NUDICLO (DICLOFENAC SODIUM/CAPSAICIN)
- Nudiclo Tabpak Kit
- Nudiclo Solupak Kit, Cream And Solution
- Flexipak Kit
- Diclopak Kit, Cream And Solution
- Capsfenac Pak Kit, Cream And Solution
TabPAK 75 mg-0.025 % kit
- Dosage information is not available
SoluPAK 1.5 %-0.025 % kit, cream and solution
- Dosage information is not available
75 mg-0.025 % kit
- Dosage information is not available
1.5 %-0.025 % kit, cream and solution
- Dosage information is not available
1.5 %-0.025 % kit, cream and solution
- Dosage information is not available
- ketorolac
- cidofovir
- Sprix
- Vistide
Contraindicated
- Oral Saline Laxative
- Osmoprep
- methotrexate sodium (PF)
- methotrexate sodium
- Methotrexate (anti-rheumatic)
- Jantoven
- Folotyn
- Fleet Pediatric
- Fleet Enema Extra
- Fleet Enema
- Enema Disposable
- Enema
- Eliquis
- Disposable Enema
- Curad Enema
- Coumadin
- apixaban
- Alimta
- pemetrexed
- Phosphate Laxative
- pralatrexate
- Preparation Cleansing
- Ready-to-use Enema
- Rheumatrex
- rivaroxaban
- sod phos mono-sod phos dibasic
- sodium phosphates
- Trexall
- warfarin
- Xarelto
Severe
Moderate
- methylprednisolone
- methylprednisolone acetate
- methylprednisolone sod suc(PF)
- methylprednisolone sodium succ
- methylprednisolone-bupivacaine
- Micardis
- Micardis Hct
- miconazole
- Millipred
- Millipred Dp
- milnacipran
- moexipril
- moexipril-hydrochlorothiazide
- Neoral
- Nexterone
- nystatin-hydrocortisone-diphen
- nystatin-TCN-HC-diphenhydramin
- Ocella
- olanzapine-fluoxetine
- olmesartan
- olmesartan-amlodipin-hcthiazid
- olmesartan-hydrochlorothiazide
- Orapred
- Orapred Odt
- Oravig
- Oxandrin
- oxandrolone
- Pacerone
- paroxetine HCl
- paroxetine mesylate
- Medrol (pak)
- Medrol
- Maxzide-25Mg
- Maxzide
- Mavik
- Luvox Cr
- Lovenox
- Lotrel
- Lotensin
- losartan-hydrochlorothiazide
- losartan
- Loryna (28)
- Lithobid
- lithium citrate
- lithium carbonate
- lisinopril-hydrochlorothiazide
- lisinopril
- Lexapro
- levomilnacipran
- Lasix
- Khedezla
- ketoconazole
- Kenalog
- irbesartan-hydrochlorothiazide
- irbesartan
- Integrilin
- Hyzaar
- hydrocortisone sod succinate
- hydrocortisone sod succ (PF)
- hydrocortisone acetate
- hydrocortisone
- hesperid-diosmin-grape seed xt
- hesp-diosm hyd-Ca dobe-diosmin
- Hepsera
- heparin, porcine (PF)
- heparin(porcine) in 0.45% NaCl
- heparin (porcine) in D5W
- heparin (porcine)
- Hemril-30
- Hecoria
- Grx Hicort 25
- Gianvi (28)
- Gengraf
- furosemide
- Fragmin
- fosinopril-hydrochlorothiazide
- fosinopril
- fondaparinux
- fluvoxamine
- fluoxetine
- fludrocortisone
- fluconazole in NaCl (iso-osm)
- fluconazole in dextrose(iso-o)
- fluconazole
- Flo-pred
- First-mary's Mouthwash
- First-duke's
- Fetzima
- Ez Use Joint-tunnel-trigger
- Exforge Hct
- Exforge
- ethacrynate sodium
- escitalopram oxalate
- erlotinib
- eptifibatide
- eprosartan-hydrochlorothiazide
- eprosartan
- Epaned
- Entocort Ec
- enoxaparin
- enalaprilat
- enalapril-hydrochlorothiazide
- enalapril maleate
- emtricitabine-tenofovir
- emtricitab-rilpivirine-tenofov
- elvitegr-cobicist-emtric-tenof
- Elmiron
- Effexor Xr
- efavirenz-emtricitabin-tenofov
- Edarbyclor
- Edarbi
- Dyrenium
- Dyazide
- duloxetine
- drospirenone-ethinyl estradiol
