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FROVATRIPTAN SUCCINATE (FROVATRIPTAN SUCCINATE)
- Migraine
2.5 mg tablet
- 1 tablet (2.5 mg) by oral route once with fluids; if headache returns, may repeat after at least 2 hours, max 3 tablets (7.5 mg)/24Hrs
frovatriptan 2.5 mg tablet
- 1 tablet (2.5 mg) by oral route once with fluids; if headache returns, may repeat after at least 2 hours, max 3 tablets (7.5 mg)/24Hrs
2.5 mg tablet
- 1 tablet (2.5 mg) by oral route once with fluids; if headache returns, may repeat after at least 2 hours, max 3 tablets (7.5 mg)/24Hrs
Migraine
- 1 tablet (2.5 mg) by oral route once with fluids; if headache returns, dose may be repeated at least 2 hours after the first dose, notto exceed 3 tablets (3 x 2.5 mg) in 24Hrs
- 1 tablet (2.5 mg) by oral route once with fluids; if headache returns, may repeat after at least 2 hours, max 3 tablets (7.5 mg)/24Hrs
- bromocriptine
- Cafergot
- Cycloset
- D.h.e.45
- dihydroergotamine
- ergoloid
- Ergomar
- ergotamine tartrate
- ergotamine-caffeine
- methylergonovine
- Migergot
- Migranal
- Parlodel
Contraindicated
- Conzip
- Nucynta
- Nucynta Er
- Synapryn
- tapentadol
- tramadol
- tramadol-acetaminophen
- tramadol-glucosamine
- Ultracet
- Ultram
- Ultram Er
Severe
Moderate
- Azilect
- Brintellix
- Brisdelle
- Celexa
- citalopram
- Cymbalta
- desvenlafaxine
- desvenlafaxine fumarate
- desvenlafaxine succinate
- duloxetine
- Effexor Xr
- Eldepryl
- escitalopram oxalate
- Fetzima
- fluoxetine
- fluvoxamine
- isocarboxazid
- Khedezla
- levomilnacipran
- Lexapro
- linezolid
- Luvox Cr
- Marplan
- Matulane
- methylene blue (antidote)
- milnacipran
- Nardil
- olanzapine-fluoxetine
- Parnate
- paroxetine HCl
- paroxetine mesylate
- Paxil
- Paxil Cr
- Pexeva
- phenelzine
- Pristiq
- procarbazine
- Prozac
- Prozac Weekly
- rasagiline
- Sarafem
- Savella
- selegiline HCl
- sertraline
- Symbyax
- tranylcypromine
- venlafaxine
- Viibryd
- vilazodone
- vortioxetine
- Zelapar
- Zoloft
- Zyvox
- Angina
- Cerebral ischemia
- Cerebrovascular accident
- Coronary artery disease
- Coronary artery spasm
- Hemiplegic migraine
- Ischemic bowel disease
- Myocardial ischemia
- Peripheral vascular disease
- Prinzmetal angina
- Serotonin syndrome
- Severe uncontrolled hypertension
Contraindicated
- Cardiac arrhythmia
- Hypertension
- Increased cardiovascular event risk
Severe
Moderate
- Raynaud's phenomenon
FROVATRIPTAN SUCCINATE (FROVATRIPTAN SUCCINATE)
- Migraine
- Chest pain
- Bone pain
- Dizziness
- Dyspepsia
- Fatigue
- Flushing
- Headache disorder
- Paresthesia
- Sensation of cold
- Sensation of warmth
- Xerostomia
More Frequent
Severe
Less Severe
- Anaphylaxis
- Angioedema
- Peripheral ischemia
- Acute abdominal pain
- Diarrhea
- Drowsy
- Dysesthesia
- Hyperhidrosis
- Hypesthesia
- Insomnia
- Jaw pain
- Nausea
- Neck pain
- Palpitations
- Rhinitis
- Sinusitis
- Sore throat
- Symptoms of anxiety
- Tinnitus
- Visual changes
- Vomiting
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- Acute myocardial infarction
- Seizure disorder
- Serotonin syndrome
- Ventricular fibrillation
- Ventricular tachycardia
Less Severe
- Hypertension
- Medication overuse headache
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Frovatriptan
No pediatric safety and efficacy established.
