PEXEVA (PAROXETINE MESYLATE)
- Generalized anxiety disorder
- Major depressive disorder
- Obsessive-compulsive disorder
- Anxiety with depression
- Panic disorder
10 mg tablet
- 2 tablets (20 mg) by oral route once daily
20 mg tablet
- 1 tablet (20 mg) by oral route once daily
30 mg tablet
- 1 tablet (30 mg) by oral route once daily
40 mg tablet
- 1 tablet (40 mg) by oral route once daily
Anxiety with depression
- 2 tablets (20 mg) by oral route once daily
- 1 tablet (20 mg) by oral route once daily
- 1 tablet (30 mg) by oral route once daily
Generalized anxiety disorder
- 2 tablets (20 mg) by oral route once daily
- 1 tablet (20 mg) by oral route once daily
- 1 tablet (30 mg) by oral route once daily
- 2 tablets (40 mg) by oral route once daily
- 1 tablet (40 mg) by oral route once daily
Major depressive disorder
- 2 tablets (20 mg) by oral route once daily
- 1 tablet (20 mg) by oral route once daily
- 1 tablet (30 mg) by oral route once daily
- 2 tablets (40 mg) by oral route once daily
- 1 tablet (40 mg) by oral route once daily
Obsessive-compulsive disorder
- 2 tablets (20 mg) by oral route once daily
- 1 tablet (20 mg) by oral route once daily
- 1 tablet (30 mg) by oral route once daily
- 2 tablets (40 mg) by oral route once daily
- 1 tablet (40 mg) by oral route once daily
- 2 tablets (60 mg) by oral route once daily
Panic disorder
- 1 tablet (10 mg) by oral route once daily
- 2 tablets (20 mg) by oral route once daily
- 1 tablet (20 mg) by oral route once daily
- 1 tablet (30 mg) by oral route once daily
- 2 tablets (40 mg) by oral route once daily
- 1 tablet (40 mg) by oral route once daily
- 2 tablets (60 mg) by oral route once daily
- Azilect
- Eldepryl
- isocarboxazid
- linezolid
- Marplan
- Matulane
- methylene blue (antidote)
- Nardil
- Orap
- Parnate
- phenelzine
- pimozide
- procarbazine
- rasagiline
- selegiline HCl
- thioridazine
- tranylcypromine
- Zelapar
- Zyvox
Contraindicated
- atomoxetine
- Brintellix
- Coumadin
- Datscan
- Demerol
- Demerol (pf)
- dextromethorphan-quinidine
- ioflupane I 123
- Jantoven
- meperidine
- meperidine (PF)
- Meperitab
- metoclopramide HCl
- Metozolv Odt
- Nuedexta
- Reglan
- Soltamox
- Strattera
- tamoxifen
- vortioxetine
- warfarin
Severe
Moderate
- abciximab
- Abilify
- Abilify Discmelt
- Abilify Maintena
- Abstral
- acetaminophen-codeine
- Actiq
- Activase
- Added Strength Headache Relief
- Added Strength Pain Reliever
- Adderall
- Adderall Xr
- Adipex-p
- Adult Low Dose Aspirin
- Advil
- Advil Allergy Sinus
- Advil Allergy-congestion Rlf
- Advil Cold & Sinus
- Advil Congestion Relief
- Advil Liqui-gel
- Advil Migraine
- Advil Pm
- Advil Pm Liqui-gels
- Aggrastat In Sodium Chloride
- Aggrenox
- Aleve
- Aleve Cold & Sinus
- Aleve Sinus & Headache
- Aleve-d Sinus & Cold
- Aleve-d Sinus & Headache
- Alka-seltzer
- Alka-seltzer Extra Strength
- Alka-seltzer Original
- Alka-seltzer Plus C/c(pe,dm)
- Alka-seltzer Plus Cold (pe)
- Alka-seltzer Plus Day-night
- Alka-seltzer Plus Night
- Alka-seltzer Pm
- All Day Pain Relief
- All Day Pain Relief Sinus & Co
- All Day Relief
- almotriptan malate
- Alsuma
- alteplase
- Amerge
- Amphetamine Salt Combo
- Anacin
- Anacin Maximum Strength
- Analgesic
- Anaprox
- Anaprox Ds
- Ansaid
- Antacid & Pain Relief
- aripiprazole
- Arthri-flex
- Arthrotec 50