- drospirenone-estradiol
- drospirenone-e.estradiol-lm.FA
- Diovan Hct
- diosmin complex no.1
- Diflucan
- Dexpak 6 Day
- Dexpak 13 Day
- Dexpak 10 Day
- dexamethasone sodium phosphate
- dexamethasone sodium phos (PF)
- Dexamethasone Intensol
- dexamethasone
- desvenlafaxine succinate
- desvenlafaxine fumarate
- desvenlafaxine
- Depo-medrol
- Demadex
- dalteparin (porcine)
- Daflonex-xl
- Cymbalta
- cyclosporine modified
- cyclosporine
- Cozaar
- cortisone
- Cortifoam
- Cortenema
- Cortef
- Cordarone
- Complera
- Colocort
- colchicine-probenecid
- clopidogrel
- citalopram
- cilostazol
- Celexa
- Celestone Soluspan
- captopril-hydrochlorothiazide
- captopril
- candesartan-hydrochlorothiazid
- candesartan
- bumetanide
- budesonide
- Brisdelle
- Brintellix
- Brilinta
- Beyaz
- betamethasone acet & sod phos
- Benicar Hct
- Benicar
- benazepril-hydrochlorothiazide
- benazepril
- Azor
- azilsartan medoxomil
- azilsartan med-chlorthalidone
- Avapro
- Avalide
- Atripla
- Atacand Hct
- Atacand
- Astagraf Xl
- Arixtra
- Aristospan Intralesional
- Aristospan Intra-articular
- Anusol-hc
- Anucort-hc
- Angeliq
- amlodipine-valsartan-hcthiazid
- amlodipine-valsartan
- amlodipine-olmesartan
- amlodipine-benazepril
- amiodarone in dextrose,iso-osm
- amiodarone
- amiloride-hydrochlorothiazide
- amiloride
- Altace
- adefovir
- Aceon
- Accuretic
- Accupril
- Accolate
- abciximab
- A-methapred
- A-hydrocort
- Paxil
- Paxil Cr
- Pediapred
- pentosan polysulfate sodium
- perindopril erbumine
- Pexeva
- Physicians Ez Use M-pred
- Plavix
- Pletal
- prednisolone
- prednisolone acetate
- prednisolone sodium phosphate
- prednisone
- Prednisone Intensol
- Prinivil
- Pristiq
- probenecid
- Proctocort
- Prograf
- Prozac
- Prozac Weekly
- quinapril
- quinapril-hydrochlorothiazide
- ramipril
- Rapamune
- Rayos
- Rectacort-hc
- Reopro
- Safyral
- Sandimmune
- Sarafem
- Savella
- sertraline
- sirolimus
- Sodium Edecrin
- Solu-cortef
- Solu-cortef (pf)
- Solu-medrol
- Solu-medrol (pf)
- Stribild
- Syeda
- Symbyax
- tacrolimus
- Tarceva
- Tarka
- telmisartan
- telmisartan-amlodipine
- telmisartan-hydrochlorothiazid
- tenofovir disoproxil fumarate
- Teveten
- Teveten Hct
- ticagrelor
- torsemide
- trandolapril
- trandolapril-verapamil
- triamcinolone acetonide
- triamcinolone hexacetonide
- triamcinolone-lidocaine
- triamterene
- triamterene-hydrochlorothiazid
- Tribenzor
- Trombonex-d
- Truvada
- Twynsta
- Uceris
- Uniretic
- Univasc
- valsartan-hydrochlorothiazide
- Vasculera
- Vaseretic
- Vasoflex Hd
- Vasotec
- Venaliv
- venlafaxine
- Veripred 20
- Vestura (28)
- Vfend
- Vfend Iv
- Viibryd
- vilazodone
- Viread
- vit C-but.broom-hesperidn-dios
- vit C-dios-rut-bioflav-butc br
- voriconazole
- vortioxetine
- Yasmin (28)
- Yaz 28
- zafirlukast
- Zarah
- Zestoretic
- Zestril
- Zoloft
- Aspirin exacerbated respiratory disease
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Drug-induced hepatitis
- Gastrointestinal perforation
- Hepatic failure
- History of roux-en-Y gastric bypass
- Post-operative from CABG surgery
- Pregnancy
- Severe hepatic disease
Contraindicated
- Abnormal hepatic function tests
- Acute myocardial infarction
- Alcoholism
- Burns
- Cerebrovascular accident
