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BOSULIF (bosutinib)
- accelerated phase Philadelphia chromosome (+) CML
- chronic phase Philadelphia chromosome (+) CML
- lymphoid blast phase Philadelphia chromosome (+) CML
- myeloid blast phase Philadelphia chromosome (+) CML
100 mg capsule
- 4 capsules (400 mg) by oral route once daily
50 mg capsule
- Dosage information is not available
Default screening record
- 4 capsules (400 mg) by oral route once daily
- 5 capsules (500 mg) by oral route once daily
- 6 capsules (600 mg) by oral route once daily
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- BCG vaccine, live (PF)
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- natalizumab
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- Tysabri
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- Acid Control (ranitidine)
- Acid Controller
- Acid Controller Complete
- Acid Reducer (cimetidine)
- Acid Reducer (famotidine)
- Acid Reducer (ranitidine)
- Acid Reducer Complete (famot)
- Acid Relief (cimetidine)
- Aciphex
- Aciphex Sprinkle
- amoxicil-clarithromy-lansopraz
- aprepitant
- atazanavir
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Belladonna-phenobarbital
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- boceprevir
- Calan
- Calan Sr
- calcium-mag-B complex-D3-hrb61
- carbamazepine
- Carbatrol
- Cardizem
- Cardizem Cd
- Cardizem La
- Cartia Xt
- Cerebyx
- cimetidine
- Cipro
- Cipro In D5W
- Cipro Xr
- ciprofloxacin
- ciprofloxacin (mixture)
- ciprofloxacin in D5W
- clarithromycin
- clozapine
- Clozaril
- Cold & Flu Fighter
- Complete
- conivaptan in 5 % dextrose
- Crixivan
- crizotinib
- cyclosporine
- cyclosporine modified
- darunavir
- deferiprone
- Deprizine
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexilant
- dexlansoprazole
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- dextromethorphan-quinidine
- Diflucan
- Dilacor Xr
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Dilt-xr
- diltiazem HCl
- Donnatal
- Dual Action Complete
- Duexis
- Emend
- enzalutamide
- Epitol
- Equetro
- Erythrocin
- erythromycin
- erythromycin-sulfisoxazole
- esomeprazole magnesium
- esomeprazole sodium
- esomeprazole strontium
- famotidine
- famotidine (PF)
- famotidine (PF)-NaCl (iso-os)
- famotidine-Ca carb-mag hydrox
- Fatigue Relief Complex
- Fazaclo
- Ferriprox
- First-lansoprazole
- First-omeprazole
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- fosamprenavir
- fosaprepitant
- fosphenytoin
- Gengraf
- Gleevec
- Heartburn Prevention
- Heartburn Relief
- Heartburn Relief (famotidine)
- Heartburn Relief (ranitidine)
- Heartburn Relief 24 Hour
- Heartburn Treatment 24 Hour
- ibuprofen-famotidine
- imatinib
- Incivek
- indinavir
- Invirase
- isoniazid-rifamp-pyrazinamide
- itraconazole
- Kaletra
- Ketek
- ketoconazole
- lansoprazole
- Lexiva
- lopinavir-ritonavir
- Luminal
- Matzim La
- Mycobutin
- Mysoline
- naproxen-esomeprazole
- nefazodone
- nelfinavir
- Neoral
- Nexium
- Nexium Iv
- Nexium Packet
- nizatidine
- Norvir
- Norvir Soft Gelatin
- Noxafil
- Nuedexta
- Omeclamox-pak
- omeprazole
- omeprazole magnesium
- Omeprazole+syrspend Sf Alka
- omeprazole-clarith-amoxicillin
- omeprazole-sodium bicarbonate
- Onmel
- pantoprazole
- Pepcid
- Pepcid Ac
- Pepcid Complete
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- posaconazole
- Prevacid
- Prevacid 24Hr
- Prevacid Solutab
- Prevpac
- Prezista
- Prilosec
- Prilosec Otc
- primidone
- Protonix
- quinidine gluconate
- quinidine sulfate
- rabeprazole
- ranitidine HCl
- Reyataz
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- ritonavir
- Sandimmune
- saquinavir mesylate
- Sporanox
- Sporanox Pulsepak
- St. John's wort
- Tagamet Hb
- Tarka
- Taztia Xt
- Tegretol
- Tegretol Xr
- telaprevir
- telithromycin
- Tiazac
- trandolapril-verapamil
- Tums Dual Action
- Vaprisol
- verapamil
- Verelan