- ASA-acetaminophen-caff-buffers
- ASA-acetaminophen-salicyl-caff
- Ascomp With Codeine
- Aspir-81
- Aspir-low
- Aspir-trin
- aspirin
- Aspirin Childrens
- Aspirin Low Dose
- Aspirin Low-strength
- aspirin, buffered
- aspirin-acetaminophen-caffeine
- aspirin-caffeine
- aspirin-calcium carbonate
- aspirin-diphenhydramine
- aspirin-diphenhydramine citrat
- aspirin-sod bicarb-citric acid
- Axert
- Back & Body Pain Reliever
- Bayer Advanced
- Bayer Aspirin
- Bayer Aspirin (with Caffeine)
- Bayer Back & Body
- Bayer Chewable Aspirin
- Bayer Childrens Aspirin
- Bayer Plus Extra Strength
- Bayer Pm
- Bc
- Bc Arthritis
- Brilinta
- bromphen-pseudoephed-codeine
- brompheniramine-PE-codeine
- Buffered Aspirin
- Bufferin
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-acetaminop-caf-cod
- butalbital-aspirin-caffeine
- Caldolor
- Cambia
- Capcof
- Capital With Codeine
- carisoprodol-ASA-codeine
- carisoprodol-aspirin
- Cataflam
- Celebrex
- celecoxib
- Cheratussin Ac
- Cheratussin Dac
- Child Aspirin
- Child Ibuprofen
- Children's Advil
- Children's Aspirin
- Children's Ibu-drops
- Children's Ibuprofen
- Children's Medi-profen
- Children's Motrin
- Children's Profen Ib
- chlorcyclizine-codeine
- chlorphen-phenyleph-DM-aspirin
- chlorphen-phenyleph-ibuprofen
- chlorphen-pseudoeph-ibuprofen
- chlorphen-pseudoephed-codeine
- chlorphenir-phenylephrn-aspirn
- chlorpheniramine-codeine
- chlorpheniramine-PE-codeine
- cilostazol
- clopidogrel
- clrcycliz-pseudoephed-codeine
- codeine sulfate
- codeine-butalbital-ASA-caff
- codeine-guaifenesin
- codeine-pyrilamine
- Cold & Sinus Pain Relief
- Cold Relief
- Cold Relief Plus
- Cold-sinus Relief
- Conzip
- Cymbalta
- Daypro
- Desoxyn
- dexbrompheniramine-PSE-codeine
- dexchlorphen-phenyleph-codeine
- Dexedrine Spansule
- dextroamphetamine
- dextroamphetamine-amphetamine
- diclofenac epolamine
- diclofenac potassium
- diclofenac sodium
- diclofenac submicronized
- diclofenac-misoprostol
- dihydrocodeine-aspirin-caff
- dipyridamole-aspirin
- doxylamine-phenylep-DM-aspirin
- Duexis
- duloxetine
- Duragesic
- E.c. Prin
- Ec-naprosyn
- Ecotrin
- Ecotrin Low Strength
- Efferves Pain Relief Antacid
- Effervescent Antacid
- Effervescent Pain Relief
- Effervescent Pain Reliever
- eletriptan HBr
- Endodan
- Enteric Coated Aspirin
- eptifibatide
- etodolac
- Excedrin Extra Strength
- Excedrin Migraine
- Extra Strength Bayer
- Feldene
- fenoprofen
- fentanyl
- fentanyl citrate
- fentanyl citrate (PF)
- Fentora
- Fioricet With Codeine
- Fiorinal
- Fiorinal-codeine #3
- Flanax
- Flector
- flurbiprofen
- Frova
- frovatriptan
- gluc-msm-coll2-hyal-antiarthr3
- glucos-msm-C-Mn-ginger-willow
- glucos-msm-C-Mn-herb#21
- glucos-msm-collagen-C-Mn-hrb21
- Glucosamine-msm Complex
- Goody's Extra Strength
- Goody's Migraine Relief
- Guaiatussin Ac
- Guaifenesin Ac
- Guaifenesin Dac
- Guiatuss Ac
- Headache Formula
- Headache Formula Added Str
- Headache Relief
- heparin (porcine)
- heparin (porcine) in D5W
- heparin(porcine) in 0.45% NaCl
- heparin, porcine (PF)
- hydrocodone-ibuprofen
- I-prin
- Ibu-drops
- Ibudone
- ibuprofen
- Ibuprofen Cold
- Ibuprofen Cold-sinus(with Pse)
- Ibuprofen Ib
- Ibuprofen Jr Strength
- ibuprofen lysine (PF)
- Ibuprofen Pm
- ibuprofen-diphenhydramine
- ibuprofen-diphenhydramine HCl
- ibuprofen-famotidine
