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GEODON (ZIPRASIDONE MESYLATE)
- Agitation associated with schizophrenia
- Mania associated with bipolar disorder
- Mixed bipolar I disorder
- Schizophrenia
- Bipolar disorder in remission
ziprasidone 20 mg capsule
- 1 capsule (20 mg) by oral route 2 times per day with food
ziprasidone 40 mg capsule
- 1 capsule (40 mg) by oral route 2 times per day with food
ziprasidone 60 mg capsule
- 1 capsule (60 mg) by oral route 2 times per day with food
ziprasidone 80 mg capsule
- 1 capsule (80 mg) by oral route 2 times per day with food
20 mg/mL (final concentration) intramuscular solution
- Dosage information is not available
20 mg capsule
- 1 capsule (20 mg) by oral route 2 times per day with food
40 mg capsule
- 1 capsule (40 mg) by oral route 2 times per day with food
60 mg capsule
- 1 capsule (60 mg) by oral route 2 times per day with food
80 mg capsule
- 1 capsule (80 mg) by oral route 2 times per day with food
Agitation associated with schizophrenia
- Inject 20 mg by intramuscular route every 4 hours not to exceed 40 mgin 24Hrs
- Inject 0.5 milliliter (10 mg) by intramuscular route every 2 hours not to exceed 40 mg in 24Hrs
Bipolar disorder in remission
- 2 capsules (40 mg) by oral route 2 times per day with food
- 1 capsule (40 mg) by oral route 2 times per day with food
- 1 capsule (60 mg) by oral route 2 times per day with food
- 1 capsule (80 mg) by oral route 2 times per day with food
- 2 capsules (80 mg) by oral route 2 times per day with food
Mania associated with bipolar disorder
- 2 capsules (40 mg) by oral route 2 times per day with food
- 1 capsule (40 mg) by oral route 2 times per day with food
- 1 capsule (60 mg) by oral route 2 times per day with food
- 1 capsule (80 mg) by oral route 2 times per day with food
- 2 capsules (80 mg) by oral route 2 times per day with food
Schizophrenia
- 1 capsule (20 mg) by oral route 2 times per day with food
- 2 capsules (40 mg) by oral route 2 times per day with food
- 1 capsule (40 mg) by oral route 2 times per day with food
- 1 capsule (60 mg) by oral route 2 times per day with food
- 1 capsule (80 mg) by oral route 2 times per day with food
- 2 capsules (80 mg) by oral route 2 times per day with food
- amiodarone
- amiodarone in dextrose,iso-osm
- Anzemet
- arsenic trioxide
- Astagraf Xl
- Avelox
- Avelox Abc Pack
- Avelox In Nacl (iso-osmotic)
- Betapace
- Betapace Af
- Celexa
- chlorpromazine
- citalopram
- Cordarone
- Corvert
- dextromethorphan-quinidine
- disopyramide
- dofetilide
- dolasetron
- droperidol
- escitalopram oxalate
- Hecoria
- ibutilide fumarate
- Lexapro
- mefloquine
- metoclopramide HCl
- Metozolv Odt
- moxifloxacin
- moxifloxacin in NaCl (iso-osm)
- Nebupent
- Nexterone
- nilotinib
- Norpace
- Norpace Cr
- Nuedexta
- Orap
- Pacerone
- pasireotide
- Pentam
- pentamidine
- pimozide
- procainamide
- Prograf
- Qualaquin
- quinidine gluconate
- quinidine sulfate
- quinine sulfate
- Reglan
- Signifor
- Sorine
- sotalol
- Sotalol Af
- tacrolimus
- Tasigna
- thioridazine
- Tikosyn
- Trisenox
Contraindicated
- Advair Diskus
- Advair Hfa
- alfuzosin
- Aloxi
- amantadine HCl
- Apokyn
- apomorphine
- arformoterol
- artemether-lumefantrine
- atazanavir
- bedaquiline
- Brovana
- budesonide-formoterol
- cabergoline
- Cardene Iv
- Cardene Iv In Dextrose
- Cardene Iv In Sodium Chloride
- Cardene Sr
