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PAXLOVID (EUA) (nirmatrelvir/ritonavir)
- COVId-19
Paxlovid 150 mg-100 mg tablets in a dose pack (Renal Dose)(EUA)
- by oral route 2 times per day per package directions for 5 days
Paxlovid 300 mg (150 mg x 2)-100 mg tablets in a dose pack (EUA)
- by oral route 2 times per day per package directions for 5 days
Default screening record
- by oral route 2 times per day per package directions
- by oral route 2 times per day per package directions for 5 days
- 3 tablets by oral route 2 times per day in the morning and evening per package directions
- 3 tablets by oral route 2 times per day in the morning and evening for 5 days per package directions
- 2 tablets by oral route 2 times per day in the morning and evening for 5 days per package directions
- 2 tablets by oral route 2 times per day in the morning and evening per package directions
- Advicor
- alfuzosin
- Altoprev
- amiodarone
- amiodarone in dextrose,iso-osm
- avanafil
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Belladonna-phenobarbital
- Brilinta
- bromocriptine
- cabergoline
- Cafergot
- calcium-mag-B complex-D3-hrb61
- Camptosar
- carbamazepine
- Carbatrol
- Cerebyx
- Cold & Flu Fighter
- conivaptan in 5 % dextrose
- Cordarone
- Cycloset
- D.h.e.45
- Detrol La
- dextromethorphan-quinidine
- dihydroergotamine
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Donnatal
- dronedarone
- dutasteride-tamsulosin
- eletriptan HBr
- enzalutamide
- Epitol
- eplerenone
- Equetro
- ergoloid
- Ergomar
- ergotamine tartrate
- ergotamine-caffeine
- ezetimibe-simvastatin
- Fatigue Relief Complex
- flecainide
- Flomax
- fosphenytoin
- Inspra
- irinotecan
- isoniazid-rifamp-pyrazinamide
- Jalyn
- Juxtapid
- Kombiglyze Xr
- Latuda
- Levitra
- lomitapide
- lovastatin
- Luminal
- lurasidone
- methylergonovine
- Mevacor
- midazolam
- midazolam (PF)
- Migergot
- Migranal
- Multaq
- Mysoline
- nevirapine
- Nexterone
- niacin-lovastatin
- niacin-simvastatin
- Nuedexta
- Orap
- Pacerone
- Parlodel
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- pimozide
- primidone
- propafenone
- quinidine gluconate
- quinidine sulfate
- Rapaflo
- Relpax
- Revatio
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- Rythmol
- Samsca
- saxagliptin-metformin
- sildenafil
- silodosin
- Simcor
- simvastatin
- St. John's wort
- Stendra
- tamsulosin
- Tegretol
- Tegretol Xr
- ticagrelor
- tolterodine
- tolvaptan
- triazolam
- Uroxatral
- Vaprisol
- vardenafil
- Viramune
- Viramune Xr
- vit C-St. John wort-elder-hb30
- Vytorin 10-10
- Vytorin 10-20
- Vytorin 10-40
- Vytorin 10-80
- Women's Complex
- Xtandi
- Zocor
Contraindicated
- A-methapred
- Abstral
- Actiq
- Adempas
- Advair Diskus
- Advair Hfa
- Alfenta
- alfentanil
- aliskiren
- aliskiren-amlodipin-hcthiazide
- aliskiren-amlodipine
- aliskiren-hydrochlorothiazide
- Altavera (28)
- Alyacen 1/35 (28)
- Alyacen 7/7/7 (28)
- Amethia
- Amethia Lo
- Amethyst
- Amturnide
- Aplenzin
- Apri
- Aranelle (28)
- Aristospan Intra-articular
- Aristospan Intralesional
- Aubra
- Aviane
- azelastine-fluticasone
- Azurette (28)
- B6-FA-B12-co Q10-herb no.225
- Balziva (28)
- Beauty & Skin Therapy
- Beyaz
- bosentan
- Breo Ellipta
- Brevicon (28)
- Briellyn
- budesonide
- budesonide-formoterol
- Buproban
- bupropion HBr
- bupropion HCl
- Camila
- Camrese
- Camrese Lo
- canagliflozin
- Caziant (28)
- Chateal
- colchicine
- colchicine-probenecid
- Colcrys
- Cryselle (28)
- Cyclafem 1/35 (28)
- Cyclafem 7/7/7 (28)
- Cyclessa (28)
- Dasetta 1/35 (28)
- Dasetta 7/7/7 (28)
- Daysee
- deferasirox
- Depo-medrol
- Depo-provera
- Depo-subq Provera 104
- desog-e.estradiol/e.estradiol
- Desogen
- desogestrel-ethinyl estradiol
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- drospirenone-e.estradiol-lm.FA
