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VAGIFEM (ESTRADIOL)
- Atrophic vaginitis associated with menopause
- Atrophy of vulva
10 mcg vaginal tablet
- Insert 1 tablet (10 mcg) by vaginal route once daily for 14 days then1 tablet (10 mcg) 2 times per week for duration of use
10 mcg vaginal tablet
- Insert 1 tablet (10 mcg) by vaginal route once daily for 14 days then1 tablet (10 mcg) 2 times per week for duration of use
10 mcg vaginal tablet
- Insert 1 tablet (10 mcg) by vaginal route once daily for 14 days then1 tablet (10 mcg) 2 times per week for duration of use
Atrophic vaginitis associated with menopause
- Insert 1 tablet (10 mcg) by vaginal route once daily for 14 days then1 tablet (10 mcg) 2 times per week for duration of use
- Insert 1 tablet (10 mcg) by vaginal route twice weekly
Atrophy of vulva
- Insert 1 tablet (10 mcg) by vaginal route once daily for 14 days then1 tablet (10 mcg) 2 times per week for duration of use
- Insert 1 tablet (10 mcg) by vaginal route twice weekly
Postmenopausal urethral atrophy
- Insert 1 tablet (10 mcg) by vaginal route once daily for 14 days then1 tablet (10 mcg) 2 times per week for duration of use
- Insert 1 tablet (10 mcg) by vaginal route twice weekly
- anastrozole
- Arimidex
- Aromasin
- exemestane
- Femara
- letrozole
Contraindicated
- None
Severe
Moderate
- A-hydrocort
- A-methapred
- Alagesic Lq
- amobarbital
- Amytal
- Anucort-hc
- Anusol-hc
- Aristospan Intra-articular
- Aristospan Intralesional
- Ascomp With Codeine
- Belladonna-phenobarbital
- betamethasone acet & sod phos
- Bivigam
- Brevital
- budesonide
- Bupap
- butabarbital
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-acetaminop-caf-cod
- butalbital-acetaminophen
- butalbital-acetaminophen-caff
- butalbital-aspirin-caffeine
- Butisol
- Capacet
- Carimune Nf Nanofiltered
- Celestone Soluspan
- Cerebyx
- codeine-butalbital-ASA-caff
- Colocort
- Cortef
- Cortenema
- Cortifoam
- cortisone
- Depo-medrol
- dexamethasone
- Dexamethasone Intensol
- dexamethasone sodium phos (PF)
- dexamethasone sodium phosphate
- Dexpak 10 Day
- Dexpak 13 Day
- Dexpak 6 Day
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Donnatal
- Entocort Ec
- Esgic
- ethotoin
- Ez Use Joint-tunnel-trigger
- Fioricet
- Fioricet With Codeine
- Fiorinal
- Fiorinal-codeine #3
- First-duke's
- First-mary's Mouthwash
- Flebogamma Dif
- Flo-pred
- fludrocortisone
- fosphenytoin
- Gamastan S/d
- Gammagard Liquid
- Gammagard S-d (iga < 1 Mcg/ml)
- Gammagard S/d
- Gammaked
- Gammaplex
- Gamunex-c
- Grx Hicort 25
- Hemril-30
- Hizentra
- hydrocortisone
- hydrocortisone acetate
- hydrocortisone sod succ (PF)
- hydrocortisone sod succinate
- immune glob(IgG)(hum)-maltose
- immune globulin (human) (IgG)
- immune globulin(hum),capr(IgG)
- Kenalog
- Luminal
- Margesic
- Marten-tab
- Medrol
- Medrol (pak)
- methohexital
- methylprednisolone
- methylprednisolone acetate
- methylprednisolone sod suc(PF)
- methylprednisolone sodium succ
- methylprednisolone-bupivacaine
- Millipred
- Millipred Dp
- Mysoline
- Nembutal Sodium
- nystatin-hydrocortisone-diphen
- nystatin-TCN-HC-diphenhydramin
- Octagam
- Orapred
- Orapred Odt
- Pediapred
- Peganone
- pentobarbital sodium
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- Physicians Ez Use M-pred
- prednisolone
- prednisolone acetate
- prednisolone sodium phosphate
- prednisone
- Prednisone Intensol
- primidone
- Privigen
- Proctocort
- Rayos
- Rectacort-hc
- secobarbital sodium
- Seconal Sodium
- Solu-cortef
- Solu-cortef (pf)
- Solu-medrol
- Solu-medrol (pf)
- Tencon
- triamcinolone acetonide
- triamcinolone hexacetonide
- triamcinolone-lidocaine
- Uceris
- Veripred 20
- Zebutal
- Disease of liver
Contraindicated
- Carcinoma of breast
- Dementia
- Endometrial carcinoma
- Estrogen-dependent neoplasm
- Hepatic porphyria
- Hereditary angioedema
- Malignant neoplasm of the ovary
- Mammography abnormal
- Neoplasm of female genital organ
Severe
Moderate
- Diabetes mellitus
- Endometriosis
- Gallbladder disease
- Hypertension
- Hypertriglyceridemia
- Hypothyroidism
- Seizure disorder