- ibuprofen-oxycodone
- ibuprofen-phenylephrine HCl
- Imitrex
- Imitrex Statdose Kit Refill
- Imitrex Statdose Pen
- Indocin
- indomethacin
- indomethacin sodium
- Infant's Ibuprofen
- Infant's Medi-profen
- Infant's Motrin
- Infants Ibu-drops
- Infants Profenib
- Integrilin
- Iophen C-nr
- ketoprofen
- ketorolac
- Lamisil
- Lazanda
- Levacet
- levmetamfetamine
- lisdexamfetamine
- Lite Coat Aspirin
- lithium carbonate
- lithium citrate
- Lithobid
- Lo-dose Aspirin
- Lortuss Ex
- M-clear Wc
- M-end Max D
- M-end Pe
- Mar-cof Bp
- Mar-cof Cg
- Maxalt
- Maxalt-mlt
- Medi-profen
- Medi-seltzer
- Mediproxen
- mefenamic acid
- meloxicam
- methamphetamine
- Midol (naproxen)
- Migraine Formula
- Migraine Pain Reliever
- Migraine Relief
- Mobic
- Motrin Ib
- Motrin Pm
- Msm Glucosamine Complex
- nabumetone
- Nalfon
- Naprelan Cr
- Naprosyn
- naproxen
- naproxen sodium
- naproxen-esomeprazole
- naproxen-pseudoephedrine
- naratriptan
- Neoprofen (ibuprofen Lysn)(pf)
- Nucynta
- Nucynta Er
- Orphenadrine Compound Forte
- Orphenadrine Compound-ds
- orphenadrine-ASA-caffeine
- oxaprozin
- oxycodone-aspirin
- Pain Relief
- Pain Relief Extra Strength
- Pain Reliever
- Pain Reliever Extra Strength
- Pain Reliever Plus
- Pain-off
- Pamprin Max
- PE-DM-ASA/doxyla-PE-DM-ASA
- Pennsaid
- Percodan
- phentermine
- phentermine-topiramate
- Phenylhistine
- Phenylhistine Dh
- piroxicam
- Plavix
- Pletal
- Poly-tussin
- Poly-tussin Ac
- Poly-tussin D
- Ponstel
- Pravachol
- pravastatin
- Pro-clear Ac
- Pro-clear Caps
- Pro-red Ac (w/ Dexchlorphenir)
- Procentra
- Promethazine Vc-codeine
- promethazine-codeine
- promethazine-phenyleph-codeine
- Provil
- pseudoephedrine-codeine-GG
- pseudoephedrine-ibuprofen
- Qsymia
- Relcof C
- Relpax
- Reopro
- Reprexain
- Retavase
- reteplase
- Risperdal
- Risperdal Consta
- Risperdal M-tab
- risperidone
- risperidone microspheres
- rizatriptan
- Rydex
- Sinus & Cold-d
- Solaraze
- Sprix
- St Joseph Aspirin
- St. Joseph Aspirin
- Statuss Green (codeine)
- Sublimaze (pf)
- Subsys
- sulindac
- sumatriptan
- sumatriptan succinate
- Sumavel Dosepro
- Super Pain Relief
- Suprenza
- Synalgos-dc
- Synapryn
- tapentadol
- tenecteplase
- terbinafine
- tetrabenazine
- ticagrelor
- ticlopidine
- tirofiban-0.9% sodium chloride
- Tnkase
- tolmetin
- tramadol
- tramadol-acetaminophen
- tramadol-glucosamine
- Tri-buffered Aspirin
- Trymine Cg
- Tusnel C
- Tylenol-codeine #3
- Tylenol-codeine #4
- Ultracet
- Ultram
- Ultram Er
- Vanquish
- Vapor Inhaler
- Vicoprofen
- Vimovo
- Virtussin Ac
- Voltaren-xr
- Vyvanse
- Wal-profen
- Wal-profen Cold-sinus
- Wal-proxen
- Women's Aspirin With Calcium
- Xenazine
- Z-tuss Ac
- Z-tuss E
- Zenzedi
- Zipsor
- Zodryl Ac 25
- Zodryl Ac 30
- Zodryl Ac 35
- Zodryl Ac 40
- Zodryl Ac 50
- Zodryl Ac 60
- Zodryl Ac 80
- Zodryl Dac 25
- Zodryl Dac 30
- Zodryl Dac 35
- Zodryl Dac 40
- Zodryl Dac 50
- Zodryl Dac 60
- Zodryl Dac 80
- Zodryl Dec 25
- Zodryl Dec 30
- Zodryl Dec 35
- Zodryl Dec 40
- Zodryl Dec 50
- Zodryl Dec 60
- Zodryl Dec 80
- zolmitriptan
- Zomig
- Zomig Zmt
- Zorvolex
- Serotonin syndrome
Contraindicated
- Angle-closure glaucoma
- Bipolar disorder
- Disease of liver
- Pregnancy
- Risk of angle-closure glaucoma due to narrow angle
- Severe renal impairment
- Suicidal ideation
- Upper GI bleed
