PROPRANOLOL-HYDROCHLOROTHIAZID (PROPRANOLOL HCL/HYDROCHLOROTHIAZIDE)
- Hypertension
propranolol 40 mg-hydrochlorothiazide 25 mg tablet
- 1 tablet by oral route 2 times per day
propranolol 80 mg-hydrochlorothiazide 25 mg tablet
- 1 tablet by oral route 2 times per day
Hypertension
- 1 tablet by oral route 2 times per day
- dofetilide
- thioridazine
- Tikosyn
Contraindicated
- Adrenaclick
- Adrenalin
- Asthmanefrin Refill
- Asthmanefrin Starter Kit
- Auvi-q
- Bronchial Mist
- Bronchial Mist Refill
- bupivacaine-epinephrine
- bupivacaine-epinephrine (PF)
- bupivacaine-epinephrine bitart
- Catapres
- Catapres-tts-1
- Catapres-tts-2
- Catapres-tts-3
- clonidine
- clonidine (PF)
- clonidine-chlorthalidone
- Clorpres
- Corlopam
- Curad Enema
- Disposable Enema
- Duraclon (pf)
- Enema
- Enema Disposable
- epinephrine
- epinephrine (PF)
- epinephrine base (refill)
- epinephrine HCl
- Epipen
- Epipen 2-pak
- Epipen Jr
- Epipen Jr 2-pak
- fenoldopam
- fingolimod
- Fleet Enema
- Fleet Enema Extra
- Fleet Pediatric
- Gilenya
- Kapvay
- lidocaine-epinephrine
- lidocaine-epinephrine (PF)
- lidocaine-epinephrine bit
- lithium carbonate
- lithium citrate
- Lithobid
- Marcaine-epinephrine
- Marcaine-epinephrine (pf)
- methenamine mand-sod biphos
- methyldopa
- methyldopa-hydrochlorothiazide
- methyldopate
- Oral Saline Laxative
- Osmoprep
- Phosphate Laxative
- Preparation Cleansing
- racepinephrine
- Ready-to-use Enema
- Reclast
- S2 Racepinephrine
- Sensorcaine-mpf/epinephrine
- Sensorcaine/epinephrine
- sod phos mono-sod phos dibasic
- sodium phosphates
- Uroqid-acid No.2
- Xylocaine-epinephrine
- Xylocaine-mpf/epinephrine
- zoledronic acid
- zoledronic acid-mannitol-water
- Zometa
Severe
Moderate
- acarbose
- Acid Reducer (cimetidine)
- Acid Relief (cimetidine)
- Adalat Cc
- Advil
- Advil Allergy Sinus
- Advil Allergy-congestion Rlf
- Advil Cold & Sinus
- Advil Congestion Relief
- Advil Liqui-gel
- Advil Migraine
- Advil Pm
- Advil Pm Liqui-gels
- Afeditab Cr
- Alagesic Lq
- Aleve
- Aleve Cold & Sinus
- Aleve Sinus & Headache
- Aleve-d Sinus & Cold
- Aleve-d Sinus & Headache
- All Day Pain Relief
- All Day Pain Relief Sinus & Co
- All Day Relief
- Amaryl
- aminophylline
- amiodarone
- amiodarone in dextrose,iso-osm
- amobarbital
- Amytal
- Anaprox
- Anaprox Ds
- Ansaid
- Apidra
- Apidra Solostar
- Ascomp With Codeine
- Belladonna-phenobarbital
- Bidil
- Bupap
- butabarbital
- Butalbital Compound W/codeine
- Butalbital Compound-codeine
- butalbital-acetaminop-caf-cod
- butalbital-acetaminophen
- butalbital-acetaminophen-caff
- butalbital-aspirin-caffeine
- Butisol
- Calan
- Calan Sr
- Caldolor
- Capacet
- Cardizem
- Cardizem Cd
- Cardizem La
- Cartia Xt
- Child Ibuprofen
- Children's Advil
- Children's Ibu-drops
- Children's Ibuprofen
- Children's Medi-profen
- Children's Motrin
- Children's Profen Ib
- chlorphen-phenyleph-ibuprofen
- chlorphen-pseudoeph-ibuprofen
- chlorpromazine
- cholestyramine (with sugar)
- Cholestyramine Light
- cholestyramine-aspartame
- cimetidine
- codeine-butalbital-ASA-caff
- Cold & Sinus Pain Relief
- Cold-sinus Relief
- Colestid
- Colestid Flavored
- colestipol
- Cordarone
- Coumadin
- dextromethorphan-quinidine
- Diabeta
- diazoxide
