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SUTENT (SUNITINIB MALATE)
- Gastrointestinal stromal tumor
- Pancreatic neuroendocrine tumor
- RCC adjuvant therapy following nephrectomy
- Renal cell carcinoma
12.5 mg capsule
- 1 capsule (12.5 mg) by oral route once daily
25 mg capsule
- 1 capsule (25 mg) by oral route once daily
37.5 mg capsule
- 1 capsule (37.5 mg) by oral route once daily
50 mg capsule
- 1 capsule (50 mg) by oral route once daily
Gastrointestinal stromal tumor
- 2 capsules (25 mg) by oral route once daily
- 2 capsules (50 mg) by oral route once daily
- 1 capsule (50 mg) by oral route once daily
- 1 capsule (12.5 mg) by oral route once daily
- 1 capsule (37.5 mg) by oral route once daily
Pancreatic neuroendocrine tumor
- 1 capsule (25 mg) by oral route once daily
- 2 capsules (25 mg) by oral route once daily
- 1 capsule (12.5 mg) by oral route once daily
- 1 capsule (37.5 mg) by oral route once daily
RCC adjuvant therapy following nephrectomy
- 2 capsules (25 mg) by oral route once daily
- 2 capsules (50 mg) by oral route once daily
- 1 capsule (50 mg) by oral route once daily
- 1 capsule (12.5 mg) by oral route once daily
- 1 capsule (37.5 mg) by oral route once daily
Renal cell carcinoma
- 2 capsules (25 mg) by oral route once daily
- 2 capsules (50 mg) by oral route once daily
- 1 capsule (50 mg) by oral route once daily
- 1 capsule (12.5 mg) by oral route once daily
- 1 capsule (37.5 mg) by oral route once daily
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- B cplx-C-St.Johnwrt-K.&S.ginsg
- BCG vaccine, live (PF)
- calcium-mag-B complex-D3-hrb61
- Cold & Flu Fighter
- Fatigue Relief Complex
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- St. John's wort
- typhoid vaccine
- varicella virus vacc live (PF)
- Varivax (pf)
- vit C-St. John wort-elder-hb30
- Vivotif Berna Vaccine
- Women's Complex
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- artemether-lumefantrine
- Avastin
- Belladonna-phenobarbital
- bevacizumab
- carbamazepine
- Carbatrol
- Cerebyx
- Coartem
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- Diflucan
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Donnatal
- dronedarone
- droperidol
- enzalutamide
- Epitol
- Equetro
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- fosphenytoin
- Geodon
- isoniazid-rifamp-pyrazinamide
- Luminal
- Multaq
- Mycobutin
- Mysoline
- Orap
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- pimozide
- primidone
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- Tegretol
- Tegretol Xr
- thioridazine
- Xtandi
- ziprasidone HCl
- ziprasidone mesylate
Severe
Moderate
- Ablavar
- alfuzosin
- amiodarone
- amiodarone in dextrose,iso-osm
- Anzemet
- Apokyn
- apomorphine
- arsenic trioxide
- Avelox
- Avelox Abc Pack
- Avelox In Nacl (iso-osmotic)
- bedaquiline
- Betapace
- Betapace Af
- Caprelsa
- Celexa
- Cipro
- Cipro In D5W
- Cipro Xr
- ciprofloxacin
- ciprofloxacin (mixture)
- ciprofloxacin in D5W
- citalopram
- clozapine
- Clozaril
- Complera
- Cordarone
- Corvert
- dasatinib
- Diskets
- disopyramide
- dofetilide
- dolasetron
- Dolophine
- Edurant
- emtricitab-rilpivirine-tenofov
- eribulin
- escitalopram oxalate
- ezogabine
- Fareston
- Fazaclo
- gadofosveset trisodium
- Halaven
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- ibutilide fumarate
- Invega
- Invega Sustenna
- Istodax
- lapatinib
- Levaquin
- Levaquin In 5 % Dextrose
- levofloxacin
- levofloxacin in D5W
- Lexapro
- methadone
- Methadone Intensol
- Methadose
- moxifloxacin
- moxifloxacin in NaCl (iso-osm)
- Nexavar
- Nexterone
- nilotinib
- norfloxacin
- Noroxin
- Norpace
- Norpace Cr
- Noxafil
- ondansetron
- ondansetron HCl
- ondansetron HCl (PF)
- Pacerone
- paliperidone
