40 | Thyrotoxicosis factitia without thyrotoxic crisis or storm |
| E05.41 | Thyrotoxicosis factitia with thyrotoxic crisis or storm |
| E05.8 | Other thyrotoxicosis |
| E05.80 | Other thyrotoxicosis without thyrotoxic crisis or storm |
| E05.81 | Other thyrotoxicosis with thyrotoxic crisis or storm |
| E05.9 | Thyrotoxicosis, unspecified |
| E05.90 | Thyrotoxicosis, unspecified without thyrotoxic crisis or storm |
| E05.91 | Thyrotoxicosis, unspecified with thyrotoxic crisis or storm |
Formulary Reference Tool