- drospirenone-ethinyl estradiol
- Duragesic
- Dymista
- Elinest
- Emoquette
- Endocet
- Endodan
- Enpresse
- Enskyce
- Entocort Ec
- Errin
- Estarylla
- estradiol valerate-dienogest
- Estrostep Fe-28
- ethynodiol diac-eth estradiol
- etonogestrel
- etonogestrel-ethinyl estradiol
- Exjade
- Ez Use Joint-tunnel-trigger
- Falmina (28)
- Femcon Fe
- fentanyl
- fentanyl citrate
- fentanyl citrate (PF)
- Fentora
- Flo-pred
- Flonase
- Flovent Diskus
- Flovent Hfa
- fluticasone
- fluticasone furoate
- fluticasone-salmeterol
- fluticasone-vilanterol
- Forfivo Xl
- Fortavit
- Generess Fe
- Gianvi (28)
- Gildagia
- Gildess
- Gildess Fe
- guanfacine
- Healthy Heart Complex
- Heather
- Hycamtin
- ibuprofen-oxycodone
- Introvale
- Intuniv Er
- Invokana
- Jencycla
- Jolessa
- Jolivette
- Junel 1.5/30 (21)
- Junel 1/20 (21)
- Junel Fe 1.5/30 (28)
- Junel Fe 1/20 (28)
- Kariva (28)
- Kelnor 1/35 (28)
- Kenalog
- Korlym
- Kurvelo
- L norgest&E estradiol-E estrad
- Larin 1/20 (21)
- Larin Fe
- Lazanda
- Leena 28
- Lessina
- Levonest (28)
- levonorg-eth estrad triphasic
- levonorgestrel
- levonorgestrel-ethinyl estrad
- Levora 0.15/30 (28)
- Levora-28
- Lo Loestrin Fe
- Loestrin 1.5/30 (21)
- Loestrin 1/20 (21)
- Loestrin Fe 1.5/30 (28)
- Loestrin Fe 1/20 (28)
- Lomedia 24 Fe
- Loryna (28)
- Loseasonique
- Low-ogestrel (28)
- Lutera (28)
- Lyza
- macitentan
- Marlissa
- Maximum Daily Green
- Medrol
- Medrol (pak)
- medroxyprogesterone
- Megavite
- Megavite Golden Years 55+
- methylprednisolone
- methylprednisolone acetate
- methylprednisolone sod suc(PF)
- methylprednisolone sodium succ
- methylprednisolone-bupivacaine
- Microgestin 1.5/30 (21)
- Microgestin 1/20 (21)
- Microgestin Fe 1.5/30 (28)
- Microgestin Fe 1/20 (28)
- mifepristone
- Millipred
- Millipred Dp
- Minastrin 24 Fe
- Mircette (28)
- Mirena
- Modicon (28)
- Mono-linyah
- Mononessa (28)
- MSM-collag-co Q10-herb no.226
- multivit-Fe-min-DNA-RNA-dsup4
- mv-iron-FA-Ca-beepoln-hb 101
- mv-mn-FA-herbs190&215-digest#4
- mv-mn-FA-lycopene-lut-#178herb
- mv-mn-iron-FA-herbal cmplx#190
- My Way
- Myzilra
- Nasacort
- Nasacort Aq
- Natazia
- Necon 0.5/35 (28)
- Necon 1/35 (28)
- Necon 1/50 (28)
- Necon 10/11 (28)
- Necon 7/7/7 (28)
- Nexplanon
- Next Choice One Dose
- Nor-qd
- Nora-be
- norelgestrom-ethinyl estradiol
- noreth-ethinyl estradiol-iron
- norethin-e.estradiol triphasic
- norethin-eth estrad biphasic
- norethindrone (contraceptive)
- norethindrone ac-eth estradiol
- norethindrone-e.estradiol-iron
- norethindrone-ethin estradiol
- norethindrone-mestranol
- norgestimate-ethinyl estradiol
- norgestrel-ethinyl estradiol
- Norinyl 1+35 (28)
- Norinyl 1+50 (28)
- Nortrel 0.5/35 (28)
- Nortrel 1/35 (21)
- Nortrel 1/35 (28)
- Nortrel 7/7/7 (28)
- Nuvaring
- Ocella
- Ogestrel (28)
- Oleptro Er
- Olysio
- Opsumit
- Orapred
- Orapred Odt
- Orsythia
- Ortho Evra
- Ortho Micronor
- Ortho Tri-cyclen (28)
- Ortho Tri-cyclen Lo (28)
- Ortho-cept (28)
- Ortho-cyclen (28)
- Ortho-novum 1/35 (28)
- Ortho-novum 7/7/7 (28)
- Ovcon-35 (28)
- Oxecta
- oxycodone
- oxycodone-acetaminophen
- oxycodone-aspirin
- Oxycontin
- Pediapred
- Percocet
- Percodan
- Philith
- Physicians Ez Use M-pred
- Pimtrea (28)
- Pirmella
- Plan B One-step
- policosan-inositol niac-garlic
- Policosanol-garlic-niacin
- Portia
- prednisolone
- prednisolone acetate
- prednisolone sodium phosphate
- prednisone
- Prednisone Intensol
- Previfem
- Primlev
- Pulmicort
- Pulmicort Flexhaler
- Qualaquin
- Quartette
- Quasense
- quinine sulfate
- Rayos
- Reclipsen (28)
- Rhinocort Aqua
- riociguat
- Roxicet
- Safyral
- salmeterol
- Seasonique
- Serevent Diskus
- simeprevir
- Skyla
- Solu-medrol
- Solu-medrol (pf)
- Sprintec (28)
- Sronyx
- Sublimaze (pf)
