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ZETIA (ezetimibe)
- high cholesterol
- combined high blood cholesterol and triglyceride level
- excess absorption of diet plant and shellfish sterols
- excessive fat in the blood
- heterozygous inherited high blood cholesterol
- homozygous inherited high blood cholesterol
10 mg tablet
- 1 tablet (10 mg) by oral route once daily
10 mg tablet
- 1 tablet (10 mg) by oral route once daily
Heterozygous familial hypercholesterolemia
- 1 tablet (10 mg) by oral route once daily
Homozygous familial hypercholesterolemia
- 1 tablet (10 mg) by oral route once daily
Hyperlipidemia
- 1 tablet (10 mg) by oral route once daily
Mixed hyperlipidemia
- 1 tablet (10 mg) by oral route once daily
Sitosterolemia
- 1 tablet (10 mg) by oral route once daily
- None
Contraindicated
- None
Severe
Moderate
- Antara
- cholestyramine (with sugar)
- Cholestyramine Light
- cholestyramine-aspartame
- Colestid
- Colestid Flavored
- colestipol
- cyclosporine
- cyclosporine modified
- fenofibrate
- fenofibrate micronized
- fenofibrate nanocrystallized
- fenofibric acid
- fenofibric acid (choline)
- Fenoglide
- Fibricor
- gemfibrozil
- Gengraf
- Lipofen
- Lofibra
- Lopid
- Neoral
- Prevalite
- Questran
- Questran Light
- Sandimmune
- Tricor
- Triglide
- Trilipix
- Rhabdomyolysis
Contraindicated
- Abnormal hepatic function tests
- Acute pancreatitis
- Disease of liver
- Myopathy with CK elevation
Severe
Moderate
- Severe renal impairment
ZETIA (ezetimibe)
- high cholesterol
- combined high blood cholesterol and triglyceride level
- excess absorption of diet plant and shellfish sterols
- excessive fat in the blood
- heterozygous inherited high blood cholesterol
- homozygous inherited high blood cholesterol
- None
- Headache disorder
More Frequent
Severe
Less Severe
- Biliary calculus
- Upper respiratory infection
- Abdominal pain with cramps
- Arthralgia
- Back pain
- Diarrhea
- Fatigue
- Influenza
- Myalgia
- Pain in extremities
- Pharyngitis
- Sinusitis
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Acute pancreatitis
- Anaphylaxis
- Angioedema
- Cholecystitis
- Erythema multiforme
- Hepatitis
- Hypersensitivity drug reaction
- Myopathy
- Rhabdomyolysis
- Skin rash
- Thrombocytopenic disorder
- Urticaria
Less Severe
- Depression
- Dizziness
- Nausea
- Paresthesia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Ezetimibe
Safety and efficacy not established in pediatrics <10 years.
- 1 Day – 10 Years
- Safety and efficacy not established in pediatrics <10 years.
Ezetimibe
- Severity Level:
C
- Additional Notes: Insuff human data avail; consider maternal benefit vs neonatal risk
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Ezetimibe
Insufficient data available; not recommended in combo with statins
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available; not recommended in combo with statins |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Heterozygous familial hypercholesterolemia | |
| E78.01 | Familial hypercholesterolemia |
| Homozygous familial hypercholesterolemia | |
| E78.01 | Familial hypercholesterolemia |
| Hypercholesterolemia | |
| E78.0 | Pure hypercholesterolemia |
| E78.00 | Pure hypercholesterolemia, unspecified |
| E78.01 | Familial hypercholesterolemia |
| Hyperlipidemia | |
| E78.2 | Mixed hyperlipidemia |
| E78.4 | Other hyperlipidemia |
| E78.49 | Other hyperlipidemia |
| E78.5 | Hyperlipidemia, unspecified |
| Mixed hyperlipidemia | |
| E78.2 | Mixed hyperlipidemia |
| Sitosterolemia | |
| E75.5 | Other lipid storage disorders |
| 0-9 | A-Z |
|---|---|
| E75.5 | Other lipid storage disorders |
| E78.0 | Pure hypercholesterolemia |
| E78.00 | Pure hypercholesterolemia, unspecified |
| E78.01 | Familial hypercholesterolemia |
| E78.01 | Familial hypercholesterolemia |
| E78.01 | Familial hypercholesterolemia |
| E78.2 | Mixed hyperlipidemia |
| E78.2 | Mixed hyperlipidemia |
| E78.4 | Other hyperlipidemia |
| E78.49 | Other hyperlipidemia |
| E78.5 | Hyperlipidemia, unspecified |
Formulary Reference Tool