- chloroquine phosphate
- Cipro
- Cipro In D5W
- Cipro Xr
- ciprofloxacin
- ciprofloxacin (mixture)
- ciprofloxacin in D5W
- clozapine
- Clozaril
- Coartem
- Complera
- crizotinib
- dasatinib
- Diflucan
- Diskets
- Dolophine
- dronedarone
- Dulera
- Edurant
- Effexor Xr
- emtricitab-rilpivirine-tenofov
- Eovist
- eribulin
- ezogabine
- Fazaclo
- felbamate
- Felbatol
- flecainide
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- fluticasone-salmeterol
- Foradil Aerolizer
- formoterol fumarate
- foscarnet
- Foscavir
- gadoxetate
- granisetron
- granisetron (PF)
- Granisol
- Halaven
- Haldol
- Haldol Decanoate
- haloperidol
- haloperidol decanoate
- haloperidol lactate
- indapamide
- Invega
- Invega Sustenna
- isradipine
- Istodax
- Kaletra
- Ketek
- lapatinib
- Levaquin
- Levaquin In 5 % Dextrose
- Levitra
- levofloxacin
- levofloxacin in D5W
- lopinavir-ritonavir
- methadone
- Methadone Intensol
- Methadose
- moexipril
- moexipril-hydrochlorothiazide
- mometasone-formoterol
- Multaq
- Nexavar
- nicardipine
- nicardipine in dextrose,iso-os
- nicardipine in NaCl (iso-os)
- norfloxacin
- Noroxin
- Noxafil
- octreotide acetate
- ofloxacin
- ondansetron
- ondansetron HCl
- ondansetron HCl (PF)
- paliperidone
- paliperidone palmitate
- palonosetron
- pazopanib
- Perforomist
- posaconazole
- Potiga
- propafenone
- quetiapine
- Reyataz
- rilpivirine
- Risperdal
- Risperdal Consta
- Risperdal M-tab
- risperidone
- risperidone microspheres
- romidepsin
- Rythmol
- salmeterol
- Sancuso
- Sandostatin
- Sandostatin Lar Depot
- Serevent Diskus
- Seroquel
- Seroquel Xr
- Sirturo
- Soltamox
- sorafenib
- Sprycel
- sunitinib
- Sutent
- Symbicort
- tamoxifen
- telavancin
- telithromycin
- tizanidine
- Tykerb
- Uniretic
- Univasc
- Uroxatral
- vardenafil
- vemurafenib
- venlafaxine
- Versacloz
- Vfend
- Vfend Iv
- Vibativ
- voriconazole
- Votrient
- Xalkori
- Zanaflex
- Zelboraf
- Zofran
- Zofran Odt
- Zuplenz
Severe
Moderate
- Ablavar
- Aplenzin
- Buproban
- bupropion HBr
- bupropion HCl
- Caprelsa
- carbidopa-levodopa
- carbidopa-levodopa-entacapone
- Comtan
- entacapone
- Fareston
- Forfivo Xl
- gadofosveset trisodium
- Mirapex
- Mirapex Er
- pramipexole
- Requip
- Requip Xl
- ropinirole
- Sinemet
- Sinemet Cr
- Stalevo 100
- Stalevo 125
- Stalevo 150
- Stalevo 200
- Stalevo 50
- Stalevo 75
- tetrabenazine
- toremifene
- vandetanib
- Wellbutrin
- Wellbutrin Sr
- Wellbutrin Xl
- Xenazine
- Zyban
- 30 day risk period post-myocardial infarction
- Acute decompensated heart failure
- Congenital long QT syndrome
- Lactating mother
- Neuroleptic malignant syndrome
- Torsades de pointes
Contraindicated
- Acquired dystonia
- Agranulocytosis
- Bradycardia
- Cardiac arrhythmia
- Cerebrovascular disorder
- Dehydration
- Diabetes mellitus
- Extrapyramidal disease
- Hypokalemia
- Hypomagnesemia
- Hypovolemia
- Metabolic syndrome X
- Myocardial ischemia
- Parkinsonism
- Senile dementia
- Suicidal ideation
- Tachyarrhythmia
- Tardive dyskinesia
Severe
Moderate
- Carcinoma of breast
- Dysphagia
- Hyperlipidemia
- Hyperprolactinemia
- Kidney disease with reduction in GFR
- Leukopenia
- Neutropenic disorder
- Obesity
- Orthostatic hypotension
- Seizure disorder
- Severe diarrhea
- Severe hepatic disease
GEODON (ZIPRASIDONE MESYLATE)
- Agitation associated with schizophrenia
- Mania associated with bipolar disorder
- Mixed bipolar I disorder