- Chronic heart failure
- Chronic kidney disease stage 4 (severe) GFR 15-29 ml/min
- Chronic kidney disease stage 5 (failure) GFr<15 ml/min
- Debilitation
- Disease of liver
- Duodenal ulcer
- Gastrointestinal hemorrhage
- Gastrointestinal perforation
- Gastrointestinal ulcer
- Hepatic porphyria
- Hypertension
- Increased cardiovascular event risk
- Increased risk of bleeding
- Increased risk of bleeding due to coagulation disorder
- Kidney disease with likely reduction in GFR
- Non-infective meningitis
- Peptic ulcer
- Skin ulcer
- Systemic mastocytosis
- Thrombotic disorder
- Tobacco smoker
Severe
Moderate
- Anemia
- Asthma
- Dehydration
- Edema
- Gastritis
- Gastrointestinal ulcer
NUDICLO (DICLOFENAC SODIUM/CAPSAICIN)
- None
- Abdominal pain with cramps
- Blistering skin
- Constipation
- Contact dermatitis
- Diarrhea
- Dyspepsia
- Insomnia
- Nausea
- Pruritus of skin
- Skin inflammation
- Skin rash
- Treatment site sequelae
- Vomiting
More Frequent
Severe
Less Severe
- Abnormal hepatic function tests
- Body fluid retention
- Edema
- Esophageal ulcer
- Gastrointestinal ulcer
- Peptic ulcer
- Pruritus of skin
- Skin rash
- Tinnitus
- Dizziness
- Drowsy
- Dysgeusia
- Dyspepsia
- Edema
- Flatulence
- Headache disorder
- Nausea
- Paresthesia
- Skin inflammation
- Skin ulcer
- Stinging of skin
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal vaginal bleeding
- Acute myocardial infarction
- Acute pancreatitis
- Agranulocytosis
- Allergic dermatitis
- Anaphylaxis
- Anemia
- Angioedema
- Aplastic anemia
- Black tarry stools
- Bloody stools
- Bloody vomit
- Body fluid retention
- Bronchospastic pulmonary disease
- Bullous dermatitis
- Burns
- Cerebrovascular accident
- Colitis
- Diarrhea
- Dyspnea
- Eosinophilia
- Epistaxis
- Erythema multiforme
- Esophagitis
- Exfoliative dermatitis
- Gastric ulcer
- Gastrointestinal hemorrhage
- Gastrointestinal perforation
- Gastrointestinal ulcer
- Heart failure
- Hematuria
- Hemolytic anemia
- Hemorrhage
- Hepatic failure
- Hepatic necrosis
- Hepatitis
- Hyperkalemia
- Hypertension
- Infection
- Interstitial nephritis
- Jaundice
- Kidney disease with reduction in GFR
- Leukopenia
- Memory impairment
- Nephrotic syndrome
- Nephrotoxicity
- Neutropenic disorder
- Non-infective meningitis
- Oliguria
- Pancytopenia
- Platelet aggregation inhibition
- Pneumonia
- Proteinuria
- Renal failure
- Renal papillary necrosis
- Respiratory depression
- Seizure disorder
- Stevens-johnson syndrome
- Thrombocytopenic disorder
- Thrombotic disorder
- Toxic epidermal necrolysis
- Urticaria
Less Severe
- Acute confusion
- Alopecia
- Appetite changes
- Asthma
- Conjunctivitis
- Depression
- Dream disorder
- Drowsy
- Ecchymosis
- Eructation
- Fever
- Flushing
- Gastritis
- General weakness
- Hearing loss
- Hyperglycemia
- Hyperhidrosis
- Hyperkinesis
- Hypertension
- Hypesthesia
- Irritability
- Localized edema
- Lymphadenopathy
- Medication overuse headache
- Palpitations
- Purpura
- Skin photosensitivity
- Stomatitis
- Symptoms of anxiety
- Syncope
- Tachycardia
- Tremor
- Weight loss
- Xerostomia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Diclofenac (Select Routes)
Safety and efficacy in pediatrics have not been established.