- Subsys
- Syeda
- Symbicort
- Tekamlo
- Tekturna
- Tekturna Hct
- Tenex
- Tilia Fe
- topotecan
- Tracleer
- trazodone
- Tri-estarylla
- Tri-legest Fe
- Tri-linyah
- Tri-norinyl (28)
- Tri-previfem (28)
- Tri-sprintec (28)
- triamcinolone acetonide
- triamcinolone hexacetonide
- triamcinolone-lidocaine
- Trinessa (28)
- Trivora (28)
- Uceris
- Velivet Triphasic Regimen (28)
- Veramyst
- Veripred 20
- Vestura (28)
- Vfend
- Vfend Iv
- Viorele (28)
- voriconazole
- Vyfemla (28)
- Wellbutrin
- Wellbutrin Sr
- Wellbutrin Xl
- Wera (28)
- Wymzya Fe
- Xartemis Xr
- Yasmin (28)
- Yaz 28
- Zarah
- Zenchent (28)
- Zenchent Fe
- Zeosa
- Zovia 1/35E (28)
- Zovia 1/50E (28)
- Zyban
Severe
Moderate
- Abilify
- Abilify Discmelt
- Abilify Maintena
- afatinib
- alprazolam
- Alprazolam Intensol
- Ambien
- Ambien Cr
- amoxicil-clarithromy-lansopraz
- Anti-diarrhea
- Anti-diarrheal (lope)-anti-gas
- Anti-diarrheal (loperamide)
- aripiprazole
- artemether-lumefantrine
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- buspirone
- cilostazol
- cinacalcet
- clarithromycin
- Coartem
- darifenacin
- Detrol
- Diamode
- Digox
- digoxin
- Diskets
- Dolophine
- Edluar
- Enablex
- eszopiclone
- fesoterodine
- Fetzima
- Gilotrif
- Imodium Multi-symptom Relief
- Intermezzo
- Istodax
- itraconazole
- ivacaftor
- Kalydeco
- ketoconazole
- Lamictal
- Lamictal Odt
- Lamictal Odt Starter (blue)
- Lamictal Odt Starter (green)
- Lamictal Odt Starter (orange)
- Lamictal Starter (blue) Kit
- Lamictal Starter (green) Kit
- Lamictal Starter (orange) Kit
- Lamictal Xr
- Lamictal Xr Starter (blue)
- Lamictal Xr Starter (green)
- Lamictal Xr Starter (orange)
- lamotrigine
- Lanoxin
- Lanoxin Pediatric
- levomilnacipran
- Lo-peramide
- loperamide
- loperamide-simethicone
- Lunesta
- mefloquine
- methadone
- Methadone Intensol
- Methadose
- Niravam
- Noxafil
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- Onglyza
- Onmel
- Pletal
- posaconazole
- Prevpac
- regorafenib
- romidepsin
- saxagliptin
- Sensipar
- solifenacin
- Soltamox
- Sporanox
- Sporanox Pulsepak
- Stivarga
- tamoxifen
- Toviaz
- Ultra A-d
- Vesicare
- Viagra
- Xanax
- Xanax Xr
- zolpidem
- Zolpimist
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
Contraindicated
- Chronic kidney disease stage 3A (moderate) GFR 45-59
- Chronic kidney disease stage 3B (moderate) GFR 30-44
Severe
Moderate
- Abnormal hepatic function tests
- Disease of liver
PAXLOVID (EUA) (nirmatrelvir/ritonavir)
- COVId-19
- None
- Diarrhea
- Dysgeusia
- Hypertension
- Myalgia
More Frequent
Severe
Less Severe
- None
- None
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Anaphylaxis
- Angioedema
- Dyspnea
- Hypersensitivity drug reaction
Less Severe
- Acute abdominal pain
- Malaise
- Nausea
- Pruritus of skin
- Urticaria
Contraindicated
None
Severe Precaution
Nirmatrelvir and Ritonavir
Not authorized for patients < 12 years of age; no safety and effectiveness established.
- 1 Day – 12 Years
- Not authorized for patients < 12 years of age; no safety and effectiveness established.
Management or Monitoring Precaution
Nirmatrelvir and Ritonavir
Not authorized for patients weighing < 40 kg; no safety and effectiveness established.
- 12 Years – 18 Years
- Not authorized for patients weighing < 40 kg; no safety and effectiveness established.
Nirmatrelvir-ritonavir
- Severity Level:
2
- Additional Notes: Insufficient human data available on developmental toxicity risk
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Nirmatrelvir-ritonavir
Ritonavir excreted; insufficient human data available
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Ritonavir excreted; insufficient human data available |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
Formulary Reference Tool