- Verelan Pm
- Versacloz
- Vfend
- Vfend Iv
- Victrelis
- Vimovo
- Viracept
- vit C-St. John wort-elder-hb30
- voriconazole
- Wal-zan 150
- Women's Complex
- Xalkori
- Xtandi
- Zantac
- Zantac Maximum Strength
- Zegerid
- Zegerid Otc
Severe
Moderate
- Acid Gone
- Acid Gone Antacid
- activated charcoal-calcium car
- Advanced Antacid-antigas
- Al hyd-Mg tr-alg ac-sod bicarb
- Alcalak
- Almacone
- Almacone-2
- alum-mag hydroxide-simeth
- aluminum hydrox-magnesium carb
- aluminum hydroxide gel
- aluminum-magnesium hydroxide
- Antacid
- Antacid Anti-gas
- Antacid Anti-gas Double Str
- Antacid Calcium
- Antacid Extra Strength
- Antacid Extra-strength
- Antacid Ii Plus Simethicone
- Antacid Liquid
- Antacid M
- Antacid Maximum Strength
- Antacid Multi-symptom
- Antacid Plus Anti-gas
- Antacid Plus Extra Strength
- Antacid Regular Strength
- Antacid Supreme
- Antacid Tablet
- Antacid Ultra Strength
- Antacid With Simethicone
- Antacid-antigas
- Antacid-antigas Ii
- Antacid-simethicone
- Antacid-simethicone Ds
- ASA-acetaminophen-caff-buffers
- aspirin, buffered
- aspirin-calcium carbonate
- Bayer Plus Extra Strength
- Buffered Aspirin
- Bufferin
- cal phos-mag hydrx-C & D3-phos
- Cal-gest Antacid
- calcium & magnesium carbonates
- Calcium Antacid
- Calcium Antacid Tropical
- Calcium Antacid Ultra Max St
- calcium carb-mag hydrox-simeth
- calcium carbonate
- calcium carbonate-mag hydroxid
- calcium-simethicone
- Children's Pepto
- Children's Soothe
- Comfort Gel
- Comfort Gel Extra Strength
- diosmin complex no.1
- Flanax
- Foaming Antacid
- Foaming Antacid Extra Strength
- Gaviscon
- Gaviscon Extra Strength
- Gelusil Antacid & Anti-gas
- Geri-lanta
- Geri-mox Antacid-antigas
- Heartburn Antacid
- Liquid Antacid
- Maalox Advanced
- Maalox Maximum Strength
- Mag-al
- Mag-al Plus
- Mag-al Plus Extra Strength
- magaldrate
- magaldrate-simethicone
- Maglox
- magnesium hydroxide
- magnesium-aluminum-alginic ac
- Masanti Double Strength
- Mi-acid
- Milk Of Magnesia
- Milk Of Magnesia Concentrated
- Mintox
- Mintox Maximum Strength
- Mintox Plus
- Ob Complete One
- Pedia-lax
- Phillips Milk Of Magnesia
- PN85-iron cb&asp g-FA-dha-fish
- Pro-cal
- Ri-gel
- Ri-gel Ii
- Ri-mag
- Ri-mag Plus
- Ri-mox
- Ri-mox Plus
- Riginic
- Rulox
- Smooth Antacid
- Supreme Antacid
- Toxin Control
- Tri-buffered Aspirin
- Tums
- Tums E-x
- Tums Extra Strength Smoothies
- Tums Freshers
- Tums Ultra
- Ultra Strength Antacid
- Ultra Strength Calcium Antacid
- Vanquish
- Vasculera
- Women's Aspirin With Calcium
- Lactation
Contraindicated
- Anemia
- Child-pugh class A hepatic impairment
- Child-pugh class B hepatic impairment
- Child-pugh class C hepatic impairment
- Chronic heart failure
- Chronic kidney disease stage 3A (moderate) GFR 45-59
- Chronic kidney disease stage 3B (moderate) GFR 30-44
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Disease of liver
- Hyperbilirubinemia
- Neutropenic disorder
- Pericardial effusion
- Peripheral edema
- Pleural effusions
- Pregnancy
- Pulmonary edema
- Severe diarrhea
- Thrombocytopenic disorder
Severe
Moderate
- Viral hepatitis B
BOSULIF (bosutinib)
- accelerated phase Philadelphia chromosome (+) CML
- chronic phase Philadelphia chromosome (+) CML
- lymphoid blast phase Philadelphia chromosome (+) CML
- myeloid blast phase Philadelphia chromosome (+) CML
- Abnormal hepatic function tests
- Anemia
- Diarrhea
- Elevated serum lipase
- Increased alanine transaminase
- Increased aspartate transaminase
- Increased creatine kinase level
- Kidney disease with reduction in GFR
- Lower respiratory infection
- Neutropenic disorder
- Thrombocytopenic disorder
- Acute abdominal pain
- Anorexia
- Back pain
- Cough
- Dizziness
- Dyspnea
- Fatigue
- Fever
- General weakness
- Headache disorder
- Hyperglycemia
- Nausea
- Pharyngitis
- Pruritus of skin
- Skin rash
- Upper respiratory infection
- Vomiting