- Digox
- digoxin
- Dilacor Xr
- Dilt-xr
- diltiazem HCl
- Donnatal
- dronedarone
- Duetact
- Duexis
- dyphylline
- Ec-naprosyn
- Elixophyllin
- Esgic
- Ez Use Joint-tunnel-trigger
- Feldene
- Fioricet
- Fioricet With Codeine
- Fiorinal
- Fiorinal-codeine #3
- Flanax
- flurbiprofen
- glimepiride
- glipizide
- glipizide-metformin
- Glucotrol
- Glucotrol Xl
- Glucovance
- glyburide
- glyburide micronized
- glyburide-metformin
- Glynase
- Glyset
- Heartburn Relief
- Humalog
- Humalog Kwikpen
- Humalog Mix 50-50
- Humalog Mix 50-50 Kwikpen
- Humalog Mix 75-25
- Humalog Mix 75-25 Kwikpen
- Humulin 70/30
- Humulin N
- Humulin N Kwikpen
- Humulin R
- Humulin R U-500 "Concentrated"
- hydralazine
- hydrocodone-ibuprofen
- I-prin
- Ibu-drops
- Ibudone
- ibuprofen
- Ibuprofen Cold
- Ibuprofen Cold-sinus(with Pse)
- Ibuprofen Ib
- Ibuprofen Jr Strength
- ibuprofen lysine (PF)
- Ibuprofen Pm
- ibuprofen-diphenhydramine
- ibuprofen-diphenhydramine HCl
- ibuprofen-famotidine
- ibuprofen-oxycodone
- ibuprofen-phenylephrine HCl
- Indocin
- indomethacin
- indomethacin sodium
- Infant's Ibuprofen
- Infant's Medi-profen
- Infant's Motrin
- Infants Ibu-drops
- Infants Profenib
- insulin asp prt-insulin aspart
- insulin aspart
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin lispro
- insulin lispro protam-lispro
- insulin NPH and regular human
- insulin regular hum U-500 conc
- insulin regular human
- isoniazid-rifamp-pyrazinamide
- isosorbide-hydralazine
- Jantoven
- Lanoxin
- Lanoxin Pediatric
- Lantus
- Lantus Solostar
- Levemir
- Levemir Flexpen
- lidocaine (PF)
- lidocaine in D5W (PF)
- Lufyllin
- Luminal
- Margesic
- Marten-tab
- Matzim La
- Maxalt
- Maxalt-mlt
- Medi-profen
- Mediproxen
- mefloquine
- meloxicam
- methimazole
- Midol (naproxen)
- miglitol
- Minipress
- Mobic
- Motrin Ib
- Motrin Pm
- Multaq
- Mycobutin
- Mysoline
- Naprelan Cr
- Naprosyn
- naproxen
- naproxen sodium
- naproxen-esomeprazole
- naproxen-pseudoephedrine
- nateglinide
- Nembutal Sodium
- Neoprofen (ibuprofen Lysn)(pf)
- Nexterone
- Nifedical Xl
- nifedipine
- Novolin 70/30
- Novolin N
- Novolin R
- Novolog
- Novolog Flexpen
- Novolog Mix 70-30
- Novolog Mix 70-30 Flexpen
- Novolog Penfill
- NPH insulin human recomb
- Nuedexta
- Pacerone
- pentobarbital sodium
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- pioglitazone-glimepiride
- piroxicam
- prazosin
- Precose
- Prevalite
- Priftin
- primidone
- Procardia
- Procardia Xl
- Proglycem
- propafenone
- propylthiouracil
- Provil
- pseudoephedrine-ibuprofen
- Questran
- Questran Light
- quinidine gluconate
- quinidine sulfate
- Reprexain
- rifabutin
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- rifapentine
- Rifater
- rizatriptan
- Rythmol
- secobarbital sodium
- Seconal Sodium
- Sinus & Cold-d
- Starlix
- sulindac
- Tagamet Hb
- Tapazole
- Tarka
- Taztia Xt
- Tencon
- Theo-24
- Theochron
- theophylline
- theophylline in dextrose 5 %
- Tiazac
- tolazamide
- tolbutamide
- trandolapril-verapamil
- triamcinolone-lidocaine
- verapamil
- Verelan
- Verelan Pm
- Vicoprofen
- Vimovo
- Wal-profen
- Wal-profen Cold-sinus
- Wal-proxen
- warfarin
- Xylocaine (cardiac) (pf)
- Zebutal
- zileuton
- Zyflo
- Zyflo Cr
- Acute decompensated heart failure
