Nystatin-Triamcinolone

Drug overview for NYSTATIN-TRIAMCINOLONE (nystatin/triamcinolone acetonide):

Generic name: NYSTATIN/TRIAMCINOLONE ACETONIDE (NYE-stat-in/TRYE-am-SIN-oh-lone)
Drug class: Topical Corticosteroids
Therapeutic class: Dermatological

Nystatin, a polyene antibiotic, is an antifungal agent. Triamcinolone acetonide is a synthetic fluorinated corticosteroid.

Triamcinolone shares the actions of the other topical corticosteroids and is used for the relief of the inflammatory manifestations of corticosteroid-responsive dermatoses. The drug is also used as a paste for adjunctive treatment to provide temporary relief of symptoms associated with oral inflammatory or ulcerative lesions resulting from trauma.

DRUG IMAGES

NYSTATIN-TRIAMCINOLONE CREAM
NYSTATIN-TRIAMCINOLONE OINTM

The following indications for NYSTATIN-TRIAMCINOLONE (nystatin/triamcinolone acetonide) have been approved by the FDA:

Indications:
Cutaneous candidiasis

Professional Synonyms:
Cutaneous candidosis
Cutaneous moniliasis

The following dosing information is available for NYSTATIN-TRIAMCINOLONE (nystatin/triamcinolone acetonide):

Dosing
Administration
NYSTATIN-TRIAMCINOLONE
NYSTATIN-TRIAMCINOLONE

Dermatologic preparations of triamcinolone acetonide are applied sparingly in thin films and are rubbed gently into the affected area 2-4 times daily. The 0.5% cream and 0.5%

ointment should be used only in the treatment of dermatoses which are refractory to treatment with lower concentrations. The 0.1 and 0.5%

creams are applied 2-3 times daily according to severity of the condition. When the aerosol is applied, an area about the size of the patient's hand is sprayed for about 2 seconds from a distance of about 7.5-15 cm 3 or 4 times daily.

Occlusive dressings may be used for severe or resistant dermatoses.

For use in the mouth, a small amount (about 0.6 cm) of the 0.1% paste is pressed to the lesion without rubbing until a thin film develops; a larger amount may be required to cover some lesions. The paste is applied at bedtime and, if necessary, 2 or 3 times daily, preferably after meals.

If substantial regeneration or repair of the oral tissues does not occur after 7 days of treatment, further investigation of the etiology of the oral lesions should be undertaken.

Dosage of nystatin is expressed in terms of USP nystatin units.

Nystatin is applied topically to the skin as a cream, ointment, or powder. Nystatin also is commercially available in fixed combination with a corticosteroid (i.e., triamcinolone acetonide) for topical application to the skin as a cream or ointment. Nystatin is applied topically to the oral cavity as an oral suspension and is administered orally as film-coated tablets. Although nystatin has been administered intravaginally, intravaginal preparations of the drug are no longer commercially available in the US.

Dosing information for NYSTATIN-TRIAMCINOLONE
DRUG LABEL	DOSING TYPE	DOSING INSTRUCTIONS
NYSTATIN-TRIAMCINOLONE OINTM	Maintenance	Adults apply to the affected area(s) by topical route 2 times per day
NYSTATIN-TRIAMCINOLONE CREAM	Maintenance	Adults apply to the affected area(s) by topical route 2 times per day in the morning and evening

Generic dosing information for NYSTATIN-TRIAMCINOLONE
DRUG LABEL	DOSING TYPE	DOSING INSTRUCTIONS
NYSTATIN-TRIAMCINOLONE OINTM	Maintenance	Adults apply to the affected area(s) by topical route 2 times per day
NYSTATIN-TRIAMCINOLONE CREAM	Maintenance	Adults apply to the affected area(s) by topical route 2 times per day in themorning and evening

Moderate List
Adrenocortical insufficiency
No disease contraindications
Telangiectasia

The following adverse reaction information is available for NYSTATIN-TRIAMCINOLONE (nystatin/triamcinolone acetonide):

Overview
Severe
Less Severe

Adverse reaction overview.

No enhanced Common Adverse Effects information available for this drug.

There are 15 severe adverse reactions.

More Frequent	Less Frequent
None.	Folliculitis Purpura Skin and skin structure infection Skin atrophy

Rare/Very Rare
Adrenocortical insufficiency Bullous dermatitis Cataracts Central serous chorioretinopathy Glaucoma Hypothalamic-pituitary insufficiency Ocular hypertension Skin hypopigmentation Skin striae Skin ulcer Urticaria

There are 28 less severe adverse reactions.

More Frequent	Less Frequent
Erythema Stinging of skin	Acute pain at drug application site Blurred vision Headache disorder Paresthesia Pruritus of skin Skin rash Telangiectasia Treatment site sequelae

Rare/Very Rare
Acneiform eruption Alopecia Blistering skin Contact dermatitis Dry skin Dyschromia Eczema Glycosuria Hirsutism Hypercortisolism Hyperesthesia Hyperglycemia Miliaria Perioral dermatitis Pruritus of skin Skin irritation Skin rash Treatment site sequelae

The following precautions are available for NYSTATIN-TRIAMCINOLONE (nystatin/triamcinolone acetonide):

Pediatric
Pregnant
Lactation
Geriatric

No enhanced Pediatric Use information available for this drug.

Contraindicated

None

Severe Precaution

None

Management or Monitoring Precaution

None

Animal reproduction studies have not been performed using topical or oral nystatin. It is not known whether nystatin can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Topical nystatin should be used during pregnancy only if potential benefits outweigh potential risks to the fetus.

Oral nystatin (oral suspension, tablets) should be used during pregnancy only if clearly needed. Fixed-combination topical preparations containing nystatin and triamcinolone acetonide should be used during pregnancy only if potential benefits outweigh potential risks to the fetus. Topical preparations containing corticosteroids should not be used extensively, in large amounts, or for prolonged periods during pregnancy.

It is not known whether nystatin is distributed into human milk. Nystatin and fixed combinations containing nystatin and triamcinolone acetonide should be used with caution in nursing women.

No enhanced Geriatric Use information available for this drug.