DUAL ACTION PAIN RELIEVER (ibuprofen/acetaminophen)

Moderate

• A-hydrocort

• A-methapred

• abciximab

• Accolate

• Accupril

• Accuretic

• acebutolol

• Aceon

• adefovir

• Adult Low Dose Aspirin

• Aggrenox

• Alka-seltzer

• Alka-seltzer Extra Strength

• Alka-seltzer Original

• Alka-seltzer Pm

• Altace

• amiloride

• amiloride-hydrochlorothiazide

• amiodarone

• amiodarone in dextrose,iso-osm

• amlodipine-benazepril

• amlodipine-olmesartan

• amlodipine-valsartan

• amlodipine-valsartan-hcthiazid

• Angeliq

• Antacid & Pain Relief

• Anucort-hc

• Anusol-hc

• Aristospan Intra-articular

• Aristospan Intralesional

• Arixtra

• ASA-acetaminophen-caff-buffers

• Aspir-81

• Aspir-low

• Aspir-trin

• aspirin

• Aspirin Childrens

• Aspirin Low Dose

• Aspirin Low-strength

• aspirin, buffered

• aspirin-calcium carbonate

• aspirin-diphenhydramine

• aspirin-sod bicarb-citric acid

• Astagraf Xl

• Atacand

• Atacand Hct

• atenolol

• atenolol-chlorthalidone

• Atripla

• Avalide

• Avapro

• azilsartan med-chlorthalidone

• azilsartan medoxomil

• Azor

• Bayer Advanced

• Bayer Aspirin

• Bayer Chewable Aspirin

• Bayer Childrens Aspirin

• Bayer Plus Extra Strength

• benazepril

• benazepril-hydrochlorothiazide

• Benicar

• Benicar Hct

• betamethasone acet & sod phos

• Betapace

• Betapace Af

• betaxolol

• Beyaz

• bisoprolol fumarate

• bisoprolol-hydrochlorothiazide

• Brevibloc

• Brevibloc In Nacl (iso-osm)

• Brilinta

• Brintellix

• Brisdelle

• budesonide

• Buffered Aspirin

• Bufferin

• bumetanide

• Bystolic

• candesartan

• candesartan-hydrochlorothiazid

• captopril

• captopril-hydrochlorothiazide

• Celestone Soluspan

• Celexa

• Child Aspirin

• Children's Aspirin

• cilostazol

• cisplatin

• citalopram

• clopidogrel

• colchicine-probenecid

• Colocort

• Complera

• Cordarone

• Corgard

• Cortef

• Cortenema

• Cortifoam

• cortisone

• Corzide

• Cozaar

• cyclosporine

• cyclosporine modified

• Cymbalta

• Daflonex-xl

• dalteparin (porcine)

• Demadex

• Depo-medrol

• desvenlafaxine

• desvenlafaxine fumarate

• desvenlafaxine succinate

• dexamethasone

• Dexamethasone Intensol

• dexamethasone sodium phos (PF)

• dexamethasone sodium phosphate

• Dexpak 10 Day

• Dexpak 13 Day

• Dexpak 6 Day

• Diflucan

• Digox

• digoxin

• diosmin complex no.1

• Diovan Hct

• dipyridamole-aspirin

• drospirenone-e.estradiol-lm.FA

• drospirenone-estradiol

• drospirenone-ethinyl estradiol

• duloxetine

• Dutoprol

• Dyazide

• Dyrenium

• E.c. Prin

• Ecotrin

• Ecotrin Low Strength

• Edarbi

• Edarbyclor

• efavirenz-emtricitabin-tenofov

• Efferves Pain Relief Antacid

• Effervescent Antacid

• Effervescent Pain Relief

• Effervescent Pain Reliever

• Effexor Xr

• Elmiron

• elvitegr-cobicist-emtric-tenof

• emtricitab-rilpivirine-tenofov

• emtricitabine-tenofovir

• enalapril maleate

• enalapril-hydrochlorothiazide

• enalaprilat

• enoxaparin

• Enteric Coated Aspirin

• Entocort Ec

• Epaned

• eprosartan

• eprosartan-hydrochlorothiazide

• eptifibatide

• erlotinib

• escitalopram oxalate

• esmolol

• esmolol in NaCl (iso-osm)