- Anuria
- Asthma
- Cardiogenic shock
- Complete atrioventricular block
- Pregnancy
- Second degree atrioventricular heart block
- Sinus bradycardia
Contraindicated
- Acute pancreatitis
- Azotemia
- Cerebrovascular anomaly associated with PHACE syndrome
- Chronic bronchitis
- Dehydration
- Gout
- Hepatic cirrhosis
- Hepatic failure
- Hyperuricemia
- Hypochloremic alkalosis
- Hypokalemia
- Hypomagnesemia
- Hyponatremia
- Hypovolemia
- Myasthenia gravis
- Neonatal hyperbilirubinemia
- Pulmonary emphysema
- Raynaud's phenomenon
- Secondary angle-closure glaucoma
- Severe chronic obstructive pulmonary disease
- Sick sinus syndrome
- Wolff-parkinson-white pattern
Severe
Moderate
- Basal cell carcinoma of skin
- Depression
- Diabetes mellitus
- Disease of liver
- Hypercalcemia
- Hypercholesterolemia
- Hyperparathyroidism
- Hypoglycemic disorder
- Kidney disease with reduction in GFR
- Myopathy
- Squamous cell carcinoma of skin
- Sympathectomy
- Systemic lupus erythematosus
- Tobacco smoker
PROPRANOLOL-HYDROCHLOROTHIAZID (PROPRANOLOL HCL/HYDROCHLOROTHIAZIDE)
- Hypertension
- Hypochloremic alkalosis
- Hypokalemia
- Hyponatremia
- Hypotension
- Fatigue
- General weakness
- Insomnia
More Frequent
Severe
Less Severe
- Bronchospastic pulmonary disease
- Chronic heart failure
- Depression
- Dizziness
- Hyperglycemia
- Hypomagnesemia
- Kidney disease with reduction in GFR
- Abdominal pain with cramps
- Abnormal sexual function
- Anorexia
- Constipation
- Diarrhea
- Dizziness
- Erectile dysfunction
- Fatigue
- Nausea
- Orthostatic hypotension
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute confusion
- Acute pancreatitis
- Acute respiratory distress syndrome
- Agranulocytosis
- Anaphylaxis
- Aplastic anemia
- Bradycardia
- Cardiac arrest
- Cardiac arrhythmia
- Erythema multiforme
- Exfoliative dermatitis
- Gout
- Hallucinations
- Heart block
- Hemolytic anemia
- Hepatitis
- Hypercalcemia
- Hyperparathyroidism
- Hypersensitivity angiitis
- Hyperuricemia
- Hypotension
- Idiopathic thrombocytopenic purpura
- Interstitial nephritis
- Interstitial pneumonitis
- Ischemic colitis
- Jaundice
- Laryngismus
- Leukopenia
- Lupus-like syndrome
- Myopia
- Neutropenic disorder
- Obstructive hyperbilirubinemia
- Orthostatic hypotension
- Peripheral vasoconstriction
- Peyronie's disease
- Pharyngitis
- Psoriasiform eruption
- Purpura
- Secondary angle-closure glaucoma
- Squamous cell carcinoma of skin
- Stevens-johnson syndrome
- Systemic lupus erythematosus
- Thrombocytopenic disorder
- Toxic epidermal necrolysis
- Urticaria
- Vasculitis
Less Severe
- Alopecia
- Basal cell carcinoma of skin
- Blurred vision
- Constipation
- Dream disorder
- Dry eye
- Dysgeusia
- Erectile dysfunction
- Erythema
- Fever
- Gastrointestinal irritation
- General weakness
- Headache disorder
- Hypercholesterolemia
- Hypertriglyceridemia
- Lethargy
- Mood changes
- Muscle spasm
- Nervousness
- Ocular irritation
- Paresthesia
- Sialoadenitis
- Skin rash
- Urticaria
- Vertigo
- Visual changes
- Xanthopsia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Propranolol_Hydrochlorothiazide
Risk of bronchospasm and congestive heart failure. No safety and efficacy of combination product.
