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INLYTA (AXITINIB)
- Renal cell carcinoma
1 mg tablet
- 2 tablets (2 mg) by oral route every 12 hours with a full glass (8 oz) water (to be taken with a 5 mg tablet for a total dose of 7 mg)
5 mg tablet
- 1 tablet (5 mg) by oral route every 12 hours with a full glass (8 oz) water
Renal cell carcinoma
- 2 tablets (2 mg) by oral route every 12 hours with a full glass (8 oz) water (this dose to taken with a 5 mg tablet for a total dose of 7 mg)
- 2 tablets (2 mg) by oral route every 12 hours with a full glass (8 oz) water (to be taken with a 5 mg tablet for a total dose of 7 mg)
- 1 tablet (5 mg) by oral route every 12 hours with a full glass (8 oz) water
- 2 tablets (10 mg) by oral route every 12 hours with a full glass(8 oz) water
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- BCG vaccine, live (PF)
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- Atripla
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Belladonna-phenobarbital
- bosentan
- calcium-mag-B complex-D3-hrb61
- carbamazepine
- Carbatrol
- Cerebyx
- clozapine
- Clozaril
- Cold & Flu Fighter
- dabrafenib
- deferiprone
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Donnatal
- efavirenz
- efavirenz-emtricitabin-tenofov
- enzalutamide
- Epitol
- Equetro
- etravirine
- Fatigue Relief Complex
- Fazaclo
- Ferriprox
- fosphenytoin
- Intelence
- isoniazid-rifamp-pyrazinamide
- Luminal
- modafinil
- Mysoline
- nafcillin
- nafcillin in dextrose iso-osm
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- Priftin
- primidone
- Provigil
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- rifapentine
- Rifater
- St. John's wort
- Sustiva
- Tafinlar
- Tegretol
- Tegretol Xr
- Tracleer
- Versacloz
- vit C-St. John wort-elder-hb30
- Women's Complex
- Xtandi
Severe
Moderate
- None
- Arterial aneurysm
- Arterial dissection
- Lactating mother
Contraindicated
- Acute myocardial infarction
- Cerebral metastases
- Cerebrovascular accident
- Chronic heart failure
- Deep venous thrombosis
- Gastrointestinal hemorrhage
- Intracerebral hemorrhage
- Posterior reversible encephalopathy syndrome
- Pregnancy
- Pulmonary thromboembolism
- Retinal vascular occlusion
- Severe hepatic disease
- Thromboembolic disorder
- Transient cerebral ischemia
Severe
Moderate
- Abnormal hepatic function tests
- Gastrointestinal fistula
- Gastrointestinal perforation
- Hypertension
- Hypothyroidism
- Proteinuria
INLYTA (AXITINIB)
- Renal cell carcinoma
- Hemorrhage
- Hypertension
- Hypothyroidism
- Leukopenia
- Lymphopenia
- Thrombocytopenic disorder
- Acute abdominal pain
- Anorexia
- Arthralgias
- Constipation
- Cough
- Dehydration
- Diarrhea
- Dizziness
- Dry skin
- Dysgeusia
- Dyspepsia
- Dyspnea
- Epistaxis
- Fatigue
- General weakness
- Headache disorder
- Myalgias
- Nausea
- Palmar-plantar erythrodysesthesia
- Proteinuria
- Pruritus of skin
- Skin rash
- Stomatitis
- Voice change
- Vomiting
- Weight loss
More Frequent
Severe
Less Severe
- Anemia
- Arterial thrombosis
- Deep venous thrombosis
- Heart failure
- Hemoptysis
- Hypercalcemia
- Hyperthyroidism
- Pulmonary thromboembolism
- Rectal bleeding
- Retinal thrombosis
- Thrombotic disorder
- Alopecia
- Elevated serum lipase
- Erythema
- Erythrocytosis
- Hemorrhoids
- Sore tongue
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Gastrointestinal fistula
- Gastrointestinal perforation
- Hepatic failure
- Hypertensive crisis
- Impaired wound healing
- Intracerebral hemorrhage
- Posterior reversible encephalopathy syndrome
- Transient cerebral ischemia
Less Severe
- None
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Axitinib
Not studied in pediatrics. No safety and efficacy. Potential risk of bone and dental abnormalities.
- 1 Day – 18 Years
- Not studied in pediatrics. No safety and efficacy. Potential risk of bone and dental abnormalities.
Axitinib
- Severity Level:
D
- Additional Notes: Based on drug pharmacology developmental toxicity is possible.
Contraindicated
Axitinib
Potential for serious adv effects; highly protein bound, excrt may be limited
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Potential for serious adv effects; highly protein bound, excrt may be limited |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Renal cell carcinoma | |
| C64 | Malignant neoplasm of kidney, except renal pelvis |
| C64.1 | Malignant neoplasm of right kidney, except renal pelvis |
| C64.2 | Malignant neoplasm of left kidney, except renal pelvis |
| C64.9 | Malignant neoplasm of unspecified kidney, except renal pelvis |
| 0-9 | A-Z |
|---|---|
| C64 | Malignant neoplasm of kidney, except renal pelvis |
| C64.1 | Malignant neoplasm of right kidney, except renal pelvis |
| C64.2 | Malignant neoplasm of left kidney, except renal pelvis |
| C64.9 | Malignant neoplasm of unspecified kidney, except renal pelvis |
Formulary Reference Tool