- paliperidone palmitate
- pasireotide
- pazopanib
- posaconazole
- Potiga
- procainamide
- propafenone
- Qualaquin
- quetiapine
- quinine sulfate
- rilpivirine
- romidepsin
- Rythmol
- Seroquel
- Seroquel Xr
- Signifor
- Sirturo
- sorafenib
- Sorine
- sotalol
- Sotalol Af
- Sprycel
- Tasigna
- telavancin
- tetrabenazine
- Tikosyn
- toremifene
- Trisenox
- Tykerb
- Uroxatral
- vandetanib
- vemurafenib
- Versacloz
- Vibativ
- Votrient
- Xenazine
- Zelboraf
- Zofran
- Zofran Odt
- Zuplenz
- Acute decompensated heart failure
- Arterial aneurysm
- Arterial dissection
- Hemolytic uremic syndrome
- Hepatic failure
- Lactating mother
- Pancreatitis
- Thrombotic thrombocytopenic purpura
Contraindicated
- Abnormal hepatic function tests
- Acute myocardial infarction
- Bradycardia
- Cardiomyopathy
- Congenital long QT syndrome
- Disease of liver
- Drug-induced hepatitis
- Heart failure
- Hemoptysis
- Hemorrhage
- Hyperbilirubinemia
- Hyperkalemia
- Hypermagnesemia
- Hypokalemia
- Hypomagnesemia
- Invasive surgical procedure
- Left ventricular failure
- Myocardial ischemia
- Nephrotic syndrome
- Posterior reversible encephalopathy syndrome
- Pregnancy
- Prolonged QT interval
- Proteinuria
- Severe hepatic disease
- Severe uncontrolled hypertension
- Thromboembolic disorder
- Torsades de pointes
Severe
Moderate
- Adrenal cortical insufficiency
- Anemia
- Diabetes mellitus
- Hyperthyroidism
- Hypoglycemic disorder
- Hypothyroidism
- Seizure disorder
- Thrombocytopenic disorder
SUTENT (SUNITINIB MALATE)
- Gastrointestinal stromal tumor
- Pancreatic neuroendocrine tumor
- RCC adjuvant therapy following nephrectomy
- Renal cell carcinoma
- Abnormal hepatic function tests
- Chronic heart failure
- Hemorrhage
- Hypertension
- Increased risk of bleeding
- Acute abdominal pain
- Anorexia
- Arthralgias
- Back pain
- Constipation
- Cough
- Diarrhea
- Dizziness
- Dry skin
- Dyschromia
- Dysgeusia
- Dyspepsia
- Dyspnea
- Fatigue
- Fever
- Flatulence
- General weakness
- Headache disorder
- Hypothyroidism
- Limb pain
- Nausea
- Peripheral edema
- Skin rash
- Stomatitis
- Vomiting
More Frequent
Severe
Less Severe
- Dehydration
- Hyperbilirubinemia
- Hypernatremia
- Hypoglycemic disorder
- Hypokalemia
- Infection
- Lymphopenia
- Neutropenic disorder
- Thrombocytopenic disorder
- Tumor hemorrhage
- Alopecia
- Myalgias
- Sore tongue
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute cerebral infarction
- Acute myocardial infarction
- Anemia
- Angioedema
- Arterial thrombosis
- Aseptic necrosis of jaw bone
- Cardiomyopathy
- Cerebrovascular accident
- Cholecystitis
- Dissection of aorta
- Erythema multiforme
- Esophagitis
- Hepatic failure
- Hepatitis
- Hypophosphatemia
- Impaired wound healing
- Kidney disease with reduction in GFR
- Left ventricular failure
- Myocardial ischemia
- Myopathy
- Necrotizing fasciitis
- Nephrotic syndrome
- New fistula formation involving an internal organ
- Palmar-plantar erythrodysesthesia
- Pancreatitis
- Pleural effusions
- Posterior reversible encephalopathy syndrome
- Prolonged QT interval
- Pulmonary thromboembolism
- Pyoderma gangrenosum
- Renal failure
- Rhabdomyolysis
- Stevens-johnson syndrome
- Thromboembolic disorder
- Thrombotic thrombocytopenic purpura
- Thyroiditis
- Torsades de pointes
- Toxic epidermal necrolysis
- Transient cerebral ischemia
Less Severe
- Hair discoloration
- Hypercortisolism
- Hyperthyroidism
- Proteinuria
- Skin and skin structure infection
- Upper respiratory infection
- Urinary tract infection
Contraindicated
None
Severe Precaution
Sunitinib
No efficacy response and poor tolerability reported in patients enrolled in small pediatric trials. Risk of cardiotoxicity and possible reversible bone growth plate dysplasia.
