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FLUOROURACIL (FLUOROURACIL)
- Actinic keratosis
- Superficial basal cell carcinoma
2 % topical solution
- Apply a sufficient amount to cover the lesions in the affected area(s) by topical route 2 times per day
5 % topical solution
- Apply a sufficient amount to cover the lesions in the affected area(s) by topical route 2 times per day
0.5 % topical cream
- Apply a thin layer to the affected area(s) by topical route once daily
1 % topical cream
- Apply a sufficient amount to cover the lesions in the affected area(s) by topical route 2 times per day
4 % topical cream
- Apply a sufficient amount to cover the lesions in the affected area(s) by topical route once daily for 4 weeks
5 % topical cream
- Apply a sufficient amount to cover the lesions in the affected area(s) by topical route 2 times per day
5 % topical cream
- Apply a sufficient amount to cover the lesions in the affected area(s) by topical route 2 times per day
Actinic keratosis
- Apply a sufficient amount to cover the lesions in the affected area(s) by topical route 2 times per day
- Apply a sufficient amount to cover the lesions in the affected area(s) by topical route 2 times per day for 2 weeks
- Apply a sufficient amount to cover the lesions in the affected area(s) by topical route 2 times per day for 6 weeks
Superficial basal cell carcinoma
- Apply a sufficient amount to cover the lesions in the affected area(s) by topical route 2 times per day
- Apply a sufficient amount to cover the lesions in the affected area(s) by topical route 2 times per day for 6 weeks
- Apply a sufficient amount to cover the lesions in the affected area(s) by topical route 2 times per day for 3 weeks
- Apply a sufficient amount to cover the lesions in the affected area(s) by topical route 2 times per day for 12 weeks
- None
Contraindicated
- None
Severe
Moderate
- None
- Dihydropyrimidine dehydrogenase deficiency
- Lactating mother
- Pregnancy
Contraindicated
- None
Severe
Moderate
- None
FLUOROURACIL (FLUOROURACIL)
- Actinic keratosis
- Superficial basal cell carcinoma
- Dermatitis due to topical drug
- Pruritus of skin
- Skin rash
- Paresthesia
- Skin photosensitivity
More Frequent
Severe
Less Severe
- None
- Pain
Less Frequent
Severe
Less Severe
Rare / Very Rare
Severe
- None
Less Severe
- Dyschromia
- Eye tearing
- Skin scaling
- Skin thickening
- Telangiectasia
Contraindicated
None
Severe Precaution
None
Management or Monitoring Precaution
Fluorouracil (Topical)
Safety and efficacy not established. Actinic keratosis rare in pediatrics.
- 1 Day – 18 Years
- Safety and efficacy not established. Actinic keratosis rare in pediatrics.
Fluorouracil (topical)
- Severity Level:
X
- Additional Notes:
Contraindicated
Fluorouracil (topical)
Some systemic absorption with topical use;Potential severe adverse effects.
| General | Excretion Potential | Effect on Infant | Notes |
| Drug should not be given to breast feeding mothers | Unknown | Not known; no or inclusive data | Some systemic absorption with topical use;Potential severe adverse effects. |
Precaution Exists
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
No Known Risk
None
| General | Excretion Potential | Effect on Infant | Notes |
| None |
Contraindicated
None
Precaution Exists
None
No Known Risk
None
- None
| Actinic keratosis | |
| L57.0 | Actinic keratosis |
| Superficial basal cell carcinoma | |
| C44.01 | Basal cell carcinoma of skin of lip |
| C44.11 | Basal cell carcinoma of skin of eyelid, including canthus |
| C44.111 | Basal cell carcinoma of skin of unspecified eyelid, including canthus |
| C44.112 | Basal cell carcinoma of skin of right eyelid, including canthus |
| C44.1121 | Basal cell carcinoma of skin of right upper eyelid, including canthus |
| C44.1122 | Basal cell carcinoma of skin of right lower eyelid, including canthus |
| C44.119 | Basal cell carcinoma of skin of left eyelid, including canthus |
| C44.1191 | Basal cell carcinoma of skin of left upper eyelid, including canthus |
| C44.1192 | Basal cell carcinoma of skin of left lower eyelid, including canthus |