Severe
Moderate
- Akathisia
- Hyponatremia
- Increased risk of bleeding
- Manic disorder
- Pathological fracture
- Seizure disorder
- SIADH syndrome
PEXEVA (PAROXETINE MESYLATE)
- Generalized anxiety disorder
- Major depressive disorder
- Obsessive-compulsive disorder
- Anxiety with depression
- Panic disorder
- None
- Abnormal sexual function
- Anorexia
- Constipation
- Diarrhea
- Disorder of ejaculation
- Dizziness
- Drowsy
- Dysuria
- General weakness
- Headache disorder
- Hyperhidrosis
- Insomnia
- Nausea
- Nervousness
- Tremor
- Urinary retention
- Visual changes
- Xerostomia
More Frequent
Severe
Less Severe
- Acute confusion
- Hypertension
- Myoclonus
- Myopathy
- Acute abdominal pain
- Aggressive behavior
- Agitation
- Arthralgias
- Back pain
- Blurred vision
- Chest pain
- Cough
- Dysgeusia
- Dyspepsia
- Erectile dysfunction
- Fatigue
- Flatulence
- Hypertonia
- Increased appetite
- Increased urinary frequency
- Lethargy
- Libido changes
- Malaise
- Mood changes
- Muscle weakness
- Myalgias
- Orgasm disorder
- Palpitations
- Paresthesia
- Pruritus of skin
- Rhinitis
- Sinusitis
- Skin rash
- Symptoms of anxiety
- Tachycardia
- Vasodilation of blood vessels
- Vertigo
- Vomiting
- Weight gain
- Weight loss
- Yawning
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Abnormal hepatic function tests
- Acquired dystonia
- Acute myocardial infarction
- Acute renal failure
- Agranulocytosis
- Akathisia
- Anaphylaxis
- Anemia
- Angina
- Aplastic anemia
- Atrial fibrillation
- Bone marrow depression
- Bradycardia
- Bundle branch block
- Cerebral ischemia
- Cerebrovascular accident
- Colitis
- Drug-induced hepatitis
- Dyskinesia
- Extrapyramidal disease
- Fracture
- Guillain-barre syndrome
- Heart block
- Heart failure
- Hemolytic anemia
- Hepatic failure
- Hypersensitivity pneumonitis
- Hypomania
- Hyponatremia
- Increased risk of bleeding
- Leukocytosis
- Leukopenia
- Lymphocytosis
- Manic disorder
- Myocardial ischemia
- Neuroleptic malignant syndrome
- Neutropenic disorder
- Optic neuritis
- Pancreatitis
- Pancytopenia
- Porphyria
- Priapism
- Pulmonary hypertension
- Pulmonary thromboembolism
- Purpura
- Rectal bleeding
- Secondary angle-closure glaucoma
- Seizure disorder
- Serotonin syndrome
- SIADH syndrome
- Stevens-johnson syndrome
- Suicidal ideation
- Supraventricular premature beats
- Thrombocytopenic disorder
- Thrombocytosis
- Torsades de pointes
- Toxic epidermal necrolysis
- Trismus
- Vasculitis
- Ventricular fibrillation
- Ventricular tachycardia
Less Severe
- Aphthous stomatitis
- Bruxism
- Candidiasis
- Chills
- Dysarthria
- Dysphagia
- Eczema
- Edema
- Eosinophilia
- Galactorrhea not associated with childbirth
- Glossitis
- Hallucinations
- Hypercholesterolemia
- Hyperkinesis
- Hyperprolactinemia
- Hypokinesia
- Hypotension
- Laryngismus
- Lymphadenopathy
- Lymphedema
- Memory impairment
- Menorrhagia
- Migraine
- Mydriasis
- Orthostatic hypotension
- Pallor
- Phlebitis
- Restless legs syndrome
- Skin photosensitivity
- Syncope
- Tinnitus
- Vaginitis
Contraindicated
None
Severe Precaution
Paroxetine
Possible increased risk of suicide, emotional lability, behavioral changes, hyperkinesia in pediatric and adolescent patients. May decrease appetite; monitor growth rate. No efficacy data for treating depression.