- 1 Day – 18 Years
- Risk of bronchospasm and congestive heart failure. No safety and efficacy of combination product.
Hydrochlorothiazide
- Severity Level:
B
- Additional Notes: Not recommended in pre-eclampsia and other pregnancy-induced hypertension.
Propranolol
- Severity Level:
1
- Additional Notes: Fda c, reports of intrauterine growth retard;monitor fetus/infant for b-blockade
Contraindicated
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Precaution Exists
Hydrochlorothiazide
Limited amounts excreted with no known adverse effects in infant.
Insuff data available; low levels excreted; unlikely to result in adv effects
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Not known; no or inclusive data | Limited amounts excreted with no known adverse effects in infant. |
Propranolol
Limited amounts excreted with no known adverse effects in infant.
Insuff data available; low levels excreted; unlikely to result in adv effects
General | Excretion Potential | Effect on Infant | Notes |
Evaluate use carefully | Excreted | Not known; no or inclusive data | Insuff data available; low levels excreted; unlikely to result in adv effects |
No Known Risk
None
General | Excretion Potential | Effect on Infant | Notes |
None |
Contraindicated
None
Precaution Exists
Hydrochlorothiazide
Cardiovascular-Increased sensitivity to effects on blood pressure. Metabolic-More likely to develop hypokalemia, hypomagnesemia, or hyponatremia. Endocrine-May exacerbate SIADH. May worsen glucose control in patients with diabetes. Renal-Not effective with CrCL < 30mL/min.
Cardiovascular-Minimize dose to decrease dizziness and falls. Pulmonary-Use caution in COPD.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | Y | N | Y | N | N | Y |
BEERS: Y HEDIS: N STOPP: Y
Propranolol
Cardiovascular-Increased sensitivity to effects on blood pressure. Metabolic-More likely to develop hypokalemia, hypomagnesemia, or hyponatremia. Endocrine-May exacerbate SIADH. May worsen glucose control in patients with diabetes. Renal-Not effective with CrCL < 30mL/min.
Cardiovascular-Minimize dose to decrease dizziness and falls. Pulmonary-Use caution in COPD.
Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
Increased Risk / Adverse Effects | N | Y | Y | N | N | N |
BEERS: N HEDIS: N STOPP: Y
No Known Risk
None
- Do not stop using this drug without first consulting your doctor. Your condition may become worse when the drug is suddenly stopped, especially if you have chest pain (angina) or heart disease (e.g., coronary artery disease, ischemic heart disease, high blood pressure). If your doctor decides you should no longer use this drug, you must gradually decrease your dose according to your doctor's instructions.<br /><br /> When gradually stopping this medication, it is recommended that you temporarily limit physical activity to decrease strain on the heart. Seek immediate medical attention if you develop: worsening chest pain, tightness/pressure in the chest, chest pain spreading to the jaw/neck/arm, unusual sweating, trouble breathing, or fast/irregular heartbeat.
Hypertension | |
I10 | Essential (primary) hypertension |
I11 | Hypertensive heart disease |
I11.0 | Hypertensive heart disease with heart failure |
I11.9 | Hypertensive heart disease without heart failure |
I12 | Hypertensive chronic kidney disease |
I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
I13 | Hypertensive heart and chronic kidney disease |
I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
I15.1 | Hypertension secondary to other renal disorders |
0-9 | A-Z |
---|---|
I10 | Essential (primary) hypertension |
I11 | Hypertensive heart disease |
I11.0 | Hypertensive heart disease with heart failure |
I11.9 | Hypertensive heart disease without heart failure |
I12 | Hypertensive chronic kidney disease |
I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
I13 | Hypertensive heart and chronic kidney disease |
I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
I15.1 | Hypertension secondary to other renal disorders |