More Frequent
Severe
Less Severe
- Dehydration
- Elevated serum amylase
- Hepatitis
- Hyperbilirubinemia
- Hyperkalemia
- Hypersensitivity drug reaction
- Hypertension
- Lymphopenia
- Pericardial effusion
- Pleural effusions
- Pneumonia
- Acne vulgaris
- Body fluid retention
- Chest pain
- Dysgeusia
- Gastritis
- Hypothyroidism
- Myalgia
- Pain
- Peripheral edema
- Tinnitus
- Urticaria
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute eruptions of skin
- Acute hepatic failure
- Acute pancreatitis
- Acute renal failure
- Acute respiratory failure
- Anaphylaxis
- Erythema multiforme
- Gastrointestinal hemorrhage
- Heart failure
- Hyperthyroidism
- Interstitial lung disease
- Left ventricular failure
- Myocardial ischemia
- Pericarditis
- Pulmonary edema
- Pulmonary hypertension
- Reactivation of hepatitis B
- Rectal bleeding
- Stevens-johnson syndrome
- Thrombotic thrombocytopenic purpura
Less Severe
- Exfoliative dermatitis
Contraindicated
None
Severe Precaution
Bosutinib
Safety and efficacy not established age < 1 year. Risk of severe diarrhea, cardiac events, increased LFTs.
- 1 Day – 364 Days
- Safety and efficacy not established age < 1 year. Risk of severe diarrhea, cardiac events, increased LFTs.
Management or Monitoring Precaution
None
Bosutinib
- Severity Level:
D
- Additional Notes: Based on drug pharmacology developmental toxicity is possible.
Contraindicated
Bosutinib
Potential for serious adverse outcomes based on mechanism of action
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Potential for serious adverse outcomes based on mechanism of action |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Bosutinib
Cardiovascular-Increased risk of cardiac failure and left ventricular dysfunction in patients of advanced age or history of prior cardiac failure.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | Y | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
| Accelerated phase philadelphia chromosome (+) CML | |
| C92.1 | Chronic myeloid leukemia, BCr/ABl-positive |
| C92.10 | Chronic myeloid leukemia, BCr/ABl-positive, not having achieved remission |
| C92.12 | Chronic myeloid leukemia, BCr/ABl-positive, in relapse |
| Chronic phase philadelphia chromosome (+) CML | |
| C92.1 | Chronic myeloid leukemia, BCr/ABl-positive |
| C92.10 | Chronic myeloid leukemia, BCr/ABl-positive, not having achieved remission |
| C92.12 | Chronic myeloid leukemia, BCr/ABl-positive, in relapse |
| Lymphoid blast phase philadelphia chromosome (+) CML | |
| C92.1 | Chronic myeloid leukemia, BCr/ABl-positive |
| C92.10 | Chronic myeloid leukemia, BCr/ABl-positive, not having achieved remission |
| C92.12 | Chronic myeloid leukemia, BCr/ABl-positive, in relapse |
| Myeloid blast phase philadelphia chromosome (+) CML | |
| C92.1 | Chronic myeloid leukemia, BCr/ABl-positive |
| C92.10 | Chronic myeloid leukemia, BCr/ABl-positive, not having achieved remission |
| C92.12 | Chronic myeloid leukemia, BCr/ABl-positive, in relapse |
| 0-9 | A-Z |
|---|---|
| C92.1 | Chronic myeloid leukemia, BCr/ABl-positive |
| C92.1 | Chronic myeloid leukemia, BCr/ABl-positive |
| C92.1 | Chronic myeloid leukemia, BCr/ABl-positive |
| C92.1 | Chronic myeloid leukemia, BCr/ABl-positive |
| C92.10 | Chronic myeloid leukemia, BCr/ABl-positive, not having achieved remission |
| C92.10 | Chronic myeloid leukemia, BCr/ABl-positive, not having achieved remission |
| C92.10 | Chronic myeloid leukemia, BCr/ABl-positive, not having achieved remission |
| C92.10 | Chronic myeloid leukemia, BCr/ABl-positive, not having achieved remission |
| C92.12 | Chronic myeloid leukemia, BCr/ABl-positive, in relapse |
| C92.12 | Chronic myeloid leukemia, BCr/ABl-positive, in relapse |
| C92.12 | Chronic myeloid leukemia, BCr/ABl-positive, in relapse |
| C92.12 | Chronic myeloid leukemia, BCr/ABl-positive, in relapse |
Formulary Reference Tool