- 1 Day – 18 Years
- Possible increased risk of suicide, emotional lability, behavioral changes, hyperkinesia in pediatric and adolescent patients. May decrease appetite; monitor growth rate. No efficacy data for treating depression.
Management or Monitoring Precaution
None
Paroxetine
- Severity Level:
D
- Additional Notes: Risk of heart defects in first trimester; pulm htn 2nd trim;behav syndr 3rd trim
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
Paroxetine
Low levels excreted, reports of irritability, sleepiness, and constipation
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Not known; no or inclusive data | Low levels excreted, reports of irritability, sleepiness, and constipation |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other important benefits. However, studies have shown that a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts.<br /><br />Therefore, it is very important to talk with the doctor about the risks and benefits of antidepressant medication (especially for people younger than 25), even if treatment is not for a mental/mood condition. Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.
Anxiety with depression | |
F41.8 | Other specified anxiety disorders |
Generalized anxiety disorder | |
F41.1 | Generalized anxiety disorder |
Major depressive disorder | |
F32 | Major depressive disorder, single episode |
F32.0 | Major depressive disorder, single episode, mild |
F32.1 | Major depressive disorder, single episode, moderate |
F32.2 | Major depressive disorder, single episode, severe without psychotic features |
F32.3 | Major depressive disorder, single episode, severe with psychotic features |
F32.4 | Major depressive disorder, single episode, in partial remission |
F32.5 | Major depressive disorder, single episode, in full remission |
F32.9 | Major depressive disorder, single episode, unspecified |
F33 | Major depressive disorder, recurrent |
F33.0 | Major depressive disorder, recurrent, mild |
F33.1 | Major depressive disorder, recurrent, moderate |
F33.2 | Major depressive disorder, recurrent severe without psychotic features |
F33.3 | Major depressive disorder, recurrent, severe with psychotic symptoms |
F33.4 | Major depressive disorder, recurrent, in remission |
F33.40 | Major depressive disorder, recurrent, in remission, unspecified |
F33.41 | Major depressive disorder, recurrent, in partial remission |
F33.42 | Major depressive disorder, recurrent, in full remission |
F33.9 | Major depressive disorder, recurrent, unspecified |
Obsessive-compulsive disorder | |
F42 | Obsessive-compulsive disorder |
F42.8 | Other obsessive-compulsive disorder |
F42.9 | Obsessive-compulsive disorder, unspecified |
F60.5 | Obsessive-compulsive personality disorder |
R46.81 | Obsessive-compulsive behavior |
Panic disorder | |
F40.01 | Agoraphobia with panic disorder |
F41.0 | Panic disorder [episodic paroxysmal anxiety] |
0-9 | A-Z |
---|---|
F32 | Major depressive disorder, single episode |
F32.0 | Major depressive disorder, single episode, mild |
F32.1 | Major depressive disorder, single episode, moderate |
F32.2 | Major depressive disorder, single episode, severe without psychotic features |
F32.3 | Major depressive disorder, single episode, severe with psychotic features |
F32.4 | Major depressive disorder, single episode, in partial remission |
F32.5 | Major depressive disorder, single episode, in full remission |
F32.9 | Major depressive disorder, single episode, unspecified |
F33 | Major depressive disorder, recurrent |
F33.0 | Major depressive disorder, recurrent, mild |
F33.1 | Major depressive disorder, recurrent, moderate |
F33.2 | Major depressive disorder, recurrent severe without psychotic features |
F33.3 | Major depressive disorder, recurrent, severe with psychotic symptoms |
F33.4 | Major depressive disorder, recurrent, in remission |
F33.40 | Major depressive disorder, recurrent, in remission, unspecified |
F33.41 | Major depressive disorder, recurrent, in partial remission |
F33.42 | Major depressive disorder, recurrent, in full remission |
F33.9 | Major depressive disorder, recurrent, unspecified |
F40.01 | Agoraphobia with panic disorder |
F41.0 | Panic disorder [episodic paroxysmal anxiety] |
F41.1 | Generalized anxiety disorder |
F41.8 | Other specified anxiety disorders |
F42 | Obsessive-compulsive disorder |
F42.8 | Other obsessive-compulsive disorder |
F42.9 | Obsessive-compulsive disorder, unspecified |
F60.5 | Obsessive-compulsive personality disorder |
R46.81 | Obsessive-compulsive behavior |