- Schizophrenia
- Bipolar disorder in remission
- Skin rash
- Akathisia
- Constipation
- Dizziness
- Drowsy
- Extrapyramidal disease
- General weakness
- Headache disorder
- Injection site sequelae
- Nausea
- Sialorrhea
- Weight gain
More Frequent
Severe
Less Severe
- Agitation
- Akathisia
- Bradycardia
- Cerebrovascular accident
- Chest pain
- Esophageal dysmotility
- Extrapyramidal disease
- Furunculosis
- Hepatitis
- Hypertension
- Hypokalemia
- Hypothermia
- Orthostatic hypotension
- Personality disorders
- Rectal bleeding
- Seizure disorder
- Tachycardia
- Acute abdominal pain
- Acute confusion
- Amenorrhea
- Anorexia
- Ataxia
- Constipation
- Cough
- Delirium
- Diarrhea
- Dysmenorrhea
- Dyspepsia
- Dysphasia
- Dyspnea
- Flank pain
- General weakness
- Hostility
- Hyperhidrosis
- Hyperlipidemia
- Hypertonia
- Hypesthesia
- Hypotonia
- Insomnia
- Memory impairment
- Myalgias
- Orthostatic hypotension
- Paresthesia
- Pruritus of skin
- Rhinitis
- Symptoms of anxiety
- Tachycardia
- Tremor
- Twitching
- Upper respiratory infection
- Visual changes
- Vomiting
- Xerostomia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Accidental fall
- Agranulocytosis
- Anemia
- Angina
- Angioedema
- Atrial fibrillation
- Atrioventricular block
- Bloody vomit
- Bradycardia
- Bundle branch block
- Cataracts
- Cerebrovascular accident
- Chorea
- Diabetes mellitus
- DRESS syndrome
- Drug-induced psychosis
- Dysphagia
- Eosinophilia
- Esophageal dysmotility
- Exfoliative dermatitis
- Facial edema
- Fecal impaction
- Fever
- First degree atrioventricular heart block
- Hemoptysis
- Hepatitis
- Hostility
- Hyperglycemia
- Hyperprolactinemia
- Hypersensitivity pneumonitis
- Hyperthyroidism
- Hypertonia
- Hypomagnesemia
- Hypothyroidism
- Jaundice
- Laryngismus
- Leukopenia
- Lymphadenopathy
- Myocarditis
- Myoclonus
- Myopathy
- Nephritis
- Neuroleptic malignant syndrome
- Neutropenic disorder
- Obstructive hyperbilirubinemia
- Ocular hemorrhage
- Pericarditis
- Priapism
- Prolonged QT interval
- Pulmonary thromboembolism
- Rectal bleeding
- Seizure disorder
- Serotonin syndrome
- Skin rash
- Sleep apnea
- Steatosis of liver
- Stevens-johnson syndrome
- Syncope
- Tardive dyskinesia
- Tenosynovitis
- Thrombocytopenic disorder
- Thrombocytosis
- Thyroiditis
- Tongue swelling
- Torsades de pointes
- Vasodilation of blood vessels
Less Severe
- Abnormal vaginal bleeding
- Acquired dystonia
- Acute abdominal pain
- Acute confusion
- Agitation
- Amenorrhea
- Arthralgias
- Ataxia
- Back pain
- Black tarry stools
- Blepharitis
- Chills
- Delirium
- Depression
- Diplopia
- Dry eye
- Dysarthria
- Dysphasia
- Dyspnea
- Ecchymosis
- Erectile dysfunction
- Fever
- Flank pain
- Flu-like symptoms
- Galactorrhea not associated with childbirth
- Gingival bleeding
- Gynecomastia
- Hyperprolactinemia
- Hypertension
- Hypothermia
- Insomnia
- Keratoconjunctivitis
- Leucoplakia of oral mucosa
- Lymphedema
- Maculopapular rash
- Nocturia
- Nystagmus
- Oral hypoesthesia
- Phlebitis
- Photophobia
- Rhinitis
- Skin photosensitivity
- Thrombophlebitis
- Tinnitus
- Tooth disorder
- Trismus
- Urinary incontinence
- Urinary retention
- Urticaria
- Vomiting
- Xerostomia
Contraindicated
None
Severe Precaution
Ziprasidone (Oral,IM)
Adverse reactions include weight gain, glucose and lipid abnormalities, QT prolongation. Safety and efficacy in pediatrics not established.