- 1 Day – 18 Years
- No pediatric safety and efficacy established.
Frovatriptan
- Severity Level:
2
- Additional Notes:
Contraindicated
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Precaution Exists
Frovatriptan
Insufficient human data; excreted in rats
| General | Excretion Potential | Effect on Infant | Notes |
| Evaluate use carefully | Unknown | Not known; no or inclusive data | Insufficient human data; excreted in rats |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
Frovatriptan
Hepatic-Elderly patients are more likely to have decreased hepatic function thus potentially decreasing drug clearance. Mean AUC was 1.5 to 2-fold higher in elderly. Cardiovascular-Hypertensive effects may be more pronounced in the elderly and increase the risk for cardiovascular events in those with cardiovascular disease. Avoid use of the drug in patient with any cerebrovascular syndrome.
| Organ / System | HEP | REN | CARD | ENDO | NEURO / PSYCH | PULM |
| Increased Risk / Adverse Effects | N | N | Y | N | N | N |
BEERS: N HEDIS: N STOPP: N
No Known Risk
None
- None
| Migraine | |
| G43 | Migraine |
| G43.0 | Migraine without aura |
| G43.00 | Migraine without aura, not intractable |
| G43.001 | Migraine without aura, not intractable, with status migrainosus |
| G43.009 | Migraine without aura, not intractable, without status migrainosus |
| G43.01 | Migraine without aura, intractable |
| G43.011 | Migraine without aura, intractable, with status migrainosus |
| G43.019 | Migraine without aura, intractable, without status migrainosus |
| G43.1 | Migraine with aura |
| G43.10 | Migraine with aura, not intractable |
| G43.101 | Migraine with aura, not intractable, with status migrainosus |
| G43.109 | Migraine with aura, not intractable, without status migrainosus |
| G43.11 | Migraine with aura, intractable |
| G43.111 | Migraine with aura, intractable, with status migrainosus |
| G43.119 | Migraine with aura, intractable, without status migrainosus |
| G43.4 | Hemiplegic migraine |
| G43.40 | Hemiplegic migraine, not intractable |
| G43.41 | Hemiplegic migraine, intractable |
| G43.7 | Chronic migraine without aura |
| G43.70 | Chronic migraine without aura, not intractable |
| G43.701 | Chronic migraine without aura, not intractable, with status migrainosus |
| G43.709 | Chronic migraine without aura, not intractable, without status migrainosus |
| G43.71 | Chronic migraine without aura, intractable |
| G43.711 | Chronic migraine without aura, intractable, with status migrainosus |
| G43.719 | Chronic migraine without aura, intractable, without status migrainosus |
| G43.8 | Other migraine |
| G43.80 | Other migraine, not intractable |
| G43.801 | Other migraine, not intractable, with status migrainosus |
| G43.809 | Other migraine, not intractable, without status migrainosus |
| G43.81 | Other migraine, intractable |
| G43.811 | Other migraine, intractable, with status migrainosus |
| G43.819 | Other migraine, intractable, without status migrainosus |
| G43.82 | Menstrual migraine, not intractable |
| G43.821 | Menstrual migraine, not intractable, with status migrainosus |
| G43.829 | Menstrual migraine, not intractable, without status migrainosus |
| G43.83 | Menstrual migraine, intractable |
| G43.831 | Menstrual migraine, intractable, with status migrainosus |
| G43.839 | Menstrual migraine, intractable, without status migrainosus |
| G43.9 | Migraine, unspecified |
| G43.90 | Migraine, unspecified, not intractable |
| G43.901 | Migraine, unspecified, not intractable, with status migrainosus |
| G43.909 | Migraine, unspecified, not intractable, without status migrainosus |
| G43.91 | Migraine, unspecified, intractable |
| G43.911 | Migraine, unspecified, intractable, with status migrainosus |