- 1 Day – 18 Years
- Safety and efficacy in pediatrics have not been established.
Diclofenac
- Severity Level:
1
- Additional Notes: Fda c before 30wks;premature closure of ductus arteriosus;early miscarriage risk
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
Capsaicin (topical)
Insufficient data available
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available |
Capsicum (systemic)
Insufficient data available
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available |
Diclofenac
Insufficient data available
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Not known; no or inclusive data | Insufficient data available |
Diclofenac (top)
Insufficient data available
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient data available |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
Diclofenac
Gastrointestinal-Increased risk for ulceration or serious GI bleed with history of PUD or GI bleed. Renal-Risk of AKI and exacerbation of CKD. Avoid with CrCl <30 mL/min. Cardiovascular-May exacerbate pre-existing hypertension, CHF. Cardiovascular thrombotic event risk, including MI and stroke, increases with duration of use. Risk for reinfarction with minimal NSAID use post-MI. Contraindicated in the setting of CABG. Hepatic-Elevated hepatic transaminases may occur with chronic use.
Gastrointestinal-Caution with history of PUD or GI bleed. Renal-Monitor patients with renal impairment. Cardiovascular-May exacerbate pre-existing hypertension, CHF. Cardiovascular thrombotic event risk, including MI and stroke, increases with duration of use. Risk for reinfarction with minimal NSAID use post-MI. Contraindicated in the setting of CABG. Hepatic-Elevated hepatic transaminases may occur with chronic use.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | Y | Y | Y | N | N | N |
BEERS: Y HEDIS: Y STOPP: Y
Diclofenac (topical)
Gastrointestinal-Increased risk for ulceration or serious GI bleed with history of PUD or GI bleed. Renal-Risk of AKI and exacerbation of CKD. Avoid with CrCl <30 mL/min. Cardiovascular-May exacerbate pre-existing hypertension, CHF. Cardiovascular thrombotic event risk, including MI and stroke, increases with duration of use. Risk for reinfarction with minimal NSAID use post-MI. Contraindicated in the setting of CABG. Hepatic-Elevated hepatic transaminases may occur with chronic use.
Gastrointestinal-Caution with history of PUD or GI bleed. Renal-Monitor patients with renal impairment. Cardiovascular-May exacerbate pre-existing hypertension, CHF. Cardiovascular thrombotic event risk, including MI and stroke, increases with duration of use. Risk for reinfarction with minimal NSAID use post-MI. Contraindicated in the setting of CABG. Hepatic-Elevated hepatic transaminases may occur with chronic use.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | Y | Y | Y | N | N | N |
BEERS: Y HEDIS: N STOPP: Y
No Known Risk
None
- Nonsteroidal anti-inflammatory drugs (including diclofenac) may rarely increase the risk for a heart attack or stroke. This effect can happen at any time while using this drug but is more likely if you use it for a long time. The risk may be greater if you have heart disease or increased risk for heart disease (for example, due to smoking, family history of heart disease, or conditions such as high blood pressure or diabetes).<br /><br /> Do not use this drug right before or after heart bypass surgery (CABG). Also, this drug may rarely cause serious (rarely fatal) bleeding from the stomach or intestines. This side effect can occur without warning symptoms at any time while using diclofenac.<br /><br />Older adults may be at higher risk for this effect. (See also Precautions and Drug Interactions sections.) Stop using diclofenac and get medical help right away if you notice any of the following rare but very serious side effects: black/bloody stools, persistent stomach/abdominal pain, vomit that looks like coffee grounds, chest/jaw/left arm pain, shortness of breath, unusual sweating, confusion, weakness on one side of the body, sudden vision changes, trouble speaking. Talk with your doctor or pharmacist about the benefits and risks of using this medication.