- Systemic lupus erythematosus
- Tobacco smoker
- Uterine leiomyoma
VAGIFEM (ESTRADIOL)
- Atrophic vaginitis associated with menopause
- Atrophy of vulva
- None
- Abdominal distension
- Back pain
- Headache disorder
- Infection
- Mastalgia
- Vulvovaginal candidiasis
- Weight gain
More Frequent
Severe
Less Severe
- None
- Acne vulgaris
- Candidiasis
- Cramps
- General weakness
- Gynecomastia
- Libido changes
- Migraine
- Pelvic pain
- Pruritus of skin
- Vaginitis
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute myocardial infarction
- Anaphylaxis
- Angioedema
- Cerebrovascular accident
- Deep venous thrombosis
- Dementia
- Endometrial carcinoma
- Endometrial hyperplasia
- Gallbladder obstruction
- Hypercalcemia
- Hypersensitivity drug reaction
- Hypertension
- Hypertriglyceridemia
- Malignant neoplasm of the ovary
- Neoplasm of breast
- Precocious puberty
- Pulmonary thromboembolism
- Retinal thrombosis
- Thromboembolic disorder
- Uterine leiomyoma
Less Severe
- Abdominal pain with cramps
- Abnormal vaginal bleeding
- Body fluid retention
- Chloasma
- Depression
- Diarrhea
- Dysmenorrhea
- Genital organ pruritus
- Insomnia
- Nipple discharge
- Urticaria
- Vaginal discharge
- Vaginal irritation
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Estrogens, Vaginal
Not indicated in pediatrics.
- 1 Day – 18 Years
- Not indicated in pediatrics.
Estradiol
- Severity Level:
2
- Additional Notes: Not indicated during pregnancy; no known dev tox
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Estradiol
Limited data indicate higher excretion may occur w/vaginal vs transderm admin
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited data indicate higher excretion may occur w/vaginal vs transderm admin |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Estrogenic Agents (vaginal)
General-Use lowest possible dose for shortest duration and in combination with a progestin as indicated to reduce the risk of endometrial hyperplasia and breast cancer. Low-dose intravaginal estrogen may be used for management of vaginal symptoms (e.g. dyspareunia, recurrent UTIs). Cardiovascular-Avoid with active or history of DVT,PE or thromboembolic disease.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | Y | Y | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- Estrogens, either used alone or with another hormone (progestin), have rarely caused very serious side effects. Discuss the risks and benefits of hormone treatment with your doctor. Estrogens should not be used to prevent heart disease or dementia.<br /><br /> Estrogens can increase the risk of cancer of the uterus (endometrial cancer). Taking a progestin as directed by your doctor can help decrease this risk. Tell your doctor right away if you have any unusual vaginal bleeding.<br /><br /> In postmenopausal women, estrogens can increase the risk of cancer of the ovaries, stroke, dementia, and serious blood clots in the legs. Estrogens alone do not appear to increase the risk of breast cancer when used for up to 7 years. Estrogen, when used with a progestin, can increase the risk of heart disease (such as heart attacks), stroke, serious blood clots in the lungs/legs, dementia, and cancer of the breast/ovaries.<br /><br /> The risk for serious side effects may depend on the dose of estrogen and the length of time it is used. Therefore, this medication should be used at the lowest effective dose and for the shortest amount of time. Discuss the use of this medication with your doctor and check with him/her regularly (for example, every 3 to 6 months) to see if you still need to take this medication.<br /><br />If you will be taking this medication long-term, you should have regular complete physical exams (for example, once a year) as directed by your doctor. See also Notes section.
| Atrophic vaginitis associated with menopause | |
| N95.2 | Postmenopausal atrophic vaginitis |
| Atrophy of vulva | |
| N90.5 | Atrophy of vulva |
| 0-9 | A-Z |
|---|---|
| N90.5 | Atrophy of vulva |
| N95.2 | Postmenopausal atrophic vaginitis |
Formulary Reference Tool