| G43.919 | Migraine, unspecified, intractable, without status migrainosus |
| G43.B | Ophthalmoplegic migraine |
| G43.B0 | Ophthalmoplegic migraine, not intractable |
| G43.B1 | Ophthalmoplegic migraine, intractable |
| G43.C | Periodic headache syndromes in child or adult |
| G43.C0 | Periodic headache syndromes in child or adult, not intractable |
| G43.C1 | Periodic headache syndromes in child or adult, intractable |
| G43.D | Abdominal migraine |
| G43.D0 | Abdominal migraine, not intractable |
| G43.D1 | Abdominal migraine, intractable |
| 0-9 | A-Z |
|---|---|
| G43 | Migraine |
| G43.0 | Migraine without aura |
| G43.00 | Migraine without aura, not intractable |
| G43.001 | Migraine without aura, not intractable, with status migrainosus |
| G43.009 | Migraine without aura, not intractable, without status migrainosus |
| G43.01 | Migraine without aura, intractable |
| G43.011 | Migraine without aura, intractable, with status migrainosus |
| G43.019 | Migraine without aura, intractable, without status migrainosus |
| G43.1 | Migraine with aura |
| G43.10 | Migraine with aura, not intractable |
| G43.101 | Migraine with aura, not intractable, with status migrainosus |
| G43.109 | Migraine with aura, not intractable, without status migrainosus |
| G43.11 | Migraine with aura, intractable |
| G43.111 | Migraine with aura, intractable, with status migrainosus |
| G43.119 | Migraine with aura, intractable, without status migrainosus |
| G43.4 | Hemiplegic migraine |
| G43.40 | Hemiplegic migraine, not intractable |
| G43.41 | Hemiplegic migraine, intractable |
| G43.7 | Chronic migraine without aura |
| G43.70 | Chronic migraine without aura, not intractable |
| G43.701 | Chronic migraine without aura, not intractable, with status migrainosus |
| G43.709 | Chronic migraine without aura, not intractable, without status migrainosus |
| G43.71 | Chronic migraine without aura, intractable |
| G43.711 | Chronic migraine without aura, intractable, with status migrainosus |
| G43.719 | Chronic migraine without aura, intractable, without status migrainosus |
| G43.8 | Other migraine |
| G43.80 | Other migraine, not intractable |
| G43.801 | Other migraine, not intractable, with status migrainosus |
| G43.809 | Other migraine, not intractable, without status migrainosus |
| G43.81 | Other migraine, intractable |
| G43.811 | Other migraine, intractable, with status migrainosus |
| G43.819 | Other migraine, intractable, without status migrainosus |
| G43.82 | Menstrual migraine, not intractable |
| G43.821 | Menstrual migraine, not intractable, with status migrainosus |
| G43.829 | Menstrual migraine, not intractable, without status migrainosus |
| G43.83 | Menstrual migraine, intractable |
| G43.831 | Menstrual migraine, intractable, with status migrainosus |
| G43.839 | Menstrual migraine, intractable, without status migrainosus |
| G43.9 | Migraine, unspecified |
| G43.90 | Migraine, unspecified, not intractable |
| G43.901 | Migraine, unspecified, not intractable, with status migrainosus |
| G43.909 | Migraine, unspecified, not intractable, without status migrainosus |
| G43.91 | Migraine, unspecified, intractable |
| G43.911 | Migraine, unspecified, intractable, with status migrainosus |
| G43.919 | Migraine, unspecified, intractable, without status migrainosus |
| G43.B | Ophthalmoplegic migraine |
| G43.B0 | Ophthalmoplegic migraine, not intractable |
| G43.B1 | Ophthalmoplegic migraine, intractable |
| G43.C | Periodic headache syndromes in child or adult |
| G43.C0 | Periodic headache syndromes in child or adult, not intractable |
| G43.C1 | Periodic headache syndromes in child or adult, intractable |
| G43.D | Abdominal migraine |
| G43.D0 | Abdominal migraine, not intractable |
| G43.D1 | Abdominal migraine, intractable |
Formulary Reference Tool