- 1 Day – 7 Years
- Adverse reactions include weight gain, glucose and lipid abnormalities, QT prolongation. Safety and efficacy in pediatrics not established.
Management or Monitoring Precaution
Ziprasidone (IM)
Risk of sedation, dystonia, extrapyramidal reactions, QT prolongation. Long term risk of hyperprolactinemia, lipid, glucose abnormalities. Safety and efficacy not established.
Risk of sedation, dystonia, extrapyramidal reactions, QT prolongation, hyperprolactinemia, lipid, glucose abnormalities. Monitor weight. No safety and efficacy per manufacturer.
- 7 Years – 18 Years
- Risk of sedation, dystonia, extrapyramidal reactions, QT prolongation. Long term risk of hyperprolactinemia, lipid, glucose abnormalities. Safety and efficacy not established.
Ziprasidone (Oral)
Risk of sedation, dystonia, extrapyramidal reactions, QT prolongation. Long term risk of hyperprolactinemia, lipid, glucose abnormalities. Safety and efficacy not established.
Risk of sedation, dystonia, extrapyramidal reactions, QT prolongation, hyperprolactinemia, lipid, glucose abnormalities. Monitor weight. No safety and efficacy per manufacturer.
- 7 Years – 18 Years
- Risk of sedation, dystonia, extrapyramidal reactions, QT prolongation, hyperprolactinemia, lipid, glucose abnormalities. Monitor weight. No safety and efficacy per manufacturer.
Ziprasidone
- Severity Level:
C
- Additional Notes: Non-teratogenic complications (resp, gi,cns) with exposure during 3rd trimester
Contraindicated
Ziprasidone
Not recommended by manufacturer;Other medications preferred
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Not recommended by manufacturer;Other medications preferred |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Ziprasidone
Neuro/Psych-Inc risk of tardive dyskinesia. CNS effects; sedation, cognit impair and inc fall risk. Avoid for behav probs of dementia/delirium unless fail nonpharm options. Inc risk of stroke, cognit decline, and death when used w/ dementia. Endocrine-May exacerbate/cause SIADH/hyponatremia. Cardiovascular-Risk of orthostat hypotens, dizziness, QT prolong. Avoid if signif CV cond. Mnt BG, lipids, wt. Gastrointestinal-May cause constipation. Urogenital-Avoid in urinary retention.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | Y | Y | N | Y |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- There may be a slightly increased risk of serious, possibly fatal side effects (such as stroke, heart failure, fast/irregular heartbeat, pneumonia) when this medication is used by older adults with dementia. This medication is not approved for the treatment of dementia-related behavior problems. Discuss the risks and benefits of this medication, as well as other effective and possibly safer treatments for dementia-related behavior problems, with the doctor.
