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SCEMBLIX (asciminib hydrochloride)
- chronic phase Philadelphia chromosome (+) CML
- chronic phase Philadelphia chromosome (+) CML with T315I
20 mg tablet
- 2 tablets (40 mg) by oral route once daily
40 mg tablet
- 2 tablets (80 mg) by oral route once daily
Default screening record
- 1 tablet (20 mg) by oral route 2 times per day
- 2 tablets (40 mg) by oral route 2 times per day
- 2 tablets (40 mg) by oral route once daily
- 1 tablet (40 mg) by oral route once daily
- 1 tablet (40 mg) by oral route 2 times per day
- 2 tablets (80 mg) by oral route once daily
- 4 tablets (160 mg) by oral route 2 times per day
- 5 tablets (200 mg) by oral route 2 times per day
- adenovirus vac live type-4 & 7
- adenovirus vaccine live type-4
- adenovirus vaccine live type-7
- BCG vaccine, live (PF)
- flu vac,qval 2013-14 (2-49yrs)
- Flumist 2013-2014
- M-m-r Ii (pf)
- measles,mumps&rubella vacc(PF)
- measles,mumps,rub,varicel(PF)
- natalizumab
- Proquad (pf)
- Rotateq Vaccine
- rotavirus vaccine live, penta
- typhoid vaccine
- Tysabri
- varicella virus vacc live (PF)
- Varivax (pf)
- Vivotif Berna Vaccine
- yellow fever vaccine live (PF)
- Yf-vax (pf)
- Zostavax (pf)
- zoster vaccine live (PF)
Contraindicated
- clozapine
- Clozaril
- deferiprone
- Fazaclo
- Ferriprox
- Versacloz
Severe
Moderate
- Advil
- Advil Allergy Sinus
- Advil Allergy-congestion Rlf
- Advil Cold & Sinus
- Advil Congestion Relief
- Advil Liqui-gel
- Advil Migraine
- Advil Pm
- Advil Pm Liqui-gels
- Aleve
- Aleve Cold & Sinus
- Aleve Sinus & Headache
- Aleve-d Sinus & Cold
- Aleve-d Sinus & Headache
- All Day Pain Relief
- All Day Pain Relief Sinus & Co
- All Day Relief
- Anaprox
- Anaprox Ds
- Ansaid
- Arthrotec 50
- Caldolor
- Cambia
- Cataflam
- Celebrex
- celecoxib
- Child Ibuprofen
- Children's Advil
- Children's Ibu-drops
- Children's Ibuprofen
- Children's Medi-profen
- Children's Motrin
- Children's Profen Ib
- chlorphen-phenyleph-ibuprofen
- chlorphen-pseudoeph-ibuprofen
- Cold & Sinus Pain Relief
- Cold-sinus Relief
- diclofenac epolamine
- diclofenac potassium
- diclofenac sodium
- diclofenac submicronized
- diclofenac-misoprostol
- Duexis
- Ec-naprosyn
- Feldene
- Flanax
- Flector
- flurbiprofen
- hydrocodone-ibuprofen
- I-prin
- Ibu-drops
- Ibudone
- ibuprofen
- Ibuprofen Cold
- Ibuprofen Cold-sinus(with Pse)
- Ibuprofen Ib
- Ibuprofen Jr Strength
- ibuprofen lysine (PF)
- Ibuprofen Pm
- ibuprofen-diphenhydramine
- ibuprofen-diphenhydramine HCl
- ibuprofen-famotidine
- ibuprofen-oxycodone
- ibuprofen-phenylephrine HCl
- Infant's Ibuprofen
- Infant's Medi-profen
- Infant's Motrin
- Infants Ibu-drops
- Infants Profenib
- Juxtapid
- lomitapide
- Medi-profen
- Mediproxen
- meloxicam
- Midol (naproxen)
- Mobic
- Motrin Ib
- Motrin Pm
- Naprelan Cr
- Naprosyn
- naproxen
- naproxen sodium
- naproxen-esomeprazole
- naproxen-pseudoephedrine
- Neoprofen (ibuprofen Lysn)(pf)
- piroxicam
- Provil
- pseudoephedrine-ibuprofen
- Reprexain
- Sinus & Cold-d
- Vicoprofen
- Vimovo
- Voltaren-xr
- Wal-profen
- Wal-profen Cold-sinus
- Wal-proxen
- Zipsor
- Zorvolex
- Lactation
Contraindicated
- Elevated serum amylase
- Elevated serum lipase
- Hypertension
- Neutropenic disorder
- Pancreatitis
- Pregnancy
- Thrombocytopenic disorder
Severe
Moderate
- Anemia
SCEMBLIX (asciminib hydrochloride)
- chronic phase Philadelphia chromosome (+) CML
- chronic phase Philadelphia chromosome (+) CML with T315I
- Anemia
- Elevated serum amylase
- Elevated serum lipase
- Increased alanine transaminase
- Neutropenic disorder
- Thrombocytopenic disorder
- Diarrhea
- Fatigue
- Hypertriglyceridemia
- Increased creatine kinase level
- Musculoskeletal pain
- Nausea
- Skin rash
- Upper respiratory infection
More Frequent
Severe
Less Severe
- Cardiac arrhythmia
- Hemorrhage
- Hyperbilirubinemia
- Hypersensitivity drug reaction
- Hypertension
- Hypocalcemia
- Hypophosphatemia
- Hypothyroidism
- Increased aspartate transaminase
- Influenza
- Lower respiratory infection
- Pancreatitis
- Pleural effusions
- Pneumonia
- Acute abdominal pain
- Anorexia
- Blurred vision
- Constipation
- Cough
- Dizziness
- Dry eye
- Dyspnea
- Edema
- Fever
- Hyperlipidemia
- Palpitations
- Peripheral neuropathy
- Pruritus of skin
- Urinary tract infection
- Urticaria
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Arterial thrombosis
- Myocardial ischemia
Less Severe
- None
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Asciminib
Safety and effectiveness not established in pediatric patients < 18 years.
- 1 Day – 18 Years
- Safety and effectiveness not established in pediatric patients < 18 years.
Asciminib
- Severity Level:
D
- Additional Notes: Based on drug pharmacology, developmental toxicity is possible
Contraindicated
Asciminib
Mfg does not rec during tx and for 1 week after last dose
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Mfg does not rec during tx and for 1 week after last dose |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Chronic phase philadelphia chromosome (+) CML | |
| C92.1 | Chronic myeloid leukemia, BCr/ABl-positive |
| C92.10 | Chronic myeloid leukemia, BCr/ABl-positive, not having achieved remission |
| C92.12 | Chronic myeloid leukemia, BCr/ABl-positive, in relapse |
| Chronic phase philadelphia chromosome (+) CML with t315I | |
| C92.1 | Chronic myeloid leukemia, BCr/ABl-positive |
| C92.10 | Chronic myeloid leukemia, BCr/ABl-positive, not having achieved remission |
| C92.12 | Chronic myeloid leukemia, BCr/ABl-positive, in relapse |
| 0-9 | A-Z |
|---|---|
| C92.1 | Chronic myeloid leukemia, BCr/ABl-positive |
| C92.1 | Chronic myeloid leukemia, BCr/ABl-positive |
| C92.10 | Chronic myeloid leukemia, BCr/ABl-positive, not having achieved remission |
| C92.10 | Chronic myeloid leukemia, BCr/ABl-positive, not having achieved remission |
| C92.12 | Chronic myeloid leukemia, BCr/ABl-positive, in relapse |
| C92.12 | Chronic myeloid leukemia, BCr/ABl-positive, in relapse |
Formulary Reference Tool