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SAMSCA (TOLVAPTAN)
- Hyponatremia
- SIADH syndrome
15 mg tablet
- 1 tablet (15 mg) by oral route once daily
30 mg tablet
- 1 tablet (30 mg) by oral route once daily
15 mg tablet
- 1 tablet (15 mg) by oral route once daily
30 mg tablet
- 1 tablet (30 mg) by oral route once daily
Hyponatremia
- 1 tablet (15 mg) by oral route once daily
- 2 tablets (30 mg) by oral route once daily
- 1 tablet (30 mg) by oral route once daily
- 2 tablets (60 mg) by oral route once daily
SIADH syndrome
- 1 tablet (15 mg) by oral route once daily
- 2 tablets (30 mg) by oral route once daily
- 1 tablet (30 mg) by oral route once daily
- 2 tablets (60 mg) by oral route once daily
- amoxicil-clarithromy-lansopraz
- atazanavir
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- boceprevir
- clarithromycin
- Crixivan
- elvitegr-cobicist-emtric-tenof
- Incivek
- indinavir
- Invirase
- itraconazole
- Kaletra
- Ketek
- ketoconazole
- lopinavir-ritonavir
- nefazodone
- nelfinavir
- Norvir
- Norvir Soft Gelatin
- Noxafil
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- Onmel
- posaconazole
- Prevpac
- Reyataz
- ritonavir
- saquinavir mesylate
- Sporanox
- Sporanox Pulsepak
- Stribild
- telaprevir
- telithromycin
- Vfend
- Vfend Iv
- Victrelis
- Viracept
- voriconazole
Contraindicated
- Alagesic Lq
- amobarbital
- Amytal
- aprepitant
- Ascomp With Codeine
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Belladonna-phenobarbital
- Bupap
- butabarbital
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-acetaminop-caf-cod
- butalbital-acetaminophen
- butalbital-acetaminophen-caff
- butalbital-aspirin-caffeine
- Butisol
- Calan
- Calan Sr
- calcium-mag-B complex-D3-hrb61
- Capacet
- carbamazepine
- Carbatrol
- Cardizem
- Cardizem Cd
- Cardizem La
- Cartia Xt
- Cerebyx
- Cipro
- Cipro In D5W
- Cipro Xr
- ciprofloxacin
- ciprofloxacin (mixture)
- ciprofloxacin in D5W
- codeine-butalbital-ASA-caff
- Cold & Flu Fighter
- crizotinib
- darunavir
- Diflucan
- Dilacor Xr
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Dilt-xr
- diltiazem HCl
- Donnatal
- Emend
- enzalutamide
- Epitol
- Equetro
- Erythrocin
- erythromycin
- erythromycin-sulfisoxazole
- Esgic
- Fatigue Relief Complex
- Fioricet
- Fioricet With Codeine
- Fiorinal
- Fiorinal-codeine #3
- fluconazole
- fluconazole in dextrose(iso-o)
- fluconazole in NaCl (iso-osm)
- fosamprenavir
- fosaprepitant
- fosphenytoin
- Gleevec
- imatinib
- isoniazid-rifamp-pyrazinamide
- Lexiva
- Luminal
- Lysodren
- Margesic
- Marten-tab
- Matzim La
- mitotane
- Mycobutin
- Mysoline
- Nembutal Sodium
- pentobarbital sodium
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- Prezista
- Priftin
- primidone
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- rifapentine
- Rifater
- secobarbital sodium
- Seconal Sodium
- sodium chloride
- St. John's wort
- Tarka
- Taztia Xt
- Tegretol
- Tegretol Xr
- Tencon
- Tiazac
- trandolapril-verapamil
- verapamil
- Verelan
- Verelan Pm
- vit C-St. John wort-elder-hb30
- Women's Complex
- Xalkori
- Xtandi
- Zebutal
Severe
Moderate
- Anti-diarrhea
- Anti-diarrheal (lope)-anti-gas
- Anti-diarrheal (loperamide)
- Diamode
- Imodium Multi-symptom Relief
- Juxtapid
- Lo-peramide
- lomitapide
- loperamide
- loperamide-simethicone
- rivaroxaban
- Ultra A-d
- Xarelto
- Anuria
- Dehydration
- Disease of liver
- Hypernatremia
- Hypovolemia
- Osmotic central pontine myelinolysis
Contraindicated
- Gastrointestinal hemorrhage
- Hyperkalemia
Severe
Moderate
- Alcoholism
- Protein-calorie malnutrition
SAMSCA (TOLVAPTAN)
- Hyponatremia
- SIADH syndrome
- None
- Constipation
- General weakness
- Increased urinary frequency
- Polydipsia
- Polyuria
- Xerostomia
More Frequent
Severe
Less Severe
- Dehydration
- Hyponatremia
- Hypovolemia
- Increased alanine transaminase
- Increased aspartate transaminase
- Anorexia
- Fever
- Hyperglycemia
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Acute respiratory insufficiency
- Anaphylaxis
- Angioedema
- Cerebrovascular accident
- Deep venous thrombosis
- Disseminated intravascular coagulation
- Gastrointestinal hemorrhage
- Hepatic failure
- Hepatocellular damage
- Hyperbilirubinemia
- Hyperkalemia
- Ischemic colitis
- Osmotic central pontine myelinolysis
- Pulmonary thromboembolism
- Rhabdomyolysis
- Thromboembolic disorder
- Ventricular fibrillation
Less Severe
- Abnormal vaginal bleeding
- Hypernatremia
- Skin rash
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Tolvaptan
Safety and efficacy not studied in pediatrics.
- 1 Day – 18 Years
- Safety and efficacy not studied in pediatrics.
Tolvaptan
- Severity Level:
C
- Additional Notes: Insufficient human data available; developmental tox in animals at 164 x mrhd
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Tolvaptan
Insuff data avail; theoretical risk of dehydration, hypovolemia in infant
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insuff data avail; theoretical risk of dehydration, hypovolemia in infant |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- Treatment with this drug should be started or restarted in a hospital for proper monitoring. If your level of sodium in the blood is raised too quickly, it may cause a serious (even fatal) condition called osmotic demyelination syndrome. The risk is higher if you have liver disease, poor nutrition, or if you use/abuse alcohol.<br /><br />Tell your doctor right away if you have symptoms such as trouble speaking/swallowing, mental/mood changes (such as confusion), weakness/involuntary movement in the arms/legs, or seizures. Do not use this medication to treat a certain kidney problem (autosomal dominant polycystic kidney disease-ADPKD). Due to the risk of serious liver damage, you must be in a special program for you to take this medication to treat ADPKD. Ask your doctor for details.
| Hyponatremia | |
| E87.1 | Hypo-osmolality and hyponatremia |
| SIADH syndrome | |
| E22.2 | Syndrome of inappropriate secretion of antidiuretic hormone |
| 0-9 | A-Z |
|---|---|
| E22.2 | Syndrome of inappropriate secretion of antidiuretic hormone |
| E87.1 | Hypo-osmolality and hyponatremia |
Formulary Reference Tool