| Agitation associated with schizophrenia | |
| R45.1 | Restlessness and agitation |
| Bipolar disorder in remission | |
| F31.7 | Bipolar disorder, currently in remission |
| F31.70 | Bipolar disorder, currently in remission, most recent episode unspecified |
| F31.71 | Bipolar disorder, in partial remission, most recent episode hypomanic |
| F31.72 | Bipolar disorder, in full remission, most recent episode hypomanic |
| F31.73 | Bipolar disorder, in partial remission, most recent episode manic |
| F31.74 | Bipolar disorder, in full remission, most recent episode manic |
| F31.75 | Bipolar disorder, in partial remission, most recent episode depressed |
| F31.76 | Bipolar disorder, in full remission, most recent episode depressed |
| F31.77 | Bipolar disorder, in partial remission, most recent episode mixed |
| F31.78 | Bipolar disorder, in full remission, most recent episode mixed |
| Mania associated with bipolar disorder | |
| F31.1 | Bipolar disorder, current episode manic without psychotic features |
| F31.10 | Bipolar disorder, current episode manic without psychotic features, unspecified |
| F31.11 | Bipolar disorder, current episode manic without psychotic features, mild |
| F31.12 | Bipolar disorder, current episode manic without psychotic features, moderate |
| F31.13 | Bipolar disorder, current episode manic without psychotic features, severe |
| F31.2 | Bipolar disorder, current episode manic severe with psychotic features |
| F31.73 | Bipolar disorder, in partial remission, most recent episode manic |
| Mixed bipolar I disorder | |
| F31.6 | Bipolar disorder, current episode mixed |
| F31.60 | Bipolar disorder, current episode mixed, unspecified |
| F31.61 | Bipolar disorder, current episode mixed, mild |
| F31.62 | Bipolar disorder, current episode mixed, moderate |
| F31.63 | Bipolar disorder, current episode mixed, severe, without psychotic features |
| F31.64 | Bipolar disorder, current episode mixed, severe, with psychotic features |
| F31.77 | Bipolar disorder, in partial remission, most recent episode mixed |
| F31.78 | Bipolar disorder, in full remission, most recent episode mixed |
| Schizophrenia | |
| F20 | Schizophrenia |
| F20.0 | Paranoid schizophrenia |
| F20.1 | Disorganized schizophrenia |
| F20.2 | Catatonic schizophrenia |
| F20.3 | Undifferentiated schizophrenia |
| F20.5 | Residual schizophrenia |
| F20.8 | Other schizophrenia |
| F20.81 | Schizophreniform disorder |
| F20.89 | Other schizophrenia |
| F20.9 | Schizophrenia, unspecified |
| 0-9 | A-Z |
|---|---|
| F20 | Schizophrenia |
| F20.0 | Paranoid schizophrenia |
| F20.1 | Disorganized schizophrenia |
| F20.2 | Catatonic schizophrenia |
| F20.3 | Undifferentiated schizophrenia |
| F20.5 | Residual schizophrenia |
| F20.8 | Other schizophrenia |
| F20.81 | Schizophreniform disorder |
| F20.89 | Other schizophrenia |
| F20.9 | Schizophrenia, unspecified |
| F31.1 | Bipolar disorder, current episode manic without psychotic features |
| F31.10 | Bipolar disorder, current episode manic without psychotic features, unspecified |
| F31.11 | Bipolar disorder, current episode manic without psychotic features, mild |
| F31.12 | Bipolar disorder, current episode manic without psychotic features, moderate |
| F31.13 | Bipolar disorder, current episode manic without psychotic features, severe |
| F31.2 | Bipolar disorder, current episode manic severe with psychotic features |
| F31.6 | Bipolar disorder, current episode mixed |
| F31.60 | Bipolar disorder, current episode mixed, unspecified |
| F31.61 | Bipolar disorder, current episode mixed, mild |
| F31.62 | Bipolar disorder, current episode mixed, moderate |
| F31.63 | Bipolar disorder, current episode mixed, severe, without psychotic features |
| F31.64 | Bipolar disorder, current episode mixed, severe, with psychotic features |
| F31.7 | Bipolar disorder, currently in remission |
| F31.70 | Bipolar disorder, currently in remission, most recent episode unspecified |
| F31.71 | Bipolar disorder, in partial remission, most recent episode hypomanic |
| F31.72 | Bipolar disorder, in full remission, most recent episode hypomanic |
| F31.73 | Bipolar disorder, in partial remission, most recent episode manic |
| F31.73 | Bipolar disorder, in partial remission, most recent episode manic |
| F31.74 | Bipolar disorder, in full remission, most recent episode manic |
| F31.75 | Bipolar disorder, in partial remission, most recent episode depressed |
| F31.76 | Bipolar disorder, in full remission, most recent episode depressed |
| F31.77 | Bipolar disorder, in partial remission, most recent episode mixed |
| F31.77 | Bipolar disorder, in partial remission, most recent episode mixed |
| F31.78 | Bipolar disorder, in full remission, most recent episode mixed |
| F31.78 | Bipolar disorder, in full remission, most recent episode mixed |
| R45.1 | Restlessness and agitation |
Formulary Reference Tool