• ethacrynate sodium

• Exforge

• Exforge Hct

• Extra Strength Bayer

• Ez Use Joint-tunnel-trigger

• Fetzima

• First-duke's

• First-mary's Mouthwash

• Flo-pred

• fluconazole

• fluconazole in dextrose(iso-o)

• fluconazole in NaCl (iso-osm)

• fludrocortisone

• fluoxetine

• fluvoxamine

• fondaparinux

• fosinopril

• fosinopril-hydrochlorothiazide

• Fragmin

• furosemide

• Gengraf

• Gianvi (28)

• Grx Hicort 25

• Hecoria

• Hemril-30

• heparin (porcine)

• heparin (porcine) in D5W

• heparin(porcine) in 0.45% NaCl

• heparin, porcine (PF)

• Hepsera

• hesp-diosm hyd-Ca dobe-diosmin

• hesperid-diosmin-grape seed xt

• hydrocortisone

• hydrocortisone acetate

• hydrocortisone sod succ (PF)

• hydrocortisone sod succinate

• Hyzaar

• Inderal La

• Inderal Xl

• Innopran Xl

• Integrilin

• irbesartan

• irbesartan-hydrochlorothiazide

• isoniazid

• isoniazid-rifamp-pyrazinamide

• Kenalog

• ketoconazole

• Khedezla

• Lanoxin

• Lanoxin Pediatric

• Lasix

• Levatol

• levomilnacipran

• Lexapro

• lisinopril

• lisinopril-hydrochlorothiazide

• Lite Coat Aspirin

• lithium carbonate

• lithium citrate

• Lithobid

• Lo-dose Aspirin

• Lopressor

• Lopressor Hct

• Loryna (28)

• losartan

• losartan-hydrochlorothiazide

• Lotensin

• Lotrel

• Lovenox

• Luvox Cr

• Mavik

• Maxzide

• Maxzide-25Mg

• Medi-seltzer

• Medrol

• Medrol (pak)

• methylprednisolone

• methylprednisolone acetate

• methylprednisolone sod suc(PF)

• methylprednisolone sodium succ

• methylprednisolone-bupivacaine

• metoprolol su-hydrochlorothiaz

• metoprolol succinate

• metoprolol ta-hydrochlorothiaz

• metoprolol tartrate

• Micardis

• Micardis Hct

• miconazole

• Millipred

• Millipred Dp

• milnacipran

• moexipril

• moexipril-hydrochlorothiazide

• nadolol

• nadolol-bendroflumethiazide

• nebivolol

• Neoral

• Nexterone

• nystatin-hydrocortisone-diphen

• nystatin-TCN-HC-diphenhydramin

• Ocella

• olanzapine-fluoxetine

• olmesartan

• olmesartan-amlodipin-hcthiazid

• olmesartan-hydrochlorothiazide

• Orapred

• Orapred Odt

• Oravig

• Oxandrin

• oxandrolone

• Pacerone

• paroxetine HCl

• paroxetine mesylate

• Paxil

• Paxil Cr

• Pediapred

• penbutolol

• pentosan polysulfate sodium

• perindopril erbumine

• Pexeva

• Physicians Ez Use M-pred

• pindolol

• Plavix

• Pletal

• prednisolone

• prednisolone acetate

• prednisolone sodium phosphate

• prednisone

• Prednisone Intensol

• Prinivil

• Pristiq

• probenecid

• Proctocort

• Prograf

• propranolol

• propranolol-hydrochlorothiazid

• Prozac

• Prozac Weekly

• quinapril

• quinapril-hydrochlorothiazide

• ramipril

• Rapamune

• Rayos

• Rectacort-hc

• Reopro

• Rifamate

• rifampin-isoniazid

• Rifater

• Safyral

• Sandimmune

• Sarafem

• Savella

• Sectral

• sertraline

• sirolimus

• Sodium Edecrin

• Solu-cortef

• Solu-cortef (pf)

• Solu-medrol

• Solu-medrol (pf)