| C44.21 | Basal cell carcinoma of skin of ear and external auricular canal |
| C44.211 | Basal cell carcinoma of skin of unspecified ear and external auricular canal |
| C44.212 | Basal cell carcinoma of skin of right ear and external auricular canal |
| C44.219 | Basal cell carcinoma of skin of left ear and external auricular canal |
| C44.31 | Basal cell carcinoma of skin of other and unspecified parts of face |
| C44.310 | Basal cell carcinoma of skin of unspecified parts of face |
| C44.311 | Basal cell carcinoma of skin of nose |
| C44.319 | Basal cell carcinoma of skin of other parts of face |
| C44.41 | Basal cell carcinoma of skin of scalp and neck |
| C44.51 | Basal cell carcinoma of skin of trunk |
| C44.510 | Basal cell carcinoma of anal skin |
| C44.511 | Basal cell carcinoma of skin of breast |
| C44.519 | Basal cell carcinoma of skin of other part of trunk |
| C44.61 | Basal cell carcinoma of skin of upper limb, including shoulder |
| C44.611 | Basal cell carcinoma of skin of unspecified upper limb, including shoulder |
| C44.612 | Basal cell carcinoma of skin of right upper limb, including shoulder |
| C44.619 | Basal cell carcinoma of skin of left upper limb, including shoulder |
| C44.71 | Basal cell carcinoma of skin of lower limb, including hip |
| C44.711 | Basal cell carcinoma of skin of unspecified lower limb, including hip |
| C44.712 | Basal cell carcinoma of skin of right lower limb, including hip |
| C44.719 | Basal cell carcinoma of skin of left lower limb, including hip |
| C44.81 | Basal cell carcinoma of overlapping sites of skin |
| C44.91 | Basal cell carcinoma of skin, unspecified |
| 0-9 | A-Z |
|---|---|
| C44.01 | Basal cell carcinoma of skin of lip |
| C44.11 | Basal cell carcinoma of skin of eyelid, including canthus |
| C44.111 | Basal cell carcinoma of skin of unspecified eyelid, including canthus |
| C44.112 | Basal cell carcinoma of skin of right eyelid, including canthus |
| C44.1121 | Basal cell carcinoma of skin of right upper eyelid, including canthus |
| C44.1122 | Basal cell carcinoma of skin of right lower eyelid, including canthus |
| C44.119 | Basal cell carcinoma of skin of left eyelid, including canthus |
| C44.1191 | Basal cell carcinoma of skin of left upper eyelid, including canthus |
| C44.1192 | Basal cell carcinoma of skin of left lower eyelid, including canthus |
| C44.21 | Basal cell carcinoma of skin of ear and external auricular canal |
| C44.211 | Basal cell carcinoma of skin of unspecified ear and external auricular canal |
| C44.212 | Basal cell carcinoma of skin of right ear and external auricular canal |
| C44.219 | Basal cell carcinoma of skin of left ear and external auricular canal |
| C44.31 | Basal cell carcinoma of skin of other and unspecified parts of face |
| C44.310 | Basal cell carcinoma of skin of unspecified parts of face |
| C44.311 | Basal cell carcinoma of skin of nose |
| C44.319 | Basal cell carcinoma of skin of other parts of face |
| C44.41 | Basal cell carcinoma of skin of scalp and neck |
| C44.51 | Basal cell carcinoma of skin of trunk |
| C44.510 | Basal cell carcinoma of anal skin |
| C44.511 | Basal cell carcinoma of skin of breast |
| C44.519 | Basal cell carcinoma of skin of other part of trunk |
| C44.61 | Basal cell carcinoma of skin of upper limb, including shoulder |
| C44.611 | Basal cell carcinoma of skin of unspecified upper limb, including shoulder |
| C44.612 | Basal cell carcinoma of skin of right upper limb, including shoulder |
| C44.619 | Basal cell carcinoma of skin of left upper limb, including shoulder |
| C44.71 | Basal cell carcinoma of skin of lower limb, including hip |
| C44.711 | Basal cell carcinoma of skin of unspecified lower limb, including hip |
| C44.712 | Basal cell carcinoma of skin of right lower limb, including hip |
| C44.719 | Basal cell carcinoma of skin of left lower limb, including hip |
| C44.81 | Basal cell carcinoma of overlapping sites of skin |
| C44.91 | Basal cell carcinoma of skin, unspecified |
| L57.0 | Actinic keratosis |
Formulary Reference Tool