- 1 Day – 18 Years
- No efficacy response and poor tolerability reported in patients enrolled in small pediatric trials. Risk of cardiotoxicity and possible reversible bone growth plate dysplasia.
Management or Monitoring Precaution
None
Sunitinib
- Severity Level:
D
- Additional Notes: Serious adv effects possible; teratogenic, embryotoxic, and fetotoxic in animals
Contraindicated
Sunitinib
Avoid during tx and for 4 weeks after last dose
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Avoid during tx and for 4 weeks after last dose |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Sunitinib
General-In clinical trials, 16% of elderly patients experienced Grade 3-4 reactions. Cardiovascular-Aortic dissection and aortic aneurysm were more frequently reported in older patients.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | Y | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- Rarely, sunitinib has caused severe (sometimes fatal) liver problems. Get medical help right away if you develop symptoms of liver problems such as persistent nausea/vomiting, severe stomach/abdominal pain, dark urine, pale stools, or yellowing eyes/skin. Your doctor will monitor for liver problems with blood tests. Tell all of your doctors and pharmacists if you have ever stopped taking sunitinib because of liver problems (including high liver enzymes).
| Gastrointestinal stromal tumor | |
| C49.A | Gastrointestinal stromal tumor |
| C49.A0 | Gastrointestinal stromal tumor, unspecified site |
| C49.A1 | Gastrointestinal stromal tumor of esophagus |
| C49.A2 | Gastrointestinal stromal tumor of stomach |
| C49.A3 | Gastrointestinal stromal tumor of small intestine |
| C49.A4 | Gastrointestinal stromal tumor of large intestine |
| C49.A5 | Gastrointestinal stromal tumor of rectum |
| C49.A9 | Gastrointestinal stromal tumor of other sites |
| Pancreatic neuroendocrine tumor | |
| C25.4 | Malignant neoplasm of endocrine pancreas |
| RCC adjuvant therapy following nephrectomy | |
| C64 | Malignant neoplasm of kidney, except renal pelvis |
| C64.1 | Malignant neoplasm of right kidney, except renal pelvis |
| C64.2 | Malignant neoplasm of left kidney, except renal pelvis |
| C64.9 | Malignant neoplasm of unspecified kidney, except renal pelvis |
| Renal cell carcinoma | |
| C64 | Malignant neoplasm of kidney, except renal pelvis |
| C64.1 | Malignant neoplasm of right kidney, except renal pelvis |
| C64.2 | Malignant neoplasm of left kidney, except renal pelvis |
| C64.9 | Malignant neoplasm of unspecified kidney, except renal pelvis |
| 0-9 | A-Z |
|---|---|
| C25.4 | Malignant neoplasm of endocrine pancreas |
| C49.A | Gastrointestinal stromal tumor |
| C49.A0 | Gastrointestinal stromal tumor, unspecified site |
| C49.A1 | Gastrointestinal stromal tumor of esophagus |
| C49.A2 | Gastrointestinal stromal tumor of stomach |
| C49.A3 | Gastrointestinal stromal tumor of small intestine |
| C49.A4 | Gastrointestinal stromal tumor of large intestine |
| C49.A5 | Gastrointestinal stromal tumor of rectum |
| C49.A9 | Gastrointestinal stromal tumor of other sites |
| C64 | Malignant neoplasm of kidney, except renal pelvis |
| C64 | Malignant neoplasm of kidney, except renal pelvis |
| C64.1 | Malignant neoplasm of right kidney, except renal pelvis |
| C64.1 | Malignant neoplasm of right kidney, except renal pelvis |
| C64.2 | Malignant neoplasm of left kidney, except renal pelvis |
| C64.2 | Malignant neoplasm of left kidney, except renal pelvis |
| C64.9 | Malignant neoplasm of unspecified kidney, except renal pelvis |
| C64.9 | Malignant neoplasm of unspecified kidney, except renal pelvis |
Formulary Reference Tool