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HYDROMORPHONE HCL-WATER (hydromorphone HCl in sterile water/PF)
- Hydromorphone (pf) In Sterile Water Intravenous Pca Syringe
- Hydromorphone (pf) In Sterile Water Injection Syringe
hydromorphone (PF) 30 mg/30 mL (1 mg/mL)-water intravenous PCA syringe
- Dosage information is not available
hydromorphone (PF) 1 mg/mL in sterile water injection syringe
- Dosage information is not available
hydromorphone (PF) 2 mg/2 mL (1 mg/mL) in water injection syringe
- Dosage information is not available
- Depade
- naltrexone
- naltrexone microspheres
- Revia
- Vivitrol
Contraindicated
- sodium oxybate
- Xyrem
Severe
Moderate
- Buprenex
- buprenorphine
- buprenorphine-naloxone
- butorphanol tartrate
- Butrans
- Fanatrex
- gabapentin
- gabapentin enacarbil
- Gralise
- Gralise 30-day Starter Pack
- Horizant
- nalbuphine
- Neurontin
- Suboxone
- Zubsolv
- Sleep apnea
Contraindicated
- Acutely deteriorating asthma
- Alcohol intoxication
- Alcohol withdrawal delirium
- Benign prostatic hyperplasia
- Bradycardia
- Cardiac arrhythmia
- Coma
- Cor pulmonale
- Debilitation
- Dehydration
- Drug abuse
- Gastrointestinal tract surgery
- History of opioid overdose
- Hypotension
- Inflammatory bowel disease
- Intracranial hypertension
- Morbid obesity
- Neoplasm of brain
- Primary adrenocortical insufficiency
- Pulmonary emphysema
- Respiratory depression
- Seizure disorder
- Shock
- Suicidal ideation
- Systemic mastocytosis
- Toxic psychosis
- Ulcerative colitis
- Urethral stricture
- Urinary retention
Severe
Moderate
- Acute abdominal pain
- Biliary spasm
- Constipation
- Disease of liver
- Drug dependence
- Gallbladder disease
- Kidney disease with reduction in GFR
- Mood changes
- Untreated hypothyroidism
HYDROMORPHONE HCL-WATER (hydromorphone HCl in sterile water/PF)
- Pruritus of skin
- Anorexia
- Constipation
- Dizziness
- Drowsy
- Dysphoric mood
- Flushing
- General weakness
- Headache disorder
- Hyperhidrosis
- Hypotension
- Mood changes
- Nausea
- Vomiting
- Xerostomia
More Frequent
Severe
Less Severe
- Acute confusion
- Atelectasis
- Bradycardia
- Ileus
- Involuntary muscle movement
- Laryngismus
- Respiratory depression
- Tachycardia
- Biliary spasm
- Blurred vision
- Diplopia
- Dyspnea
- Insomnia
- Miosis
- Nervousness
- Sedation
- Syncope
- Vertigo
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Adrenal cortical insufficiency
- Allergic dermatitis
- Anaphylaxis
- Androgen deficiency
- Angioedema
- Body fluid retention
- Bronchospastic pulmonary disease
- Dehydration
- Dyskinesia
- Encephalopathy
- Extrasystoles
- Gastrointestinal hypomotility
- Hallucinations
- Hypertension
- Hyperuricemia
- Hyperventilation
- Hypogonadotropic hypogonadism
- Hypoxia
- Intracranial hypertension
- Myoclonus
- Orthostatic hypotension
- Seizure disorder
- Severe hypotension
- Skin rash
- Sleep apnea
- Suicidal ideation
- Urticaria
Less Severe
- Abdominal distension
- Abnormal sexual function
- Acute abdominal pain
- Aggressive behavior
- Agitation
- Arthralgias
- Ataxia
- Chills
- Cramps
- Depression
- Diarrhea
- Dream disorder
- Dry eye
- Dysarthria
- Dysgeusia
- Dysphagia
- Dysuria
- Edema of the oral soft tissue
- Erectile dysfunction
- Eructation
- Erythema
- Euphoria
- Flatulence
- Gastroenteritis
- Hyperreflexia
- Hypesthesia
- Increased appetite
- Increased urinary frequency
- Infertility
- Lethargy
- Libido changes
- Muscle rigidity
- Muscle spasm
- Nystagmus
- Palpitations
- Paranoid disorder
- Paresthesia
- Peripheral edema
- Sedation hangover effect
- Sneezing
- Symptoms of anxiety
- Tinnitus
- Tremor
- Urinary retention
- Weight loss
Contraindicated
None
Severe Precaution
Narcotic Analgesics, Systemic
Potential increased sensitivity to effects, adverse CNS effects and respiratory depression.
