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LEQVIO (INCLISIRAN)
- Heterozygous familial hypercholesterolemia
- Hypercholesterolemia
- Mixed hyperlipidemia
Default screening record
- Inject 1.5 milliliters (284 mg) by subcutaneous route every 6 months in the abdomen, thigh, or outer area of upper arm (rotate sites)
- Inject 1.5 milliliters (284 mg) initially, then at 3 months, and thenevery 6 months by subcutaneous route in the abdomen, thigh, or outer area of upper arm (rotate sites)
- None
Contraindicated
- None
Severe
Moderate
- None
- None
Contraindicated
- None
Severe
Moderate
- None
LEQVIO (INCLISIRAN)
- Heterozygous familial hypercholesterolemia
- Hypercholesterolemia
- Mixed hyperlipidemia
- None
- None
More Frequent
Severe
Less Severe
- None
- None
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- None
Less Severe
- None
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
None
Inclisiran
- Severity Level:
D
- Additional Notes: Insuff human data; based on drug pharmacology dev tox possible
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- Carbamazepine may rarely cause very serious (possibly fatal) skin reactions. Some people in certain ethnic groups (such as people of Asian/South Asian descent) are at greater risk. Your doctor may order a blood test to measure your risk before you start this medication.<br /><br />If the blood test shows you are at greater risk, your doctor should discuss the risks and benefits of carbamazepine and other treatment choices with you. Such skin reactions have developed mostly within the first few months of treatment. Get medical help right away if you develop any of the following symptoms: skin rash/blisters/peeling, itching, or swelling.<br /><br />Ask your doctor or pharmacist for more details. This drug has rarely caused very serious blood disorders (aplastic anemia, agranulocytosis). Your doctor will monitor your blood counts to minimize the chance of these side effects.<br /><br />Keep all medical and lab appointments. Get medical help right away if any of these rare but very serious side effects occur: signs of infection (such as sore throat that doesn't go away, fever, swollen lymph nodes), unusual weakness/tiredness, shortness of breath, or easy bleeding/bruising.
Formulary Reference Tool