• Sorine

• sotalol

• Sotalol Af

• St Joseph Aspirin

• St. Joseph Aspirin

• Stribild

• Syeda

• Symbyax

• tacrolimus

• Tarceva

• Tarka

• telmisartan

• telmisartan-amlodipine

• telmisartan-hydrochlorothiazid

• tenofovir disoproxil fumarate

• Tenoretic 100

• Tenoretic 50

• Tenormin

• Teveten

• Teveten Hct

• ticagrelor

• timolol maleate

• Toprol Xl

• torsemide

• trandolapril

• trandolapril-verapamil

• Tri-buffered Aspirin

• triamcinolone acetonide

• triamcinolone hexacetonide

• triamcinolone-lidocaine

• triamterene

• triamterene-hydrochlorothiazid

• Tribenzor

• Trombonex-d

• Truvada

• Twynsta

• Uceris

• Uniretic

• Univasc

• valsartan-hydrochlorothiazide

• Vanquish

• Vasculera

• Vaseretic

• Vasoflex Hd

• Vasotec

• Venaliv

• venlafaxine

• Veripred 20

• Vestura (28)

• Vfend

• Vfend Iv

• Viibryd

• vilazodone

• Viread

• vit C-but.broom-hesperidn-dios

• vit C-dios-rut-bioflav-butc br

• voriconazole

• vortioxetine

• Women's Aspirin With Calcium

• Yasmin (28)

• Yaz 28

• zafirlukast

• Zarah

• Zebeta

• Zestoretic

• Zestril

• Ziac

• Zoloft

Moderate

• Chronic heart failure

• Disease of liver

• Hypertension

• Increased risk of bleeding due to coagulation disorder

• Kidney disease with likely reduction in GFR

• Tobacco smoker

Acetaminophen

• Severity Level:

  2

• Additional Notes: Available data suggest no known risk; otc product, no fda pregnancy warnings

Ibuprofen

• Severity Level:

  1

• Additional Notes: Not recommended near or after 20 weeks gestation

Contraindicated

None

General	Excretion Potential	Effect on Infant	Notes
			None

Precaution Exists

None

General	Excretion Potential	Effect on Infant	Notes
			None

No Known Risk

Acetaminophen

Low levels excreted with low risk for adverse effects in infant

Low levels in breast milk, with no known resulting adverse effect on infant

General	Excretion Potential	Effect on Infant	Notes
No known risks; does not adversely affect lactation	Excreted	No adverse effect	Low levels excreted with low risk for adverse effects in infant

Ibuprofen

Low levels excreted with low risk for adverse effects in infant

Low levels in breast milk, with no known resulting adverse effect on infant

General	Excretion Potential	Effect on Infant	Notes
No known risks; does not adversely affect lactation	Excreted	No adverse effect	Low levels in breast milk, with no known resulting adverse effect on infant

Contraindicated

None

Precaution Exists

Acetaminophen (oral,rectal)

Hepatic-Elderly may be more susceptible to hepatotoxicity. Strict adherence to a maximum daily dose is recommended, and the maximum dose recommendation varies between 3000-3800 mg depending on strength used and source of the recommendation.

Gastrointestinal-Risk for ulceration or serious GI bleed; highest with history of PUD or GI bleed. Renal-Risk of AKI and exacerbation of CKD. Avoid with CrCl <30 mL/min. Cardiovascular-May exacerbate pre-existing hypertension or CHF. Risk of MI and stroke. This risk may occur early in treatment and increases with duration of use. Risk for reinfarction with minimal NSAID use post-MI. Contraindicated with CABG. Hepatic-Elevated hepatic transaminases may occur with chronic use.

Organ / System	HEP	REN	CARD	ENDO	NEURO / PSYCH	PULM
Increased Risk / Adverse Effects	N	Y	N	N	N	N

BEERS: N     HEDIS: N     STOPP: N

Ibuprofen

Hepatic-Elderly may be more susceptible to hepatotoxicity. Strict adherence to a maximum daily dose is recommended, and the maximum dose recommendation varies between 3000-3800 mg depending on strength used and source of the recommendation.

Gastrointestinal-Risk for ulceration or serious GI bleed; highest with history of PUD or GI bleed. Renal-Risk of AKI and exacerbation of CKD. Avoid with CrCl <30 mL/min. Cardiovascular-May exacerbate pre-existing hypertension or CHF. Risk of MI and stroke. This risk may occur early in treatment and increases with duration of use. Risk for reinfarction with minimal NSAID use post-MI. Contraindicated with CABG. Hepatic-Elevated hepatic transaminases may occur with chronic use.

Organ / System	HEP	REN	CARD	ENDO	NEURO / PSYCH	PULM
Increased Risk / Adverse Effects	Y	Y	Y	N	N	N

BEERS: Y     HEDIS: Y     STOPP: Y

No Known Risk

None

0-9	A-Z