- 1 Day – 2 Years
- Potential increased sensitivity to effects, adverse CNS effects and respiratory depression.
Management or Monitoring Precaution
None
Hydromorphone
- Severity Level:
2
- Additional Notes: Neonatal withdrawal/resp.depress. w/chronic or high dose
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Hydromorphone
Limited data report adverse effects; monitor for dyspnea,feeding difficulties
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Excreted | Drug shown to have adverse effect | Limited data report adverse effects; monitor for dyspnea,feeding difficulties |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Hydromorphone (injection)
General-Consider adding naloxone Rx. Pulmonary-Life threatening respiratory depression risk with high doses, cachexia, or debilitation due to altered pharmacokinetics (poor fat stores, muscle wasting, or altered clearance). Monitor closely at initiation and dose titration. Neuro/Psych-Risk for increased confusion and delirium. May increase fall risk. Avoid treatment with 3 or more CNS active drugs. Gastrointestinal-Constipation risk. Urogenital-Urinary retention risk.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | Y | Y | Y | Y | N |
BEERS: Y HEDIS: N STOPP: Y
No Known Risk
None
- This medication comes in several strengths. Be sure you are using the correct strength. The higher strength product should only be used if you have been using opioid pain medications for a long time.<br /><br />Use of the higher strength medication by someone who is not regularly using opioid pain relievers can cause very serious (possibly fatal) breathing problems. Hydromorphone has a risk for abuse and addiction, which can lead to overdose and death. Hydromorphone may also cause severe, possibly fatal, breathing problems.<br /><br />To lower your risk, your doctor should have you use the smallest dose of hydromorphone that works, and use it for the shortest possible time. See also How to Use section for more information about addiction. The risk for severe breathing problems is higher when you start this medication and after a dose increase, or if you use the wrong dose/strength.<br /><br />Using this medication with alcohol or other drugs that can cause drowsiness or breathing problems may cause very serious side effects, including death. Be sure you know how to use hydromorphone and what other drugs you should avoid using with it. See also Drug Interactions section.<br /><br />Get medical help right away if any of these very serious side effects occur: slow/shallow breathing, unusual lightheadedness, severe drowsiness/dizziness, difficulty waking up. Keep this medicine in a safe place to prevent theft, misuse, or abuse. If someone accidentally swallows this drug, get emergency help right away.<br /><br /> Before using this medication, women of childbearing age should talk with their doctor(s) about the risks and benefits. Tell your doctor if you are pregnant or if you plan to become pregnant. During pregnancy, this medication should be used only when clearly needed.<br /><br />It may slightly increase the risk of birth defects if used during the first two months of pregnancy. Also, using it for a long time or in high doses near the expected delivery date may harm the unborn baby. To lessen the risk, use the smallest effective dose for the shortest possible time.<br /><br /> Babies born to mothers who use this drug for a long time may develop severe (possibly fatal) withdrawal symptoms. Tell the doctor right away if you notice any symptoms in your newborn baby such as crying that doesn't stop, slow/shallow breathing, irritability, shaking, vomiting, diarrhea, poor feeding, or difficulty gaining weight.
Formulary Reference Tool