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GUANFACINE HCL (GUANFACINE HCL)
- Hypertension
1 mg tablet
- 1 tablet (1 mg) by oral route once daily at bedtime
2 mg tablet
- 1 tablet (2 mg) by oral route once daily at bedtime
guanfacine 1 mg tablet
- 1 tablet (1 mg) by oral route once daily at bedtime
guanfacine 2 mg tablet
- 1 tablet (2 mg) by oral route once daily at bedtime
Hypertension
- 1 tablet (1 mg) by oral route once daily at bedtime
- 2 tablets (2 mg) by oral route once daily at bedtime
- 1 tablet (2 mg) by oral route once daily at bedtime
- 3 tablets (3 mg) by oral route once daily at bedtime
- None
Contraindicated
- amoxicil-clarithromy-lansopraz
- Aptivus
- B cplx-C-St.Johnwrt-K.&S.ginsg
- Belladonna-phenobarbital
- Biaxin
- Biaxin Xl
- Biaxin Xl Pak
- boceprevir
- calcium-mag-B complex-D3-hrb61
- carbamazepine
- Carbatrol
- Cerebyx
- clarithromycin
- Cold & Flu Fighter
- conivaptan in 5 % dextrose
- Crixivan
- Dilantin
- Dilantin Extended
- Dilantin Infatabs
- Dilantin Kapseal
- Dilantin-125
- Donnatal
- elvitegr-cobicist-emtric-tenof
- enzalutamide
- Epitol
- Equetro
- Fatigue Relief Complex
- fosphenytoin
- Incivek
- indinavir
- Invirase
- isoniazid-rifamp-pyrazinamide
- itraconazole
- Kaletra
- Ketek
- ketoconazole
- lopinavir-ritonavir
- Luminal
- Mysoline
- nefazodone
- nelfinavir
- Norvir
- Norvir Soft Gelatin
- Noxafil
- Omeclamox-pak
- omeprazole-clarith-amoxicillin
- Onmel
- phenobarb-hyoscy-atropine-scop
- phenobarbital
- phenobarbital sodium
- Phenytek
- phenytoin
- phenytoin sodium
- phenytoin sodium extended
- posaconazole
- Prevpac
- primidone
- Rifadin
- Rifamate
- rifampin
- rifampin-isoniazid
- Rifater
- ritonavir
- saquinavir mesylate
- Sporanox
- Sporanox Pulsepak
- St. John's wort
- Stribild
- Tegretol
- Tegretol Xr
- telaprevir
- telithromycin
- tipranavir
- Vaprisol
- Vfend
- Vfend Iv
- Victrelis
- Viracept
- vit C-St. John wort-elder-hb30
- voriconazole
- Women's Complex
- Xtandi
Severe
Moderate
- None
- None
Contraindicated
- Bradycardia
- Hypotension
- Suicidal ideation
Severe
Moderate
- Alcohol intoxication
- Drowsy
- Orthostatic hypotension
GUANFACINE HCL (GUANFACINE HCL)
- Hypertension
- None
- Drowsy
- Fatigue
- Sedation
- Weight gain
- Xerostomia
More Frequent
Severe
Less Severe
- None
- Acute confusion
- Anorexia
- Constipation
- Dizziness
- Dyspepsia
- Erectile dysfunction
- General weakness
- Headache disorder
- Hypotension
- Increased urinary frequency
- Insomnia
- Irritability
- Lethargy
- Libido changes
- Nausea
- Nightmares
- Palpitations
- Urinary incontinence
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Atrioventricular block
- Bradycardia
- Chest pain
- Encephalopathy
- Exfoliative dermatitis
- Hypersensitivity drug reaction
- Seizure disorder
- Sinus node dysfunction
- Suicidal
- Suicidal ideation
- Tachycardia
Less Severe
- Acute abdominal pain
- Alopecia
- Arthralgias
- Blurred vision
- Conjunctivitis
- Cramps in legs
- Depression
- Dysgeusia
- Dyspnea
- Edema
- Hallucinations
- Malaise
- Myalgias
- Pallor
- Paresthesia
- Pruritus of skin
- Raynaud's phenomenon
- Skin inflammation
- Skin rash
- Symptoms of anxiety
- Syncope
- Tremor
- Vertigo
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Guanfacine
Long acting dose form approved age >5 years. Reports of aggression, manic behavior, hallucinations, suicide. Safety and effectiveness not established.
- 1 Day – 12 Years
- Long acting dose form approved age >5 years. Reports of aggression, manic behavior, hallucinations, suicide. Safety and effectiveness not established.
Guanfacine Hydrochloride
- Severity Level:
B
- Additional Notes:
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Guanfacine Hydrochloride
Excreted in rat studies. decreases prolactin concentration in serum
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Excreted in rat studies. decreases prolactin concentration in serum |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Guanfacine
Cardiovascular-More sensitive to bradycardia and orthostatic hypotension. Neuro/Psych-May be highly sedating. May exacerbate pre-existing depression. Renal-Use caution with renal impairment; monitor blood pressure closely.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | Y | Y | Y | Y | N | N |
BEERS: Y HEDIS: Y STOPP: Y
No Known Risk
None
- None
| Hypertension | |
| I10 | Essential (primary) hypertension |
| I11 | Hypertensive heart disease |
| I11.0 | Hypertensive heart disease with heart failure |
| I11.9 | Hypertensive heart disease without heart failure |
| I12 | Hypertensive chronic kidney disease |
| I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
| I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13 | Hypertensive heart and chronic kidney disease |
| I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
| I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
| I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
| I15.1 | Hypertension secondary to other renal disorders |
| 0-9 | A-Z |
|---|---|
| I10 | Essential (primary) hypertension |
| I11 | Hypertensive heart disease |
| I11.0 | Hypertensive heart disease with heart failure |
| I11.9 | Hypertensive heart disease without heart failure |
| I12 | Hypertensive chronic kidney disease |
| I12.0 | Hypertensive chronic kidney disease with stage 5 chronic kidney disease or end stage renal disease |
| I12.9 | Hypertensive chronic kidney disease with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13 | Hypertensive heart and chronic kidney disease |
| I13.0 | Hypertensive heart and chronic kidney disease with heart failure and stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.1 | Hypertensive heart and chronic kidney disease without heart failure |
| I13.10 | Hypertensive heart and chronic kidney disease without heart failure, with stage 1 through stage 4 chronic kidney disease, or unspecified chronic kidney disease |
| I13.11 | Hypertensive heart and chronic kidney disease without heart failure, with stage 5 chronic kidney disease, or end stage renal disease |
| I13.2 | Hypertensive heart and chronic kidney disease with heart failure and with stage 5 chronic kidney disease, or end stage renal disease |
| I15.1 | Hypertension secondary to other renal disorders |
Formulary Reference Tool